YGL119W / COQ8

Protein required for ubiquinone biosynthesis and respiratory growth; exhibits genetic interaction with COQ9, suggesting a common function; similar to prokaryotic proteins involved in early steps of ubiquinone biosynthesis; COQ8 has a paralog, YBR230W-A, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL119W / COQ8

Click on Significant Values for Screen Details ID:SGTC_36|Compound:0335-0881|FD-Score:12.60|P-value:9.87E-32 ID:SGTC_64|Compound:000l-0018|FD-Score:30.30|P-value:4.08E-172 ID:SGTC_67|Compound:0335-0847|FD-Score:13.40|P-value:8.47E-36 ID:SGTC_86|Compound:0417-1630|FD-Score:19.10|P-value:4.37E-70 ID:SGTC_119|Compound:0121-0043|FD-Score:5.34|P-value:3.40E-7 ID:SGTC_134|Compound:0269-0018|FD-Score:20.30|P-value:4.58E-79 ID:SGTC_137|Compound:0438-0332|FD-Score:8.71|P-value:3.31E-16 ID:SGTC_142|Compound:0335-0849|FD-Score:28.00|P-value:9.41E-148 ID:SGTC_158|Compound:k038-0087|FD-Score:22.60|P-value:1.83E-97 ID:SGTC_165|Compound:k038-0023|FD-Score:7.12|P-value:1.97E-11 ID:SGTC_168|Compound:3970-0862|FD-Score:4.78|P-value:4.25E-6 ID:SGTC_197|Compound:4544-0043|FD-Score:-3.65|P-value:4.41E-4 ID:SGTC_200|Compound:k038-0079|FD-Score:10.00|P-value:8.07E-21 ID:SGTC_216|Compound:k038-0035|FD-Score:12.70|P-value:2.14E-32 ID:SGTC_236|Compound:1509-0011|FD-Score:19.80|P-value:4.06E-75 ID:SGTC_275|Compound:trichlorophene|FD-Score:4.87|P-value:2.91E-6 ID:SGTC_294|Compound:k038-0071|FD-Score:6.05|P-value:9.68E-9 ID:SGTC_340|Compound:k038-0059|FD-Score:9.29|P-value:3.64E-18 ID:SGTC_365|Compound:0121-0052|FD-Score:4.99|P-value:1.74E-6 ID:SGTC_367|Compound:0335-0881|FD-Score:8.13|P-value:2.41E-14 ID:SGTC_386|Compound:1509-0011|FD-Score:13.10|P-value:4.47E-34 ID:SGTC_635|Compound:k038-0028|FD-Score:6.63|P-value:3.73E-10 ID:SGTC_649|Compound:1123-0311|FD-Score:-3.70|P-value:3.80E-4 ID:SGTC_759|Compound:3486-0358|FD-Score:3.45|P-value:6.43E-4 ID:SGTC_770|Compound:0389-1121|FD-Score:-3.79|P-value:2.77E-4 ID:SGTC_777|Compound:1315-0167|FD-Score:4.72|P-value:5.66E-6 ID:SGTC_794|Compound:k038-0031|FD-Score:13.50|P-value:5.24E-36 ID:SGTC_816|Compound:0325-0417|FD-Score:3.41|P-value:7.16E-4 ID:SGTC_824|Compound:1304-0008|FD-Score:4.26|P-value:3.58E-5 ID:SGTC_872|Compound:0588-0139|FD-Score:3.91|P-value:1.31E-4 ID:SGTC_1061|Compound:3448-9325|FD-Score:3.53|P-value:4.82E-4 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:4.78|P-value:4.21E-6 ID:SGTC_1221|Compound:2958-7315|FD-Score:4.17|P-value:5.04E-5 ID:SGTC_1377|Compound:2944-0135|FD-Score:3.35|P-value:8.61E-4 ID:SGTC_1445|Compound:4239-0156|FD-Score:4.03|P-value:8.60E-5 ID:SGTC_1447|Compound:4239-0816|FD-Score:3.47|P-value:6.02E-4 ID:SGTC_1479|Compound:0549-0158|FD-Score:4.11|P-value:6.38E-5 ID:SGTC_1516|Compound:st013856|FD-Score:-4.62|P-value:1.23E-5 ID:SGTC_1635|Compound:st007035|FD-Score:34.40|P-value:1.15E-221 ID:SGTC_1637|Compound:st007924|FD-Score:-4.36|P-value:3.52E-5 ID:SGTC_1686|Compound:st019653|FD-Score:4.90|P-value:2.52E-6 ID:SGTC_1693|Compound:xanthone|FD-Score:3.63|P-value:3.49E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-3.55|P-value:6.15E-4 ID:SGTC_1754|Compound:st042065|FD-Score:-6.36|P-value:2.94E-9 ID:SGTC_1800|Compound:st050079|FD-Score:-3.75|P-value:3.22E-4 ID:SGTC_1818|Compound:st052136|FD-Score:-4.30|P-value:4.43E-5 ID:SGTC_1874|Compound:staurosporine|FD-Score:3.36|P-value:8.48E-4 ID:SGTC_2111|Compound:5486399|FD-Score:4.01|P-value:9.36E-5 ID:SGTC_2295|Compound:7971645|FD-Score:3.58|P-value:4.08E-4 ID:SGTC_2393|Compound:9031399|FD-Score:3.44|P-value:6.50E-4 ID:SGTC_2506|Compound:ethyl hematommate|FD-Score:4.12|P-value:6.08E-5 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:-3.46|P-value:8.17E-4 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:-4.18|P-value:6.92E-5 ID:SGTC_2611|Compound:pyromycin|FD-Score:3.63|P-value:3.51E-4 ID:SGTC_2698|Compound:st077697|FD-Score:-3.94|P-value:1.62E-4 ID:SGTC_2996|Compound:9066192|FD-Score:4.37|P-value:2.35E-5 ID:SGTC_3155|Compound:9099265|FD-Score:3.79|P-value:2.01E-4 ID:SGTC_3170|Compound:9103054|FD-Score:3.87|P-value:1.54E-4 ID:SGTC_3200|Compound:9114385|FD-Score:3.55|P-value:4.60E-4 ID:SGTC_3278|Compound:9139605|FD-Score:3.36|P-value:8.41E-4 ID:SGTC_3320|Compound:9137005|FD-Score:3.56|P-value:4.41E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:12.60|P-value:9.87E-32 ID:SGTC_64|Compound:000l-0018|FD-Score:30.30|P-value:4.08E-172 ID:SGTC_67|Compound:0335-0847|FD-Score:13.40|P-value:8.47E-36 ID:SGTC_86|Compound:0417-1630|FD-Score:19.10|P-value:4.37E-70 ID:SGTC_119|Compound:0121-0043|FD-Score:5.34|P-value:3.40E-7 ID:SGTC_134|Compound:0269-0018|FD-Score:20.30|P-value:4.58E-79 ID:SGTC_137|Compound:0438-0332|FD-Score:8.71|P-value:3.31E-16 ID:SGTC_142|Compound:0335-0849|FD-Score:28.00|P-value:9.41E-148 ID:SGTC_158|Compound:k038-0087|FD-Score:22.60|P-value:1.83E-97 ID:SGTC_165|Compound:k038-0023|FD-Score:7.12|P-value:1.97E-11 ID:SGTC_168|Compound:3970-0862|FD-Score:4.78|P-value:4.25E-6 ID:SGTC_197|Compound:4544-0043|FD-Score:-3.65|P-value:4.41E-4 ID:SGTC_200|Compound:k038-0079|FD-Score:10.00|P-value:8.07E-21 ID:SGTC_216|Compound:k038-0035|FD-Score:12.70|P-value:2.14E-32 ID:SGTC_236|Compound:1509-0011|FD-Score:19.80|P-value:4.06E-75 ID:SGTC_275|Compound:trichlorophene|FD-Score:4.87|P-value:2.91E-6 ID:SGTC_294|Compound:k038-0071|FD-Score:6.05|P-value:9.68E-9 ID:SGTC_340|Compound:k038-0059|FD-Score:9.29|P-value:3.64E-18 ID:SGTC_365|Compound:0121-0052|FD-Score:4.99|P-value:1.74E-6 ID:SGTC_367|Compound:0335-0881|FD-Score:8.13|P-value:2.41E-14 ID:SGTC_386|Compound:1509-0011|FD-Score:13.10|P-value:4.47E-34 ID:SGTC_635|Compound:k038-0028|FD-Score:6.63|P-value:3.73E-10 ID:SGTC_649|Compound:1123-0311|FD-Score:-3.70|P-value:3.80E-4 ID:SGTC_759|Compound:3486-0358|FD-Score:3.45|P-value:6.43E-4 ID:SGTC_770|Compound:0389-1121|FD-Score:-3.79|P-value:2.77E-4 ID:SGTC_777|Compound:1315-0167|FD-Score:4.72|P-value:5.66E-6 ID:SGTC_794|Compound:k038-0031|FD-Score:13.50|P-value:5.24E-36 ID:SGTC_816|Compound:0325-0417|FD-Score:3.41|P-value:7.16E-4 ID:SGTC_824|Compound:1304-0008|FD-Score:4.26|P-value:3.58E-5 ID:SGTC_872|Compound:0588-0139|FD-Score:3.91|P-value:1.31E-4 ID:SGTC_1061|Compound:3448-9325|FD-Score:3.53|P-value:4.82E-4 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:4.78|P-value:4.21E-6 