YGL155W / CDC43

Beta subunit of geranylgeranyltransferase type I, catalyzes geranylgeranylation to the cysteine residue in proteins containing a C-terminal CaaX sequence ending in Leu or Phe; has substrates important for morphogenesis

Zygosity: Heterozygous strain
fixedexpanded
Profile for YGL155W / CDC43

Click on Significant Values for Screen Details ID:SGTC_41|Compound:0478-0632|FD-Score:3.23|P-value:1.47E-4 ID:SGTC_133|Compound:0724-0033|FD-Score:2.99|P-value:3.86E-4 ID:SGTC_144|Compound:4161-2749|FD-Score:-5.37|P-value:1.59E-9 ID:SGTC_145|Compound:3737-0113|FD-Score:-4.35|P-value:8.29E-7 ID:SGTC_148|Compound:3253-0744|FD-Score:-3.99|P-value:5.71E-6 ID:SGTC_153|Compound:4077-0274|FD-Score:3.27|P-value:1.22E-4 ID:SGTC_155|Compound:k072-0202|FD-Score:3.01|P-value:3.59E-4 ID:SGTC_156|Compound:3474-0145|FD-Score:3.64|P-value:2.26E-5 ID:SGTC_178|Compound:4092-0806|FD-Score:-2.93|P-value:6.52E-4 ID:SGTC_637|Compound:1181-0519|FD-Score:3.56|P-value:3.30E-5 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.01|P-value:4.77E-4 ID:SGTC_825|Compound:1988-2224|FD-Score:-3.22|P-value:2.01E-4 ID:SGTC_1033|Compound:k072-0102|FD-Score:3.63|P-value:2.32E-5 ID:SGTC_1034|Compound:k072-0165|FD-Score:3.22|P-value:1.51E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.38|P-value:7.04E-7 ID:SGTC_1130|Compound:3454-2858|FD-Score:3.50|P-value:4.41E-5 ID:SGTC_1134|Compound:3477-0009|FD-Score:3.29|P-value:1.11E-4 ID:SGTC_1170|Compound:0310-0127|FD-Score:3.45|P-value:5.57E-5 ID:SGTC_1630|Compound:st005209|FD-Score:3.04|P-value:3.17E-4 ID:SGTC_1636|Compound:st007707|FD-Score:3.44|P-value:5.71E-5 ID:SGTC_1721|Compound:st082152|FD-Score:-3.53|P-value:5.23E-5 ID:SGTC_1779|Compound:st039427|FD-Score:3.97|P-value:4.48E-6 ID:SGTC_1789|Compound:tunicamycin|FD-Score:-3.45|P-value:7.65E-5 ID:SGTC_2076|Compound:5212012|FD-Score:2.92|P-value:5.16E-4 ID:SGTC_2140|Compound:5586273|FD-Score:-3.04|P-value:4.27E-4 ID:SGTC_2320|Compound:7373003|FD-Score:-3.02|P-value:4.57E-4 ID:SGTC_2340|Compound:7987427|FD-Score:2.96|P-value:4.36E-4 ID:SGTC_2400|Compound:5203494|FD-Score:-3.55|P-value:4.78E-5 ID:SGTC_2424|Compound:5537928|FD-Score:-3.02|P-value:4.63E-4 ID:SGTC_2429|Compound:5902844|FD-Score:3.49|P-value:4.48E-5 ID:SGTC_2489|Compound:cantharidin|FD-Score:-2.97|P-value:5.76E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.96|P-value:4.57E-6 ID:SGTC_2502|Compound:avocadyne acetate|FD-Score:-3.83|P-value:1.26E-5 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:-3.41|P-value:8.97E-5 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:-3.21|P-value:2.17E-4 ID:SGTC_2535|Compound:4',4'-dimethoxydalbergione|FD-Score:-3.48|P-value:6.63E-5 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:-3.07|P-value:3.85E-4 ID:SGTC_2606|Compound:farnesol|FD-Score:-2.89|P-value:7.77E-4 ID:SGTC_2801|Compound:7907800|FD-Score:-3.10|P-value:3.43E-4 ID:SGTC_2967|Compound:9089538|FD-Score:4.83|P-value:3.35E-8 ID:SGTC_2971|Compound:9092186|FD-Score:-3.09|P-value:3.45E-4 ID:SGTC_2973|Compound:9094665|FD-Score:5.78|P-value:5.28E-11 ID:SGTC_3120|Compound:9124077|FD-Score:45.60|P-value:0 ID:SGTC_3133|Compound:9127736|FD-Score:-3.06|P-value:4.02E-4 ID:SGTC_3210|Compound:9128157|FD-Score:3.48|P-value:4.80E-5 ID:SGTC_3213|Compound:9129884|FD-Score:-3.51|P-value:5.72E-5 ID:SGTC_3288|Compound:9119690|FD-Score:19.30|P-value:2.10E-102 ID:SGTC_3304|Compound:9125678|FD-Score:51.80|P-value:0 ID:SGTC_41|Compound:0478-0632|FD-Score:3.23|P-value:1.47E-4 ID:SGTC_133|Compound:0724-0033|FD-Score:2.99|P-value:3.86E-4 ID:SGTC_144|Compound:4161-2749|FD-Score:-5.37|P-value:1.59E-9 ID:SGTC_145|Compound:3737-0113|FD-Score:-4.35|P-value:8.29E-7 ID:SGTC_148|Compound:3253-0744|FD-Score:-3.99|P-value:5.71E-6 ID:SGTC_153|Compound:4077-0274|FD-Score:3.27|P-value:1.22E-4 ID:SGTC_155|Compound:k072-0202|FD-Score:3.01|P-value:3.59E-4 ID:SGTC_156|Compound:3474-0145|FD-Score:3.64|P-value:2.26E-5 ID:SGTC_178|Compound:4092-0806|FD-Score:-2.93|P-value:6.52E-4 ID:SGTC_637|Compound:1181-0519|FD-Score:3.56|P-value:3.30E-5 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.01|P-value:4.77E-4 ID:SGTC_825|Compound:1988-2224|FD-Score:-3.22|P-value:2.01E-4 ID:SGTC_1033|Compound:k072-0102|FD-Score:3.63|P-value:2.32E-5 ID:SGTC_1034|Compound:k072-0165|FD-Score:3.22|P-value:1.51E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.38|P-value:7.04E-7 ID:SGTC_1130|Compound:3454-2858|FD-Score:3.50|P-value:4.41E-5 ID:SGTC_1134|Compound:3477-0009|FD-Score:3.29|P-value:1.11E-4 ID:SGTC_1170|Compound:0310-0127|FD-Score:3.45|P-value:5.57E-5 ID:SGTC_1630|Compound:st005209|FD-Score:3.04|P-value:3.17E-4 ID:SGTC_1636|Compound:st007707|FD-Score:3.44|P-value:5.71E-5 ID:SGTC_1721|Compound:st082152|FD-Score:-3.53|P-value:5.23E-5 ID:SGTC_1779|Compound:st039427|FD-Score:3.97|P-value:4.48E-6 ID:SGTC_1789|Compound:tunicamycin|FD-Score:-3.45|P-value:7.65E-5 ID:SGTC_2076|Compound:5212012|FD-Score:2.92|P-value:5.16E-4 ID:SGTC_2140|Compound:5586273|FD-Score:-3.04|P-value:4.27E-4 ID:SGTC_2320|Compound:7373003|FD-Score:-3.02|P-value:4.57E-4 ID:SGTC_2340|Compound:7987427|FD-Score:2.96|P-value:4.36E-4 ID:SGTC_2400|Compound:5203494|FD-Score:-3.55|P-value:4.78E-5 ID:SGTC_2424|Compound:5537928|FD-Score:-3.02|P-value:4.63E-4 ID:SGTC_2429|Compound:5902844|FD-Score:3.49|P-value:4.48E-5 ID:SGTC_2489|Compound:cantharidin|FD-Score:-2.97|P-value:5.76E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.96|P-value:4.57E-6 ID:SGTC_2502|Compound:avocadyne acetate|FD-Score:-3.83|P-value:1.26E-5 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:-3.41|P-value:8.97E-5 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:-3.21|P-value:2.17E-4 ID:SGTC_2535|Compound:4',4'-dimethoxydalbergione|FD-Score:-3.48|P-value:6.63E-5 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:-3.07|P-value:3.85E-4 ID:SGTC_2606|Compound:farnesol|FD-Score:-2.89|P-value:7.77E-4 ID:SGTC_2801|Compound:7907800|FD-Score:-3.10|P-value:3.43E-4 ID:SGTC_2967|Compound:9089538|FD-Score:4.83|P-value:3.35E-8 ID:SGTC_2971|Compound:9092186|FD-Score:-3.09|P-value:3.45E-4 ID:SGTC_2973|Compound:9094665|FD-Score:5.78|P-value:5.28E-11 ID:SGTC_3120|Compound:9124077|FD-Score:45.60|P-value:0 ID:SGTC_3133|Compound:9127736|FD-Score:-3.06|P-value:4.02E-4 ID:SGTC_3210|Compound:9128157|FD-Score:3.48|P-value:4.80E-5 ID:SGTC_3213|Compound:9129884|FD-Score:-3.51|P-value:5.72E-5 ID:SGTC_3288|Compound:9119690|FD-Score:19.30|P-value:2.10E-102 ID:SGTC_3304|Compound:9125678|FD-Score:51.80|P-value:0

Top fitness defect scores for YGL155W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_3304 9125678 51.80 46.1 µM 0 1 0 10.90
2 SGTC_3120 9124077 45.60 49.5 µM 0 1 0 14.30
3 SGTC_3288 9119690 19.30 36.2 µM 2.10E-102 2 3.01E-83 4.08
4 SGTC_2973 9094665 5.78 18.0 µM 5.28E-11 NEO1 7 3.67E-9 0.51
5 SGTC_2967 9089538 4.83 49.9 µM 3.35E-8 6 6.89E-7 0.01
6 SGTC_1779 st039427 3.97 55.0 µM 4.48E-6 3 3.67E-5 0.55
7 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.96 3.7 µM 4.57E-6 13 3.73E-5 0.08
8 SGTC_156 3474-0145 3.64 5.6 µM 2.26E-5 endomembrane recycling 8 1.37E-4 0.05
9 SGTC_1033 k072-0102 3.63 21.3 µM 2.32E-5 60S ribosome export 7 1.40E-4 0.01
10 SGTC_637 1181-0519 3.56 7.3 µM 3.30E-5 fatty acid desaturase (OLE1) 12 1.86E-4 0.09
11 SGTC_1130 3454-2858 3.50 15.9 µM 4.41E-5 NEO1 17 2.36E-4 0.06
12 SGTC_2429 5902844 3.49 64.4 µM 4.48E-5 12 2.39E-4 0.24
13 SGTC_3210 9128157 3.48 49.5 µM 4.80E-5 18 2.53E-4 0.05
14 SGTC_1170 0310-0127 3.45 64.8 µM 5.57E-5 15 2.85E-4 0.04
15 SGTC_1636 st007707 3.44 68.9 µM 5.71E-5 11 2.91E-4 0.10
16 SGTC_1134 3477-0009 3.29 42.5 µM 1.11E-4 23 4.98E-4 0.17
17 SGTC_153 4077-0274 3.27 519.7 µM 1.22E-4 13 5.40E-4 0.04
18 SGTC_41 0478-0632 3.23 82.6 µM 1.47E-4 21 6.27E-4 0.01
19 SGTC_1034 k072-0165 3.22 12.7 µM 1.51E-4 Golgi 13 6.42E-4 0.01
20 SGTC_1630 st005209 3.04 31.3 µM 3.17E-4 6 0.00117 0.02

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.902 0 YKL019W RAM2 het Alpha subunit of both the farnesyltransferase and type I geranylgeranyltransferase that catalyze prenylation of proteins containing a CAAX consensus motif; essential protein required for membrane localization of Ras proteins and a-factor
0.638 0 YLR230W_d YLR230W_d het Dubious open reading frame unlikely to encode a functional protein; overlaps 5' end of essential CDC42 gene which encodes a small Rho-like GTPase essential for establishment and maintenance of cell polarity
0.587 1.74E-309 YLR229C CDC42 het Small rho-like GTPase, essential for establishment and maintenance of cell polarity; mutants have defects in the organization of actin and septins
0.546 4.84E-260 YKL058W TOA2 het TFIIA small subunit; involved in transcriptional activation, acts as antirepressor or as coactivator; homologous to smallest subunit of human and Drosophila TFIIA; protein abundance increases in response to DNA replication stress
0.475 2.81E-188 YLR153C ACS2 het Acetyl-coA synthetase isoform which, along with Acs1p, is the nuclear source of acetyl-coA for histone acetylation; mutants affect global transcription; required for growth on glucose; expressed under anaerobic conditions
0.345 2.30E-94 YDR309C GIC2 hom Redundant rho-like GTPase Cdc42p effector; homolog of Gic1p; involved in initiation of budding and cellular polarization; interacts with Cdc42p via the Cdc42/Rac-interactive binding (CRIB) domain and with PI(4,5)P2 via a polybasic region
0.272 7.01E-58 YML017W PSP2 hom Asn rich cytoplasmic protein that contains RGG motifs; high-copy suppressor of group II intron-splicing defects of a mutation in MRS2 and of a conditional mutation in POL1 (DNA polymerase alpha); possible role in mitochondrial mRNA splicing
0.246 5.30E-47 YDL090C RAM1 hom Beta subunit of the CAAX farnesyltransferase (FTase) that prenylates the a-factor mating pheromone and Ras proteins; required for the membrane localization of Ras proteins and a-factor; homolog of the mammalian FTase beta subunit
0.217 5.05E-37 YGL049C TIF4632 hom Translation initiation factor eIF4G, subunit of the mRNA cap-binding protein complex (eIF4F) that also contains eIF4E (Cdc33p); associates with the poly(A)-binding protein Pab1p, also interacts with eIF4A (Tif1p); TIF4632 has a paralog, TIF4631, that arose from the whole genome duplication
0.215 2.42E-36 YMR033W ARP9 het Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation
0.213 7.25E-36 YPR034W ARP7 het Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation
0.192 3.15E-29 YJL167W ERG20 het Farnesyl pyrophosphate synthetase, has both dimethylallyltranstransferase and geranyltranstransferase activities; catalyzes the formation of C15 farnesyl pyrophosphate units for isoprenoid and sterol biosynthesis
0.184 5.57E-27 YGL154C LYS5 hom Phosphopantetheinyl transferase involved in lysine biosynthesis; converts inactive apo-form of Lys2p (alpha-aminoadipate reductase) into catalytically active holo-form by posttranslational addition of phosphopantetheine
0.176 1.36E-24 YGR198W YPP1 het Cargo-transport protein involved in endocytosis; interacts with phosphatidylinositol-4-kinase Stt4; GFP-fusion protein localizes to the cytoplasm; YGR198W is an essential gene
0.174 2.71E-24 YLR033W RSC58 het Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance