HIPHOP chemogenomics database

YGL137W / SEC27

Essential beta'-coat protein of the COPI coatomer, involved in ER-to-Golgi and Golgi-to-ER transport; contains WD40 domains that mediate cargo selective interactions; 45% sequence identity to mammalian beta'-COP

Zygosity: Heterozygous strain

fixedexpanded
Profile for YGL137W / SEC27

Click on Significant Values for Screen Details

Top fitness defect scores for YGL137W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value	Screen Clearance
1	SGTC_778	3456-2434	7.89	196.0 µM	7.91E-15	mitochondrial response to ROS	2	1.56E-15	1.15
2	SGTC_141	0443-0274	7.17	32.3 µM	1.42E-12	mitochondrial response to ROS	1	3.85E-13	1.66
3	SGTC_1597	7-benzyloxygramine	7.10	47.5 µM	2.25E-12	calcium & mitochondrial duress	28	6.28E-13	0.14
4	SGTC_2427	5545055	5.33	42.8 µM	9.30E-8		2	4.90E-8	0.18
5	SGTC_2688	kanamycin b	5.16	96.7 µM	2.26E-7	calcium & mitochondrial duress	2	1.26E-7	0.01
6	SGTC_597	k018-0003	4.99	82.8 µM	5.19E-7	RNA pol III & RNase P/MRP	2	3.02E-7	1.08
7	SGTC_1170	0310-0127	4.93	64.8 µM	6.81E-7		5	4.02E-7	0.49
8	SGTC_245	methotrexate	4.90	289.6 µM	8.06E-7		9	4.80E-7	0.43
9	SGTC_431	k089-0097	4.23	107.0 µM	1.67E-5	iron homeostasis	14	1.18E-5	0.21
10	SGTC_2968	9090663	4.21	33.4 µM	1.82E-5		9	1.29E-5	0.13
11	SGTC_2724	maprotiline	4.11	69.6 µM	2.73E-5	ERG2	5	1.98E-5	0.14
12	SGTC_2067	5224629	4.09	34.1 µM	2.98E-5		10	2.16E-5	0.04
13	SGTC_1896	st058441	3.99	89.0 µM	4.50E-5		5	3.34E-5	0.22
14	SGTC_1033	k072-0102	3.98	21.3 µM	4.60E-5	60S ribosome export	5	3.41E-5	0.12
15	SGTC_1593	justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one	3.92	54.9 µM	5.98E-5	redox potentiating	7	4.50E-5	0.32
16	SGTC_3165	9101544	3.90	49.5 µM	6.31E-5		3	4.76E-5	0.23
17	SGTC_2393	9031399	3.87	185.9 µM	7.16E-5	RNA processing & uracil transport	12	5.44E-5	0.02
18	SGTC_2404	5161160	3.86	200.0 µM	7.56E-5		9	5.76E-5	0.11
19	SGTC_819	1013-0258	3.81	27.7 µM	8.98E-5		5	6.90E-5	0.25
20	SGTC_1758	st042942	3.81	75.2 µM	9.14E-5		3	7.04E-5	0.06

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.169	5.08E-23	YKL202W_d	YKL202W_d	hom	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.138	1.28E-15	YJL165C	HAL5	hom	Putative protein kinase; overexpression increases sodium and lithium tolerance, whereas gene disruption increases cation and low pH sensitivity and impairs potassium uptake, suggesting a role in regulation of Trk1p and/or Trk2p transporters; HAL5 has a paralog, KKQ8, that arose from the whole genome duplication
0.137	1.51E-15	YKL196C	YKT6	het	Vesicle membrane protein (v-SNARE) with acyltransferase activity; involved in trafficking to and within the Golgi, endocytic trafficking to the vacuole, and vacuolar fusion; membrane localization due to prenylation at the carboxy-terminus
0.135	3.96E-15	YGL011C	SCL1	het	Alpha 1 subunit of the 20S proteasome involved in the degradation of ubiquitinated substrates; 20S proteasome is the core complex of the 26S proteasome; essential for growth; detected in the mitochondria
0.131	2.94E-14	YMR308C	PSE1	het	Karyopherin/importin that interacts with the nuclear pore complex; acts as the nuclear import receptor for specific proteins, including Pdr1p, Yap1p, Ste12p, and Aft1p
0.130	3.75E-14	YOR218C_d	YOR218C_d	het	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene RFC1/YOR217W
0.127	1.90E-13	YDR089W	YDR089W	hom	Protein of unknown function; deletion confers resistance to nickel; contains an SPX domain, which is found in proteins involved in phosphate homeostasis; relocalizes from vacuole to cytoplasm upon DNA replication stress
0.125	3.39E-13	YLR210W	CLB4	hom	B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the G2/M transition; may be involved in DNA replication and spindle assembly; accumulates during S phase and G2, then targeted for ubiquitin-mediated degradation
0.123	1.02E-12	YDL088C	ASM4	hom	FG-nucleoporin component of central core of nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport; induces membrane tubulation, which may contribute to nuclear pore assembly; ASM4 has a paralog, NUP53, that arose from the whole genome duplication
0.122	1.43E-12	YDR101C	ARX1	hom	Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit biogenesis; interacts directly with Alb1; responsible for Tif6 recycling defects in absence of Rei1; associated with the ribosomal export complex
0.120	3.11E-12	YDR416W	SYF1	het	Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; null mutant has splicing defect and arrests in G2/M; homologs in human and C. elegans
0.115	2.03E-11	YPL010W	RET3	het	Zeta subunit of the coatomer complex (COPI), which coats Golgi-derived transport vesicles; involved in retrograde transport between Golgi and ER
0.115	2.27E-11	YGR253C	PUP2	het	Alpha 5 subunit of the 20S proteasome involved in ubiquitin-dependent catabolism; human homolog is subunit zeta
0.115	2.72E-11	YLR315W	NKP2	hom	Central kinetochore protein and subunit of the Ctf19 complex; mutants have elevated rates of chromosome loss; orthologous to fission yeast kinetochore protein cnl2
0.114	2.99E-11	YFR051C	RET2	het	Delta subunit of the coatomer complex (COPI), which coats Golgi-derived transport vesicles; involved in retrograde transport between Golgi and ER