YGL120C / PRP43

RNA helicase in the DEAH-box family, functions in both RNA polymerase I and polymerase II transcript metabolism, involved in release of the lariat-intron from the spliceosome

Zygosity: Heterozygous strain
fixedexpanded
Profile for YGL120C / PRP43

Click on Significant Values for Screen Details ID:SGTC_38|Compound:0929-0051|FD-Score:-3.94|P-value:1.90E-5 ID:SGTC_141|Compound:0443-0274|FD-Score:-4.90|P-value:1.55E-7 ID:SGTC_353|Compound:1988-1175|FD-Score:3.52|P-value:1.25E-4 ID:SGTC_357|Compound:1325-0123|FD-Score:3.06|P-value:7.23E-4 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:3.03|P-value:8.09E-4 ID:SGTC_615|Compound:k087-0205|FD-Score:2.99|P-value:9.20E-4 ID:SGTC_670|Compound:4204-0025|FD-Score:-3.32|P-value:2.58E-4 ID:SGTC_686|Compound:1319-0111|FD-Score:-3.39|P-value:1.92E-4 ID:SGTC_843|Compound:0310-0051|FD-Score:4.69|P-value:5.33E-7 ID:SGTC_896|Compound:0964-0007|FD-Score:3.16|P-value:5.04E-4 ID:SGTC_898|Compound:1000-0849|FD-Score:3.25|P-value:3.62E-4 ID:SGTC_931|Compound:2812-0076|FD-Score:4.70|P-value:4.97E-7 ID:SGTC_961|Compound:1252-1571|FD-Score:3.49|P-value:1.40E-4 ID:SGTC_1036|Compound:k216-0215|FD-Score:-3.49|P-value:1.30E-4 ID:SGTC_1253|Compound:0550-0034|FD-Score:3.12|P-value:5.79E-4 ID:SGTC_1353|Compound:1498-1206|FD-Score:-4.93|P-value:1.29E-7 ID:SGTC_1510|Compound:1123-0200|FD-Score:-4.43|P-value:1.82E-6 ID:SGTC_1655|Compound:st012546|FD-Score:3.65|P-value:7.32E-5 ID:SGTC_1824|Compound:st053723|FD-Score:4.29|P-value:4.02E-6 ID:SGTC_1948|Compound:st076329|FD-Score:3.28|P-value:3.23E-4 ID:SGTC_1953|Compound:st076800|FD-Score:-3.10|P-value:6.01E-4 ID:SGTC_1954|Compound:st077032|FD-Score:3.16|P-value:5.03E-4 ID:SGTC_1985|Compound:st071382|FD-Score:-3.39|P-value:1.93E-4 ID:SGTC_1989|Compound:st071868|FD-Score:-3.20|P-value:4.15E-4 ID:SGTC_1991|Compound:st073000|FD-Score:-3.32|P-value:2.61E-4 ID:SGTC_2109|Compound:5483026|FD-Score:3.99|P-value:1.64E-5 ID:SGTC_2110|Compound:5483698|FD-Score:3.56|P-value:1.05E-4 ID:SGTC_2320|Compound:7373003|FD-Score:-4.64|P-value:6.18E-7 ID:SGTC_2325|Compound:6158266|FD-Score:-3.46|P-value:1.49E-4 ID:SGTC_2327|Compound:6189656|FD-Score:3.63|P-value:7.82E-5 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:3.40|P-value:2.01E-4 ID:SGTC_2537|Compound:larixol|FD-Score:4.31|P-value:3.53E-6 ID:SGTC_2622|Compound:2-methoxyxanthone|FD-Score:3.14|P-value:5.35E-4 ID:SGTC_2713|Compound:st079149|FD-Score:-4.52|P-value:1.15E-6 ID:SGTC_2849|Compound:9019321|FD-Score:3.24|P-value:3.73E-4 ID:SGTC_2975|Compound:9084847|FD-Score:4.24|P-value:4.99E-6 ID:SGTC_2977|Compound:9011197|FD-Score:-3.00|P-value:8.60E-4 ID:SGTC_2983|Compound:9022671|FD-Score:-7.16|P-value:3.79E-14 ID:SGTC_2985|Compound:9022375|FD-Score:6.47|P-value:7.84E-12 ID:SGTC_3044|Compound:9093193|FD-Score:3.39|P-value:2.10E-4 ID:SGTC_3055|Compound:9094636|FD-Score:4.00|P-value:1.55E-5 ID:SGTC_3068|Compound:9116768|FD-Score:4.60|P-value:8.31E-7 ID:SGTC_3071|Compound:9117417|FD-Score:-3.86|P-value:2.72E-5 ID:SGTC_3083|Compound:9117465|FD-Score:3.77|P-value:4.44E-5 ID:SGTC_3088|Compound:9117578|FD-Score:4.63|P-value:7.10E-7 ID:SGTC_3100|Compound:9120536|FD-Score:4.01|P-value:1.49E-5 ID:SGTC_3143|Compound:9086658|FD-Score:3.33|P-value:2.65E-4 ID:SGTC_3146|Compound:9095609|FD-Score:4.26|P-value:4.69E-6 ID:SGTC_3148|Compound:9097893|FD-Score:-2.98|P-value:9.07E-4 ID:SGTC_3154|Compound:9100113|FD-Score:3.11|P-value:6.13E-4 ID:SGTC_3157|Compound:9099274|FD-Score:-4.13|P-value:7.76E-6 ID:SGTC_3216|Compound:9129716|FD-Score:-3.17|P-value:4.58E-4 ID:SGTC_3229|Compound:9132204|FD-Score:3.58|P-value:9.61E-5 ID:SGTC_3231|Compound:9132313|FD-Score:-3.28|P-value:3.02E-4 ID:SGTC_3244|Compound:9134489|FD-Score:-3.79|P-value:3.77E-5 ID:SGTC_3252|Compound:9135871|FD-Score:-3.30|P-value:2.75E-4 ID:SGTC_3289|Compound:9119912|FD-Score:-3.32|P-value:2.56E-4 ID:SGTC_3307|Compound:9126885|FD-Score:-2.96|P-value:9.71E-4 ID:SGTC_38|Compound:0929-0051|FD-Score:-3.94|P-value:1.90E-5 ID:SGTC_141|Compound:0443-0274|FD-Score:-4.90|P-value:1.55E-7 ID:SGTC_353|Compound:1988-1175|FD-Score:3.52|P-value:1.25E-4 ID:SGTC_357|Compound:1325-0123|FD-Score:3.06|P-value:7.23E-4 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:3.03|P-value:8.09E-4 ID:SGTC_615|Compound:k087-0205|FD-Score:2.99|P-value:9.20E-4 ID:SGTC_670|Compound:4204-0025|FD-Score:-3.32|P-value:2.58E-4 ID:SGTC_686|Compound:1319-0111|FD-Score:-3.39|P-value:1.92E-4 ID:SGTC_843|Compound:0310-0051|FD-Score:4.69|P-value:5.33E-7 ID:SGTC_896|Compound:0964-0007|FD-Score:3.16|P-value:5.04E-4 ID:SGTC_898|Compound:1000-0849|FD-Score:3.25|P-value:3.62E-4 ID:SGTC_931|Compound:2812-0076|FD-Score:4.70|P-value:4.97E-7 ID:SGTC_961|Compound:1252-1571|FD-Score:3.49|P-value:1.40E-4 ID:SGTC_1036|Compound:k216-0215|FD-Score:-3.49|P-value:1.30E-4 ID:SGTC_1253|Compound:0550-0034|FD-Score:3.12|P-value:5.79E-4 ID:SGTC_1353|Compound:1498-1206|FD-Score:-4.93|P-value:1.29E-7 ID:SGTC_1510|Compound:1123-0200|FD-Score:-4.43|P-value:1.82E-6 ID:SGTC_1655|Compound:st012546|FD-Score:3.65|P-value:7.32E-5 ID:SGTC_1824|Compound:st053723|FD-Score:4.29|P-value:4.02E-6 ID:SGTC_1948|Compound:st076329|FD-Score:3.28|P-value:3.23E-4 ID:SGTC_1953|Compound:st076800|FD-Score:-3.10|P-value:6.01E-4 ID:SGTC_1954|Compound:st077032|FD-Score:3.16|P-value:5.03E-4 ID:SGTC_1985|Compound:st071382|FD-Score:-3.39|P-value:1.93E-4 ID:SGTC_1989|Compound:st071868|FD-Score:-3.20|P-value:4.15E-4 ID:SGTC_1991|Compound:st073000|FD-Score:-3.32|P-value:2.61E-4 ID:SGTC_2109|Compound:5483026|FD-Score:3.99|P-value:1.64E-5 ID:SGTC_2110|Compound:5483698|FD-Score:3.56|P-value:1.05E-4 ID:SGTC_2320|Compound:7373003|FD-Score:-4.64|P-value:6.18E-7 ID:SGTC_2325|Compound:6158266|FD-Score:-3.46|P-value:1.49E-4 ID:SGTC_2327|Compound:6189656|FD-Score:3.63|P-value:7.82E-5 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:3.40|P-value:2.01E-4 ID:SGTC_2537|Compound:larixol|FD-Score:4.31|P-value:3.53E-6 ID:SGTC_2622|Compound:2-methoxyxanthone|FD-Score:3.14|P-value:5.35E-4 ID:SGTC_2713|Compound:st079149|FD-Score:-4.52|P-value:1.15E-6 ID:SGTC_2849|Compound:9019321|FD-Score:3.24|P-value:3.73E-4 ID:SGTC_2975|Compound:9084847|FD-Score:4.24|P-value:4.99E-6 ID:SGTC_2977|Compound:9011197|FD-Score:-3.00|P-value:8.60E-4 ID:SGTC_2983|Compound:9022671|FD-Score:-7.16|P-value:3.79E-14 ID:SGTC_2985|Compound:9022375|FD-Score:6.47|P-value:7.84E-12 ID:SGTC_3044|Compound:9093193|FD-Score:3.39|P-value:2.10E-4 ID:SGTC_3055|Compound:9094636|FD-Score:4.00|P-value:1.55E-5 ID:SGTC_3068|Compound:9116768|FD-Score:4.60|P-value:8.31E-7 ID:SGTC_3071|Compound:9117417|FD-Score:-3.86|P-value:2.72E-5 ID:SGTC_3083|Compound:9117465|FD-Score:3.77|P-value:4.44E-5 ID:SGTC_3088|Compound:9117578|FD-Score:4.63|P-value:7.10E-7 ID:SGTC_3100|Compound:9120536|FD-Score:4.01|P-value:1.49E-5 ID:SGTC_3143|Compound:9086658|FD-Score:3.33|P-value:2.65E-4 ID:SGTC_3146|Compound:9095609|FD-Score:4.26|P-value:4.69E-6 ID:SGTC_3148|Compound:9097893|FD-Score:-2.98|P-value:9.07E-4 ID:SGTC_3154|Compound:9100113|FD-Score:3.11|P-value:6.13E-4 ID:SGTC_3157|Compound:9099274|FD-Score:-4.13|P-value:7.76E-6 ID:SGTC_3216|Compound:9129716|FD-Score:-3.17|P-value:4.58E-4 ID:SGTC_3229|Compound:9132204|FD-Score:3.58|P-value:9.61E-5 ID:SGTC_3231|Compound:9132313|FD-Score:-3.28|P-value:3.02E-4 ID:SGTC_3244|Compound:9134489|FD-Score:-3.79|P-value:3.77E-5 ID:SGTC_3252|Compound:9135871|FD-Score:-3.30|P-value:2.75E-4 ID:SGTC_3289|Compound:9119912|FD-Score:-3.32|P-value:2.56E-4 ID:SGTC_3307|Compound:9126885|FD-Score:-2.96|P-value:9.71E-4

Top fitness defect scores for YGL120C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2985 9022375 6.47 71.4 µM 7.84E-12 RPP1 & pyrimidine depletion 2 4.87E-11 1.43
2 SGTC_931 2812-0076 4.70 566.0 µM 4.97E-7 1 1.31E-6 0.36
3 SGTC_843 0310-0051 4.69 143.0 µM 5.33E-7 2 1.39E-6 0.88
4 SGTC_3088 9117578 4.63 49.5 µM 7.10E-7 amide catabolism 1 1.82E-6 0.85
5 SGTC_3068 9116768 4.60 49.5 µM 8.31E-7 4 2.10E-6 0.53
6 SGTC_2537 larixol 4.31 68.9 µM 3.53E-6 4 8.01E-6 0.24
7 SGTC_1824 st053723 4.29 68.6 µM 4.02E-6 3 9.02E-6 0.37
8 SGTC_3146 9095609 4.26 49.5 µM 4.69E-6 4 1.04E-5 0.31
9 SGTC_2975 9084847 4.24 53.7 µM 4.99E-6 8 1.10E-5 0.07
10 SGTC_3100 9120536 4.01 49.5 µM 1.49E-5 8 3.02E-5 0.04
11 SGTC_3055 9094636 4.00 49.5 µM 1.55E-5 8 3.14E-5 0.04
12 SGTC_2109 5483026 3.99 200.0 µM 1.64E-5 RSC complex & mRNA processing 35 3.30E-5 0.04
13 SGTC_3083 9117465 3.77 49.5 µM 4.44E-5 7 8.31E-5 0.16
14 SGTC_1655 st012546 3.65 55.1 µM 7.32E-5 7 1.32E-4 0.02
15 SGTC_2327 6189656 3.63 200.0 µM 7.82E-5 12 1.40E-4 0.22
16 SGTC_3229 9132204 3.58 49.5 µM 9.61E-5 1 1.70E-4 0.61
17 SGTC_2110 5483698 3.56 200.0 µM 1.05E-4 TSC3-RPN4 10 1.84E-4 0.08
18 SGTC_353 1988-1175 3.52 58.3 µM 1.25E-4 unfolded protein response 11 2.17E-4 0.07
19 SGTC_961 1252-1571 3.49 372.0 µM 1.40E-4 10 2.40E-4 0.28
20 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 3.40 92.6 µM 2.01E-4 16 3.35E-4 0.02

