YGL147C / RPL9A

Ribosomal 60S subunit protein L9A; nearly identical to paralog Rpl9Bp; homologous to mammalian ribosomal protein L9 and bacterial L6

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL147C / RPL9A

Click on Significant Values for Screen Details ID:SGTC_55|Compound:0767-0285|FD-Score:-3.69|P-value:1.20E-4 ID:SGTC_68|Compound:0986-0284|FD-Score:-3.60|P-value:1.69E-4 ID:SGTC_69|Compound:0096-0274|FD-Score:3.15|P-value:8.56E-4 ID:SGTC_93|Compound:0109-0045|FD-Score:3.91|P-value:5.07E-5 ID:SGTC_118|Compound:0083-0097|FD-Score:3.44|P-value:3.11E-4 ID:SGTC_174|Compound:3553-0389|FD-Score:3.44|P-value:3.18E-4 ID:SGTC_421|Compound:streptovitacin|FD-Score:-3.46|P-value:2.87E-4 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:3.67|P-value:1.31E-4 ID:SGTC_497|Compound:capsazepine|FD-Score:3.66|P-value:1.37E-4 ID:SGTC_531|Compound:3788-1495|FD-Score:-3.31|P-value:4.86E-4 ID:SGTC_708|Compound:3448-5400|FD-Score:4.20|P-value:1.47E-5 ID:SGTC_758|Compound:0868-0029|FD-Score:-3.83|P-value:6.88E-5 ID:SGTC_830|Compound:4076-0286|FD-Score:3.13|P-value:9.37E-4 ID:SGTC_840|Compound:0245-0196|FD-Score:3.99|P-value:3.66E-5 ID:SGTC_879|Compound:0831-1030|FD-Score:-3.12|P-value:9.35E-4 ID:SGTC_880|Compound:0833-0487|FD-Score:4.55|P-value:3.07E-6 ID:SGTC_922|Compound:1866-0035|FD-Score:-3.20|P-value:7.25E-4 ID:SGTC_974|Compound:1326-0144|FD-Score:4.17|P-value:1.68E-5 ID:SGTC_990|Compound:3985-0011|FD-Score:-3.74|P-value:9.65E-5 ID:SGTC_993|Compound:3909-8757|FD-Score:-5.45|P-value:2.85E-8 ID:SGTC_994|Compound:3910-0338|FD-Score:3.56|P-value:1.99E-4 ID:SGTC_1041|Compound:0206-0046|FD-Score:3.78|P-value:8.51E-5 ID:SGTC_1232|Compound:0279-0259|FD-Score:3.94|P-value:4.51E-5 ID:SGTC_1258|Compound:0671-0043|FD-Score:3.33|P-value:4.65E-4 ID:SGTC_1296|Compound:1068-0102|FD-Score:3.40|P-value:3.59E-4 ID:SGTC_1374|Compound:2889-5571|FD-Score:4.35|P-value:7.66E-6 ID:SGTC_1375|Compound:2910-0797|FD-Score:-3.24|P-value:6.12E-4 ID:SGTC_1381|Compound:2324-0066|FD-Score:3.83|P-value:7.02E-5 ID:SGTC_1639|Compound:Lupinine o-methylbenzoicacid ester hydrochloride|FD-Score:3.20|P-value:7.45E-4 ID:SGTC_1759|Compound:st043059|FD-Score:4.15|P-value:1.81E-5 ID:SGTC_1845|Compound:st056753|FD-Score:3.29|P-value:5.27E-4 ID:SGTC_2020|Compound:4017018|FD-Score:4.15|P-value:1.87E-5 ID:SGTC_2358|Compound:9037157|FD-Score:3.87|P-value:5.94E-5 ID:SGTC_2366|Compound:9070441|FD-Score:-4.01|P-value:3.22E-5 ID:SGTC_2434|Compound:5670830|FD-Score:3.98|P-value:3.72E-5 ID:SGTC_2481|Compound:5478948|FD-Score:3.23|P-value:6.61E-4 ID:SGTC_2513|Compound:baicalein|FD-Score:-3.18|P-value:7.64E-4 ID:SGTC_2770|Compound:toltrazuril|FD-Score:3.46|P-value:2.92E-4 ID:SGTC_2793|Compound:7325131|FD-Score:3.51|P-value:2.45E-4 ID:SGTC_2850|Compound:9015429|FD-Score:3.48|P-value:2.68E-4 ID:SGTC_2852|Compound:9023854|FD-Score:3.45|P-value:3.00E-4 ID:SGTC_2932|Compound:9016711|FD-Score:3.62|P-value:1.58E-4 ID:SGTC_3110|Compound:9122132|FD-Score:-3.54|P-value:2.12E-4 ID:SGTC_3118|Compound:9124250|FD-Score:4.43|P-value:5.28E-6 ID:SGTC_3119|Compound:9125183|FD-Score:3.37|P-value:3.99E-4 ID:SGTC_55|Compound:0767-0285|FD-Score:-3.69|P-value:1.20E-4 ID:SGTC_68|Compound:0986-0284|FD-Score:-3.60|P-value:1.69E-4 ID:SGTC_69|Compound:0096-0274|FD-Score:3.15|P-value:8.56E-4 ID:SGTC_93|Compound:0109-0045|FD-Score:3.91|P-value:5.07E-5 ID:SGTC_118|Compound:0083-0097|FD-Score:3.44|P-value:3.11E-4 ID:SGTC_174|Compound:3553-0389|FD-Score:3.44|P-value:3.18E-4 ID:SGTC_421|Compound:streptovitacin|FD-Score:-3.46|P-value:2.87E-4 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:3.67|P-value:1.31E-4 ID:SGTC_497|Compound:capsazepine|FD-Score:3.66|P-value:1.37E-4 ID:SGTC_531|Compound:3788-1495|FD-Score:-3.31|P-value:4.86E-4 ID:SGTC_708|Compound:3448-5400|FD-Score:4.20|P-value:1.47E-5 ID:SGTC_758|Compound:0868-0029|FD-Score:-3.83|P-value:6.88E-5 ID:SGTC_830|Compound:4076-0286|FD-Score:3.13|P-value:9.37E-4 ID:SGTC_840|Compound:0245-0196|FD-Score:3.99|P-value:3.66E-5 ID:SGTC_879|Compound:0831-1030|FD-Score:-3.12|P-value:9.35E-4 ID:SGTC_880|Compound:0833-0487|FD-Score:4.55|P-value:3.07E-6 ID:SGTC_922|Compound:1866-0035|FD-Score:-3.20|P-value:7.25E-4 ID:SGTC_974|Compound:1326-0144|FD-Score:4.17|P-value:1.68E-5 ID:SGTC_990|Compound:3985-0011|FD-Score:-3.74|P-value:9.65E-5 ID:SGTC_993|Compound:3909-8757|FD-Score:-5.45|P-value:2.85E-8 ID:SGTC_994|Compound:3910-0338|FD-Score:3.56|P-value:1.99E-4 ID:SGTC_1041|Compound:0206-0046|FD-Score:3.78|P-value:8.51E-5 ID:SGTC_1232|Compound:0279-0259|FD-Score:3.94|P-value:4.51E-5 ID:SGTC_1258|Compound:0671-0043|FD-Score:3.33|P-value:4.65E-4 ID:SGTC_1296|Compound:1068-0102|FD-Score:3.40|P-value:3.59E-4 ID:SGTC_1374|Compound:2889-5571|FD-Score:4.35|P-value:7.66E-6 ID:SGTC_1375|Compound:2910-0797|FD-Score:-3.24|P-value:6.12E-4 ID:SGTC_1381|Compound:2324-0066|FD-Score:3.83|P-value:7.02E-5 ID:SGTC_1639|Compound:Lupinine o-methylbenzoicacid ester hydrochloride|FD-Score:3.20|P-value:7.45E-4 ID:SGTC_1759|Compound:st043059|FD-Score:4.15|P-value:1.81E-5 ID:SGTC_1845|Compound:st056753|FD-Score:3.29|P-value:5.27E-4 ID:SGTC_2020|Compound:4017018|FD-Score:4.15|P-value:1.87E-5 ID:SGTC_2358|Compound:9037157|FD-Score:3.87|P-value:5.94E-5 ID:SGTC_2366|Compound:9070441|FD-Score:-4.01|P-value:3.22E-5 ID:SGTC_2434|Compound:5670830|FD-Score:3.98|P-value:3.72E-5 ID:SGTC_2481|Compound:5478948|FD-Score:3.23|P-value:6.61E-4 ID:SGTC_2513|Compound:baicalein|FD-Score:-3.18|P-value:7.64E-4 ID:SGTC_2770|Compound:toltrazuril|FD-Score:3.46|P-value:2.92E-4 ID:SGTC_2793|Compound:7325131|FD-Score:3.51|P-value:2.45E-4 ID:SGTC_2850|Compound:9015429|FD-Score:3.48|P-value:2.68E-4 ID:SGTC_2852|Compound:9023854|FD-Score:3.45|P-value:3.00E-4 ID:SGTC_2932|Compound:9016711|FD-Score:3.62|P-value:1.58E-4 ID:SGTC_3110|Compound:9122132|FD-Score:-3.54|P-value:2.12E-4 ID:SGTC_3118|Compound:9124250|FD-Score:4.43|P-value:5.28E-6 ID:SGTC_3119|Compound:9125183|FD-Score:3.37|P-value:3.99E-4

Top fitness defect scores for YGL147C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_880 0833-0487 4.55 87.2 µM 3.07E-6 mitochondrial processes 12 2.73E-6
2 SGTC_3118 9124250 4.43 49.5 µM 5.28E-6 8 4.72E-6
3 SGTC_1374 2889-5571 4.35 141.0 µM 7.66E-6 RSC complex & mRNA processing 29 6.86E-6
4 SGTC_708 3448-5400 4.20 146.0 µM 1.47E-5 38 1.33E-5
5 SGTC_974 1326-0144 4.17 138.0 µM 1.68E-5 ERG2 35 1.51E-5
6 SGTC_1759 st043059 4.15 70.0 µM 1.81E-5 amide catabolism 22 1.63E-5
7 SGTC_2020 4017018 4.15 200.0 µM 1.87E-5 14 1.69E-5
8 SGTC_840 0245-0196 3.99 390.0 µM 3.66E-5 12 3.33E-5
9 SGTC_2434 5670830 3.98 169.9 µM 3.72E-5 24 3.39E-5
10 SGTC_1232 0279-0259 3.94 161.0 µM 4.51E-5 18 4.11E-5
11 SGTC_93 0109-0045 3.91 59.2 µM 5.07E-5 DNA damage response 48 4.63E-5
12 SGTC_2358 9037157 3.87 4.0 µM 5.94E-5 33 5.44E-5
13 SGTC_1381 2324-0066 3.83 62.1 µM 7.02E-5 32 6.43E-5
14 SGTC_1041 0206-0046 3.78 107.0 µM 8.51E-5 39 7.81E-5
15 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 3.67 8.0 µM 1.31E-4 34 1.21E-4
16 SGTC_497 capsazepine 3.66 133.0 µM 1.37E-4 18 1.26E-4
17 SGTC_2932 9016711 3.62 44.5 µM 1.58E-4 57 1.46E-4
18 SGTC_994 3910-0338 3.56 138.0 µM 1.99E-4 calcium & mitochondrial duress 63 1.84E-4
19 SGTC_2793 7325131 3.51 81.8 µM 2.45E-4 24 2.27E-4
20 SGTC_2850 9015429 3.48 58.4 µM 2.68E-4 26 2.49E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.107 4.41E-10 YDL210W UGA4 hom Permease that serves as a gamma-aminobutyrate (GABA) transport protein involved in the utilization of GABA as a nitrogen source; catalyzes the transport of putrescine and delta-aminolevulinic acid (ALA); localized to the vacuolar membrane
0.095 3.97E-8 YDR242W AMD2 hom Putative amidase
0.092 9.22E-8 YJR053W BFA1 hom Component of the GTPase-activating Bfa1p-Bub2p complex involved in multiple cell cycle checkpoint pathways that control exit from mitosis
0.085 7.44E-7 YGR230W BNS1 hom Protein with some similarity to Spo12p; overexpression bypasses need for Spo12p, but not required for meiosis
0.085 8.15E-7 YOR085W OST3 hom Gamma subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; Ost3p is important for N-glycosylation of a subset of proteins
0.084 1.05E-6 YLR040C_p YLR040C_p hom Protein of unknown function; localizes to the cell wall; predicted to be a GPI-attached protein; upregulated by Mcm1p-Alpha1p transcription factor; partially overlaps the dubious ORF YLR041W; mRNA identified as translated by ribosome profiling data; YLR040C is not essential
0.083 1.52E-6 YHL045W_d YHL045W_d hom Putative protein of unknown function; not an essential gene
0.081 2.32E-6 YPL113C_p YPL113C_p hom Glyoxylate reductase; acts on glyoxylate and hydroxypyruvate substrates; YPL113C is not an essential gene
0.081 2.42E-6 YHR171W ATG7 hom Autophagy-related protein and dual specificity member of the E1 family of ubiquitin-activating enzymes; mediates the conjugation of Atg12p with Atg5p and Atg8p with phosphatidylethanolamine, required steps in autophagosome formation
0.079 4.40E-6 YML025C YML6 het Mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L4 ribosomal protein and human mitoribosomal MRP-L4 protein; essential for viability, unlike most other mitoribosomal proteins
0.079 4.50E-6 YMR097C MTG1 hom Putative GTPase peripheral to the mitochondrial inner membrane, essential for respiratory competence, likely functions in assembly of the large ribosomal subunit, has homologs in plants and animals
0.078 5.89E-6 YDR418W RPL12B hom Ribosomal 60S subunit protein L12B; rpl12a rpl12b double mutant exhibits slow growth and slow translation; homologous to mammalian ribosomal protein L12 and bacterial L11; RPL12B has a paralog, RPL12A, that arose from the whole genome duplication
0.075 1.20E-5 YBR258C SHG1 hom Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres
0.075 1.25E-5 YML029W USA1 hom Scaffold subunit of the Hrd1p ubiquitin ligase that also promotes ligase oligomerization; involved in ER-associated protein degradation (ERAD); interacts with the U1 snRNP-specific protein, Snp1p
0.075 1.41E-5 YGL003C CDH1 hom Cell-cycle regulated activator of the anaphase-promoting complex/cyclosome (APC/C), which directs ubiquitination of cyclins resulting in mitotic exit; targets the APC/C to specific substrates including Cdc20p, Ase1p, Cin8p and Fin1p