YGL133W / ITC1

Subunit of the ATP-dependent Isw2p-Itc1p chromatin remodeling complex, required for repression of a-specific genes, repression of early meiotic genes during mitotic growth, and repression of INO1; similar to mammalian Acf1p, the regulatory subunit of the mammalian ATP-utilizing chromatin assembly and modifying factor (ACF) complex

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL133W / ITC1

Click on Significant Values for Screen Details ID:SGTC_64|Compound:000l-0018|FD-Score:3.49|P-value:4.87E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:6.02|P-value:7.22E-9 ID:SGTC_158|Compound:k038-0087|FD-Score:3.30|P-value:9.08E-4 ID:SGTC_216|Compound:k038-0035|FD-Score:3.29|P-value:9.16E-4 ID:SGTC_263|Compound:alizarin|FD-Score:3.44|P-value:5.76E-4 ID:SGTC_304|Compound:1310-0298|FD-Score:-4.18|P-value:5.36E-5 ID:SGTC_384|Compound:k007-0144|FD-Score:3.36|P-value:7.36E-4 ID:SGTC_515|Compound:4092-1064|FD-Score:3.58|P-value:3.62E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:3.36|P-value:7.29E-4 ID:SGTC_689|Compound:0833-0039|FD-Score:-4.17|P-value:5.66E-5 ID:SGTC_690|Compound:glyoxal|FD-Score:11.40|P-value:3.84E-27 ID:SGTC_733|Compound:4069-0007|FD-Score:3.93|P-value:1.02E-4 ID:SGTC_768|Compound:0384-0033|FD-Score:3.61|P-value:3.22E-4 ID:SGTC_805|Compound:3852-0218|FD-Score:3.36|P-value:7.46E-4 ID:SGTC_819|Compound:1013-0258|FD-Score:3.49|P-value:4.77E-4 ID:SGTC_846|Compound:0335-0850|FD-Score:3.34|P-value:7.89E-4 ID:SGTC_902|Compound:1120-0002|FD-Score:3.50|P-value:4.66E-4 ID:SGTC_955|Compound:1216-0110|FD-Score:5.59|P-value:7.11E-8 ID:SGTC_1092|Compound:toremifene|FD-Score:-3.68|P-value:3.31E-4 ID:SGTC_1095|Compound:3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran|FD-Score:3.45|P-value:5.46E-4 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:3.34|P-value:7.91E-4 ID:SGTC_1170|Compound:0310-0127|FD-Score:5.59|P-value:7.20E-8 ID:SGTC_1224|Compound:0823-0416|FD-Score:3.64|P-value:2.91E-4 ID:SGTC_1395|Compound:3486-0190|FD-Score:3.34|P-value:7.84E-4 ID:SGTC_1459|Compound:k035-0031|FD-Score:-3.51|P-value:5.87E-4 ID:SGTC_1461|Compound:k072-0203|FD-Score:-3.84|P-value:1.89E-4 ID:SGTC_1510|Compound:1123-0200|FD-Score:3.78|P-value:1.75E-4 ID:SGTC_1526|Compound:st051518|FD-Score:-4.87|P-value:3.14E-6 ID:SGTC_1762|Compound:st045503|FD-Score:3.94|P-value:1.00E-4 ID:SGTC_1812|Compound:st052057|FD-Score:3.70|P-value:2.36E-4 ID:SGTC_1814|Compound:st052110|FD-Score:-5.43|P-value:2.39E-7 ID:SGTC_1844|Compound:rapamycin|FD-Score:4.13|P-value:4.80E-5 ID:SGTC_1885|Compound:st057546|FD-Score:-4.22|P-value:4.71E-5 ID:SGTC_2082|Compound:5219693|FD-Score:-3.71|P-value:3.04E-4 ID:SGTC_2166|Compound:5933061|FD-Score:4.20|P-value:3.68E-5 ID:SGTC_2186|Compound:6124449|FD-Score:3.68|P-value:2.50E-4 ID:SGTC_2317|Compound:5986382|FD-Score:-4.13|P-value:6.66E-5 ID:SGTC_2319|Compound:6033012|FD-Score:-6.68|P-value:2.70E-10 ID:SGTC_2322|Compound:7413319|FD-Score:7.48|P-value:1.03E-12 ID:SGTC_2398|Compound:5228213|FD-Score:3.42|P-value:6.01E-4 ID:SGTC_2444|Compound:5485484|FD-Score:6.08|P-value:5.38E-9 ID:SGTC_2504|Compound:purpurogallin|FD-Score:3.63|P-value:2.96E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-4.50|P-value:1.52E-5 ID:SGTC_2596|Compound:sinensetin|FD-Score:-3.43|P-value:7.70E-4 ID:SGTC_2724|Compound:maprotiline|FD-Score:3.29|P-value:9.31E-4 ID:SGTC_2743|Compound:auranofin|FD-Score:4.71|P-value:4.53E-6 ID:SGTC_2807|Compound:7945238|FD-Score:4.08|P-value:5.93E-5 ID:SGTC_2828|Compound:7998861|FD-Score:3.59|P-value:3.40E-4 ID:SGTC_2844|Compound:9010103|FD-Score:-3.78|P-value:2.34E-4 ID:SGTC_2878|Compound:9043973|FD-Score:-4.18|P-value:5.46E-5 ID:SGTC_2896|Compound:9052656|FD-Score:4.74|P-value:3.87E-6 ID:SGTC_2916|Compound:7875993|FD-Score:4.74|P-value:3.87E-6 ID:SGTC_2947|Compound:9072639|FD-Score:4.86|P-value:2.33E-6 ID:SGTC_2991|Compound:9074669|FD-Score:4.14|P-value:4.60E-5 ID:SGTC_3132|Compound:9126706|FD-Score:3.52|P-value:4.35E-4 ID:SGTC_3158|Compound:9100007|FD-Score:3.62|P-value:3.07E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:3.49|P-value:4.87E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:6.02|P-value:7.22E-9 ID:SGTC_158|Compound:k038-0087|FD-Score:3.30|P-value:9.08E-4 ID:SGTC_216|Compound:k038-0035|FD-Score:3.29|P-value:9.16E-4 ID:SGTC_263|Compound:alizarin|FD-Score:3.44|P-value:5.76E-4 ID:SGTC_304|Compound:1310-0298|FD-Score:-4.18|P-value:5.36E-5 ID:SGTC_384|Compound:k007-0144|FD-Score:3.36|P-value:7.36E-4 ID:SGTC_515|Compound:4092-1064|FD-Score:3.58|P-value:3.62E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:3.36|P-value:7.29E-4 ID:SGTC_689|Compound:0833-0039|FD-Score:-4.17|P-value:5.66E-5 ID:SGTC_690|Compound:glyoxal|FD-Score:11.40|P-value:3.84E-27 ID:SGTC_733|Compound:4069-0007|FD-Score:3.93|P-value:1.02E-4 ID:SGTC_768|Compound:0384-0033|FD-Score:3.61|P-value:3.22E-4 ID:SGTC_805|Compound:3852-0218|FD-Score:3.36|P-value:7.46E-4 ID:SGTC_819|Compound:1013-0258|FD-Score:3.49|P-value:4.77E-4 ID:SGTC_846|Compound:0335-0850|FD-Score:3.34|P-value:7.89E-4 ID:SGTC_902|Compound:1120-0002|FD-Score:3.50|P-value:4.66E-4 ID:SGTC_955|Compound:1216-0110|FD-Score:5.59|P-value:7.11E-8 ID:SGTC_1092|Compound:toremifene|FD-Score:-3.68|P-value:3.31E-4 ID:SGTC_1095|Compound:3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran|FD-Score:3.45|P-value:5.46E-4 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:3.34|P-value:7.91E-4 ID:SGTC_1170|Compound:0310-0127|FD-Score:5.59|P-value:7.20E-8 ID:SGTC_1224|Compound:0823-0416|FD-Score:3.64|P-value:2.91E-4 ID:SGTC_1395|Compound:3486-0190|FD-Score:3.34|P-value:7.84E-4 ID:SGTC_1459|Compound:k035-0031|FD-Score:-3.51|P-value:5.87E-4 ID:SGTC_1461|Compound:k072-0203|FD-Score:-3.84|P-value:1.89E-4 ID:SGTC_1510|Compound:1123-0200|FD-Score:3.78|P-value:1.75E-4 ID:SGTC_1526|Compound:st051518|FD-Score:-4.87|P-value:3.14E-6 ID:SGTC_1762|Compound:st045503|FD-Score:3.94|P-value:1.00E-4 ID:SGTC_1812|Compound:st052057|FD-Score:3.70|P-value:2.36E-4 ID:SGTC_1814|Compound:st052110|FD-Score:-5.43|P-value:2.39E-7 ID:SGTC_1844|Compound:rapamycin|FD-Score:4.13|P-value:4.80E-5 ID:SGTC_1885|Compound:st057546|FD-Score:-4.22|P-value:4.71E-5 ID:SGTC_2082|Compound:5219693|FD-Score:-3.71|P-value:3.04E-4 ID:SGTC_2166|Compound:5933061|FD-Score:4.20|P-value:3.68E-5 ID:SGTC_2186|Compound:6124449|FD-Score:3.68|P-value:2.50E-4 ID:SGTC_2317|Compound:5986382|FD-Score:-4.13|P-value:6.66E-5 ID:SGTC_2319|Compound:6033012|FD-Score:-6.68|P-value:2.70E-10 ID:SGTC_2322|Compound:7413319|FD-Score:7.48|P-value:1.03E-12 ID:SGTC_2398|Compound:5228213|FD-Score:3.42|P-value:6.01E-4 ID:SGTC_2444|Compound:5485484|FD-Score:6.08|P-value:5.38E-9 ID:SGTC_2504|Compound:purpurogallin|FD-Score:3.63|P-value:2.96E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-4.50|P-value:1.52E-5 ID:SGTC_2596|Compound:sinensetin|FD-Score:-3.43|P-value:7.70E-4 ID:SGTC_2724|Compound:maprotiline|FD-Score:3.29|P-value:9.31E-4 ID:SGTC_2743|Compound:auranofin|FD-Score:4.71|P-value:4.53E-6 ID:SGTC_2807|Compound:7945238|FD-Score:4.08|P-value:5.93E-5 ID:SGTC_2828|Compound:7998861|FD-Score:3.59|P-value:3.40E-4 ID:SGTC_2844|Compound:9010103|FD-Score:-3.78|P-value:2.34E-4 ID:SGTC_2878|Compound:9043973|FD-Score:-4.18|P-value:5.46E-5 ID:SGTC_2896|Compound:9052656|FD-Score:4.74|P-value:3.87E-6 ID:SGTC_2916|Compound:7875993|FD-Score:4.74|P-value:3.87E-6 ID:SGTC_2947|Compound:9072639|FD-Score:4.86|P-value:2.33E-6 ID:SGTC_2991|Compound:9074669|FD-Score:4.14|P-value:4.60E-5 ID:SGTC_3132|Compound:9126706|FD-Score:3.52|P-value:4.35E-4 ID:SGTC_3158|Compound:9100007|FD-Score:3.62|P-value:3.07E-4

Top fitness defect scores for YGL133W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_690 glyoxal 11.40 20.3 µM 3.84E-27 14 1.41E-30
2 SGTC_2322 7413319 7.48 38.2 µM 1.03E-12 ERAD & cell cycle 39 3.70E-14
3 SGTC_2444 5485484 6.08 36.4 µM 5.38E-9 6 6.13E-10
4 SGTC_103 0844-0104 6.02 51.8 µM 7.22E-9 ERAD & cell cycle 78 8.55E-10
5 SGTC_955 1216-0110 5.59 33.0 µM 7.11E-8 sphingolipid biosynthesis & PDR1 38 1.14E-8
6 SGTC_1170 0310-0127 5.59 64.8 µM 7.20E-8 4 1.16E-8
7 SGTC_2947 9072639 4.86 7.7 µM 2.33E-6 tubulin folding & SWR complex 20 5.91E-7
8 SGTC_2916 7875993 4.74 68.8 µM 3.87E-6 9 1.05E-6
9 SGTC_2896 9052656 4.74 71.4 µM 3.87E-6 endomembrane recycling 67 1.05E-6
10 SGTC_2743 auranofin 4.71 4.3 µM 4.53E-6 RPP1 & pyrimidine depletion 20 1.25E-6
11 SGTC_2166 5933061 4.20 31.5 µM 3.68E-5 tubulin folding & SWR complex 30 1.33E-5
12 SGTC_2991 9074669 4.14 71.4 µM 4.60E-5 azole & statin 52 1.71E-5
13 SGTC_1844 rapamycin 4.13 4.0 nM 4.80E-5 150 1.80E-5
14 SGTC_2807 7945238 4.08 52.0 µM 5.93E-5 18 2.28E-5
15 SGTC_1762 st045503 3.94 25.5 µM 1.00E-4 27 4.12E-5
16 SGTC_733 4069-0007 3.93 56.1 µM 1.02E-4 ERAD & cell cycle 87 4.19E-5
17 SGTC_1510 1123-0200 3.78 71.5 µM 1.75E-4 49 7.70E-5
18 SGTC_1812 st052057 3.70 4.3 µM 2.36E-4 calcium & mitochondrial duress 34 1.08E-4
19 SGTC_2186 6124449 3.68 200.0 µM 2.50E-4 RSC complex & mRNA processing 24 1.15E-4
20 SGTC_1224 0823-0416 3.64 294.0 µM 2.91E-4 17 1.37E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.188 4.10E-28 YOL002C IZH2 hom Plasma membrane protein involved in zinc homeostasis and osmotin-induced apoptosis; transcription regulated by Zap1p, zinc and fatty acid levels; similar to mammalian adiponectins; deletion increases sensitivity to elevated zinc
0.188 4.72E-28 YOR304W ISW2 hom ATP-dependent DNA translocase involved in chromatin remodeling; ATPase component that, with Itc1p, forms a complex required for repression of a-specific genes, INO1, and early meiotic genes during mitotic growth
0.184 4.71E-27 YML014W TRM9 hom tRNA methyltransferase; catalyzes modification of wobble bases in tRNA anticodons to 2, 5-methoxycarbonylmethyluridine and 5-methoxycarbonylmethyl-2-thiouridine; may act as part of a complex with Trm112p; deletion mutation increases translational infidelity, including amino acid misincorporation and -1 frameshifting, and also confers resistance to zymocin; null mutant displays activation of stress responses
0.182 2.60E-26 YGR077C PEX8 hom Intraperoxisomal organizer of the peroxisomal import machinery; organizes the formation of the importomer complex, bridging the docking complex with the RING finger complex; tightly associated with the lumenal face of the peroxisomal membrane; essential for peroxisome biogenesis; binds PTS1-signal receptor Pex5p, and PTS2-signal receptor Pex7p
0.179 1.76E-25 YMR022W UBC7 hom Ubiquitin conjugating enzyme, involved in the ER-associated protein degradation pathway; requires Cue1p for recruitment to the ER membrane; proposed to be involved in chromatin assembly
0.172 9.66E-24 YKL213C DOA1 hom WD repeat protein required for ubiquitin-mediated protein degradation; forms a complex with Cdc48p; plays a role in controlling cellular ubiquitin concentration; also promotes efficient NHEJ in postdiauxic/stationary phase; protein increases in abundance and relocalizes from nucleus to nuclear periphery upon DNA replication stress
0.172 8.54E-24 YGR190C_d YGR190C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene HIP1/YGR191W
0.170 4.45E-23 YOR104W PIN2 hom Protein that induces appearance of [PIN+] prion when overproduced; predicted to be palmitoylated
0.167 1.59E-22 YDR186C YDR186C hom Putative protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.157 4.75E-20 YKR014C YPT52 hom Rab family GTPase, similar to Ypt51p and Ypt53p and to mammalian rab5; required for vacuolar protein sorting and endocytosis; protein abundance increases in response to DNA replication stress
0.157 5.04E-20 YIL030C SSM4 hom Ubiquitin-protein ligase involved in ER-associated protein degradation; located in the ER/nuclear envelope; ssm4 mutation suppresses mRNA instability caused by an rna14 mutation
0.157 7.48E-20 YMR067C UBX4 hom UBX domain-containing protein that interacts with Cdc48p; involved in degradation of polyubiquitinated proteins via the ERAD (ER-associated degradation) pathway; modulates the Cdc48p-Nplp-Ufd1p AAA ATPase complex during its role in delivery of misfolded proteins to the proteasome; protein abundance increases in response to DNA replication stress
0.155 1.76E-19 YDR199W_d YDR199W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene VPS64; computationally predicted to have thiol-disulfide oxidoreductase activity
0.154 2.27E-19 YDL100C GET3 hom Guanine nucleotide exchange factor for Gpa1p; amplifies G protein signaling; subunit of the GET complex, which is involved in Golgi to ER trafficking and insertion of proteins into the ER membrane; has low-level ATPase activity; protein abundance increases in response to DNA replication stress
0.154 3.35E-19 YER019C-A SBH2 hom Ssh1p-Sss1p-Sbh2p complex component, involved in protein translocation into the endoplasmic reticulum; homologous to Sbh1p