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.132 1.73E-14 YOR159C SME1 het Core Sm protein Sm E; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm E
0.108 4.06E-10 YDL112W TRM3 hom 2'-O-ribose methyltransferase, catalyzes the ribose methylation of the guanosine nucleotide at position 18 of tRNAs
0.103 2.56E-9 YHR166C CDC23 het Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition
0.102 3.81E-9 YBR285W_p YBR285W_p hom Putative protein of unknown function; YBR285W is not an essential gene
0.098 1.45E-8 YFR031C SMC2 het Subunit of the condensin complex; essential SMC chromosomal ATPase family member that forms a complex with Smc4p to form the active ATPase; Smc2p/Smc4p complex binds DNA; required for clustering of tRNA genes at the nucleolus
0.097 2.05E-8 YDR376W ARH1 het Oxidoreductase of the mitochondrial inner membrane, involved in cytoplasmic and mitochondrial iron homeostasis and required for activity of Fe-S cluster-containing enzymes; one of the few mitochondrial proteins essential for viability
0.090 1.56E-7 YNL161W CBK1 het Serine/threonine protein kinase of the the RAM signaling network; Ndr/LATS family member; binds regulatory subunit Mob2p; involved in regulation of cellular morphogenesis, polarized growth, and septum destruction; phosphorylation by Cbk1p regulates localization and activity of Ace2p transcription factor and Ssd1p translational repressor; Cbk1p activity is regulated by both phosphorylation and specific localization; relocalizes to cytoplasm upon DNA replication stress
0.088 2.92E-7 YDR478W SNM1 het Subunit of RNase MRP, which cleaves pre-rRNA and has a role in cell cycle-regulated degradation of daughter cell-specific mRNAs; binds to the NME1 RNA subunit of RNase MRP
0.088 3.44E-7 YHR118C ORC6 het Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; phosphorylated by Cdc28p
0.086 5.93E-7 YLR117C CLF1 het Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; homolog of Drosophila crooked neck protein; interacts with U1 snRNP proteins
0.085 7.90E-7 YMR316C-B_d YMR316C-B_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.084 1.01E-6 YJL194W CDC6 het Essential ATP-binding protein required for DNA replication; component of the pre-replicative complex (pre-RC) which requires ORC to associate with chromatin and is in turn required for Mcm2-7p DNA association; homologous to S. pombe Cdc18p; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.083 1.43E-6 YOR081C TGL5 hom Bifunctional enzyme with triacylglycerol lipase and lysophosphatidic acid acyltransferase activity; involved in triacylglycerol mobilization; localizes to lipid particles; potential Cdc28p substrate
0.080 3.40E-6 YLR211C_p YLR211C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR211C is not an essential gene; ORF contains an intron
0.079 4.34E-6 YDL079C MRK1 hom Glycogen synthase kinase 3 (GSK-3) homolog; one of four GSK-3 homologs in S. cerevisiae that function to activate Msn2p-dependent transcription of stress responsive genes and that function in protein degradation