ID:SGTC_1221|Compound:2958-7315|FD-Score:4.17|P-value:5.04E-5 ID:SGTC_1377|Compound:2944-0135|FD-Score:3.35|P-value:8.61E-4 ID:SGTC_1445|Compound:4239-0156|FD-Score:4.03|P-value:8.60E-5 ID:SGTC_1447|Compound:4239-0816|FD-Score:3.47|P-value:6.02E-4 ID:SGTC_1479|Compound:0549-0158|FD-Score:4.11|P-value:6.38E-5 ID:SGTC_1516|Compound:st013856|FD-Score:-4.62|P-value:1.23E-5 ID:SGTC_1635|Compound:st007035|FD-Score:34.40|P-value:1.15E-221 ID:SGTC_1637|Compound:st007924|FD-Score:-4.36|P-value:3.52E-5 ID:SGTC_1686|Compound:st019653|FD-Score:4.90|P-value:2.52E-6 ID:SGTC_1693|Compound:xanthone|FD-Score:3.63|P-value:3.49E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-3.55|P-value:6.15E-4 ID:SGTC_1754|Compound:st042065|FD-Score:-6.36|P-value:2.94E-9 ID:SGTC_1800|Compound:st050079|FD-Score:-3.75|P-value:3.22E-4 ID:SGTC_1818|Compound:st052136|FD-Score:-4.30|P-value:4.43E-5 ID:SGTC_1874|Compound:staurosporine|FD-Score:3.36|P-value:8.48E-4 ID:SGTC_2111|Compound:5486399|FD-Score:4.01|P-value:9.36E-5 ID:SGTC_2295|Compound:7971645|FD-Score:3.58|P-value:4.08E-4 ID:SGTC_2393|Compound:9031399|FD-Score:3.44|P-value:6.50E-4 ID:SGTC_2506|Compound:ethyl hematommate|FD-Score:4.12|P-value:6.08E-5 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:-3.46|P-value:8.17E-4 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:-4.18|P-value:6.92E-5 ID:SGTC_2611|Compound:pyromycin|FD-Score:3.63|P-value:3.51E-4 ID:SGTC_2698|Compound:st077697|FD-Score:-3.94|P-value:1.62E-4 ID:SGTC_2996|Compound:9066192|FD-Score:4.37|P-value:2.35E-5 ID:SGTC_3155|Compound:9099265|FD-Score:3.79|P-value:2.01E-4 ID:SGTC_3170|Compound:9103054|FD-Score:3.87|P-value:1.54E-4 ID:SGTC_3200|Compound:9114385|FD-Score:3.55|P-value:4.60E-4 ID:SGTC_3278|Compound:9139605|FD-Score:3.36|P-value:8.41E-4 ID:SGTC_3320|Compound:9137005|FD-Score:3.56|P-value:4.41E-4

Top fitness defect scores for YGL119W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1635 st007035 34.40 42.4 µM 1.15E-221 4 1.32E-259
2 SGTC_64 000l-0018 30.30 272.1 µM 4.08E-172 ubiquinone biosynthesis & proteasome 3 2.03E-201
3 SGTC_142 0335-0849 28.00 62.7 µM 9.41E-148 ubiquinone biosynthesis & proteasome 3 8.16E-173
4 SGTC_158 k038-0087 22.60 26.4 µM 1.83E-97 ubiquinone biosynthesis & proteasome 3 8.65E-114
5 SGTC_134 0269-0018 20.30 6.9 µM 4.58E-79 7 3.34E-92
6 SGTC_236 1509-0011 19.80 5.3 µM 4.06E-75 55 1.43E-87
7 SGTC_86 0417-1630 19.10 471.9 µM 4.37E-70 ubiquinone biosynthesis & proteasome 4 1.14E-81
8 SGTC_794 k038-0031 13.50 316.0 µM 5.24E-36 ubiquinone biosynthesis & proteasome 6 1.01E-41
9 SGTC_67 0335-0847 13.40 266.0 µM 8.47E-36 ubiquinone biosynthesis & proteasome 13 1.77E-41
10 SGTC_386 1509-0011 13.10 3.1 µM 4.47E-34 30 1.84E-39
11 SGTC_216 k038-0035 12.70 28.4 µM 2.14E-32 ubiquinone biosynthesis & proteasome 3 1.71E-37
12 SGTC_36 0335-0881 12.60 14.2 µM 9.87E-32 ubiquinone biosynthesis & proteasome 14 1.02E-36
13 SGTC_200 k038-0079 10.00 37.5 µM 8.07E-21 ubiquinone biosynthesis & proteasome 6 5.97E-24
14 SGTC_340 k038-0059 9.29 454.0 µM 3.64E-18 ubiquinone biosynthesis & proteasome 4 7.55E-21
15 SGTC_137 0438-0332 8.71 85.4 µM 3.31E-16 ubiquinone biosynthesis & proteasome 31 1.46E-18
16 SGTC_367 0335-0881 8.13 7.1 µM 2.41E-14 ubiquinone biosynthesis & proteasome 10 2.18E-16
17 SGTC_165 k038-0023 7.12 64.4 µM 1.97E-11 ubiquinone biosynthesis & proteasome 13 5.45E-13
18 SGTC_635 k038-0028 6.63 24.7 µM 3.73E-10 ubiquinone biosynthesis & proteasome 12 1.67E-11
19 SGTC_294 k038-0071 6.05 157.0 µM 9.68E-9 ubiquinone biosynthesis & proteasome 15 7.40E-10
20 SGTC_119 0121-0043 5.34 24.8 µM 3.40E-7 mitochondrial stress 40 4.62E-8

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.804 0 YNR042W_d YNR042W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene COQ2
0.799 0 YDR204W COQ4 hom Protein with a role in ubiquinone (Coenzyme Q) biosynthesis, possibly functioning in stabilization of Coq7p; located on the matrix face of the mitochondrial inner membrane; component of a mitochondrial ubiquinone-synthesizing complex
0.773 0 YNR041C COQ2 hom Para hydroxybenzoate: polyprenyl transferase, catalyzes the second step in ubiquinone (coenzyme Q) biosynthesis
0.758 0 YLR201C COQ9 hom Protein required for ubiquinone (coenzyme Q) biosynthesis and respiratory growth; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes
0.754 0 YOR125C CAT5 hom Protein required for ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes; required for gluconeogenic gene activation
0.714 0 YGR255C COQ6 hom Putative flavin-dependent monooxygenase; involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes; human COX6 can rescue a yeast cox6 mutant and is implicated in steroid-resistant nephrotic syndrome (SRNS)
0.676 0 YOL096C COQ3 hom O-methyltransferase, catalyzes two different O-methylation steps in ubiquinone (Coenzyme Q) biosynthesis; component of a mitochondrial ubiquinone-synthesizing complex; phosphoprotein
0.633 0 YBR003W COQ1 hom Hexaprenyl pyrophosphate synthetase, catalyzes the first step in ubiquinone (coenzyme Q) biosynthesis
0.596 3.85E-321 YDR148C KGD2 hom Dihydrolipoyl transsuccinylase, component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes the oxidative decarboxylation of alpha-ketoglutarate to succinyl-CoA in the TCA cycle; phosphorylated
0.593 2.36E-317 YOR254C SEC63 het Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
0.547 1.52E-260 YLR202C_d YLR202C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YLR201C; ORF contains a putative intron
0.532 2.91E-244 YMR110C HFD1 hom Hexadecenal dehydrogenase; involved in the conversion of sphingosine 1-phosphate breakdown product hexadecenal to hexadecenoic acid; located in the mitochondrial outer membrane and also in lipid particles; has similarity to ALDH3A2, a human fatty aldehyde dehydrogenase (FALDH) mutated in Sjogren-Larsson syndrome, a neurocutaneous disorder
0.527 6.28E-239 YOL008W COQ10 hom Coenzyme Q (ubiquinone) binding protein, functions in the delivery of Q6 to its proper location for electron transport during respiration; START domain protein with homologs in bacteria and eukaryotes
0.525 1.73E-236 YML034C-A_d YML034C-A_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.515 8.86E-227 YPR064W_d YPR064W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data