HIPHOP chemogenomics database

YGL132W_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene SNT2/YGL131C

Zygosity: Homozygous strain

fixedexpanded
Profile for YGL132W / YGL132W

Click on Significant Values for Screen Details

Top fitness defect scores for YGL132W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_922	1866-0035	7.46	480.0 µM	2.21E-17	excess fatty acid	10	4.24E-14
2	SGTC_1854	st056233	5.87	32.9 µM	1.97E-11	amide catabolism	3	2.14E-9
3	SGTC_1779	st039427	5.46	55.0 µM	4.08E-10		3	2.36E-8
4	SGTC_716	1683-5115	5.37	658.0 µM	7.88E-10		5	3.97E-8
5	SGTC_2689	tacrolimus	4.91	100.0 µM	1.74E-8		26	4.63E-7
6	SGTC_2805	7950783	4.59	58.4 µM	1.27E-7		14	2.24E-6
7	SGTC_2564	betulinic acid	4.55	100.0 µM	1.59E-7		22	2.68E-6
8	SGTC_1255	0566-0045	4.47	221.0 µM	2.53E-7	excess fatty acid	21	3.88E-6
9	SGTC_1177	0983-0204	4.11	23.6 µM	1.94E-6		14	1.96E-5
10	SGTC_2354	9060492	4.08	162.0 µM	2.28E-6		13	2.23E-5
11	SGTC_1101	ebselen	3.95	5.3 µM	4.57E-6		23	3.89E-5
12	SGTC_65	0798-0905	3.80	35.0 µM	1.02E-5	calcium & mitochondrial duress	94	7.37E-5
13	SGTC_1996	st072960	3.63	66.8 µM	2.28E-5		26	1.40E-4
14	SGTC_2353	9059630	3.60	146.7 µM	2.64E-5		26	1.57E-4
15	SGTC_3149	9097855	3.60	49.5 µM	2.71E-5	Golgi	37	1.61E-4
16	SGTC_1851	st056236	3.52	18.9 µM	3.90E-5		24	2.15E-4
17	SGTC_2690	usnic acid	3.51	100.0 µM	4.05E-5		43	2.22E-4
18	SGTC_3205	9113483	3.44	49.5 µM	5.56E-5		52	2.86E-4
19	SGTC_798	1287-0182	3.32	476.0 µM	9.76E-5		48	4.48E-4
20	SGTC_2808	7946468	3.27	45.5 µM	1.21E-4		56	5.34E-4

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.147	9.02E-18	YGL230C_p	YGL230C_p	hom	Putative protein of unknown function; non-essential gene
0.143	6.99E-17	YDR479C	PEX29	hom	Peroxisomal integral membrane peroxin; involved in the regulation of peroxisomal size, number and distribution; genetic interactions suggest that Pex28p and Pex29p act at steps upstream of those mediated by Pex30p, Pex31p, and Pex32p; forms ER foci upon DNA replication stress
0.117	1.07E-11	YOR007C	SGT2	hom	Glutamine-rich cytoplasmic cochaperone; serves as a scaffold bringing together Get4, Get5p, and other TRC complex members that are required to mediate posttranslational insertion of tail-anchored proteins into the ER membrane; interacts with the prion domain of Sup35p; amyloid sensor; plays a role in targeting chaperones to prion aggregates; has similarity to human cochaperone SGT; forms cytoplasmic foci upon DNA replication stress
0.114	3.07E-11	YLR324W	PEX30	hom	Peroxisomal integral membrane protein, involved in negative regulation of peroxisome number; partially functionally redundant with Pex31p; genetic interactions suggest action at a step downstream of steps mediated by Pex28p and Pex29p
0.102	2.95E-9	YDR247W	VHS1	hom	Cytoplasmic serine/threonine protein kinase; identified as a high-copy suppressor of the synthetic lethality of a sis2 sit4 double mutant, suggesting a role in G1/S phase progression; homolog of Sks1p
0.101	4.96E-9	YJL150W_d	YJL150W_d	hom	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.100	6.99E-9	YGR295C	COS6	hom	Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins
0.097	1.55E-8	YBR086C	IST2	hom	Cortical ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; localizes to the mother cell in small-budded cells and to the bud in medium- and large-budded cells; mRNA is transported to the bud tip by an actomyosin-driven process
0.097	2.01E-8	YHR001W	OSH7	hom	Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability
0.096	2.59E-8	YBR156C	SLI15	hom	Subunit of the conserved chromosomal passenger complex (CPC; Ipl1p-Sli15p-Bir1p-Nbl1p), which regulates kinetochore-microtubule attachments, activation of the spindle tension checkpoint, and mitotic spindle disassembly
0.094	5.28E-8	YDR329C	PEX3	hom	Peroxisomal membrane protein (PMP) required for proper localization and stability of PMPs; anchors peroxisome retention factor Inp1p at the peroxisomal membrane; interacts with Pex19p
0.093	7.03E-8	YLR164W	SHH4	hom	Mitochondrial inner membrane protein of unknown function; similar to Tim18p and Sdh4p; a fraction copurifies with Sdh3p, but Shh4p is neither a stoichiometric subunit of succinate dehydrogenase nor of the TIM22 translocase; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner
0.090	1.75E-7	YDL225W	SHS1	hom	Component of the septin ring that is required for cytokinesis; septins are GTP-binding proteins that assemble into rod-like hetero-oligomers that can associate with other rods to form filaments; septin rings at the mother-bud neck act as scaffolds for recruiting cell division factors and as barriers to prevent diffusion of specific proteins; undergoes sumoylation and phosphorylation during mitosis; protein abundance increases in response to DNA replication stress
0.090	1.75E-7	YBR162W-A	YSY6	hom	Protein whose expression suppresses a secretory pathway mutation in E. coli; has similarity to the mammalian RAMP4 protein involved in secretion
0.089	2.11E-7	YJL157C	FAR1	hom	Cyclin-dependent kinase inhibitor; mediates cell cycle arrest in response to pheromone; also forms a complex with Cdc24p, Ste4p, and Ste18p that may specify the direction of polarized growth during mating; potential Cdc28p substrate; relocalizes from nucleus to cytoplasm upon DNA replication stress