YGL124C / MON1

Protein required for fusion of cvt-vesicles and autophagosomes with the vacuole; associates, as a complex with Ccz1p, with a perivacuolar compartment; potential Cdc28p substrate

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL124C / MON1

Click on Significant Values for Screen Details ID:SGTC_65|Compound:0798-0905|FD-Score:5.57|P-value:8.83E-8 ID:SGTC_103|Compound:0844-0104|FD-Score:3.40|P-value:7.25E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:-5.54|P-value:9.74E-8 ID:SGTC_208|Compound:k072-0098|FD-Score:3.54|P-value:4.59E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:3.82|P-value:1.73E-4 ID:SGTC_245|Compound:methotrexate|FD-Score:3.79|P-value:1.92E-4 ID:SGTC_309|Compound:k408-0051|FD-Score:-5.05|P-value:1.06E-6 ID:SGTC_310|Compound:1273-0058|FD-Score:-4.81|P-value:3.10E-6 ID:SGTC_391|Compound:gliotoxin|FD-Score:3.89|P-value:1.32E-4 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:3.42|P-value:6.70E-4 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:-3.86|P-value:1.43E-4 ID:SGTC_515|Compound:4092-1064|FD-Score:3.31|P-value:9.75E-4 ID:SGTC_516|Compound:3992-2719|FD-Score:4.05|P-value:7.20E-5 ID:SGTC_528|Compound:3492-0019|FD-Score:3.91|P-value:1.24E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:8.87|P-value:4.49E-17 ID:SGTC_569|Compound:4130-2812|FD-Score:-3.81|P-value:1.72E-4 ID:SGTC_649|Compound:1123-0311|FD-Score:3.50|P-value:5.19E-4 ID:SGTC_660|Compound:4031-1742|FD-Score:5.35|P-value:2.66E-7 ID:SGTC_722|Compound:3534-0461|FD-Score:3.39|P-value:7.53E-4 ID:SGTC_733|Compound:4069-0007|FD-Score:4.72|P-value:4.85E-6 ID:SGTC_788|Compound:1182-0090|FD-Score:3.34|P-value:8.64E-4 ID:SGTC_797|Compound:k781-0471|FD-Score:3.39|P-value:7.43E-4 ID:SGTC_841|Compound:0251-0215|FD-Score:4.07|P-value:6.75E-5 ID:SGTC_1016|Compound:4226-1401|FD-Score:4.16|P-value:4.74E-5 ID:SGTC_1026|Compound:k007-1105|FD-Score:3.64|P-value:3.28E-4 ID:SGTC_1091|Compound:telmisartan|FD-Score:4.50|P-value:1.22E-5 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:6.26|P-value:2.15E-9 ID:SGTC_1145|Compound:3546-0597|FD-Score:-3.65|P-value:3.06E-4 ID:SGTC_1297|Compound:1068-0111|FD-Score:4.90|P-value:2.21E-6 ID:SGTC_1315|Compound:1237-0019|FD-Score:3.66|P-value:3.06E-4 ID:SGTC_1321|Compound:1326-2144|FD-Score:4.05|P-value:7.43E-5 ID:SGTC_1324|Compound:1418-0026|FD-Score:3.79|P-value:1.90E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:8.51|P-value:7.08E-16 ID:SGTC_1581|Compound:himbacine|FD-Score:4.16|P-value:4.79E-5 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:3.81|P-value:1.80E-4 ID:SGTC_1658|Compound:st012944|FD-Score:5.90|P-value:1.54E-8 ID:SGTC_1687|Compound:st020778|FD-Score:3.73|P-value:2.38E-4 ID:SGTC_1730|Compound:st033808|FD-Score:3.56|P-value:4.25E-4 ID:SGTC_1746|Compound:st038117|FD-Score:-4.32|P-value:2.48E-5 ID:SGTC_1754|Compound:st042065|FD-Score:3.57|P-value:4.04E-4 ID:SGTC_1791|Compound:st048313|FD-Score:3.76|P-value:2.14E-4 ID:SGTC_1800|Compound:st050079|FD-Score:5.75|P-value:3.51E-8 ID:SGTC_1801|Compound:st050089|FD-Score:3.69|P-value:2.73E-4 ID:SGTC_1803|Compound:st050068|FD-Score:4.52|P-value:1.15E-5 ID:SGTC_1822|Compound:st052468|FD-Score:-3.68|P-value:2.74E-4 ID:SGTC_1877|Compound:wortmannin|FD-Score:4.76|P-value:4.10E-6 ID:SGTC_1909|Compound:st060837|FD-Score:3.85|P-value:1.55E-4 ID:SGTC_1911|Compound:st060208|FD-Score:-4.37|P-value:2.00E-5 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:5.57|P-value:8.88E-8 ID:SGTC_1930|Compound:st074634|FD-Score:-7.69|P-value:2.61E-13 ID:SGTC_1955|Compound:wogonin|FD-Score:-3.41|P-value:6.67E-4 ID:SGTC_2062|Compound:5245942|FD-Score:3.81|P-value:1.78E-4 ID:SGTC_2108|Compound:5365811|FD-Score:3.70|P-value:2.58E-4 ID:SGTC_2154|Compound:5570129|FD-Score:3.66|P-value:2.97E-4 ID:SGTC_2195|Compound:6536160|FD-Score:4.20|P-value:4.07E-5 ID:SGTC_2279|Compound:7948423|FD-Score:-3.47|P-value:5.46E-4 ID:SGTC_2300|Compound:7976697|FD-Score:4.37|P-value:2.07E-5 ID:SGTC_2389|Compound:9091542|FD-Score:3.39|P-value:7.41E-4 ID:SGTC_2398|Compound:5228213|FD-Score:4.04|P-value:7.66E-5 ID:SGTC_2475|Compound:5812728|FD-Score:5.15|P-value:6.77E-7 ID:SGTC_2481|Compound:5478948|FD-Score:5.05|P-value:1.08E-6 ID:SGTC_2586|Compound:curcumin|FD-Score:3.94|P-value:1.10E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:-4.21|P-value:3.74E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.03|P-value:7.80E-5 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:-4.91|P-value:1.96E-6 ID:SGTC_2779|Compound:methotrexate|FD-Score:7.70|P-value:2.48E-13 ID:SGTC_2831|Compound:7999036|FD-Score:-4.32|P-value:2.42E-5 ID:SGTC_2835|Compound:9006588|FD-Score:5.85|P-value:2.07E-8 ID:SGTC_2887|Compound:9044784|FD-Score:3.65|P-value:3.15E-4 ID:SGTC_2947|Compound:9072639|FD-Score:3.80|P-value:1.82E-4 ID:SGTC_2951|Compound:9072950|FD-Score:3.62|P-value:3.47E-4 ID:SGTC_2972|Compound:9093619|FD-Score:-3.50|P-value:5.03E-4 ID:SGTC_2982|Compound:9019404|FD-Score:3.57|P-value:4.12E-4 ID:SGTC_2991|Compound:9074669|FD-Score:4.97|P-value:1.55E-6 ID:SGTC_3075|Compound:9116269|FD-Score:-5.78|P-value:2.76E-8 ID:SGTC_3097|Compound:9117246|FD-Score:3.37|P-value:7.93E-4 ID:SGTC_3135|Compound:9127742|FD-Score:4.49|P-value:1.27E-5 ID:SGTC_3136|Compound:9095672|FD-Score:-4.43|P-value:1.55E-5 ID:SGTC_3143|Compound:9086658|FD-Score:-3.42|P-value:6.60E-4 ID:SGTC_3145|Compound:9085516|FD-Score:3.33|P-value:8.92E-4 ID:SGTC_3193|Compound:9111931|FD-Score:4.37|P-value:2.12E-5 ID:SGTC_3296|Compound:9122258|FD-Score:3.39|P-value:7.35E-4 ID:SGTC_3308|Compound:9128332|FD-Score:3.84|P-value:1.60E-4 ID:SGTC_3337|Compound:9144342|FD-Score:-3.49|P-value:5.13E-4 ID:SGTC_65|Compound:0798-0905|FD-Score:5.57|P-value:8.83E-8 ID:SGTC_103|Compound:0844-0104|FD-Score:3.40|P-value:7.25E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:-5.54|P-value:9.74E-8 ID:SGTC_208|Compound:k072-0098|FD-Score:3.54|P-value:4.59E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:3.82|P-value:1.73E-4 ID:SGTC_245|Compound:methotrexate|FD-Score:3.79|P-value:1.92E-4 ID:SGTC_309|Compound:k408-0051|FD-Score:-5.05|P-value:1.06E-6 ID:SGTC_310|Compound:1273-0058|FD-Score:-4.81|P-value:3.10E-6 ID:SGTC_391|Compound:gliotoxin|FD-Score:3.89|P-value:1.32E-4 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:3.42|P-value:6.70E-4 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:-3.86|P-value:1.43E-4 ID:SGTC_515|Compound:4092-1064|FD-Score:3.31|P-value:9.75E-4 ID:SGTC_516|Compound:3992-2719|FD-Score:4.05|P-value:7.20E-5 ID:SGTC_528|Compound:3492-0019|FD-Score:3.91|P-value:1.24E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:8.87|P-value:4.49E-17 ID:SGTC_569|Compound:4130-2812|FD-Score:-3.81|P-value:1.72E-4 ID:SGTC_649|Compound:1123-0311|FD-Score:3.50|P-value:5.19E-4 ID:SGTC_660|Compound:4031-1742|FD-Score:5.35|P-value:2.66E-7 ID:SGTC_722|Compound:3534-0461|FD-Score:3.39|P-value:7.53E-4 ID:SGTC_733|Compound:4069-0007|FD-Score:4.72|P-value:4.85E-6 ID:SGTC_788|Compound:1182-0090|FD-Score:3.34|P-value:8.64E-4 ID:SGTC_797|Compound:k781-0471|FD-Score:3.39|P-value:7.43E-4 ID:SGTC_841|Compound:0251-0215|FD-Score:4.07|P-value:6.75E-5 ID:SGTC_1016|Compound:4226-1401|FD-Score:4.16|P-value:4.74E-5 ID:SGTC_1026|Compound:k007-1105|FD-Score:3.64|P-value:3.28E-4 ID:SGTC_1091|Compound:telmisartan|FD-Score:4.50|P-value:1.22E-5 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:6.26|P-value:2.15E-9 ID:SGTC_1145|Compound:3546-0597|FD-Score:-3.65|P-value:3.06E-4 ID:SGTC_1297|Compound:1068-0111|FD-Score:4.90|P-value:2.21E-6 ID:SGTC_1315|Compound:1237-0019|FD-Score:3.66|P-value:3.06E-4 ID:SGTC_1321|Compound:1326-2144|FD-Score:4.05|P-value:7.43E-5 ID:SGTC_1324|Compound:1418-0026|FD-Score:3.79|P-value:1.90E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:8.51|P-value:7.08E-16 ID:SGTC_1581|Compound:himbacine|FD-Score:4.16|P-value:4.79E-5 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:3.81|P-value:1.80E-4 ID:SGTC_1658|Compound:st012944|FD-Score:5.90|P-value:1.54E-8 ID:SGTC_1687|Compound:st020778|FD-Score:3.73|P-value:2.38E-4 ID:SGTC_1730|Compound:st033808|FD-Score:3.56|P-value:4.25E-4 ID:SGTC_1746|Compound:st038117|FD-Score:-4.32|P-value:2.48E-5 ID:SGTC_1754|Compound:st042065|FD-Score:3.57|P-value:4.04E-4 ID:SGTC_1791|Compound:st048313|FD-Score:3.76|P-value:2.14E-4 ID:SGTC_1800|Compound:st050079|FD-Score:5.75|P-value:3.51E-8 ID:SGTC_1801|Compound:st050089|FD-Score:3.69|P-value:2.73E-4 ID:SGTC_1803|Compound:st050068|FD-Score:4.52|P-value:1.15E-5 ID:SGTC_1822|Compound:st052468|FD-Score:-3.68|P-value:2.74E-4 ID:SGTC_1877|Compound:wortmannin|FD-Score:4.76|P-value:4.10E-6 ID:SGTC_1909|Compound:st060837|FD-Score:3.85|P-value:1.55E-4 ID:SGTC_1911|Compound:st060208|FD-Score:-4.37|P-value:2.00E-5 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:5.57|P-value:8.88E-8 ID:SGTC_1930|Compound:st074634|FD-Score:-7.69|P-value:2.61E-13 ID:SGTC_1955|Compound:wogonin|FD-Score:-3.41|P-value:6.67E-4 ID:SGTC_2062|Compound:5245942|FD-Score:3.81|P-value:1.78E-4 ID:SGTC_2108|Compound:5365811|FD-Score:3.70|P-value:2.58E-4 ID:SGTC_2154|Compound:5570129|FD-Score:3.66|P-value:2.97E-4 ID:SGTC_2195|Compound:6536160|FD-Score:4.20|P-value:4.07E-5 ID:SGTC_2279|Compound:7948423|FD-Score:-3.47|P-value:5.46E-4 ID:SGTC_2300|Compound:7976697|FD-Score:4.37|P-value:2.07E-5 ID:SGTC_2389|Compound:9091542|FD-Score:3.39|P-value:7.41E-4 ID:SGTC_2398|Compound:5228213|FD-Score:4.04|P-value:7.66E-5 ID:SGTC_2475|Compound:5812728|FD-Score:5.15|P-value:6.77E-7 ID:SGTC_2481|Compound:5478948|FD-Score:5.05|P-value:1.08E-6 ID:SGTC_2586|Compound:curcumin|FD-Score:3.94|P-value:1.10E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:-4.21|P-value:3.74E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.03|P-value:7.80E-5 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:-4.91|P-value:1.96E-6 ID:SGTC_2779|Compound:methotrexate|FD-Score:7.70|P-value:2.48E-13 ID:SGTC_2831|Compound:7999036|FD-Score:-4.32|P-value:2.42E-5 ID:SGTC_2835|Compound:9006588|FD-Score:5.85|P-value:2.07E-8 ID:SGTC_2887|Compound:9044784|FD-Score:3.65|P-value:3.15E-4 ID:SGTC_2947|Compound:9072639|FD-Score:3.80|P-value:1.82E-4 ID:SGTC_2951|Compound:9072950|FD-Score:3.62|P-value:3.47E-4 ID:SGTC_2972|Compound:9093619|FD-Score:-3.50|P-value:5.03E-4 ID:SGTC_2982|Compound:9019404|FD-Score:3.57|P-value:4.12E-4 ID:SGTC_2991|Compound:9074669|FD-Score:4.97|P-value:1.55E-6 ID:SGTC_3075|Compound:9116269|FD-Score:-5.78|P-value:2.76E-8 ID:SGTC_3097|Compound:9117246|FD-Score:3.37|P-value:7.93E-4 ID:SGTC_3135|Compound:9127742|FD-Score:4.49|P-value:1.27E-5 ID:SGTC_3136|Compound:9095672|FD-Score:-4.43|P-value:1.55E-5 ID:SGTC_3143|Compound:9086658|FD-Score:-3.42|P-value:6.60E-4 ID:SGTC_3145|Compound:9085516|FD-Score:3.33|P-value:8.92E-4 ID:SGTC_3193|Compound:9111931|FD-Score:4.37|P-value:2.12E-5 ID:SGTC_3296|Compound:9122258|FD-Score:3.39|P-value:7.35E-4 ID:SGTC_3308|Compound:9128332|FD-Score:3.84|P-value:1.60E-4 ID:SGTC_3337|Compound:9144342|FD-Score:-3.49|P-value:5.13E-4

Top fitness defect scores for YGL124C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_568 1193-0097 8.87 7.5 µM 4.49E-17 ERAD & cell cycle 30 3.76E-19
2 SGTC_1495 4469-0029 8.51 237.0 µM 7.08E-16 21 8.57E-18
3 SGTC_2779 methotrexate 7.70 400.0 µM 2.48E-13 7 6.58E-15
4 SGTC_1110 3-hydroxy-3'-methoxyflavone 6.26 1.2 µM 2.15E-9 iron homeostasis 12 1.91E-10
5 SGTC_1658 st012944 5.90 20.0 µM 1.54E-8 iron homeostasis 30 1.77E-9
6 SGTC_2835 9006588 5.85 71.4 µM 2.07E-8 8 2.48E-9
7 SGTC_1800 st050079 5.75 29.1 µM 3.51E-8 NEO1-PIK1 45 4.49E-9
8 SGTC_65 0798-0905 5.57 35.0 µM 8.83E-8 calcium & mitochondrial duress 42 1.28E-8
9 SGTC_1926 methyl fluorone black 5.57 53.6 µM 8.88E-8 DNA intercalators 25 1.29E-8
10 SGTC_660 4031-1742 5.35 102.0 µM 2.66E-7 redox potentiating 16 4.45E-8
11 SGTC_2475 5812728 5.15 15.0 µM 6.77E-7 mitochondrial processes 10 1.28E-7
12 SGTC_2481 5478948 5.05 45.2 µM 1.08E-6 PDR1 17 2.17E-7
13 SGTC_2991 9074669 4.97 71.4 µM 1.55E-6 azole & statin 34 3.28E-7
14 SGTC_1297 1068-0111 4.90 14.1 µM 2.21E-6 3 4.89E-7
15 SGTC_1877 wortmannin 4.76 25.0 µM 4.10E-6 70 9.84E-7
16 SGTC_733 4069-0007 4.72 56.1 µM 4.85E-6 ERAD & cell cycle 60 1.19E-6
17 SGTC_1803 st050068 4.52 52.4 µM 1.15E-5 NEO1-PIK1 138 3.15E-6
18 SGTC_1091 telmisartan 4.50 47.6 µM 1.22E-5 5 3.38E-6
19 SGTC_3135 9127742 4.49 49.5 µM 1.27E-5 12 3.52E-6
20 SGTC_2300 7976697 4.37 71.6 µM 2.07E-5 ERG2 22 6.12E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.313 7.60E-77 YGL212W VAM7 hom Vacuolar SNARE protein; functions with Vam3p in vacuolar protein trafficking; has an N-terminal PX domain (phosphoinositide-binding module) that binds PtdIns-3-P and mediates membrane binding; SNAP-25 homolog; protein abundance increases in response to DNA replication stress
0.296 5.65E-69 YDR080W VPS41 hom Vacuolar membrane protein that is a subunit of the homotypic vacuole fusion and vacuole protein sorting (HOPS) complex; essential for membrane docking and fusion at the Golgi-to-endosome and endosome-to-vacuole stages of protein transport
0.287 8.59E-65 YBR131W CCZ1 hom Protein involved in vacuolar assembly, essential for autophagy and the cytoplasm-to-vacuole pathway
0.256 2.27E-51 YML001W YPT7 hom Rab family GTPase; GTP-binding protein of the rab family; required for homotypic fusion event in vacuole inheritance, for endosome-endosome fusion; interacts with the cargo selection/retromer complex for retrograde sorting; similar to mammalian Rab7
0.251 2.93E-49 YDL077C VAM6 hom Vacuolar protein that plays a critical role in the tethering steps of vacuolar membrane fusion by facilitating guanine nucleotide exchange on small guanosine triphosphatase Ypt7p
0.237 5.30E-44 YJL024C APS3 hom Small subunit of the clathrin-associated adaptor complex AP-3; involved in vacuolar protein sorting; related to the sigma subunit of the mammalian clathrin AP-3 complex; suppressor of loss of casein kinase 1 function; protein abundance increases in response to DNA replication stress
0.211 2.92E-35 YGR261C APL6 hom Beta3-like subunit of the yeast AP-3 complex; functions in transport of alkaline phosphatase to the vacuole via the alternate pathway; exists in both cytosolic and peripherally associated membrane-bound pools
0.190 1.42E-28 YAL002W VPS8 hom Membrane-binding component of the CORVET complex; involved in endosomal vesicle tethering and fusion in the endosome to vacuole protein targeting pathway; interacts with Vps21p; contains RING finger motif
0.189 2.26E-28 YBR288C APM3 hom Mu3-like subunit of the clathrin associated protein complex (AP-3); functions in transport of alkaline phosphatase to the vacuole via the alternate pathway
0.181 5.08E-26 YOR036W PEP12 hom Target membrane receptor (t-SNARE) for vesicular intermediates traveling between the Golgi apparatus and the vacuole; controls entry of biosynthetic, endocytic, and retrograde traffic into the prevacuolar compartment; syntaxin
0.171 2.55E-23 YDR323C PEP7 hom Multivalent adaptor protein that facilitates vesicle-mediated vacuolar protein sorting by ensuring high-fidelity vesicle docking and fusion, which are essential for targeting of vesicles to the endosome; required for vacuole inheritance
0.170 3.98E-23 YCL008C STP22 hom Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; homologous to the mouse and human Tsg101 tumor susceptibility gene; mutants exhibit a Class E Vps phenotype
0.170 4.37E-23 YOL002C IZH2 hom Plasma membrane protein involved in zinc homeostasis and osmotin-induced apoptosis; transcription regulated by Zap1p, zinc and fatty acid levels; similar to mammalian adiponectins; deletion increases sensitivity to elevated zinc
0.168 1.20E-22 YGR166W TRS65 hom Subunit of TRAPPII, a multimeric guanine nucleotide-exchange factor for Ypt1p; involved in intra-Golgi traffic and the retrograde pathway from the endosome to Golgi; role in cell wall beta-glucan biosynthesis and the stress response
0.168 1.24E-22 YML037C_p YML037C_p hom Putative protein of unknown function with some characteristics of a transcriptional activator; may be a target of Dbf2p-Mob1p kinase; GFP-fusion protein co-localizes with clathrin-coated vesicles; YML037C is not an essential gene