YGL126W / SCS3

Protein required for inositol prototrophy; required for normal ER membrane biosynthesis; ortholog of the FIT family of proteins involved in triglyceride droplet biosynthesis and homologous to human FIT2; disputed role in the synthesis of inositol phospholipids from inositol

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL126W / SCS3

Click on Significant Values for Screen Details ID:SGTC_114|Compound:0364-0001|FD-Score:7.62|P-value:7.99E-14 ID:SGTC_384|Compound:k007-0144|FD-Score:4.40|P-value:1.06E-5 ID:SGTC_686|Compound:1319-0111|FD-Score:3.55|P-value:2.97E-4 ID:SGTC_694|Compound:1315-0438|FD-Score:-3.57|P-value:2.63E-4 ID:SGTC_708|Compound:3448-5400|FD-Score:-3.32|P-value:6.43E-4 ID:SGTC_723|Compound:4182-0001|FD-Score:3.86|P-value:9.52E-5 ID:SGTC_724|Compound:3910-0327|FD-Score:4.11|P-value:3.50E-5 ID:SGTC_741|Compound:4582-0002|FD-Score:3.48|P-value:3.82E-4 ID:SGTC_947|Compound:3447-0010|FD-Score:3.43|P-value:4.54E-4 ID:SGTC_962|Compound:1254-0300|FD-Score:3.57|P-value:2.81E-4 ID:SGTC_1096|Compound:rimcazole|FD-Score:-3.23|P-value:8.69E-4 ID:SGTC_1124|Compound:fisetin|FD-Score:4.36|P-value:1.24E-5 ID:SGTC_1126|Compound:isoteolin|FD-Score:3.72|P-value:1.61E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:8.15|P-value:1.51E-15 ID:SGTC_1257|Compound:0669-0121|FD-Score:-3.51|P-value:3.31E-4 ID:SGTC_1378|Compound:2093-0007|FD-Score:3.24|P-value:8.62E-4 ID:SGTC_1379|Compound:2144-0755|FD-Score:-3.29|P-value:7.18E-4 ID:SGTC_1411|Compound:3909-8223|FD-Score:3.21|P-value:9.73E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-4.33|P-value:1.31E-5 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:3.77|P-value:1.34E-4 ID:SGTC_1601|Compound:4'-hydroxyflavanone|FD-Score:5.55|P-value:3.97E-8 ID:SGTC_2125|Compound:5246583|FD-Score:3.24|P-value:8.59E-4 ID:SGTC_2126|Compound:5251174|FD-Score:4.07|P-value:4.09E-5 ID:SGTC_2131|Compound:toluylene red|FD-Score:4.40|P-value:1.04E-5 ID:SGTC_2165|Compound:5727197|FD-Score:6.28|P-value:6.22E-10 ID:SGTC_2239|Compound:6685329|FD-Score:-3.23|P-value:8.55E-4 ID:SGTC_2321|Compound:7390090|FD-Score:4.41|P-value:1.01E-5 ID:SGTC_2323|Compound:6148992|FD-Score:-3.52|P-value:3.19E-4 ID:SGTC_2327|Compound:6189656|FD-Score:4.17|P-value:2.75E-5 ID:SGTC_2328|Compound:6201408|FD-Score:-4.69|P-value:2.67E-6 ID:SGTC_2546|Compound:rhodinyl acetate|FD-Score:6.26|P-value:7.04E-10 ID:SGTC_2556|Compound:citropten|FD-Score:-3.29|P-value:7.09E-4 ID:SGTC_2757|Compound:clomiphene|FD-Score:3.33|P-value:6.50E-4 ID:SGTC_2858|Compound:9025781|FD-Score:3.21|P-value:9.45E-4 ID:SGTC_2956|Compound:9076196|FD-Score:5.02|P-value:6.12E-7 ID:SGTC_2960|Compound:9079389|FD-Score:-3.96|P-value:6.18E-5 ID:SGTC_2961|Compound:9083290|FD-Score:4.11|P-value:3.57E-5 ID:SGTC_2987|Compound:9018338|FD-Score:3.21|P-value:9.62E-4 ID:SGTC_2989|Compound:9073649|FD-Score:3.61|P-value:2.41E-4 ID:SGTC_2990|Compound:9074105|FD-Score:3.58|P-value:2.69E-4 ID:SGTC_2992|Compound:9074591|FD-Score:4.29|P-value:1.69E-5 ID:SGTC_2999|Compound:9069765|FD-Score:-3.33|P-value:6.27E-4 ID:SGTC_3001|Compound:9076041|FD-Score:-3.67|P-value:1.83E-4 ID:SGTC_3005|Compound:9076496|FD-Score:3.80|P-value:1.20E-4 ID:SGTC_3011|Compound:9081274|FD-Score:-4.25|P-value:1.86E-5 ID:SGTC_3015|Compound:9080845|FD-Score:5.27|P-value:1.69E-7 ID:SGTC_114|Compound:0364-0001|FD-Score:7.62|P-value:7.99E-14 ID:SGTC_384|Compound:k007-0144|FD-Score:4.40|P-value:1.06E-5 ID:SGTC_686|Compound:1319-0111|FD-Score:3.55|P-value:2.97E-4 ID:SGTC_694|Compound:1315-0438|FD-Score:-3.57|P-value:2.63E-4 ID:SGTC_708|Compound:3448-5400|FD-Score:-3.32|P-value:6.43E-4 ID:SGTC_723|Compound:4182-0001|FD-Score:3.86|P-value:9.52E-5 ID:SGTC_724|Compound:3910-0327|FD-Score:4.11|P-value:3.50E-5 ID:SGTC_741|Compound:4582-0002|FD-Score:3.48|P-value:3.82E-4 ID:SGTC_947|Compound:3447-0010|FD-Score:3.43|P-value:4.54E-4 ID:SGTC_962|Compound:1254-0300|FD-Score:3.57|P-value:2.81E-4 ID:SGTC_1096|Compound:rimcazole|FD-Score:-3.23|P-value:8.69E-4 ID:SGTC_1124|Compound:fisetin|FD-Score:4.36|P-value:1.24E-5 ID:SGTC_1126|Compound:isoteolin|FD-Score:3.72|P-value:1.61E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:8.15|P-value:1.51E-15 ID:SGTC_1257|Compound:0669-0121|FD-Score:-3.51|P-value:3.31E-4 ID:SGTC_1378|Compound:2093-0007|FD-Score:3.24|P-value:8.62E-4 ID:SGTC_1379|Compound:2144-0755|FD-Score:-3.29|P-value:7.18E-4 ID:SGTC_1411|Compound:3909-8223|FD-Score:3.21|P-value:9.73E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-4.33|P-value:1.31E-5 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:3.77|P-value:1.34E-4 ID:SGTC_1601|Compound:4'-hydroxyflavanone|FD-Score:5.55|P-value:3.97E-8 ID:SGTC_2125|Compound:5246583|FD-Score:3.24|P-value:8.59E-4 ID:SGTC_2126|Compound:5251174|FD-Score:4.07|P-value:4.09E-5 ID:SGTC_2131|Compound:toluylene red|FD-Score:4.40|P-value:1.04E-5 ID:SGTC_2165|Compound:5727197|FD-Score:6.28|P-value:6.22E-10 ID:SGTC_2239|Compound:6685329|FD-Score:-3.23|P-value:8.55E-4 ID:SGTC_2321|Compound:7390090|FD-Score:4.41|P-value:1.01E-5 ID:SGTC_2323|Compound:6148992|FD-Score:-3.52|P-value:3.19E-4 ID:SGTC_2327|Compound:6189656|FD-Score:4.17|P-value:2.75E-5 ID:SGTC_2328|Compound:6201408|FD-Score:-4.69|P-value:2.67E-6 ID:SGTC_2546|Compound:rhodinyl acetate|FD-Score:6.26|P-value:7.04E-10 ID:SGTC_2556|Compound:citropten|FD-Score:-3.29|P-value:7.09E-4 ID:SGTC_2757|Compound:clomiphene|FD-Score:3.33|P-value:6.50E-4 ID:SGTC_2858|Compound:9025781|FD-Score:3.21|P-value:9.45E-4 ID:SGTC_2956|Compound:9076196|FD-Score:5.02|P-value:6.12E-7 ID:SGTC_2960|Compound:9079389|FD-Score:-3.96|P-value:6.18E-5 ID:SGTC_2961|Compound:9083290|FD-Score:4.11|P-value:3.57E-5 ID:SGTC_2987|Compound:9018338|FD-Score:3.21|P-value:9.62E-4 ID:SGTC_2989|Compound:9073649|FD-Score:3.61|P-value:2.41E-4 ID:SGTC_2990|Compound:9074105|FD-Score:3.58|P-value:2.69E-4 ID:SGTC_2992|Compound:9074591|FD-Score:4.29|P-value:1.69E-5 ID:SGTC_2999|Compound:9069765|FD-Score:-3.33|P-value:6.27E-4 ID:SGTC_3001|Compound:9076041|FD-Score:-3.67|P-value:1.83E-4 ID:SGTC_3005|Compound:9076496|FD-Score:3.80|P-value:1.20E-4 ID:SGTC_3011|Compound:9081274|FD-Score:-4.25|P-value:1.86E-5 ID:SGTC_3015|Compound:9080845|FD-Score:5.27|P-value:1.69E-7

Top fitness defect scores for YGL126W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1161 k007-0610 8.15 110.0 µM 1.51E-15 ERAD & cell cycle 23 1.78E-16
2 SGTC_114 0364-0001 7.62 490.3 µM 7.99E-14 5 1.22E-14
3 SGTC_2165 5727197 6.28 32.1 µM 6.22E-10 11 1.71E-10
4 SGTC_2546 rhodinyl acetate 6.26 100.0 µM 7.04E-10 2 1.95E-10
5 SGTC_1601 4'-hydroxyflavanone 5.55 55.5 µM 3.97E-8 RPP1 & pyrimidine depletion 14 1.44E-8
6 SGTC_3015 9080845 5.27 49.5 µM 1.69E-7 1 6.70E-8
7 SGTC_2956 9076196 5.02 2.5 µM 6.12E-7 5 2.64E-7
8 SGTC_2321 7390090 4.41 138.8 µM 1.01E-5 18 5.23E-6
9 SGTC_2131 toluylene red 4.40 5.3 µM 1.04E-5 60S ribosome export 14 5.42E-6
10 SGTC_384 k007-0144 4.40 5.2 µM 1.06E-5 ERAD & cell cycle 47 5.51E-6
11 SGTC_1124 fisetin 4.36 1.2 µM 1.24E-5 24 6.50E-6
12 SGTC_2992 9074591 4.29 71.4 µM 1.69E-5 12 9.06E-6
13 SGTC_2327 6189656 4.17 200.0 µM 2.75E-5 18 1.52E-5
14 SGTC_724 3910-0327 4.11 137.0 µM 3.50E-5 ERG2 16 1.97E-5
15 SGTC_2961 9083290 4.11 32.5 µM 3.57E-5 15 2.00E-5
16 SGTC_2126 5251174 4.07 33.9 µM 4.09E-5 27 2.32E-5
17 SGTC_723 4182-0001 3.86 115.0 µM 9.52E-5 30 5.69E-5
18 SGTC_3005 9076496 3.80 71.4 µM 1.20E-4 7 7.31E-5
19 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 3.77 54.9 µM 1.34E-4 redox potentiating 61 8.22E-5
20 SGTC_1126 isoteolin 3.72 1.0 µM 1.61E-4 36 9.97E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.199 3.02E-31 YDL072C YET3 hom Protein of unknown function; YET3 null mutant decreases the level of secreted invertase; homolog of human BAP31 protein; protein abundance increases in response to DNA replication stress
0.160 1.23E-20 YDR179C CSN9 hom Subunit of the Cop9 signalosome, which is required for deneddylation, or removal of the ubiquitin-like protein Rub1p from Cdc53p (cullin); involved in adaptation to pheromone signaling
0.153 6.69E-19 YIL030C SSM4 hom Ubiquitin-protein ligase involved in ER-associated protein degradation; located in the ER/nuclear envelope; ssm4 mutation suppresses mRNA instability caused by an rna14 mutation
0.151 1.27E-18 YDR479C PEX29 hom Peroxisomal integral membrane peroxin; involved in the regulation of peroxisomal size, number and distribution; genetic interactions suggest that Pex28p and Pex29p act at steps upstream of those mediated by Pex30p, Pex31p, and Pex32p; forms ER foci upon DNA replication stress
0.144 6.51E-17 YDR186C YDR186C hom Putative protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.138 1.29E-15 YDL148C NOP14 het Nucleolar protein, forms a complex with Noc4p that mediates maturation and nuclear export of 40S ribosomal subunits; also present in the small subunit processome complex, which is required for processing of pre-18S rRNA
0.136 2.87E-15 YLR380W CSR1 hom Phosphatidylinositol transfer protein; has a potential role in regulating lipid and fatty acid metabolism under heme-depleted conditions; interacts specifically with thioredoxin peroxidase; may have a role in oxidative stress resistance; protein abundance increases in response to DNA replication stress
0.130 3.63E-14 YDR459C PFA5 hom Palmitoyltransferase with autoacylation activity; likely functions in pathway(s) outside Ras; member of a family of putative palmitoyltransferases containing an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain
0.129 6.60E-14 YJR052W RAD7 hom Protein that recognizes and binds damaged DNA in an ATP-dependent manner (with Rad16p) during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 4 (NEF4) and the Elongin-Cullin-Socs (ECS) ligase complex
0.128 1.37E-13 YDL222C FMP45 hom Integral membrane protein localized to mitochondria (untagged protein); required for sporulation and maintaining sphingolipid content; has sequence similarity to SUR7 and YNL194C
0.127 1.49E-13 YGR292W MAL12 hom Maltase (alpha-D-glucosidase), inducible protein involved in maltose catabolism; encoded in the MAL1 complex locus; hydrolyzes the disaccharides maltose, turanose, maltotriose, and sucrose
0.125 4.32E-13 YLR136C TIS11 hom mRNA-binding protein expressed during iron starvation; binds to a sequence element in the 3'-untranslated regions of specific mRNAs to mediate their degradation; involved in iron homeostasis; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress
0.124 5.57E-13 YDR346C SVF1 hom Protein with a potential role in cell survival pathways, required for the diauxic growth shift; expression in mammalian cells increases survival under conditions inducing apoptosis; mutant has increased aneuploidy tolerance
0.124 6.05E-13 YOR245C DGA1 hom Diacylglycerol acyltransferase, catalyzes the terminal step of triacylglycerol (TAG) formation, acylates diacylglycerol using acyl-CoA as an acyl donor, localized to lipid particles
0.124 6.66E-13 YJL171C YJL171C hom GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress