YGL122C / NAB2

Nuclear polyadenylated RNA-binding protein; required for nuclear mRNA export and poly(A) tail length control; binds nuclear pore protein Mlp1p; autoregulates mRNA levels; related to human hnRNPs; nuclear localization sequence binds Kap104p; protein abundance increases in response to DNA replication stress

Zygosity: Heterozygous strain
fixedexpanded
Profile for YGL122C / NAB2

Click on Significant Values for Screen Details ID:SGTC_177|Compound:1327-0068|FD-Score:-3.02|P-value:2.32E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:-2.94|P-value:3.29E-4 ID:SGTC_399|Compound:oxolinic acid|FD-Score:4.18|P-value:5.77E-7 ID:SGTC_400|Compound:oxethazaine|FD-Score:-3.77|P-value:6.11E-6 ID:SGTC_404|Compound:fumagillin|FD-Score:-4.33|P-value:2.59E-7 ID:SGTC_418|Compound:lividomycin a|FD-Score:2.75|P-value:6.78E-4 ID:SGTC_424|Compound:splitomicin|FD-Score:4.29|P-value:3.08E-7 ID:SGTC_425|Compound:3825-7017|FD-Score:4.23|P-value:4.24E-7 ID:SGTC_429|Compound:1112-0049|FD-Score:3.05|P-value:1.95E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:-2.71|P-value:8.36E-4 ID:SGTC_773|Compound:4358-1457|FD-Score:3.12|P-value:1.41E-4 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:3.31|P-value:5.94E-5 ID:SGTC_995|Compound:3931-2021|FD-Score:2.74|P-value:7.01E-4 ID:SGTC_1212|Compound:0520-0165|FD-Score:3.06|P-value:1.84E-4 ID:SGTC_1294|Compound:1000-1494|FD-Score:3.00|P-value:2.39E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-2.69|P-value:9.08E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.00|P-value:2.57E-4 ID:SGTC_1475|Compound:4092-1048|FD-Score:3.00|P-value:2.41E-4 ID:SGTC_1601|Compound:4'-hydroxyflavanone|FD-Score:3.00|P-value:2.39E-4 ID:SGTC_1672|Compound:st016598|FD-Score:2.79|P-value:5.75E-4 ID:SGTC_1688|Compound:st021091|FD-Score:3.49|P-value:2.52E-5 ID:SGTC_1701|Compound:st028638|FD-Score:-3.08|P-value:1.79E-4 ID:SGTC_1730|Compound:st033808|FD-Score:2.75|P-value:6.86E-4 ID:SGTC_1848|Compound:st056003|FD-Score:-4.05|P-value:1.30E-6 ID:SGTC_1888|Compound:azatryptophan|FD-Score:2.68|P-value:9.21E-4 ID:SGTC_1916|Compound:st067606|FD-Score:-2.82|P-value:5.39E-4 ID:SGTC_2012|Compound:4023501|FD-Score:7.16|P-value:4.33E-17 ID:SGTC_2035|Compound:5154463|FD-Score:3.10|P-value:1.58E-4 ID:SGTC_2241|Compound:6772625|FD-Score:-3.67|P-value:1.06E-5 ID:SGTC_2278|Compound:7948257|FD-Score:2.92|P-value:3.42E-4 ID:SGTC_2282|Compound:7944268|FD-Score:5.08|P-value:1.78E-9 ID:SGTC_2308|Compound:7584454|FD-Score:4.14|P-value:7.47E-7 ID:SGTC_2311|Compound:7694451|FD-Score:3.20|P-value:9.73E-5 ID:SGTC_2323|Compound:6148992|FD-Score:4.36|P-value:2.00E-7 ID:SGTC_2363|Compound:9053361|FD-Score:-2.68|P-value:9.48E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:3.22|P-value:9.08E-5 ID:SGTC_2415|Compound:st077333|FD-Score:2.80|P-value:5.56E-4 ID:SGTC_2436|Compound:5633522|FD-Score:2.89|P-value:3.84E-4 ID:SGTC_2437|Compound:5741531|FD-Score:3.03|P-value:2.10E-4 ID:SGTC_2438|Compound:5259590|FD-Score:2.83|P-value:4.98E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:3.07|P-value:1.76E-4 ID:SGTC_2564|Compound:betulinic acid|FD-Score:3.47|P-value:2.71E-5 ID:SGTC_2569|Compound:tetrandrine|FD-Score:2.93|P-value:3.23E-4 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:-3.63|P-value:1.28E-5 ID:SGTC_2575|Compound:plumbagin|FD-Score:-4.57|P-value:5.67E-8 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:-2.94|P-value:3.30E-4 ID:SGTC_2616|Compound:abietic acid|FD-Score:2.98|P-value:2.59E-4 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:-4.68|P-value:2.97E-8 ID:SGTC_2818|Compound:7996756|FD-Score:-2.93|P-value:3.41E-4 ID:SGTC_2826|Compound:7992541|FD-Score:-3.25|P-value:8.21E-5 ID:SGTC_2827|Compound:7993847|FD-Score:-2.76|P-value:6.82E-4 ID:SGTC_2933|Compound:9026794|FD-Score:3.84|P-value:4.01E-6 ID:SGTC_3203|Compound:9113543|FD-Score:3.47|P-value:2.75E-5 ID:SGTC_3204|Compound:9114183|FD-Score:-2.92|P-value:3.56E-4 ID:SGTC_3210|Compound:9128157|FD-Score:5.61|P-value:3.57E-11 ID:SGTC_177|Compound:1327-0068|FD-Score:-3.02|P-value:2.32E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:-2.94|P-value:3.29E-4 ID:SGTC_399|Compound:oxolinic acid|FD-Score:4.18|P-value:5.77E-7 ID:SGTC_400|Compound:oxethazaine|FD-Score:-3.77|P-value:6.11E-6 ID:SGTC_404|Compound:fumagillin|FD-Score:-4.33|P-value:2.59E-7 ID:SGTC_418|Compound:lividomycin a|FD-Score:2.75|P-value:6.78E-4 ID:SGTC_424|Compound:splitomicin|FD-Score:4.29|P-value:3.08E-7 ID:SGTC_425|Compound:3825-7017|FD-Score:4.23|P-value:4.24E-7 ID:SGTC_429|Compound:1112-0049|FD-Score:3.05|P-value:1.95E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:-2.71|P-value:8.36E-4 ID:SGTC_773|Compound:4358-1457|FD-Score:3.12|P-value:1.41E-4 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:3.31|P-value:5.94E-5 ID:SGTC_995|Compound:3931-2021|FD-Score:2.74|P-value:7.01E-4 ID:SGTC_1212|Compound:0520-0165|FD-Score:3.06|P-value:1.84E-4 ID:SGTC_1294|Compound:1000-1494|FD-Score:3.00|P-value:2.39E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-2.69|P-value:9.08E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.00|P-value:2.57E-4 ID:SGTC_1475|Compound:4092-1048|FD-Score:3.00|P-value:2.41E-4 ID:SGTC_1601|Compound:4'-hydroxyflavanone|FD-Score:3.00|P-value:2.39E-4 ID:SGTC_1672|Compound:st016598|FD-Score:2.79|P-value:5.75E-4 ID:SGTC_1688|Compound:st021091|FD-Score:3.49|P-value:2.52E-5 ID:SGTC_1701|Compound:st028638|FD-Score:-3.08|P-value:1.79E-4 ID:SGTC_1730|Compound:st033808|FD-Score:2.75|P-value:6.86E-4 ID:SGTC_1848|Compound:st056003|FD-Score:-4.05|P-value:1.30E-6 ID:SGTC_1888|Compound:azatryptophan|FD-Score:2.68|P-value:9.21E-4 ID:SGTC_1916|Compound:st067606|FD-Score:-2.82|P-value:5.39E-4 ID:SGTC_2012|Compound:4023501|FD-Score:7.16|P-value:4.33E-17 ID:SGTC_2035|Compound:5154463|FD-Score:3.10|P-value:1.58E-4 ID:SGTC_2241|Compound:6772625|FD-Score:-3.67|P-value:1.06E-5 ID:SGTC_2278|Compound:7948257|FD-Score:2.92|P-value:3.42E-4 ID:SGTC_2282|Compound:7944268|FD-Score:5.08|P-value:1.78E-9 ID:SGTC_2308|Compound:7584454|FD-Score:4.14|P-value:7.47E-7 ID:SGTC_2311|Compound:7694451|FD-Score:3.20|P-value:9.73E-5 ID:SGTC_2323|Compound:6148992|FD-Score:4.36|P-value:2.00E-7 ID:SGTC_2363|Compound:9053361|FD-Score:-2.68|P-value:9.48E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:3.22|P-value:9.08E-5 ID:SGTC_2415|Compound:st077333|FD-Score:2.80|P-value:5.56E-4 ID:SGTC_2436|Compound:5633522|FD-Score:2.89|P-value:3.84E-4 ID:SGTC_2437|Compound:5741531|FD-Score:3.03|P-value:2.10E-4 ID:SGTC_2438|Compound:5259590|FD-Score:2.83|P-value:4.98E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:3.07|P-value:1.76E-4 ID:SGTC_2564|Compound:betulinic acid|FD-Score:3.47|P-value:2.71E-5 ID:SGTC_2569|Compound:tetrandrine|FD-Score:2.93|P-value:3.23E-4 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:-3.63|P-value:1.28E-5 ID:SGTC_2575|Compound:plumbagin|FD-Score:-4.57|P-value:5.67E-8 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:-2.94|P-value:3.30E-4 ID:SGTC_2616|Compound:abietic acid|FD-Score:2.98|P-value:2.59E-4 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:-4.68|P-value:2.97E-8 ID:SGTC_2818|Compound:7996756|FD-Score:-2.93|P-value:3.41E-4 ID:SGTC_2826|Compound:7992541|FD-Score:-3.25|P-value:8.21E-5 ID:SGTC_2827|Compound:7993847|FD-Score:-2.76|P-value:6.82E-4 ID:SGTC_2933|Compound:9026794|FD-Score:3.84|P-value:4.01E-6 ID:SGTC_3203|Compound:9113543|FD-Score:3.47|P-value:2.75E-5 ID:SGTC_3204|Compound:9114183|FD-Score:-2.92|P-value:3.56E-4 ID:SGTC_3210|Compound:9128157|FD-Score:5.61|P-value:3.57E-11

Top fitness defect scores for YGL122C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2012 4023501 7.16 200.0 µM 4.33E-17 1 3.99E-13 0.96
2 SGTC_3210 9128157 5.61 49.5 µM 3.57E-11 2 1.03E-8 0.50
3 SGTC_2282 7944268 5.08 200.0 µM 1.78E-9 RPP1 & pyrimidine depletion 6 1.90E-7 0.18
4 SGTC_2323 6148992 4.36 148.3 µM 2.00E-7 11 6.52E-6 0.10
5 SGTC_424 splitomicin 4.29 100.0 mM 3.08E-7 2 9.01E-6 0.22
6 SGTC_425 3825-7017 4.23 13.1 µM 4.24E-7 7 1.14E-5 0.36
7 SGTC_399 oxolinic acid 4.18 75.0 µM 5.77E-7 1 1.44E-5 0.41
8 SGTC_2308 7584454 4.14 197.6 µM 7.47E-7 8 1.75E-5 0.13
9 SGTC_2933 9026794 3.84 32.5 µM 4.01E-6 5 6.18E-5 0.24
10 SGTC_1688 st021091 3.49 57.6 µM 2.52E-5 5 2.46E-4 0.09
11 SGTC_2564 betulinic acid 3.47 100.0 µM 2.71E-5 13 2.60E-4 0.24
12 SGTC_3203 9113543 3.47 49.5 µM 2.75E-5 13 2.63E-4 0.11
13 SGTC_920 mycophenolic acid 3.31 780.4 nM 5.94E-5 8 4.69E-4 0.02
14 SGTC_2405 ticlatone 3.22 3.5 µM 9.08E-5 28 6.46E-4 0.02
15 SGTC_2311 7694451 3.20 200.0 µM 9.73E-5 22 6.81E-4 0.14
16 SGTC_773 4358-1457 3.12 44.6 µM 1.41E-4 15 8.99E-4 0.03
17 SGTC_2035 5154463 3.10 94.6 µM 1.58E-4 21 9.80E-4 0.00
18 SGTC_2563 tomatine 3.07 8.5 µM 1.76E-4 24 0.00107 0.05
19 SGTC_1212 0520-0165 3.06 585.0 µM 1.84E-4 16 0.00110 0.02
20 SGTC_429 1112-0049 3.05 25.5 µM 1.95E-4 DNA damage response 18 0.00115 0.04

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.160 9.64E-21 YLL017W YLL017W hom Non-essential Ras guanine nucleotide exchange factor (GEF); localized to the membrane; expressed in poor nutrient conditions and on nonfermentable carbon sources; contains a stop codon in S288C, full-length gene includes YLL016W; SDC25 has a paralog, CDC25, that arose from the whole genome duplication
0.146 2.41E-17 YGR017W_p YGR017W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the cytoplasm
0.136 2.79E-15 YLR390W-A CCW14 hom Covalently linked cell wall glycoprotein, present in the inner layer of the cell wall
0.133 1.08E-14 YOR282W_d YOR282W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps essential, verified gene PLP2/YOR281C
0.118 6.46E-12 YDL079C MRK1 hom Glycogen synthase kinase 3 (GSK-3) homolog; one of four GSK-3 homologs in S. cerevisiae that function to activate Msn2p-dependent transcription of stress responsive genes and that function in protein degradation
0.114 4.28E-11 YJL109C UTP10 het Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA; mutant has increased aneuploidy tolerance
0.104 1.47E-9 YFL055W AGP3 hom Low-affinity amino acid permease, may act to supply the cell with amino acids as nitrogen source in nitrogen-poor conditions; transcription is induced under conditions of sulfur limitation; plays a role in regulating Ty1 transposition
0.102 3.59E-9 YNL105W_d RRT16_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene INP52; identified in a screen for mutants with decreased levels of rDNA transcription
0.099 8.70E-9 YKL020C SPT23 hom ER membrane protein involved in regulation of OLE1 transcription, acts with homolog Mga2p; inactive ER form dimerizes and one subunit is then activated by ubiquitin/proteasome-dependent processing followed by nuclear targeting
0.096 2.76E-8 YLR225C_p YLR225C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR225C is not an essential gene
0.095 2.99E-8 YDR160W SSY1 het Component of the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p), which senses external amino acid concentration and transmits intracellular signals that result in regulation of expression of amino acid permease genes
0.095 3.41E-8 YKL078W DHR2 het Predominantly nucleolar DEAH-box ATP-dependent RNA helicase, required for 18S rRNA synthesis
0.094 4.48E-8 YGR035W-A_p YGR035W-A_p hom Putative protein of unknown function
0.094 4.88E-8 YDR370C DXO1 hom Protein with decapping and 5′-3′ exoRNase activity; similar to Rai1p
0.093 6.75E-8 YGR023W MTL1 hom Putative plasma membrane sensor, involved in cell integrity signaling and stress response during glucose starvation and oxidative stress; has structural and functional similarity to Mid2p