YGL137W / SEC27

Essential beta'-coat protein of the COPI coatomer, involved in ER-to-Golgi and Golgi-to-ER transport; contains WD40 domains that mediate cargo selective interactions; 45% sequence identity to mammalian beta'-COP

Zygosity: Heterozygous strain
fixedexpanded
Profile for YGL137W / SEC27

Click on Significant Values for Screen Details ID:SGTC_141|Compound:0443-0274|FD-Score:7.17|P-value:1.42E-12 ID:SGTC_178|Compound:4092-0806|FD-Score:-3.75|P-value:1.92E-4 ID:SGTC_187|Compound:1488-2104|FD-Score:3.15|P-value:9.58E-4 ID:SGTC_245|Compound:methotrexate|FD-Score:4.90|P-value:8.06E-7 ID:SGTC_310|Compound:1273-0058|FD-Score:-3.31|P-value:8.65E-4 ID:SGTC_426|Compound:0988-0037|FD-Score:3.78|P-value:1.01E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:4.23|P-value:1.67E-5 ID:SGTC_455|Compound:paf C-16|FD-Score:3.37|P-value:4.50E-4 ID:SGTC_597|Compound:k018-0003|FD-Score:4.99|P-value:5.19E-7 ID:SGTC_778|Compound:3456-2434|FD-Score:7.89|P-value:7.91E-15 ID:SGTC_819|Compound:1013-0258|FD-Score:3.81|P-value:8.98E-5 ID:SGTC_820|Compound:1582-0060|FD-Score:3.30|P-value:5.73E-4 ID:SGTC_825|Compound:1988-2224|FD-Score:-4.06|P-value:5.88E-5 ID:SGTC_837|Compound:0091-0265|FD-Score:3.49|P-value:2.94E-4 ID:SGTC_918|Compound:glabranin|FD-Score:3.66|P-value:1.56E-4 ID:SGTC_927|Compound:2425-1185|FD-Score:-3.30|P-value:9.08E-4 ID:SGTC_950|Compound:1165-0508|FD-Score:-3.42|P-value:6.06E-4 ID:SGTC_1025|Compound:k007-0731|FD-Score:3.60|P-value:1.99E-4 ID:SGTC_1033|Compound:k072-0102|FD-Score:3.98|P-value:4.60E-5 ID:SGTC_1036|Compound:k216-0215|FD-Score:-4.96|P-value:1.18E-6 ID:SGTC_1058|Compound:3448-5425|FD-Score:3.60|P-value:2.01E-4 ID:SGTC_1170|Compound:0310-0127|FD-Score:4.93|P-value:6.81E-7 ID:SGTC_1171|Compound:0368-0077|FD-Score:3.78|P-value:1.01E-4 ID:SGTC_1212|Compound:0520-0165|FD-Score:3.33|P-value:5.17E-4 ID:SGTC_1218|Compound:1348-1416|FD-Score:3.79|P-value:9.86E-5 ID:SGTC_1355|Compound:1499-0035|FD-Score:3.56|P-value:2.29E-4 ID:SGTC_1385|Compound:3091-4834|FD-Score:3.25|P-value:6.84E-4 ID:SGTC_1430|Compound:4049-0248|FD-Score:3.19|P-value:8.39E-4 ID:SGTC_1479|Compound:0549-0158|FD-Score:3.27|P-value:6.28E-4 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:3.92|P-value:5.98E-5 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:7.10|P-value:2.25E-12 ID:SGTC_1758|Compound:st042942|FD-Score:3.81|P-value:9.14E-5 ID:SGTC_1888|Compound:azatryptophan|FD-Score:-4.44|P-value:1.22E-5 ID:SGTC_1894|Compound:3',6'-dihydroxyflavone|FD-Score:-3.51|P-value:4.48E-4 ID:SGTC_1896|Compound:st058441|FD-Score:3.99|P-value:4.50E-5 ID:SGTC_2067|Compound:5224629|FD-Score:4.09|P-value:2.98E-5 ID:SGTC_2074|Compound:5212007|FD-Score:3.47|P-value:3.13E-4 ID:SGTC_2165|Compound:5727197|FD-Score:3.26|P-value:6.49E-4 ID:SGTC_2393|Compound:9031399|FD-Score:3.87|P-value:7.16E-5 ID:SGTC_2394|Compound:5221648|FD-Score:3.20|P-value:8.11E-4 ID:SGTC_2404|Compound:5161160|FD-Score:3.86|P-value:7.56E-5 ID:SGTC_2427|Compound:5545055|FD-Score:5.33|P-value:9.30E-8 ID:SGTC_2429|Compound:5902844|FD-Score:3.50|P-value:2.83E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:-4.87|P-value:1.78E-6 ID:SGTC_2688|Compound:kanamycin b|FD-Score:5.16|P-value:2.26E-7 ID:SGTC_2720|Compound:fluspirilene|FD-Score:3.68|P-value:1.46E-4 ID:SGTC_2724|Compound:maprotiline|FD-Score:4.11|P-value:2.73E-5 ID:SGTC_2831|Compound:7999036|FD-Score:3.46|P-value:3.23E-4 ID:SGTC_2834|Compound:9001755|FD-Score:-8.29|P-value:9.81E-16 ID:SGTC_2849|Compound:9019321|FD-Score:-3.52|P-value:4.26E-4 ID:SGTC_2880|Compound:9042983|FD-Score:-3.28|P-value:9.53E-4 ID:SGTC_2948|Compound:9070189|FD-Score:-4.62|P-value:5.47E-6 ID:SGTC_2964|Compound:9083345|FD-Score:-4.70|P-value:3.82E-6 ID:SGTC_2965|Compound:9082772|FD-Score:-10.60|P-value:1.14E-24 ID:SGTC_2968|Compound:9090663|FD-Score:4.21|P-value:1.82E-5 ID:SGTC_2991|Compound:9074669|FD-Score:3.55|P-value:2.37E-4 ID:SGTC_3165|Compound:9101544|FD-Score:3.90|P-value:6.31E-5 ID:SGTC_3166|Compound:9102297|FD-Score:-3.51|P-value:4.49E-4 ID:SGTC_3295|Compound:9122362|FD-Score:-4.77|P-value:2.76E-6 ID:SGTC_141|Compound:0443-0274|FD-Score:7.17|P-value:1.42E-12 ID:SGTC_178|Compound:4092-0806|FD-Score:-3.75|P-value:1.92E-4 ID:SGTC_187|Compound:1488-2104|FD-Score:3.15|P-value:9.58E-4 ID:SGTC_245|Compound:methotrexate|FD-Score:4.90|P-value:8.06E-7 ID:SGTC_310|Compound:1273-0058|FD-Score:-3.31|P-value:8.65E-4 ID:SGTC_426|Compound:0988-0037|FD-Score:3.78|P-value:1.01E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:4.23|P-value:1.67E-5 ID:SGTC_455|Compound:paf C-16|FD-Score:3.37|P-value:4.50E-4 ID:SGTC_597|Compound:k018-0003|FD-Score:4.99|P-value:5.19E-7 ID:SGTC_778|Compound:3456-2434|FD-Score:7.89|P-value:7.91E-15 ID:SGTC_819|Compound:1013-0258|FD-Score:3.81|P-value:8.98E-5 ID:SGTC_820|Compound:1582-0060|FD-Score:3.30|P-value:5.73E-4 ID:SGTC_825|Compound:1988-2224|FD-Score:-4.06|P-value:5.88E-5 ID:SGTC_837|Compound:0091-0265|FD-Score:3.49|P-value:2.94E-4 ID:SGTC_918|Compound:glabranin|FD-Score:3.66|P-value:1.56E-4 ID:SGTC_927|Compound:2425-1185|FD-Score:-3.30|P-value:9.08E-4 ID:SGTC_950|Compound:1165-0508|FD-Score:-3.42|P-value:6.06E-4 ID:SGTC_1025|Compound:k007-0731|FD-Score:3.60|P-value:1.99E-4 ID:SGTC_1033|Compound:k072-0102|FD-Score:3.98|P-value:4.60E-5 ID:SGTC_1036|Compound:k216-0215|FD-Score:-4.96|P-value:1.18E-6 ID:SGTC_1058|Compound:3448-5425|FD-Score:3.60|P-value:2.01E-4 ID:SGTC_1170|Compound:0310-0127|FD-Score:4.93|P-value:6.81E-7 ID:SGTC_1171|Compound:0368-0077|FD-Score:3.78|P-value:1.01E-4 ID:SGTC_1212|Compound:0520-0165|FD-Score:3.33|P-value:5.17E-4 ID:SGTC_1218|Compound:1348-1416|FD-Score:3.79|P-value:9.86E-5 ID:SGTC_1355|Compound:1499-0035|FD-Score:3.56|P-value:2.29E-4 ID:SGTC_1385|Compound:3091-4834|FD-Score:3.25|P-value:6.84E-4 ID:SGTC_1430|Compound:4049-0248|FD-Score:3.19|P-value:8.39E-4 ID:SGTC_1479|Compound:0549-0158|FD-Score:3.27|P-value:6.28E-4 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:3.92|P-value:5.98E-5 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:7.10|P-value:2.25E-12 ID:SGTC_1758|Compound:st042942|FD-Score:3.81|P-value:9.14E-5 ID:SGTC_1888|Compound:azatryptophan|FD-Score:-4.44|P-value:1.22E-5 ID:SGTC_1894|Compound:3',6'-dihydroxyflavone|FD-Score:-3.51|P-value:4.48E-4 ID:SGTC_1896|Compound:st058441|FD-Score:3.99|P-value:4.50E-5 ID:SGTC_2067|Compound:5224629|FD-Score:4.09|P-value:2.98E-5 ID:SGTC_2074|Compound:5212007|FD-Score:3.47|P-value:3.13E-4 ID:SGTC_2165|Compound:5727197|FD-Score:3.26|P-value:6.49E-4 ID:SGTC_2393|Compound:9031399|FD-Score:3.87|P-value:7.16E-5 ID:SGTC_2394|Compound:5221648|FD-Score:3.20|P-value:8.11E-4 ID:SGTC_2404|Compound:5161160|FD-Score:3.86|P-value:7.56E-5 ID:SGTC_2427|Compound:5545055|FD-Score:5.33|P-value:9.30E-8 ID:SGTC_2429|Compound:5902844|FD-Score:3.50|P-value:2.83E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:-4.87|P-value:1.78E-6 ID:SGTC_2688|Compound:kanamycin b|FD-Score:5.16|P-value:2.26E-7 ID:SGTC_2720|Compound:fluspirilene|FD-Score:3.68|P-value:1.46E-4 ID:SGTC_2724|Compound:maprotiline|FD-Score:4.11|P-value:2.73E-5 ID:SGTC_2831|Compound:7999036|FD-Score:3.46|P-value:3.23E-4 ID:SGTC_2834|Compound:9001755|FD-Score:-8.29|P-value:9.81E-16 ID:SGTC_2849|Compound:9019321|FD-Score:-3.52|P-value:4.26E-4 ID:SGTC_2880|Compound:9042983|FD-Score:-3.28|P-value:9.53E-4 ID:SGTC_2948|Compound:9070189|FD-Score:-4.62|P-value:5.47E-6 ID:SGTC_2964|Compound:9083345|FD-Score:-4.70|P-value:3.82E-6 ID:SGTC_2965|Compound:9082772|FD-Score:-10.60|P-value:1.14E-24 ID:SGTC_2968|Compound:9090663|FD-Score:4.21|P-value:1.82E-5 ID:SGTC_2991|Compound:9074669|FD-Score:3.55|P-value:2.37E-4 ID:SGTC_3165|Compound:9101544|FD-Score:3.90|P-value:6.31E-5 ID:SGTC_3166|Compound:9102297|FD-Score:-3.51|P-value:4.49E-4 ID:SGTC_3295|Compound:9122362|FD-Score:-4.77|P-value:2.76E-6

Top fitness defect scores for YGL137W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_778 3456-2434 7.89 196.0 µM 7.91E-15 mitochondrial response to ROS 2 1.56E-15 1.15
2 SGTC_141 0443-0274 7.17 32.3 µM 1.42E-12 mitochondrial response to ROS 1 3.85E-13 1.66
3 SGTC_1597 7-benzyloxygramine 7.10 47.5 µM 2.25E-12 calcium & mitochondrial duress 28 6.28E-13 0.14
4 SGTC_2427 5545055 5.33 42.8 µM 9.30E-8 2 4.90E-8 0.18
5 SGTC_2688 kanamycin b 5.16 96.7 µM 2.26E-7 calcium & mitochondrial duress 2 1.26E-7 0.01
6 SGTC_597 k018-0003 4.99 82.8 µM 5.19E-7 RNA pol III & RNase P/MRP 2 3.02E-7 1.08
7 SGTC_1170 0310-0127 4.93 64.8 µM 6.81E-7 5 4.02E-7 0.49
8 SGTC_245 methotrexate 4.90 289.6 µM 8.06E-7 9 4.80E-7 0.43
9 SGTC_431 k089-0097 4.23 107.0 µM 1.67E-5 iron homeostasis 14 1.18E-5 0.21
10 SGTC_2968 9090663 4.21 33.4 µM 1.82E-5 9 1.29E-5 0.13
11 SGTC_2724 maprotiline 4.11 69.6 µM 2.73E-5 ERG2 5 1.98E-5 0.14
12 SGTC_2067 5224629 4.09 34.1 µM 2.98E-5 10 2.16E-5 0.04
13 SGTC_1896 st058441 3.99 89.0 µM 4.50E-5 5 3.34E-5 0.22
14 SGTC_1033 k072-0102 3.98 21.3 µM 4.60E-5 60S ribosome export 5 3.41E-5 0.12
15 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 3.92 54.9 µM 5.98E-5 redox potentiating 7 4.50E-5 0.32
16 SGTC_3165 9101544 3.90 49.5 µM 6.31E-5 3 4.76E-5 0.23
17 SGTC_2393 9031399 3.87 185.9 µM 7.16E-5 RNA processing & uracil transport 12 5.44E-5 0.02
18 SGTC_2404 5161160 3.86 200.0 µM 7.56E-5 9 5.76E-5 0.11
19 SGTC_819 1013-0258 3.81 27.7 µM 8.98E-5 5 6.90E-5 0.25
20 SGTC_1758 st042942 3.81 75.2 µM 9.14E-5 3 7.04E-5 0.06

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.169 5.08E-23 YKL202W_d YKL202W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.138 1.28E-15 YJL165C HAL5 hom Putative protein kinase; overexpression increases sodium and lithium tolerance, whereas gene disruption increases cation and low pH sensitivity and impairs potassium uptake, suggesting a role in regulation of Trk1p and/or Trk2p transporters; HAL5 has a paralog, KKQ8, that arose from the whole genome duplication
0.137 1.51E-15 YKL196C YKT6 het Vesicle membrane protein (v-SNARE) with acyltransferase activity; involved in trafficking to and within the Golgi, endocytic trafficking to the vacuole, and vacuolar fusion; membrane localization due to prenylation at the carboxy-terminus
0.135 3.96E-15 YGL011C SCL1 het Alpha 1 subunit of the 20S proteasome involved in the degradation of ubiquitinated substrates; 20S proteasome is the core complex of the 26S proteasome; essential for growth; detected in the mitochondria
0.131 2.94E-14 YMR308C PSE1 het Karyopherin/importin that interacts with the nuclear pore complex; acts as the nuclear import receptor for specific proteins, including Pdr1p, Yap1p, Ste12p, and Aft1p
0.130 3.75E-14 YOR218C_d YOR218C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene RFC1/YOR217W
0.127 1.90E-13 YDR089W YDR089W hom Protein of unknown function; deletion confers resistance to nickel; contains an SPX domain, which is found in proteins involved in phosphate homeostasis; relocalizes from vacuole to cytoplasm upon DNA replication stress
0.125 3.39E-13 YLR210W CLB4 hom B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the G2/M transition; may be involved in DNA replication and spindle assembly; accumulates during S phase and G2, then targeted for ubiquitin-mediated degradation
0.123 1.02E-12 YDL088C ASM4 hom FG-nucleoporin component of central core of nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport; induces membrane tubulation, which may contribute to nuclear pore assembly; ASM4 has a paralog, NUP53, that arose from the whole genome duplication
0.122 1.43E-12 YDR101C ARX1 hom Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit biogenesis; interacts directly with Alb1; responsible for Tif6 recycling defects in absence of Rei1; associated with the ribosomal export complex
0.120 3.11E-12 YDR416W SYF1 het Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; null mutant has splicing defect and arrests in G2/M; homologs in human and C. elegans
0.115 2.03E-11 YPL010W RET3 het Zeta subunit of the coatomer complex (COPI), which coats Golgi-derived transport vesicles; involved in retrograde transport between Golgi and ER
0.115 2.27E-11 YGR253C PUP2 het Alpha 5 subunit of the 20S proteasome involved in ubiquitin-dependent catabolism; human homolog is subunit zeta
0.115 2.72E-11 YLR315W NKP2 hom Central kinetochore protein and subunit of the Ctf19 complex; mutants have elevated rates of chromosome loss; orthologous to fission yeast kinetochore protein cnl2
0.114 2.99E-11 YFR051C RET2 het Delta subunit of the coatomer complex (COPI), which coats Golgi-derived transport vesicles; involved in retrograde transport between Golgi and ER