YGL128C / CWC23

Component of a complex containing Cef1p, putatively involved in pre-mRNA splicing; has similarity to E. coli DnaJ and other DnaJ-like proteins and to S. pombe Cwf23p

Zygosity: Heterozygous strain
fixedexpanded
Profile for YGL128C / CWC23

Click on Significant Values for Screen Details ID:SGTC_74|Compound:000s-0487|FD-Score:-4.64|P-value:6.56E-8 ID:SGTC_78|Compound:0336-0123|FD-Score:-4.50|P-value:1.56E-7 ID:SGTC_132|Compound:0417-1715|FD-Score:-2.86|P-value:5.49E-4 ID:SGTC_157|Compound:1348-1695|FD-Score:3.20|P-value:1.67E-4 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:6.37|P-value:3.67E-13 ID:SGTC_323|Compound:4013-0906|FD-Score:-3.18|P-value:1.46E-4 ID:SGTC_343|Compound:4130-2827|FD-Score:3.19|P-value:1.73E-4 ID:SGTC_355|Compound:1311-2252|FD-Score:-3.20|P-value:1.32E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:-3.36|P-value:6.54E-5 ID:SGTC_384|Compound:k007-0144|FD-Score:4.68|P-value:7.12E-8 ID:SGTC_568|Compound:1193-0097|FD-Score:3.01|P-value:3.72E-4 ID:SGTC_598|Compound:3937-0236|FD-Score:-3.92|P-value:4.01E-6 ID:SGTC_666|Compound:0272-0154|FD-Score:2.91|P-value:5.74E-4 ID:SGTC_787|Compound:4152-0075|FD-Score:-2.94|P-value:3.91E-4 ID:SGTC_847|Compound:0342-0274|FD-Score:3.27|P-value:1.26E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:2.93|P-value:5.24E-4 ID:SGTC_998|Compound:3996-0085|FD-Score:3.35|P-value:8.88E-5 ID:SGTC_1039|Compound:k821-0043|FD-Score:3.13|P-value:2.27E-4 ID:SGTC_1040|Compound:k898-0338|FD-Score:-2.77|P-value:7.74E-4 ID:SGTC_1323|Compound:1348-1351|FD-Score:-3.06|P-value:2.43E-4 ID:SGTC_1357|Compound:1503-1303|FD-Score:3.23|P-value:1.49E-4 ID:SGTC_1455|Compound:4262-0120|FD-Score:-4.13|P-value:1.32E-6 ID:SGTC_1464|Compound:k208-0027|FD-Score:-4.71|P-value:4.25E-8 ID:SGTC_1509|Compound:1326-1131|FD-Score:-3.24|P-value:1.13E-4 ID:SGTC_1512|Compound:0259-0544|FD-Score:2.79|P-value:9.13E-4 ID:SGTC_1515|Compound:3460-0031|FD-Score:3.16|P-value:2.02E-4 ID:SGTC_1601|Compound:4'-hydroxyflavanone|FD-Score:3.22|P-value:1.53E-4 ID:SGTC_1632|Compound:st005650|FD-Score:-3.05|P-value:2.53E-4 ID:SGTC_1633|Compound:st005664|FD-Score:-3.99|P-value:2.86E-6 ID:SGTC_1635|Compound:st007035|FD-Score:5.57|P-value:1.93E-10 ID:SGTC_1637|Compound:st007924|FD-Score:-3.55|P-value:2.57E-5 ID:SGTC_1721|Compound:st082152|FD-Score:-2.90|P-value:4.58E-4 ID:SGTC_1780|Compound:st038448|FD-Score:-3.04|P-value:2.62E-4 ID:SGTC_1849|Compound:st056239|FD-Score:3.98|P-value:4.02E-6 ID:SGTC_1894|Compound:3',6'-dihydroxyflavone|FD-Score:3.19|P-value:1.78E-4 ID:SGTC_1941|Compound:st076221|FD-Score:3.07|P-value:2.97E-4 ID:SGTC_1953|Compound:st076800|FD-Score:-3.05|P-value:2.52E-4 ID:SGTC_1970|Compound:st070122|FD-Score:3.48|P-value:4.83E-5 ID:SGTC_2053|Compound:5265679|FD-Score:3.11|P-value:2.45E-4 ID:SGTC_2135|Compound:5326629|FD-Score:3.23|P-value:1.47E-4 ID:SGTC_2158|Compound:5657123|FD-Score:-3.07|P-value:2.35E-4 ID:SGTC_2162|Compound:5663267|FD-Score:-3.56|P-value:2.50E-5 ID:SGTC_2180|Compound:6301957|FD-Score:-2.86|P-value:5.53E-4 ID:SGTC_2183|Compound:6420625|FD-Score:2.95|P-value:4.72E-4 ID:SGTC_2236|Compound:dapsone|FD-Score:3.29|P-value:1.15E-4 ID:SGTC_2304|Compound:7443016|FD-Score:5.94|P-value:1.22E-11 ID:SGTC_2305|Compound:7443522|FD-Score:6.69|P-value:2.63E-14 ID:SGTC_2308|Compound:7584454|FD-Score:-2.89|P-value:4.93E-4 ID:SGTC_2313|Compound:7726885|FD-Score:-3.63|P-value:1.81E-5 ID:SGTC_2328|Compound:6201408|FD-Score:3.07|P-value:2.89E-4 ID:SGTC_2379|Compound:9035213|FD-Score:-3.33|P-value:7.42E-5 ID:SGTC_2385|Compound:9074692|FD-Score:2.83|P-value:7.78E-4 ID:SGTC_2444|Compound:5485484|FD-Score:2.85|P-value:7.13E-4 ID:SGTC_2456|Compound:5770359|FD-Score:-3.12|P-value:1.89E-4 ID:SGTC_2481|Compound:5478948|FD-Score:-2.76|P-value:8.23E-4 ID:SGTC_2482|Compound:5981709|FD-Score:4.56|P-value:1.55E-7 ID:SGTC_2507|Compound:purpurin|FD-Score:3.12|P-value:2.37E-4 ID:SGTC_2560|Compound:caryophyllene|FD-Score:3.42|P-value:6.41E-5 ID:SGTC_2699|Compound:st077704|FD-Score:3.48|P-value:4.80E-5 ID:SGTC_2807|Compound:7945238|FD-Score:-2.76|P-value:8.19E-4 ID:SGTC_2951|Compound:9072950|FD-Score:-3.04|P-value:2.67E-4 ID:SGTC_3126|Compound:9127922|FD-Score:3.11|P-value:2.53E-4 ID:SGTC_3210|Compound:9128157|FD-Score:-5.88|P-value:1.21E-11 ID:SGTC_74|Compound:000s-0487|FD-Score:-4.64|P-value:6.56E-8 ID:SGTC_78|Compound:0336-0123|FD-Score:-4.50|P-value:1.56E-7 ID:SGTC_132|Compound:0417-1715|FD-Score:-2.86|P-value:5.49E-4 ID:SGTC_157|Compound:1348-1695|FD-Score:3.20|P-value:1.67E-4 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:6.37|P-value:3.67E-13 ID:SGTC_323|Compound:4013-0906|FD-Score:-3.18|P-value:1.46E-4 ID:SGTC_343|Compound:4130-2827|FD-Score:3.19|P-value:1.73E-4 ID:SGTC_355|Compound:1311-2252|FD-Score:-3.20|P-value:1.32E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:-3.36|P-value:6.54E-5 ID:SGTC_384|Compound:k007-0144|FD-Score:4.68|P-value:7.12E-8 ID:SGTC_568|Compound:1193-0097|FD-Score:3.01|P-value:3.72E-4 ID:SGTC_598|Compound:3937-0236|FD-Score:-3.92|P-value:4.01E-6 ID:SGTC_666|Compound:0272-0154|FD-Score:2.91|P-value:5.74E-4 ID:SGTC_787|Compound:4152-0075|FD-Score:-2.94|P-value:3.91E-4 ID:SGTC_847|Compound:0342-0274|FD-Score:3.27|P-value:1.26E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:2.93|P-value:5.24E-4 ID:SGTC_998|Compound:3996-0085|FD-Score:3.35|P-value:8.88E-5 ID:SGTC_1039|Compound:k821-0043|FD-Score:3.13|P-value:2.27E-4 ID:SGTC_1040|Compound:k898-0338|FD-Score:-2.77|P-value:7.74E-4 ID:SGTC_1323|Compound:1348-1351|FD-Score:-3.06|P-value:2.43E-4 ID:SGTC_1357|Compound:1503-1303|FD-Score:3.23|P-value:1.49E-4 ID:SGTC_1455|Compound:4262-0120|FD-Score:-4.13|P-value:1.32E-6 ID:SGTC_1464|Compound:k208-0027|FD-Score:-4.71|P-value:4.25E-8 ID:SGTC_1509|Compound:1326-1131|FD-Score:-3.24|P-value:1.13E-4 ID:SGTC_1512|Compound:0259-0544|FD-Score:2.79|P-value:9.13E-4 ID:SGTC_1515|Compound:3460-0031|FD-Score:3.16|P-value:2.02E-4 ID:SGTC_1601|Compound:4'-hydroxyflavanone|FD-Score:3.22|P-value:1.53E-4 ID:SGTC_1632|Compound:st005650|FD-Score:-3.05|P-value:2.53E-4 ID:SGTC_1633|Compound:st005664|FD-Score:-3.99|P-value:2.86E-6 ID:SGTC_1635|Compound:st007035|FD-Score:5.57|P-value:1.93E-10 ID:SGTC_1637|Compound:st007924|FD-Score:-3.55|P-value:2.57E-5 ID:SGTC_1721|Compound:st082152|FD-Score:-2.90|P-value:4.58E-4 ID:SGTC_1780|Compound:st038448|FD-Score:-3.04|P-value:2.62E-4 ID:SGTC_1849|Compound:st056239|FD-Score:3.98|P-value:4.02E-6 ID:SGTC_1894|Compound:3',6'-dihydroxyflavone|FD-Score:3.19|P-value:1.78E-4 ID:SGTC_1941|Compound:st076221|FD-Score:3.07|P-value:2.97E-4 ID:SGTC_1953|Compound:st076800|FD-Score:-3.05|P-value:2.52E-4 ID:SGTC_1970|Compound:st070122|FD-Score:3.48|P-value:4.83E-5 ID:SGTC_2053|Compound:5265679|FD-Score:3.11|P-value:2.45E-4 ID:SGTC_2135|Compound:5326629|FD-Score:3.23|P-value:1.47E-4 ID:SGTC_2158|Compound:5657123|FD-Score:-3.07|P-value:2.35E-4 ID:SGTC_2162|Compound:5663267|FD-Score:-3.56|P-value:2.50E-5 ID:SGTC_2180|Compound:6301957|FD-Score:-2.86|P-value:5.53E-4 ID:SGTC_2183|Compound:6420625|FD-Score:2.95|P-value:4.72E-4 ID:SGTC_2236|Compound:dapsone|FD-Score:3.29|P-value:1.15E-4 ID:SGTC_2304|Compound:7443016|FD-Score:5.94|P-value:1.22E-11 ID:SGTC_2305|Compound:7443522|FD-Score:6.69|P-value:2.63E-14 ID:SGTC_2308|Compound:7584454|FD-Score:-2.89|P-value:4.93E-4 ID:SGTC_2313|Compound:7726885|FD-Score:-3.63|P-value:1.81E-5 ID:SGTC_2328|Compound:6201408|FD-Score:3.07|P-value:2.89E-4 ID:SGTC_2379|Compound:9035213|FD-Score:-3.33|P-value:7.42E-5 ID:SGTC_2385|Compound:9074692|FD-Score:2.83|P-value:7.78E-4 ID:SGTC_2444|Compound:5485484|FD-Score:2.85|P-value:7.13E-4 ID:SGTC_2456|Compound:5770359|FD-Score:-3.12|P-value:1.89E-4 ID:SGTC_2481|Compound:5478948|FD-Score:-2.76|P-value:8.23E-4 ID:SGTC_2482|Compound:5981709|FD-Score:4.56|P-value:1.55E-7 ID:SGTC_2507|Compound:purpurin|FD-Score:3.12|P-value:2.37E-4 ID:SGTC_2560|Compound:caryophyllene|FD-Score:3.42|P-value:6.41E-5 ID:SGTC_2699|Compound:st077704|FD-Score:3.48|P-value:4.80E-5 ID:SGTC_2807|Compound:7945238|FD-Score:-2.76|P-value:8.19E-4 ID:SGTC_2951|Compound:9072950|FD-Score:-3.04|P-value:2.67E-4 ID:SGTC_3126|Compound:9127922|FD-Score:3.11|P-value:2.53E-4 ID:SGTC_3210|Compound:9128157|FD-Score:-5.88|P-value:1.21E-11

Top fitness defect scores for YGL128C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2305 7443522 6.69 69.2 µM 2.63E-14 3 1.14E-11 1.61
2 SGTC_219 mitoxanthrone 6.37 164.4 µM 3.67E-13 DNA intercalators 6 9.16E-11 1.30
3 SGTC_2304 7443016 5.94 91.4 µM 1.22E-11 1 1.46E-9 1.22
4 SGTC_1635 st007035 5.57 42.4 µM 1.93E-10 8 1.30E-8 0.15
5 SGTC_384 k007-0144 4.68 5.2 µM 7.12E-8 ERAD & cell cycle 10 1.41E-6 0.07
6 SGTC_2482 5981709 4.56 142.7 µM 1.55E-7 PDR1 9 2.61E-6 0.11
7 SGTC_1849 st056239 3.98 19.2 µM 4.02E-6 RPP1 & pyrimidine depletion 3 3.47E-5 0.17
8 SGTC_2699 st077704 3.48 54.6 µM 4.80E-5 endomembrane recycling 6 2.51E-4 0.01
9 SGTC_1970 st070122 3.48 35.8 µM 4.83E-5 TSC3-RPN4 12 2.52E-4 0.02
10 SGTC_2560 caryophyllene 3.42 100.0 µM 6.41E-5 13 3.17E-4 0.03
11 SGTC_998 3996-0085 3.35 177.0 µM 8.88E-5 4 4.11E-4 0.07
12 SGTC_2236 dapsone 3.29 200.0 µM 1.15E-4 2 5.04E-4 0.03
13 SGTC_847 0342-0274 3.27 5.5 µM 1.26E-4 9 5.44E-4 0.07
14 SGTC_2135 5326629 3.23 150.4 µM 1.47E-4 RPP1 & pyrimidine depletion 11 6.16E-4 0.11
15 SGTC_1357 1503-1303 3.23 39.5 µM 1.49E-4 17 6.23E-4 0.04
16 SGTC_1601 4'-hydroxyflavanone 3.22 55.5 µM 1.53E-4 RPP1 & pyrimidine depletion 12 6.35E-4 0.05
17 SGTC_157 1348-1695 3.20 65.8 µM 1.67E-4 iron homeostasis 43 6.83E-4 0.08
18 SGTC_343 4130-2827 3.19 29.8 µM 1.73E-4 8 7.01E-4 0.01
19 SGTC_1894 3',6'-dihydroxyflavone 3.19 78.7 µM 1.78E-4 14 7.18E-4 0.06
20 SGTC_1515 3460-0031 3.16 42.1 µM 2.02E-4 DNA intercalators 17 7.95E-4 0.07

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.168 9.72E-23 YNR018W RCF2 hom Cytochrome c oxidase subunit; has a role in assembly of respiratory supercomplexes; similar to Rcf1p, and either Rcf1p or Rcf2p is required for late-stage assembly of the Cox12p and Cox13p subunits and for cytochrome c oxidase activity; associates with the cytochrome c oxidase - cytochrome bc1 supercomplex; null mutant accumulates reactive oxygen species; member of the conserved hypoxia induced gene family; C. elegans homolog is functional in yeast
0.163 2.76E-21 YMR151W_d YIM2_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1
0.149 5.07E-18 YLL009C COX17 hom Copper metallochaperone that transfers copper to Sco1p and Cox11p for eventual delivery to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs
0.144 4.95E-17 YPL189C-A COA2 hom Cytochrome oxidase assembly factor; null mutation results in respiratory deficiency with specific loss of cytochrome oxidase activity; functions downstream of assembly factors Mss51p and Coa1p and interacts with assembly factor Shy1p
0.140 4.61E-16 YKL087C CYT2 hom Cytochrome c1 heme lyase, involved in maturation of cytochrome c1, which is a subunit of the mitochondrial ubiquinol-cytochrome-c reductase; links heme covalently to apocytochrome c1
0.136 2.45E-15 YEL059C-A SOM1 hom Subunit of the mitochondrial inner membrane peptidase, which is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates; contains twin cysteine-x9-cysteine motifs
0.133 8.67E-15 YGL191W COX13 hom Subunit VIa of cytochrome c oxidase; present in a subclass of cytochrome c oxidase complexes that may have a role in mimimizing generation of reactive oxygen species; not essential for cytochrome c oxidase activity but may modulate activity in response to ATP; required for assembly of Rcf2p into cytochrome c oxidase - cytochrome bc1 supercomplexes
0.133 1.17E-14 YPL013C MRPS16 hom Mitochondrial ribosomal protein of the small subunit
0.129 7.83E-14 YIL098C FMC1 hom Mitochondrial matrix protein, required for assembly or stability at high temperature of the F1 sector of mitochondrial F1F0 ATP synthase; null mutant temperature sensitive growth on glycerol is suppressed by multicopy expression of Odc1p
0.114 3.34E-11 YKL155C RSM22 hom Mitochondrial ribosomal protein of the small subunit; also predicted to be an S-adenosylmethionine-dependent methyltransferase
0.113 5.42E-11 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.110 1.62E-10 YLR038C COX12 hom Subunit VIb of cytochrome c oxidase; cytochrome c oxidase is also known as respiratory Complex IV and is the terminal member of the mitochondrial inner membrane electron transport chain; required for assembly of cytochrome c oxidase but not required for activity after assembly; phosphorylated; easily released from the intermembrane space, suggesting a loose association with Complex IV
0.110 1.87E-10 YGR183C QCR9 hom Subunit 9 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; required for electron transfer at the ubiquinol oxidase site of the complex
0.109 2.29E-10 YGR070W ROM1 hom GDP/GTP exchange protein (GEP) for Rho1p; mutations are synthetically lethal with mutations in rom2, which also encodes a GEP
0.109 2.61E-10 YDR082W STN1 het Telomere end-binding and capping protein, plays a key role with Pol12p in linking telomerase action with completion of lagging strand synthesis, and in a regulatory step required for telomere capping