YGL127C / SOH1

Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; involved in telomere maintenance; conserved with other metazoan MED31 subunits

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL127C / SOH1

Click on Significant Values for Screen Details ID:SGTC_7|Compound:0192-1582|FD-Score:3.71|P-value:2.45E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.29|P-value:9.66E-4 ID:SGTC_149|Compound:3970-0822|FD-Score:4.14|P-value:5.10E-5 ID:SGTC_151|Compound:3013-0144|FD-Score:-3.46|P-value:5.72E-4 ID:SGTC_212|Compound:3807-4682|FD-Score:3.86|P-value:1.44E-4 ID:SGTC_214|Compound:4373-3496|FD-Score:3.86|P-value:1.43E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:-5.03|P-value:1.09E-6 ID:SGTC_580|Compound:1123-0028|FD-Score:5.22|P-value:4.74E-7 ID:SGTC_673|Compound:1082-0474|FD-Score:4.24|P-value:3.49E-5 ID:SGTC_740|Compound:k014-0057|FD-Score:3.43|P-value:6.50E-4 ID:SGTC_754|Compound:3474-0146|FD-Score:4.39|P-value:1.91E-5 ID:SGTC_839|Compound:0122-0028|FD-Score:3.75|P-value:2.17E-4 ID:SGTC_871|Compound:0574-0004|FD-Score:3.96|P-value:1.01E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:-3.42|P-value:6.44E-4 ID:SGTC_927|Compound:2425-1185|FD-Score:3.30|P-value:9.69E-4 ID:SGTC_990|Compound:3985-0011|FD-Score:-3.80|P-value:1.74E-4 ID:SGTC_994|Compound:3910-0338|FD-Score:6.30|P-value:1.66E-9 ID:SGTC_1003|Compound:4049-0218|FD-Score:3.73|P-value:2.29E-4 ID:SGTC_1119|Compound:parthenolide|FD-Score:3.48|P-value:5.43E-4 ID:SGTC_1322|Compound:1348-1070|FD-Score:-3.44|P-value:5.98E-4 ID:SGTC_1516|Compound:st013856|FD-Score:3.95|P-value:1.05E-4 ID:SGTC_1520|Compound:flindersine|FD-Score:-3.85|P-value:1.43E-4 ID:SGTC_1522|Compound:st012842|FD-Score:-4.28|P-value:2.84E-5 ID:SGTC_1712|Compound:st032288|FD-Score:4.38|P-value:2.00E-5 ID:SGTC_1718|Compound:roemerine|FD-Score:-5.02|P-value:1.14E-6 ID:SGTC_1724|Compound:st037281|FD-Score:3.39|P-value:7.41E-4 ID:SGTC_1730|Compound:st033808|FD-Score:5.13|P-value:7.37E-7 ID:SGTC_1798|Compound:st045719|FD-Score:3.64|P-value:3.17E-4 ID:SGTC_1835|Compound:st008666|FD-Score:3.80|P-value:1.82E-4 ID:SGTC_1838|Compound:st055369|FD-Score:4.35|P-value:2.22E-5 ID:SGTC_1892|Compound:st058411|FD-Score:-4.07|P-value:6.43E-5 ID:SGTC_2109|Compound:5483026|FD-Score:6.28|P-value:1.82E-9 ID:SGTC_2164|Compound:5685496|FD-Score:3.79|P-value:1.90E-4 ID:SGTC_2215|Compound:7188065|FD-Score:3.68|P-value:2.73E-4 ID:SGTC_2229|Compound:7354935|FD-Score:4.07|P-value:6.68E-5 ID:SGTC_2306|Compound:7482397|FD-Score:-4.58|P-value:8.10E-6 ID:SGTC_2320|Compound:7373003|FD-Score:4.52|P-value:1.11E-5 ID:SGTC_2365|Compound:9042475|FD-Score:3.55|P-value:4.33E-4 ID:SGTC_2400|Compound:5203494|FD-Score:-3.45|P-value:5.85E-4 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:4.27|P-value:3.12E-5 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:4.73|P-value:4.39E-6 ID:SGTC_2688|Compound:kanamycin b|FD-Score:6.18|P-value:3.19E-9 ID:SGTC_2737|Compound:bleomycin|FD-Score:4.98|P-value:1.47E-6 ID:SGTC_2752|Compound:diclazuril|FD-Score:3.49|P-value:5.23E-4 ID:SGTC_2757|Compound:clomiphene|FD-Score:4.02|P-value:8.12E-5 ID:SGTC_2782|Compound:7736369|FD-Score:3.39|P-value:7.41E-4 ID:SGTC_2803|Compound:7707263|FD-Score:5.58|P-value:8.09E-8 ID:SGTC_2835|Compound:9006588|FD-Score:3.47|P-value:5.65E-4 ID:SGTC_2863|Compound:9028737|FD-Score:4.41|P-value:1.75E-5 ID:SGTC_2912|Compound:7964298|FD-Score:4.39|P-value:1.92E-5 ID:SGTC_3088|Compound:9117578|FD-Score:3.34|P-value:8.71E-4 ID:SGTC_3233|Compound:9132340|FD-Score:3.82|P-value:1.70E-4 ID:SGTC_3265|Compound:9137266|FD-Score:-3.30|P-value:9.47E-4 ID:SGTC_3266|Compound:9136860|FD-Score:-3.70|P-value:2.48E-4 ID:SGTC_3289|Compound:9119912|FD-Score:-3.34|P-value:8.23E-4 ID:SGTC_3293|Compound:9120939|FD-Score:4.36|P-value:2.11E-5 ID:SGTC_7|Compound:0192-1582|FD-Score:3.71|P-value:2.45E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.29|P-value:9.66E-4 ID:SGTC_149|Compound:3970-0822|FD-Score:4.14|P-value:5.10E-5 ID:SGTC_151|Compound:3013-0144|FD-Score:-3.46|P-value:5.72E-4 ID:SGTC_212|Compound:3807-4682|FD-Score:3.86|P-value:1.44E-4 ID:SGTC_214|Compound:4373-3496|FD-Score:3.86|P-value:1.43E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:-5.03|P-value:1.09E-6 ID:SGTC_580|Compound:1123-0028|FD-Score:5.22|P-value:4.74E-7 ID:SGTC_673|Compound:1082-0474|FD-Score:4.24|P-value:3.49E-5 ID:SGTC_740|Compound:k014-0057|FD-Score:3.43|P-value:6.50E-4 ID:SGTC_754|Compound:3474-0146|FD-Score:4.39|P-value:1.91E-5 ID:SGTC_839|Compound:0122-0028|FD-Score:3.75|P-value:2.17E-4 ID:SGTC_871|Compound:0574-0004|FD-Score:3.96|P-value:1.01E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:-3.42|P-value:6.44E-4 ID:SGTC_927|Compound:2425-1185|FD-Score:3.30|P-value:9.69E-4 ID:SGTC_990|Compound:3985-0011|FD-Score:-3.80|P-value:1.74E-4 ID:SGTC_994|Compound:3910-0338|FD-Score:6.30|P-value:1.66E-9 ID:SGTC_1003|Compound:4049-0218|FD-Score:3.73|P-value:2.29E-4 ID:SGTC_1119|Compound:parthenolide|FD-Score:3.48|P-value:5.43E-4 ID:SGTC_1322|Compound:1348-1070|FD-Score:-3.44|P-value:5.98E-4 ID:SGTC_1516|Compound:st013856|FD-Score:3.95|P-value:1.05E-4 ID:SGTC_1520|Compound:flindersine|FD-Score:-3.85|P-value:1.43E-4 ID:SGTC_1522|Compound:st012842|FD-Score:-4.28|P-value:2.84E-5 ID:SGTC_1712|Compound:st032288|FD-Score:4.38|P-value:2.00E-5 ID:SGTC_1718|Compound:roemerine|FD-Score:-5.02|P-value:1.14E-6 ID:SGTC_1724|Compound:st037281|FD-Score:3.39|P-value:7.41E-4 ID:SGTC_1730|Compound:st033808|FD-Score:5.13|P-value:7.37E-7 ID:SGTC_1798|Compound:st045719|FD-Score:3.64|P-value:3.17E-4 ID:SGTC_1835|Compound:st008666|FD-Score:3.80|P-value:1.82E-4 ID:SGTC_1838|Compound:st055369|FD-Score:4.35|P-value:2.22E-5 ID:SGTC_1892|Compound:st058411|FD-Score:-4.07|P-value:6.43E-5 ID:SGTC_2109|Compound:5483026|FD-Score:6.28|P-value:1.82E-9 ID:SGTC_2164|Compound:5685496|FD-Score:3.79|P-value:1.90E-4 ID:SGTC_2215|Compound:7188065|FD-Score:3.68|P-value:2.73E-4 ID:SGTC_2229|Compound:7354935|FD-Score:4.07|P-value:6.68E-5 ID:SGTC_2306|Compound:7482397|FD-Score:-4.58|P-value:8.10E-6 ID:SGTC_2320|Compound:7373003|FD-Score:4.52|P-value:1.11E-5 ID:SGTC_2365|Compound:9042475|FD-Score:3.55|P-value:4.33E-4 ID:SGTC_2400|Compound:5203494|FD-Score:-3.45|P-value:5.85E-4 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:4.27|P-value:3.12E-5 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:4.73|P-value:4.39E-6 ID:SGTC_2688|Compound:kanamycin b|FD-Score:6.18|P-value:3.19E-9 ID:SGTC_2737|Compound:bleomycin|FD-Score:4.98|P-value:1.47E-6 ID:SGTC_2752|Compound:diclazuril|FD-Score:3.49|P-value:5.23E-4 ID:SGTC_2757|Compound:clomiphene|FD-Score:4.02|P-value:8.12E-5 ID:SGTC_2782|Compound:7736369|FD-Score:3.39|P-value:7.41E-4 ID:SGTC_2803|Compound:7707263|FD-Score:5.58|P-value:8.09E-8 ID:SGTC_2835|Compound:9006588|FD-Score:3.47|P-value:5.65E-4 ID:SGTC_2863|Compound:9028737|FD-Score:4.41|P-value:1.75E-5 ID:SGTC_2912|Compound:7964298|FD-Score:4.39|P-value:1.92E-5 ID:SGTC_3088|Compound:9117578|FD-Score:3.34|P-value:8.71E-4 ID:SGTC_3233|Compound:9132340|FD-Score:3.82|P-value:1.70E-4 ID:SGTC_3265|Compound:9137266|FD-Score:-3.30|P-value:9.47E-4 ID:SGTC_3266|Compound:9136860|FD-Score:-3.70|P-value:2.48E-4 ID:SGTC_3289|Compound:9119912|FD-Score:-3.34|P-value:8.23E-4 ID:SGTC_3293|Compound:9120939|FD-Score:4.36|P-value:2.11E-5

Top fitness defect scores for YGL127C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_994 3910-0338 6.30 138.0 µM 1.66E-9 calcium & mitochondrial duress 11 1.50E-10
2 SGTC_2109 5483026 6.28 200.0 µM 1.82E-9 RSC complex & mRNA processing 2 1.66E-10
3 SGTC_2688 kanamycin b 6.18 96.7 µM 3.19E-9 calcium & mitochondrial duress 148 3.14E-10
4 SGTC_2803 7707263 5.58 71.4 µM 8.09E-8 8 1.21E-8
5 SGTC_580 1123-0028 5.22 41.0 µM 4.74E-7 DNA damage response 8 8.89E-8
6 SGTC_1730 st033808 5.13 45.1 µM 7.37E-7 9 1.46E-7
7 SGTC_2737 bleomycin 4.98 30.5 nM 1.47E-6 Golgi 57 3.18E-7
8 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 4.73 100.0 µM 4.39E-6 17 1.10E-6
9 SGTC_2320 7373003 4.52 200.0 µM 1.11E-5 13 3.11E-6
10 SGTC_2863 9028737 4.41 58.4 µM 1.75E-5 3 5.22E-6
11 SGTC_754 3474-0146 4.39 171.0 µM 1.91E-5 copper-dependent oxidative stress 15 5.74E-6
12 SGTC_2912 7964298 4.39 10.9 µM 1.92E-5 cell wall 82 5.76E-6
13 SGTC_1712 st032288 4.38 53.4 µM 2.00E-5 calcium & mitochondrial duress 157 6.06E-6
14 SGTC_3293 9120939 4.36 62.0 µM 2.11E-5 12 6.44E-6
15 SGTC_1838 st055369 4.35 84.5 µM 2.22E-5 13 6.81E-6
16 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 4.27 92.6 µM 3.12E-5 19 9.99E-6
17 SGTC_673 1082-0474 4.24 110.0 µM 3.49E-5 RSC complex & mRNA processing 55 1.13E-5
18 SGTC_149 3970-0822 4.14 46.1 µM 5.10E-5 tubulin folding & SWR complex 90 1.74E-5
19 SGTC_2229 7354935 4.07 190.0 µM 6.68E-5 RSC complex & mRNA processing 9 2.35E-5
20 SGTC_2757 clomiphene 4.02 4.2 µM 8.12E-5 fatty acid desaturase (OLE1) 37 2.93E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.163 2.78E-21 YOR236W DFR1 het Dihydrofolate reductase involved in tetrahydrofolate biosynthesis; required for respiratory metabolism
0.148 8.40E-18 YHR041C SRB2 hom Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; general transcription factor involved in telomere maintenance
0.145 3.06E-17 YHR064C SSZ1 hom Hsp70 protein that interacts with Zuo1p (a DnaJ homolog) to form a ribosome-associated complex that binds the ribosome via the Zuo1p subunit; also involved in pleiotropic drug resistance via sequential activation of PDR1 and PDR5; binds ATP
0.132 1.35E-14 YDR443C SSN2 hom Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for stable association of Srb10p-Srb11p kinase; essential for transcriptional regulation
0.132 2.08E-14 YNL246W VPS75 hom NAP family histone chaperone; binds to histones and Rtt109p, stimulating histone acetyltransferase activity; possesses nucleosome assembly activity in vitro; proposed role in vacuolar protein sorting and in double-strand break repair; protein abundance increases in response to DNA replication stress
0.127 1.34E-13 YOR312C RPL20B hom Ribosomal 60S subunit protein L20B; homologous to mammalian ribosomal protein L18A, no bacterial homolog; RPL20B has a paralog, RPL20A, that arose from the whole genome duplication
0.126 2.63E-13 YGR078C PAC10 hom Part of the heteromeric co-chaperone GimC/prefoldin complex, which promotes efficient protein folding
0.125 4.08E-13 YFL002C SPB4 het Putative ATP-dependent RNA helicase, nucleolar protein required for synthesis of 60S ribosomal subunits at a late step in the pathway; sediments with 66S pre-ribosomes in sucrose gradients
0.122 1.47E-12 YHR205W SCH9 hom AGC family protein kinase; functional ortholog of mammalian S6 kinase; phosphorylated by Tor1p and required for TORC1-mediated regulation of ribosome biogenesis, translation initiation, and entry into G0 phase; involved in transactivation of osmostress-responsive genes; regulates G1 progression, cAPK activity and nitrogen activation of the FGM pathway; integrates nutrient signals and stress signals from sphingolipids to regulate lifespan
0.120 3.14E-12 YKL176C LST4 hom Protein possibly involved in a post-Golgi secretory pathway; required for the transport of nitrogen-regulated amino acid permease Gap1p from the Golgi to the cell surface
0.119 5.30E-12 YER165W PAB1 het Poly(A) binding protein, part of the 3'-end RNA-processing complex, mediates interactions between the 5' cap structure and the 3' mRNA poly(A) tail, involved in control of poly(A) tail length, interacts with translation factor eIF-4G
0.113 4.97E-11 YDR404C RPB7 het RNA polymerase II subunit B16; forms two subunit dissociable complex with Rpb4p; involved in recruitment of 3'-end processing factors to transcribing RNA polymerase II complex and in export of mRNA to cytoplasm under stress conditions; also involved in translation initiation
0.113 5.47E-11 YKR097W PCK1 hom Phosphoenolpyruvate carboxykinase, key enzyme in gluconeogenesis, catalyzes early reaction in carbohydrate biosynthesis, glucose represses transcription and accelerates mRNA degradation, regulated by Mcm1p and Cat8p, located in the cytosol
0.112 7.59E-11 YML127W RSC9 het Component of the RSC chromatin remodeling complex; DNA-binding protein involved in the synthesis of rRNA and in transcriptional repression and activation of genes regulated by the Target of Rapamycin (TOR) pathway
0.111 1.22E-10 YJL081C ARP4 het Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes