YGL129C / RSM23

Mitochondrial ribosomal protein of the small subunit, has similarity to mammalian apoptosis mediator proteins; null mutation prevents induction of apoptosis by overproduction of metacaspase Mca1p

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL129C / RSM23

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:5.57|P-value:1.85E-7 ID:SGTC_19|Compound:0279-0214|FD-Score:3.81|P-value:2.35E-4 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:3.90|P-value:1.78E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:5.29|P-value:6.89E-7 ID:SGTC_63|Compound:0099-0242|FD-Score:8.45|P-value:7.63E-15 ID:SGTC_70|Compound:0141-0289|FD-Score:6.41|P-value:2.50E-9 ID:SGTC_119|Compound:0121-0043|FD-Score:3.48|P-value:7.09E-4 ID:SGTC_149|Compound:3970-0822|FD-Score:3.78|P-value:2.62E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:-4.04|P-value:1.56E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:7.90|P-value:3.29E-13 ID:SGTC_236|Compound:1509-0011|FD-Score:8.33|P-value:1.76E-14 ID:SGTC_275|Compound:trichlorophene|FD-Score:6.01|P-value:2.11E-8 ID:SGTC_310|Compound:1273-0058|FD-Score:9.42|P-value:5.35E-18 ID:SGTC_346|Compound:4513-0042|FD-Score:-4.40|P-value:4.23E-5 ID:SGTC_352|Compound:k048-0007|FD-Score:-5.50|P-value:4.40E-7 ID:SGTC_358|Compound:0075-0058|FD-Score:5.59|P-value:1.66E-7 ID:SGTC_374|Compound:0880-0231|FD-Score:-4.41|P-value:4.14E-5 ID:SGTC_394|Compound:menadione|FD-Score:-4.37|P-value:4.74E-5 ID:SGTC_398|Compound:bronopol|FD-Score:5.41|P-value:3.86E-7 ID:SGTC_437|Compound:s-farnesyl-l-cysteine methyl ester|FD-Score:4.45|P-value:2.31E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.86|P-value:2.96E-4 ID:SGTC_596|Compound:1155-0152|FD-Score:3.48|P-value:7.11E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:-3.51|P-value:8.87E-4 ID:SGTC_748|Compound:0136-0228|FD-Score:3.66|P-value:3.90E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:3.72|P-value:3.19E-4 ID:SGTC_892|Compound:0929-0076|FD-Score:3.99|P-value:1.26E-4 ID:SGTC_940|Compound:3232-1287|FD-Score:3.90|P-value:1.77E-4 ID:SGTC_950|Compound:1165-0508|FD-Score:-5.32|P-value:9.94E-7 ID:SGTC_1133|Compound:3473-0247|FD-Score:3.97|P-value:1.38E-4 ID:SGTC_1216|Compound:1165-0504|FD-Score:-3.79|P-value:3.74E-4 ID:SGTC_1219|Compound:1469-0211|FD-Score:-3.77|P-value:3.92E-4 ID:SGTC_1361|Compound:1608-0041|FD-Score:3.84|P-value:2.12E-4 ID:SGTC_1424|Compound:4048-1941|FD-Score:3.84|P-value:2.19E-4 ID:SGTC_1456|Compound:k015-0012|FD-Score:5.05|P-value:1.99E-6 ID:SGTC_1573|Compound:oleylamine|FD-Score:3.42|P-value:8.52E-4 ID:SGTC_1707|Compound:st032323|FD-Score:-4.04|P-value:1.60E-4 ID:SGTC_1806|Compound:st050005|FD-Score:3.48|P-value:6.92E-4 ID:SGTC_1812|Compound:st052057|FD-Score:3.46|P-value:7.35E-4 ID:SGTC_1919|Compound:st067113|FD-Score:-3.74|P-value:4.34E-4 ID:SGTC_1962|Compound:st076595|FD-Score:-3.99|P-value:1.85E-4 ID:SGTC_2013|Compound:4024628|FD-Score:3.76|P-value:2.82E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:-4.76|P-value:1.06E-5 ID:SGTC_2250|Compound:alverine citrate|FD-Score:4.06|P-value:1.01E-4 ID:SGTC_2258|Compound:7960471|FD-Score:3.78|P-value:2.63E-4 ID:SGTC_2292|Compound:7671323|FD-Score:3.76|P-value:2.80E-4 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:3.36|P-value:0.00100 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:3.48|P-value:7.07E-4 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:3.59|P-value:4.89E-4 ID:SGTC_2630|Compound:antimycin a|FD-Score:3.52|P-value:6.23E-4 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:-3.53|P-value:8.49E-4 ID:SGTC_2661|Compound:dactinomycin|FD-Score:3.74|P-value:2.99E-4 ID:SGTC_2804|Compound:7954240|FD-Score:3.48|P-value:6.98E-4 ID:SGTC_2813|Compound:7971799|FD-Score:3.67|P-value:3.82E-4 ID:SGTC_2844|Compound:9010103|FD-Score:5.85|P-value:4.73E-8 ID:SGTC_2896|Compound:9052656|FD-Score:-3.79|P-value:3.64E-4 ID:SGTC_2977|Compound:9011197|FD-Score:4.52|P-value:1.76E-5 ID:SGTC_2983|Compound:9022671|FD-Score:3.43|P-value:8.07E-4 ID:SGTC_3152|Compound:9099253|FD-Score:4.03|P-value:1.10E-4 ID:SGTC_10|Compound:0279-0212|FD-Score:5.57|P-value:1.85E-7 ID:SGTC_19|Compound:0279-0214|FD-Score:3.81|P-value:2.35E-4 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:3.90|P-value:1.78E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:5.29|P-value:6.89E-7 ID:SGTC_63|Compound:0099-0242|FD-Score:8.45|P-value:7.63E-15 ID:SGTC_70|Compound:0141-0289|FD-Score:6.41|P-value:2.50E-9 ID:SGTC_119|Compound:0121-0043|FD-Score:3.48|P-value:7.09E-4 ID:SGTC_149|Compound:3970-0822|FD-Score:3.78|P-value:2.62E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:-4.04|P-value:1.56E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:7.90|P-value:3.29E-13 ID:SGTC_236|Compound:1509-0011|FD-Score:8.33|P-value:1.76E-14 ID:SGTC_275|Compound:trichlorophene|FD-Score:6.01|P-value:2.11E-8 ID:SGTC_310|Compound:1273-0058|FD-Score:9.42|P-value:5.35E-18 ID:SGTC_346|Compound:4513-0042|FD-Score:-4.40|P-value:4.23E-5 ID:SGTC_352|Compound:k048-0007|FD-Score:-5.50|P-value:4.40E-7 ID:SGTC_358|Compound:0075-0058|FD-Score:5.59|P-value:1.66E-7 ID:SGTC_374|Compound:0880-0231|FD-Score:-4.41|P-value:4.14E-5 ID:SGTC_394|Compound:menadione|FD-Score:-4.37|P-value:4.74E-5 ID:SGTC_398|Compound:bronopol|FD-Score:5.41|P-value:3.86E-7 ID:SGTC_437|Compound:s-farnesyl-l-cysteine methyl ester|FD-Score:4.45|P-value:2.31E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.86|P-value:2.96E-4 ID:SGTC_596|Compound:1155-0152|FD-Score:3.48|P-value:7.11E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:-3.51|P-value:8.87E-4 ID:SGTC_748|Compound:0136-0228|FD-Score:3.66|P-value:3.90E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:3.72|P-value:3.19E-4 ID:SGTC_892|Compound:0929-0076|FD-Score:3.99|P-value:1.26E-4 ID:SGTC_940|Compound:3232-1287|FD-Score:3.90|P-value:1.77E-4 ID:SGTC_950|Compound:1165-0508|FD-Score:-5.32|P-value:9.94E-7 ID:SGTC_1133|Compound:3473-0247|FD-Score:3.97|P-value:1.38E-4 ID:SGTC_1216|Compound:1165-0504|FD-Score:-3.79|P-value:3.74E-4 ID:SGTC_1219|Compound:1469-0211|FD-Score:-3.77|P-value:3.92E-4 ID:SGTC_1361|Compound:1608-0041|FD-Score:3.84|P-value:2.12E-4 ID:SGTC_1424|Compound:4048-1941|FD-Score:3.84|P-value:2.19E-4 ID:SGTC_1456|Compound:k015-0012|FD-Score:5.05|P-value:1.99E-6 ID:SGTC_1573|Compound:oleylamine|FD-Score:3.42|P-value:8.52E-4 ID:SGTC_1707|Compound:st032323|FD-Score:-4.04|P-value:1.60E-4 ID:SGTC_1806|Compound:st050005|FD-Score:3.48|P-value:6.92E-4 ID:SGTC_1812|Compound:st052057|FD-Score:3.46|P-value:7.35E-4 ID:SGTC_1919|Compound:st067113|FD-Score:-3.74|P-value:4.34E-4 ID:SGTC_1962|Compound:st076595|FD-Score:-3.99|P-value:1.85E-4 ID:SGTC_2013|Compound:4024628|FD-Score:3.76|P-value:2.82E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:-4.76|P-value:1.06E-5 ID:SGTC_2250|Compound:alverine citrate|FD-Score:4.06|P-value:1.01E-4 ID:SGTC_2258|Compound:7960471|FD-Score:3.78|P-value:2.63E-4 ID:SGTC_2292|Compound:7671323|FD-Score:3.76|P-value:2.80E-4 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:3.36|P-value:0.00100 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:3.48|P-value:7.07E-4 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:3.59|P-value:4.89E-4 ID:SGTC_2630|Compound:antimycin a|FD-Score:3.52|P-value:6.23E-4 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:-3.53|P-value:8.49E-4 ID:SGTC_2661|Compound:dactinomycin|FD-Score:3.74|P-value:2.99E-4 ID:SGTC_2804|Compound:7954240|FD-Score:3.48|P-value:6.98E-4 ID:SGTC_2813|Compound:7971799|FD-Score:3.67|P-value:3.82E-4 ID:SGTC_2844|Compound:9010103|FD-Score:5.85|P-value:4.73E-8 ID:SGTC_2896|Compound:9052656|FD-Score:-3.79|P-value:3.64E-4 ID:SGTC_2977|Compound:9011197|FD-Score:4.52|P-value:1.76E-5 ID:SGTC_2983|Compound:9022671|FD-Score:3.43|P-value:8.07E-4 ID:SGTC_3152|Compound:9099253|FD-Score:4.03|P-value:1.10E-4

Top fitness defect scores for YGL129C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_310 1273-0058 9.42 1.1 µM 5.35E-18 mitochondrial stress 53 2.17E-21
2 SGTC_63 0099-0242 8.45 26.7 µM 7.63E-15 mitochondrial stress 4 1.46E-17
3 SGTC_236 1509-0011 8.33 5.3 µM 1.76E-14 238 4.04E-17
4 SGTC_173 1273-0061 7.90 2.7 µM 3.29E-13 mitochondrial stress 69 1.41E-15
5 SGTC_70 0141-0289 6.41 43.3 µM 2.50E-9 mitochondrial stress 69 7.04E-11
6 SGTC_275 trichlorophene 6.01 5.7 µM 2.11E-8 mitochondrial stress 119 9.22E-10
7 SGTC_2844 9010103 5.85 26.0 µM 4.73E-8 4 2.45E-9
8 SGTC_358 0075-0058 5.59 9.4 µM 1.66E-7 23 1.11E-8
9 SGTC_10 0279-0212 5.57 42.6 µM 1.85E-7 TRP & mitochondrial translation 37 1.27E-8
10 SGTC_398 bronopol 5.41 33.3 µM 3.86E-7 RNA processing & uracil transport 11 3.08E-8
11 SGTC_58 0957-0393 5.29 9.0 µM 6.89E-7 cell wall 256 6.19E-8
12 SGTC_1456 k015-0012 5.05 13.0 µM 1.99E-6 12 2.22E-7
13 SGTC_2977 9011197 4.52 71.4 µM 1.76E-5 10 3.05E-6
14 SGTC_437 s-farnesyl-l-cysteine methyl ester 4.45 6.7 µM 2.31E-5 7 4.22E-6
15 SGTC_2250 alverine citrate 4.06 130.0 µM 1.01E-4 145 2.49E-5
16 SGTC_3152 9099253 4.03 49.5 µM 1.10E-4 NEO1-PIK1 124 2.76E-5
17 SGTC_892 0929-0076 3.99 29.0 µM 1.26E-4 TRP & mitochondrial translation 37 3.24E-5
18 SGTC_1133 3473-0247 3.97 50.0 µM 1.38E-4 RSC complex & mRNA processing 48 3.61E-5
19 SGTC_940 3232-1287 3.90 54.8 µM 1.77E-4 NEO1 40 4.85E-5
20 SGTC_28 pentachloropyridine N-oxide 3.90 1.6 µM 1.78E-4 TSC3-RPN4 73 4.88E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.416 1.57E-140 YER087W AIM10 hom Protein with similarity to tRNA synthetases; non-tagged protein is detected in purified mitochondria; null mutant is viable and displays elevated frequency of mitochondrial genome loss
0.389 2.99E-121 YMR287C DSS1 hom 3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs
0.377 1.29E-113 YDR065W RRG1 hom Protein of unknown function, required for vacuolar acidification and mitochondrial genome maintenance; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.371 2.33E-109 YLR260W LCB5 hom Minor sphingoid long-chain base kinase, paralog of Lcb4p responsible for few percent of the total activity, possibly involved in synthesis of long-chain base phosphates, which function as signaling molecules
0.369 6.07E-109 YMR193W MRPL24 hom Mitochondrial ribosomal protein of the large subunit; two mitochondrial ribosomal proteins, YmL14 and YmL24, have been assigned to the same gene
0.367 1.66E-107 YNL005C MRP7 hom Mitochondrial ribosomal protein of the large subunit
0.364 7.66E-106 YGR102C GTF1 hom Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; transposon insertion mutant is salt sensitive and null mutant has growth defects; non-tagged protein is detected in purified mitochondria
0.364 1.50E-105 YER077C_p YER077C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; null mutation results in a decrease in plasma membrane electron transport
0.363 2.20E-105 YDR296W MHR1 hom Protein involved in homologous recombination in mitochondria; required for recombination-dependent mtDNA partitioning; involved in stimulation of mitochondrial DNA replication in response to oxidative stress
0.361 1.37E-103 YPL040C ISM1 hom Mitochondrial isoleucyl-tRNA synthetase, null mutant is deficient in respiratory growth
0.357 3.60E-101 YMR072W ABF2 hom Mitochondrial DNA-binding protein involved in mitochondrial DNA replication and recombination, member of HMG1 DNA-binding protein family; activity may be regulated by protein kinase A phosphorylation
0.356 1.14E-100 YDR237W MRPL7 hom Mitochondrial ribosomal protein of the large subunit; MRPL7 produces both YmL5 and YmL7, which are two different modified forms of the same protein
0.353 5.04E-99 YMR293C HER2 hom Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; required for remodeling of ER caused by Hmg2p overexpression; similar to bacterial GatA glutamyl-tRNA amidotransferase
0.352 1.40E-98 YCR071C IMG2 hom Mitochondrial ribosomal protein of the large subunit
0.352 1.09E-98 YMR228W MTF1 hom Mitochondrial RNA polymerase specificity factor; has structural similarity to S-adenosylmethionine-dependent methyltransferases and functional similarity to bacterial sigma-factors; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation