YGL132W_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene SNT2/YGL131C

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL132W / YGL132W

Click on Significant Values for Screen Details ID:SGTC_35|Compound:0133-0054|FD-Score:-2.87|P-value:5.48E-4 ID:SGTC_40|Compound:0327-0103|FD-Score:-2.89|P-value:5.03E-4 ID:SGTC_65|Compound:0798-0905|FD-Score:3.80|P-value:1.02E-5 ID:SGTC_676|Compound:falcarinol|FD-Score:3.07|P-value:2.92E-4 ID:SGTC_711|Compound:k292-0785|FD-Score:-2.94|P-value:4.12E-4 ID:SGTC_716|Compound:1683-5115|FD-Score:5.37|P-value:7.88E-10 ID:SGTC_722|Compound:3534-0461|FD-Score:-3.19|P-value:1.41E-4 ID:SGTC_764|Compound:1951-2361|FD-Score:-5.41|P-value:4.45E-10 ID:SGTC_798|Compound:1287-0182|FD-Score:3.32|P-value:9.76E-5 ID:SGTC_816|Compound:0325-0417|FD-Score:2.94|P-value:4.93E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:7.46|P-value:2.21E-17 ID:SGTC_994|Compound:3910-0338|FD-Score:-4.28|P-value:6.11E-7 ID:SGTC_1003|Compound:4049-0218|FD-Score:-3.39|P-value:5.79E-5 ID:SGTC_1021|Compound:4476-0760|FD-Score:3.01|P-value:3.72E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:2.90|P-value:5.75E-4 ID:SGTC_1097|Compound:itavastatin|FD-Score:-2.75|P-value:8.89E-4 ID:SGTC_1101|Compound:ebselen|FD-Score:3.95|P-value:4.57E-6 ID:SGTC_1138|Compound:3761-0006|FD-Score:2.86|P-value:6.79E-4 ID:SGTC_1177|Compound:0983-0204|FD-Score:4.11|P-value:1.94E-6 ID:SGTC_1220|Compound:1838-0075|FD-Score:2.84|P-value:7.19E-4 ID:SGTC_1255|Compound:0566-0045|FD-Score:4.47|P-value:2.53E-7 ID:SGTC_1271|Compound:0832-2808|FD-Score:3.02|P-value:3.49E-4 ID:SGTC_1275|Compound:0867-0008|FD-Score:2.76|P-value:9.83E-4 ID:SGTC_1451|Compound:4152-0210|FD-Score:3.19|P-value:1.77E-4 ID:SGTC_1629|Compound:st005085|FD-Score:-3.15|P-value:1.74E-4 ID:SGTC_1779|Compound:st039427|FD-Score:5.46|P-value:4.08E-10 ID:SGTC_1851|Compound:st056236|FD-Score:3.52|P-value:3.90E-5 ID:SGTC_1854|Compound:st056233|FD-Score:5.87|P-value:1.97E-11 ID:SGTC_1906|Compound:st060206|FD-Score:3.18|P-value:1.81E-4 ID:SGTC_1916|Compound:st067606|FD-Score:3.06|P-value:3.07E-4 ID:SGTC_1996|Compound:st072960|FD-Score:3.63|P-value:2.28E-5 ID:SGTC_2353|Compound:9059630|FD-Score:3.60|P-value:2.64E-5 ID:SGTC_2354|Compound:9060492|FD-Score:4.08|P-value:2.28E-6 ID:SGTC_2564|Compound:betulinic acid|FD-Score:4.55|P-value:1.59E-7 ID:SGTC_2601|Compound:securinine|FD-Score:-2.83|P-value:6.43E-4 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:-3.38|P-value:6.26E-5 ID:SGTC_2610|Compound:ononetin|FD-Score:-3.11|P-value:2.00E-4 ID:SGTC_2689|Compound:tacrolimus|FD-Score:4.91|P-value:1.74E-8 ID:SGTC_2690|Compound:usnic acid|FD-Score:3.51|P-value:4.05E-5 ID:SGTC_2755|Compound:lomerizine|FD-Score:-4.40|P-value:3.05E-7 ID:SGTC_2782|Compound:7736369|FD-Score:-2.99|P-value:3.42E-4 ID:SGTC_2797|Compound:7859098|FD-Score:-3.34|P-value:7.31E-5 ID:SGTC_2805|Compound:7950783|FD-Score:4.59|P-value:1.27E-7 ID:SGTC_2808|Compound:7946468|FD-Score:3.27|P-value:1.21E-4 ID:SGTC_2882|Compound:9058044|FD-Score:3.00|P-value:3.84E-4 ID:SGTC_2903|Compound:5923464|FD-Score:-2.92|P-value:4.54E-4 ID:SGTC_3145|Compound:9085516|FD-Score:-3.05|P-value:2.62E-4 ID:SGTC_3149|Compound:9097855|FD-Score:3.60|P-value:2.71E-5 ID:SGTC_3205|Compound:9113483|FD-Score:3.44|P-value:5.56E-5 ID:SGTC_35|Compound:0133-0054|FD-Score:-2.87|P-value:5.48E-4 ID:SGTC_40|Compound:0327-0103|FD-Score:-2.89|P-value:5.03E-4 ID:SGTC_65|Compound:0798-0905|FD-Score:3.80|P-value:1.02E-5 ID:SGTC_676|Compound:falcarinol|FD-Score:3.07|P-value:2.92E-4 ID:SGTC_711|Compound:k292-0785|FD-Score:-2.94|P-value:4.12E-4 ID:SGTC_716|Compound:1683-5115|FD-Score:5.37|P-value:7.88E-10 ID:SGTC_722|Compound:3534-0461|FD-Score:-3.19|P-value:1.41E-4 ID:SGTC_764|Compound:1951-2361|FD-Score:-5.41|P-value:4.45E-10 ID:SGTC_798|Compound:1287-0182|FD-Score:3.32|P-value:9.76E-5 ID:SGTC_816|Compound:0325-0417|FD-Score:2.94|P-value:4.93E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:7.46|P-value:2.21E-17 ID:SGTC_994|Compound:3910-0338|FD-Score:-4.28|P-value:6.11E-7 ID:SGTC_1003|Compound:4049-0218|FD-Score:-3.39|P-value:5.79E-5 ID:SGTC_1021|Compound:4476-0760|FD-Score:3.01|P-value:3.72E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:2.90|P-value:5.75E-4 ID:SGTC_1097|Compound:itavastatin|FD-Score:-2.75|P-value:8.89E-4 ID:SGTC_1101|Compound:ebselen|FD-Score:3.95|P-value:4.57E-6 ID:SGTC_1138|Compound:3761-0006|FD-Score:2.86|P-value:6.79E-4 ID:SGTC_1177|Compound:0983-0204|FD-Score:4.11|P-value:1.94E-6 ID:SGTC_1220|Compound:1838-0075|FD-Score:2.84|P-value:7.19E-4 ID:SGTC_1255|Compound:0566-0045|FD-Score:4.47|P-value:2.53E-7 ID:SGTC_1271|Compound:0832-2808|FD-Score:3.02|P-value:3.49E-4 ID:SGTC_1275|Compound:0867-0008|FD-Score:2.76|P-value:9.83E-4 ID:SGTC_1451|Compound:4152-0210|FD-Score:3.19|P-value:1.77E-4 ID:SGTC_1629|Compound:st005085|FD-Score:-3.15|P-value:1.74E-4 ID:SGTC_1779|Compound:st039427|FD-Score:5.46|P-value:4.08E-10 ID:SGTC_1851|Compound:st056236|FD-Score:3.52|P-value:3.90E-5 ID:SGTC_1854|Compound:st056233|FD-Score:5.87|P-value:1.97E-11 ID:SGTC_1906|Compound:st060206|FD-Score:3.18|P-value:1.81E-4 ID:SGTC_1916|Compound:st067606|FD-Score:3.06|P-value:3.07E-4 ID:SGTC_1996|Compound:st072960|FD-Score:3.63|P-value:2.28E-5 ID:SGTC_2353|Compound:9059630|FD-Score:3.60|P-value:2.64E-5 ID:SGTC_2354|Compound:9060492|FD-Score:4.08|P-value:2.28E-6 ID:SGTC_2564|Compound:betulinic acid|FD-Score:4.55|P-value:1.59E-7 ID:SGTC_2601|Compound:securinine|FD-Score:-2.83|P-value:6.43E-4 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:-3.38|P-value:6.26E-5 ID:SGTC_2610|Compound:ononetin|FD-Score:-3.11|P-value:2.00E-4 ID:SGTC_2689|Compound:tacrolimus|FD-Score:4.91|P-value:1.74E-8 ID:SGTC_2690|Compound:usnic acid|FD-Score:3.51|P-value:4.05E-5 ID:SGTC_2755|Compound:lomerizine|FD-Score:-4.40|P-value:3.05E-7 ID:SGTC_2782|Compound:7736369|FD-Score:-2.99|P-value:3.42E-4 ID:SGTC_2797|Compound:7859098|FD-Score:-3.34|P-value:7.31E-5 ID:SGTC_2805|Compound:7950783|FD-Score:4.59|P-value:1.27E-7 ID:SGTC_2808|Compound:7946468|FD-Score:3.27|P-value:1.21E-4 ID:SGTC_2882|Compound:9058044|FD-Score:3.00|P-value:3.84E-4 ID:SGTC_2903|Compound:5923464|FD-Score:-2.92|P-value:4.54E-4 ID:SGTC_3145|Compound:9085516|FD-Score:-3.05|P-value:2.62E-4 ID:SGTC_3149|Compound:9097855|FD-Score:3.60|P-value:2.71E-5 ID:SGTC_3205|Compound:9113483|FD-Score:3.44|P-value:5.56E-5

Top fitness defect scores for YGL132W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_922 1866-0035 7.46 480.0 µM 2.21E-17 excess fatty acid 10 4.24E-14
2 SGTC_1854 st056233 5.87 32.9 µM 1.97E-11 amide catabolism 3 2.14E-9
3 SGTC_1779 st039427 5.46 55.0 µM 4.08E-10 3 2.36E-8
4 SGTC_716 1683-5115 5.37 658.0 µM 7.88E-10 5 3.97E-8
5 SGTC_2689 tacrolimus 4.91 100.0 µM 1.74E-8 26 4.63E-7
6 SGTC_2805 7950783 4.59 58.4 µM 1.27E-7 14 2.24E-6
7 SGTC_2564 betulinic acid 4.55 100.0 µM 1.59E-7 22 2.68E-6
8 SGTC_1255 0566-0045 4.47 221.0 µM 2.53E-7 excess fatty acid 21 3.88E-6
9 SGTC_1177 0983-0204 4.11 23.6 µM 1.94E-6 14 1.96E-5
10 SGTC_2354 9060492 4.08 162.0 µM 2.28E-6 13 2.23E-5
11 SGTC_1101 ebselen 3.95 5.3 µM 4.57E-6 23 3.89E-5
12 SGTC_65 0798-0905 3.80 35.0 µM 1.02E-5 calcium & mitochondrial duress 94 7.37E-5
13 SGTC_1996 st072960 3.63 66.8 µM 2.28E-5 26 1.40E-4
14 SGTC_2353 9059630 3.60 146.7 µM 2.64E-5 26 1.57E-4
15 SGTC_3149 9097855 3.60 49.5 µM 2.71E-5 Golgi 37 1.61E-4
16 SGTC_1851 st056236 3.52 18.9 µM 3.90E-5 24 2.15E-4
17 SGTC_2690 usnic acid 3.51 100.0 µM 4.05E-5 43 2.22E-4
18 SGTC_3205 9113483 3.44 49.5 µM 5.56E-5 52 2.86E-4
19 SGTC_798 1287-0182 3.32 476.0 µM 9.76E-5 48 4.48E-4
20 SGTC_2808 7946468 3.27 45.5 µM 1.21E-4 56 5.34E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.147 9.02E-18 YGL230C_p YGL230C_p hom Putative protein of unknown function; non-essential gene
0.143 6.99E-17 YDR479C PEX29 hom Peroxisomal integral membrane peroxin; involved in the regulation of peroxisomal size, number and distribution; genetic interactions suggest that Pex28p and Pex29p act at steps upstream of those mediated by Pex30p, Pex31p, and Pex32p; forms ER foci upon DNA replication stress
0.117 1.07E-11 YOR007C SGT2 hom Glutamine-rich cytoplasmic cochaperone; serves as a scaffold bringing together Get4, Get5p, and other TRC complex members that are required to mediate posttranslational insertion of tail-anchored proteins into the ER membrane; interacts with the prion domain of Sup35p; amyloid sensor; plays a role in targeting chaperones to prion aggregates; has similarity to human cochaperone SGT; forms cytoplasmic foci upon DNA replication stress
0.114 3.07E-11 YLR324W PEX30 hom Peroxisomal integral membrane protein, involved in negative regulation of peroxisome number; partially functionally redundant with Pex31p; genetic interactions suggest action at a step downstream of steps mediated by Pex28p and Pex29p
0.102 2.95E-9 YDR247W VHS1 hom Cytoplasmic serine/threonine protein kinase; identified as a high-copy suppressor of the synthetic lethality of a sis2 sit4 double mutant, suggesting a role in G1/S phase progression; homolog of Sks1p
0.101 4.96E-9 YJL150W_d YJL150W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.100 6.99E-9 YGR295C COS6 hom Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins
0.097 1.55E-8 YBR086C IST2 hom Cortical ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; localizes to the mother cell in small-budded cells and to the bud in medium- and large-budded cells; mRNA is transported to the bud tip by an actomyosin-driven process
0.097 2.01E-8 YHR001W OSH7 hom Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability
0.096 2.59E-8 YBR156C SLI15 hom Subunit of the conserved chromosomal passenger complex (CPC; Ipl1p-Sli15p-Bir1p-Nbl1p), which regulates kinetochore-microtubule attachments, activation of the spindle tension checkpoint, and mitotic spindle disassembly
0.094 5.28E-8 YDR329C PEX3 hom Peroxisomal membrane protein (PMP) required for proper localization and stability of PMPs; anchors peroxisome retention factor Inp1p at the peroxisomal membrane; interacts with Pex19p
0.093 7.03E-8 YLR164W SHH4 hom Mitochondrial inner membrane protein of unknown function; similar to Tim18p and Sdh4p; a fraction copurifies with Sdh3p, but Shh4p is neither a stoichiometric subunit of succinate dehydrogenase nor of the TIM22 translocase; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner
0.090 1.75E-7 YDL225W SHS1 hom Component of the septin ring that is required for cytokinesis; septins are GTP-binding proteins that assemble into rod-like hetero-oligomers that can associate with other rods to form filaments; septin rings at the mother-bud neck act as scaffolds for recruiting cell division factors and as barriers to prevent diffusion of specific proteins; undergoes sumoylation and phosphorylation during mitosis; protein abundance increases in response to DNA replication stress
0.090 1.75E-7 YBR162W-A YSY6 hom Protein whose expression suppresses a secretory pathway mutation in E. coli; has similarity to the mammalian RAMP4 protein involved in secretion
0.089 2.11E-7 YJL157C FAR1 hom Cyclin-dependent kinase inhibitor; mediates cell cycle arrest in response to pheromone; also forms a complex with Cdc24p, Ste4p, and Ste18p that may specify the direction of polarized growth during mating; potential Cdc28p substrate; relocalizes from nucleus to cytoplasm upon DNA replication stress