YGL131C / SNT2

DNA binding protein with similarity to the S. pombe Snt2 protein; RING finger ubiquitin ligase (E3) involved in ubiquitylation and degradation of excess histones; interacts with Ubc4p; null mutant sensitive to hydroxyurea (HU); computational analysis suggests that Snt2p is a transcription factor with a role in regulation of expression of genes encoding amine transporters; relocalizes from nucleus to cytoplasm upon DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL131C / SNT2

Click on Significant Values for Screen Details ID:SGTC_74|Compound:000s-0487|FD-Score:-3.39|P-value:1.47E-4 ID:SGTC_230|Compound:MPP+|FD-Score:-2.99|P-value:7.07E-4 ID:SGTC_799|Compound:1310-0557|FD-Score:3.11|P-value:4.74E-4 ID:SGTC_817|Compound:1391-0715|FD-Score:-2.93|P-value:8.84E-4 ID:SGTC_965|Compound:1291-5240|FD-Score:3.83|P-value:2.36E-5 ID:SGTC_996|Compound:3970-0799|FD-Score:5.84|P-value:2.61E-10 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:3.52|P-value:9.08E-5 ID:SGTC_1131|Compound:3454-3128|FD-Score:3.20|P-value:3.42E-4 ID:SGTC_1241|Compound:0364-0022|FD-Score:7.09|P-value:2.32E-14 ID:SGTC_1243|Compound:0416-0003|FD-Score:-3.76|P-value:2.96E-5 ID:SGTC_1268|Compound:0828-0275|FD-Score:3.31|P-value:2.22E-4 ID:SGTC_1303|Compound:1160-0052|FD-Score:-4.39|P-value:1.41E-6 ID:SGTC_1311|Compound:1190-0148|FD-Score:6.01|P-value:7.94E-11 ID:SGTC_1383|Compound:3049-0032|FD-Score:4.37|P-value:1.72E-6 ID:SGTC_1391|Compound:3442-0225|FD-Score:6.06|P-value:5.72E-11 ID:SGTC_1395|Compound:3486-0190|FD-Score:3.71|P-value:4.07E-5 ID:SGTC_1401|Compound:3807-4679|FD-Score:3.64|P-value:5.54E-5 ID:SGTC_1402|Compound:3909-7673|FD-Score:-3.13|P-value:4.17E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.38|P-value:1.53E-4 ID:SGTC_1563|Compound:conessine|FD-Score:3.26|P-value:2.67E-4 ID:SGTC_1569|Compound:carminic acid|FD-Score:3.75|P-value:3.30E-5 ID:SGTC_1695|Compound:st026914|FD-Score:-2.99|P-value:6.97E-4 ID:SGTC_1697|Compound:st025554|FD-Score:-3.00|P-value:6.67E-4 ID:SGTC_1709|Compound:st033179|FD-Score:-3.02|P-value:6.16E-4 ID:SGTC_1938|Compound:st074717|FD-Score:3.13|P-value:4.36E-4 ID:SGTC_1946|Compound:st076057|FD-Score:3.65|P-value:5.33E-5 ID:SGTC_1997|Compound:st073024|FD-Score:3.21|P-value:3.26E-4 ID:SGTC_2002|Compound:4023503|FD-Score:3.24|P-value:2.87E-4 ID:SGTC_2008|Compound:4012253|FD-Score:-4.42|P-value:1.17E-6 ID:SGTC_2009|Compound:4012297|FD-Score:3.68|P-value:4.55E-5 ID:SGTC_2024|Compound:5144227|FD-Score:2.98|P-value:7.78E-4 ID:SGTC_2041|Compound:5107442|FD-Score:3.13|P-value:4.39E-4 ID:SGTC_2181|Compound:6316240|FD-Score:-3.28|P-value:2.25E-4 ID:SGTC_2316|Compound:5844804|FD-Score:7.12|P-value:1.76E-14 ID:SGTC_2325|Compound:6158266|FD-Score:-4.30|P-value:2.25E-6 ID:SGTC_2372|Compound:9071633|FD-Score:3.14|P-value:4.29E-4 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:3.02|P-value:6.71E-4 ID:SGTC_2458|Compound:5808907|FD-Score:3.31|P-value:2.15E-4 ID:SGTC_2468|Compound:5987765|FD-Score:3.15|P-value:4.16E-4 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:-4.40|P-value:1.32E-6 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:-4.28|P-value:2.40E-6 ID:SGTC_2537|Compound:larixol|FD-Score:6.52|P-value:2.03E-12 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:-4.84|P-value:1.19E-7 ID:SGTC_2641|Compound:levomentholum|FD-Score:2.93|P-value:9.16E-4 ID:SGTC_2644|Compound:guaiazulene|FD-Score:2.94|P-value:9.11E-4 ID:SGTC_2693|Compound:st077581|FD-Score:3.19|P-value:3.52E-4 ID:SGTC_2784|Compound:7567673|FD-Score:-3.99|P-value:1.03E-5 ID:SGTC_2899|Compound:9053889|FD-Score:2.98|P-value:7.81E-4 ID:SGTC_2925|Compound:9010536|FD-Score:2.93|P-value:9.43E-4 ID:SGTC_3202|Compound:9113761|FD-Score:-3.09|P-value:4.86E-4 ID:SGTC_3313|Compound:9133968|FD-Score:3.68|P-value:4.57E-5 ID:SGTC_74|Compound:000s-0487|FD-Score:-3.39|P-value:1.47E-4 ID:SGTC_230|Compound:MPP+|FD-Score:-2.99|P-value:7.07E-4 ID:SGTC_799|Compound:1310-0557|FD-Score:3.11|P-value:4.74E-4 ID:SGTC_817|Compound:1391-0715|FD-Score:-2.93|P-value:8.84E-4 ID:SGTC_965|Compound:1291-5240|FD-Score:3.83|P-value:2.36E-5 ID:SGTC_996|Compound:3970-0799|FD-Score:5.84|P-value:2.61E-10 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:3.52|P-value:9.08E-5 ID:SGTC_1131|Compound:3454-3128|FD-Score:3.20|P-value:3.42E-4 ID:SGTC_1241|Compound:0364-0022|FD-Score:7.09|P-value:2.32E-14 ID:SGTC_1243|Compound:0416-0003|FD-Score:-3.76|P-value:2.96E-5 ID:SGTC_1268|Compound:0828-0275|FD-Score:3.31|P-value:2.22E-4 ID:SGTC_1303|Compound:1160-0052|FD-Score:-4.39|P-value:1.41E-6 ID:SGTC_1311|Compound:1190-0148|FD-Score:6.01|P-value:7.94E-11 ID:SGTC_1383|Compound:3049-0032|FD-Score:4.37|P-value:1.72E-6 ID:SGTC_1391|Compound:3442-0225|FD-Score:6.06|P-value:5.72E-11 ID:SGTC_1395|Compound:3486-0190|FD-Score:3.71|P-value:4.07E-5 ID:SGTC_1401|Compound:3807-4679|FD-Score:3.64|P-value:5.54E-5 ID:SGTC_1402|Compound:3909-7673|FD-Score:-3.13|P-value:4.17E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.38|P-value:1.53E-4 ID:SGTC_1563|Compound:conessine|FD-Score:3.26|P-value:2.67E-4 ID:SGTC_1569|Compound:carminic acid|FD-Score:3.75|P-value:3.30E-5 ID:SGTC_1695|Compound:st026914|FD-Score:-2.99|P-value:6.97E-4 ID:SGTC_1697|Compound:st025554|FD-Score:-3.00|P-value:6.67E-4 ID:SGTC_1709|Compound:st033179|FD-Score:-3.02|P-value:6.16E-4 ID:SGTC_1938|Compound:st074717|FD-Score:3.13|P-value:4.36E-4 ID:SGTC_1946|Compound:st076057|FD-Score:3.65|P-value:5.33E-5 ID:SGTC_1997|Compound:st073024|FD-Score:3.21|P-value:3.26E-4 ID:SGTC_2002|Compound:4023503|FD-Score:3.24|P-value:2.87E-4 ID:SGTC_2008|Compound:4012253|FD-Score:-4.42|P-value:1.17E-6 ID:SGTC_2009|Compound:4012297|FD-Score:3.68|P-value:4.55E-5 ID:SGTC_2024|Compound:5144227|FD-Score:2.98|P-value:7.78E-4 ID:SGTC_2041|Compound:5107442|FD-Score:3.13|P-value:4.39E-4 ID:SGTC_2181|Compound:6316240|FD-Score:-3.28|P-value:2.25E-4 ID:SGTC_2316|Compound:5844804|FD-Score:7.12|P-value:1.76E-14 ID:SGTC_2325|Compound:6158266|FD-Score:-4.30|P-value:2.25E-6 ID:SGTC_2372|Compound:9071633|FD-Score:3.14|P-value:4.29E-4 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:3.02|P-value:6.71E-4 ID:SGTC_2458|Compound:5808907|FD-Score:3.31|P-value:2.15E-4 ID:SGTC_2468|Compound:5987765|FD-Score:3.15|P-value:4.16E-4 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:-4.40|P-value:1.32E-6 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:-4.28|P-value:2.40E-6 ID:SGTC_2537|Compound:larixol|FD-Score:6.52|P-value:2.03E-12 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:-4.84|P-value:1.19E-7 ID:SGTC_2641|Compound:levomentholum|FD-Score:2.93|P-value:9.16E-4 ID:SGTC_2644|Compound:guaiazulene|FD-Score:2.94|P-value:9.11E-4 ID:SGTC_2693|Compound:st077581|FD-Score:3.19|P-value:3.52E-4 ID:SGTC_2784|Compound:7567673|FD-Score:-3.99|P-value:1.03E-5 ID:SGTC_2899|Compound:9053889|FD-Score:2.98|P-value:7.81E-4 ID:SGTC_2925|Compound:9010536|FD-Score:2.93|P-value:9.43E-4 ID:SGTC_3202|Compound:9113761|FD-Score:-3.09|P-value:4.86E-4 ID:SGTC_3313|Compound:9133968|FD-Score:3.68|P-value:4.57E-5

Top fitness defect scores for YGL131C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2316 5844804 7.12 197.4 µM 1.76E-14 3 5.37E-13
2 SGTC_1241 0364-0022 7.09 50.8 µM 2.32E-14 ERG2 3 6.84E-13
3 SGTC_2537 larixol 6.52 68.9 µM 2.03E-12 3 3.56E-11
4 SGTC_1391 3442-0225 6.06 151.0 µM 5.72E-11 1 6.83E-10
5 SGTC_1311 1190-0148 6.01 100.0 µM 7.94E-11 azole & statin 9 9.13E-10
6 SGTC_996 3970-0799 5.84 1.8 µM 2.61E-10 39 2.62E-9
7 SGTC_1383 3049-0032 4.37 20.7 µM 1.72E-6 60S ribosome export 17 6.30E-6
8 SGTC_965 1291-5240 3.83 308.0 µM 2.36E-5 33 6.46E-5
9 SGTC_1569 carminic acid 3.75 40.6 µM 3.30E-5 21 8.69E-5
10 SGTC_1395 3486-0190 3.71 4.3 µM 4.07E-5 20 1.05E-4
11 SGTC_2009 4012297 3.68 12.1 µM 4.55E-5 cell wall signaling 71 1.16E-4
12 SGTC_3313 9133968 3.68 57.0 µM 4.57E-5 9 1.16E-4
13 SGTC_1946 st076057 3.65 65.1 µM 5.33E-5 7 1.33E-4
14 SGTC_1401 3807-4679 3.64 7.6 µM 5.54E-5 tubulin folding & SWR complex 25 1.38E-4
15 SGTC_1083 didemethylchlorpromazine sulfoxide 3.52 707.4 nM 9.08E-5 redox potentiating 103 2.14E-4
16 SGTC_2458 5808907 3.31 16.4 µM 2.15E-4 13 4.61E-4
17 SGTC_1268 0828-0275 3.31 2.5 µM 2.22E-4 43 4.73E-4
18 SGTC_1563 conessine 3.26 56.1 µM 2.67E-4 37 5.58E-4
19 SGTC_2002 4023503 3.24 131.0 µM 2.87E-4 mitochondrial processes 66 5.96E-4
20 SGTC_1997 st073024 3.21 93.8 µM 3.26E-4 24 6.66E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.232 2.99E-42 YML118W NGL3 hom 3'-5' exonuclease specific for poly-A RNAs; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p; NGL3 has a paralog, NGL2, that arose from the whole genome duplication
0.225 8.26E-40 YDL086W_p YDL086W_p hom Putative carboxymethylenebutenolidase; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YDL086W is not an essential gene
0.205 2.54E-33 YBR085W AAC3 hom Mitochondrial inner membrane ADP/ATP translocator; exchanges cytosolic ADP for mitochondrially synthesized ATP; expressed under anaerobic conditions; similar to Aac1p; has roles in maintenance of viability and in respiration; AAC3 has a paralog, PET9, that arose from the whole genome duplication
0.203 1.86E-32 YMR106C YKU80 hom Subunit of the telomeric Ku complex (Yku70p-Yku80p), involved in telomere length maintenance, structure and telomere position effect; relocates to sites of double-strand cleavage to promote nonhomologous end joining during DSB repair
0.194 7.45E-30 YBR084W MIS1 hom Mitochondrial C1-tetrahydrofolate synthase, involved in interconversion between different oxidation states of tetrahydrofolate (THF); provides activities of formyl-THF synthetase, methenyl-THF cyclohydrolase, and methylene-THF dehydrogenase
0.185 2.74E-27 YDL186W_p YDL186W_p hom Putative protein of unknown function; YDL186W is not an essential gene
0.185 2.60E-27 YDL171C GLT1 hom NAD(+)-dependent glutamate synthase (GOGAT), synthesizes glutamate from glutamine and alpha-ketoglutarate; with Gln1p, forms the secondary pathway for glutamate biosynthesis from ammonia; expression regulated by nitrogen source
0.185 3.89E-27 YDR277C MTH1 hom Negative regulator of the glucose-sensing signal transduction pathway, required for repression of transcription by Rgt1p; interacts with Rgt1p and the Snf3p and Rgt2p glucose sensors; phosphorylated by Yck1p, triggering Mth1p degradation
0.180 7.50E-26 YGR019W UGA1 hom Gamma-aminobutyrate (GABA) transaminase; also known as 4-aminobutyrate aminotransferase; involved in the 4-aminobutyrate and glutamate degradation pathways; required for normal oxidative stress tolerance and nitrogen utilization; protein abundance increases in response to DNA replication stress
0.178 3.36E-25 YLR154C RNH203 hom Ribonuclease H2 subunit, required for RNase H2 activity; related to human AGS3 that causes Aicardi-Goutieres syndrome
0.175 1.58E-24 YGL205W POX1 hom Fatty-acyl coenzyme A oxidase, involved in the fatty acid beta-oxidation pathway; localized to the peroxisomal matrix
0.175 1.67E-24 YDR339C FCF1 het Putative PINc domain nuclease required for early cleavages of 35S pre-rRNA and maturation of 18S rRNA; component of the SSU (small subunit) processome involved in 40S ribosomal subunit biogenesis; copurifies with Faf1p
0.157 6.30E-20 YDR505C PSP1 hom Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition; PSP1 has a paralog, YLR177W, that arose from the whole genome duplication
0.156 1.24E-19 YDL099W BUG1 hom Cis-golgi localized protein involved in ER to Golgi transport; forms a complex with the mammalian GRASP65 homolog, Grh1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes
0.155 2.10E-19 YDL180W_p YDL180W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole