YGL144C / ROG1

Protein with putative serine active lipase domain; ROG1 has a paralog, YDL109C, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL144C / ROG1

Click on Significant Values for Screen Details ID:SGTC_60|Compound:0986-0278|FD-Score:3.51|P-value:3.41E-4 ID:SGTC_278|Compound:4092-0821|FD-Score:3.33|P-value:6.44E-4 ID:SGTC_302|Compound:1094-0063|FD-Score:3.82|P-value:1.11E-4 ID:SGTC_404|Compound:fumagillin|FD-Score:-3.89|P-value:8.24E-5 ID:SGTC_413|Compound:propylparaben|FD-Score:4.79|P-value:1.76E-6 ID:SGTC_419|Compound:nsc-638432|FD-Score:-3.60|P-value:2.42E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:3.60|P-value:2.50E-4 ID:SGTC_1047|Compound:2043-3044|FD-Score:-4.57|P-value:4.78E-6 ID:SGTC_1052|Compound:3253-3998|FD-Score:-3.59|P-value:2.53E-4 ID:SGTC_1409|Compound:3909-8004|FD-Score:3.39|P-value:5.18E-4 ID:SGTC_1430|Compound:4049-0248|FD-Score:-3.36|P-value:5.71E-4 ID:SGTC_1722|Compound:st034304|FD-Score:6.11|P-value:1.72E-9 ID:SGTC_1723|Compound:st034307|FD-Score:4.20|P-value:2.41E-5 ID:SGTC_1797|Compound:st048695|FD-Score:4.12|P-value:3.38E-5 ID:SGTC_1800|Compound:st050079|FD-Score:3.32|P-value:6.63E-4 ID:SGTC_1818|Compound:st052136|FD-Score:5.49|P-value:5.51E-8 ID:SGTC_1836|Compound:st055642|FD-Score:-3.21|P-value:9.38E-4 ID:SGTC_1992|Compound:st073643|FD-Score:3.36|P-value:5.69E-4 ID:SGTC_2033|Compound:5192550|FD-Score:3.59|P-value:2.55E-4 ID:SGTC_2043|Compound:5101342|FD-Score:3.88|P-value:8.77E-5 ID:SGTC_2044|Compound:5102272|FD-Score:4.16|P-value:2.87E-5 ID:SGTC_2280|Compound:7785178|FD-Score:4.10|P-value:3.61E-5 ID:SGTC_2569|Compound:tetrandrine|FD-Score:3.64|P-value:2.16E-4 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:-4.94|P-value:8.53E-7 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:-3.68|P-value:1.81E-4 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-10.70|P-value:1.49E-25 ID:SGTC_2692|Compound:st077426|FD-Score:-3.61|P-value:2.33E-4 ID:SGTC_2834|Compound:9001755|FD-Score:-3.19|P-value:9.88E-4 ID:SGTC_2931|Compound:9014674|FD-Score:3.21|P-value:9.45E-4 ID:SGTC_3037|Compound:9091026|FD-Score:5.96|P-value:4.03E-9 ID:SGTC_3198|Compound:9112019|FD-Score:4.44|P-value:8.88E-6 ID:SGTC_60|Compound:0986-0278|FD-Score:3.51|P-value:3.41E-4 ID:SGTC_278|Compound:4092-0821|FD-Score:3.33|P-value:6.44E-4 ID:SGTC_302|Compound:1094-0063|FD-Score:3.82|P-value:1.11E-4 ID:SGTC_404|Compound:fumagillin|FD-Score:-3.89|P-value:8.24E-5 ID:SGTC_413|Compound:propylparaben|FD-Score:4.79|P-value:1.76E-6 ID:SGTC_419|Compound:nsc-638432|FD-Score:-3.60|P-value:2.42E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:3.60|P-value:2.50E-4 ID:SGTC_1047|Compound:2043-3044|FD-Score:-4.57|P-value:4.78E-6 ID:SGTC_1052|Compound:3253-3998|FD-Score:-3.59|P-value:2.53E-4 ID:SGTC_1409|Compound:3909-8004|FD-Score:3.39|P-value:5.18E-4 ID:SGTC_1430|Compound:4049-0248|FD-Score:-3.36|P-value:5.71E-4 ID:SGTC_1722|Compound:st034304|FD-Score:6.11|P-value:1.72E-9 ID:SGTC_1723|Compound:st034307|FD-Score:4.20|P-value:2.41E-5 ID:SGTC_1797|Compound:st048695|FD-Score:4.12|P-value:3.38E-5 ID:SGTC_1800|Compound:st050079|FD-Score:3.32|P-value:6.63E-4 ID:SGTC_1818|Compound:st052136|FD-Score:5.49|P-value:5.51E-8 ID:SGTC_1836|Compound:st055642|FD-Score:-3.21|P-value:9.38E-4 ID:SGTC_1992|Compound:st073643|FD-Score:3.36|P-value:5.69E-4 ID:SGTC_2033|Compound:5192550|FD-Score:3.59|P-value:2.55E-4 ID:SGTC_2043|Compound:5101342|FD-Score:3.88|P-value:8.77E-5 ID:SGTC_2044|Compound:5102272|FD-Score:4.16|P-value:2.87E-5 ID:SGTC_2280|Compound:7785178|FD-Score:4.10|P-value:3.61E-5 ID:SGTC_2569|Compound:tetrandrine|FD-Score:3.64|P-value:2.16E-4 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:-4.94|P-value:8.53E-7 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:-3.68|P-value:1.81E-4 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-10.70|P-value:1.49E-25 ID:SGTC_2692|Compound:st077426|FD-Score:-3.61|P-value:2.33E-4 ID:SGTC_2834|Compound:9001755|FD-Score:-3.19|P-value:9.88E-4 ID:SGTC_2931|Compound:9014674|FD-Score:3.21|P-value:9.45E-4 ID:SGTC_3037|Compound:9091026|FD-Score:5.96|P-value:4.03E-9 ID:SGTC_3198|Compound:9112019|FD-Score:4.44|P-value:8.88E-6

Top fitness defect scores for YGL144C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1722 st034304 6.11 3.6 µM 1.72E-9 mitochondrial processes 7 5.03E-10
2 SGTC_3037 9091026 5.96 49.5 µM 4.03E-9 NEO1-PIK1 49 1.25E-9
3 SGTC_1818 st052136 5.49 56.3 µM 5.51E-8 NEO1-PIK1 17 2.03E-8
4 SGTC_413 propylparaben 4.79 100.0 µM 1.76E-6 amide catabolism 9 8.16E-7
5 SGTC_3198 9112019 4.44 49.5 µM 8.88E-6 mitochondrial processes 8 4.56E-6
6 SGTC_1723 st034307 4.20 2.5 µM 2.41E-5 mitochondrial processes 22 1.32E-5
7 SGTC_2044 5102272 4.16 200.0 µM 2.87E-5 6 1.59E-5
8 SGTC_1797 st048695 4.12 56.8 µM 3.38E-5 NEO1 69 1.90E-5
9 SGTC_2280 7785178 4.10 200.0 µM 3.61E-5 8 2.03E-5
10 SGTC_2043 5101342 3.88 149.0 µM 8.77E-5 SWF1 & branched chain AA biosynthesis 21 5.23E-5
11 SGTC_302 1094-0063 3.82 18.9 µM 1.11E-4 14 6.75E-5
12 SGTC_2569 tetrandrine 3.64 100.0 µM 2.16E-4 29 1.37E-4
13 SGTC_893 0958-0369 3.60 48.9 µM 2.50E-4 35 1.60E-4
14 SGTC_2033 5192550 3.59 145.0 µM 2.55E-4 22 1.63E-4
15 SGTC_60 0986-0278 3.51 202.0 µM 3.41E-4 24 2.22E-4
16 SGTC_1409 3909-8004 3.39 61.9 µM 5.18E-4 43 3.47E-4
17 SGTC_1992 st073643 3.36 23.3 µM 5.69E-4 mitochondrial processes 23 3.83E-4
18 SGTC_278 4092-0821 3.33 23.9 µM 6.44E-4 plasma membrane duress 67 4.37E-4
19 SGTC_1800 st050079 3.32 29.1 µM 6.63E-4 NEO1-PIK1 179 4.51E-4
20 SGTC_2931 9014674 3.21 55.7 µM 9.45E-4 54 6.57E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.305 1.93E-73 YER066W_p RRT13_p hom Putative protein of unknown function; non-essential gene identified in a screen for mutants with decreased levels of rDNA transcription
0.267 1.17E-55 YLR395C COX8 hom Subunit VIII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain
0.256 1.94E-51 YGL146C_p RRT6_p hom Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; contains two putative transmembrane spans, but no significant homology to other known proteins
0.225 7.02E-40 YGR015C_p YGR015C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion
0.191 7.06E-29 YCR102W-A_d YCR102W-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.184 4.65E-27 YNL220W ADE12 hom Adenylosuccinate synthase, catalyzes the first step in synthesis of adenosine monophosphate from inosine 5'monophosphate during purine nucleotide biosynthesis; exhibits binding to single-stranded autonomously replicating (ARS) core sequence
0.183 1.33E-26 YOR300W_d YOR300W_d hom Dubious open reading frame, unlikely to encode a protein; overlaps with verified gene BUD7/YOR299W; mutation affects bipolar budding and bud site selection, though phenotype could be due to the mutation's effects on BUD7
0.180 6.51E-26 YER071C_p TDA2_p hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; null mutant is sensitive to expression of the top1-T722A allele
0.180 1.01E-25 YEL049W PAU2 hom Member of the seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme
0.173 5.87E-24 YHR194W MDM31 hom Mitochondrial protein that may have a role in phospholipid metabolism; inner membrane protein with similarity to Mdm32p; required for normal mitochondrial morphology and inheritance; interacts genetically with MMM1, MMM2, MDM10, MDM12, and MDM34
0.171 1.51E-23 YER068W MOT2 hom Ubiquitin-protein ligase subunit of the CCR4-NOT complex; with Ubc4p, ubiquitinates nascent polypeptide-associated complex subunits and histone demethyase Jhd2p; CCR4-NOT has roles in transcription regulation, mRNA degradation, and post-transcriptional modifications
0.169 5.16E-23 YIL115C NUP159 het FG-nucleoporin component of central core of the nuclear pore complex (NPC); also part of the NPC cytoplasmic filaments; contributes directly to nucleocytoplasmic transport; regulates ADP release from the ATP-dependent RNA helicase Dbp5p; forms a stable association with Nup82p, Gle2p and two other FG-nucleoporins (Nsp1p and Nup116p)
0.168 1.00E-22 YNR067C DSE4 hom Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother
0.168 1.04E-22 YPL100W ATG21 hom Phosphoinositide binding protein required for vesicle formation in the cytoplasm-to-vacuole targeting (Cvt) pathway; binds both phosphatidylinositol (3,5)-bisphosphate and phosphatidylinositol 3-phosphate; WD-40 repeat protein
0.149 5.07E-18 YBR245C ISW1 hom ATPase subunit of imitation-switch (ISWI) class chromatin remodelers; ATPase; forms a complex with Ioc3p (Isw1a), and a complex with Ioc2p and Ioc4p (Isw1b); Isw1a and Isw1b have partially overlapping and distinct roles, Isw1a involved in repression of transcription initiation and Isw1b involved in regulation of transcription elongation; Isw1b recruited to open reading frames by H3K36 methylation and acts with Chd1p to prevent trans-histone exchange over coding regions