YGL159W_p

Putative protein of unknown function; deletion mutant has no detectable phenotype

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL159W / YGL159W

Click on Significant Values for Screen Details ID:SGTC_72|Compound:0744-0168|FD-Score:-3.55|P-value:4.09E-4 ID:SGTC_300|Compound:r073-0011|FD-Score:4.12|P-value:5.50E-5 ID:SGTC_315|Compound:k915-0449|FD-Score:3.34|P-value:8.59E-4 ID:SGTC_345|Compound:1362-0200|FD-Score:3.44|P-value:6.19E-4 ID:SGTC_526|Compound:4469-0568|FD-Score:3.52|P-value:4.74E-4 ID:SGTC_535|Compound:2293-4129|FD-Score:-4.55|P-value:9.18E-6 ID:SGTC_557|Compound:1315-0110|FD-Score:-3.58|P-value:3.72E-4 ID:SGTC_651|Compound:3253-0966|FD-Score:4.26|P-value:3.23E-5 ID:SGTC_757|Compound:1066-0008|FD-Score:3.52|P-value:4.72E-4 ID:SGTC_1040|Compound:k898-0338|FD-Score:5.06|P-value:1.02E-6 ID:SGTC_1045|Compound:1348-1485|FD-Score:-4.06|P-value:6.54E-5 ID:SGTC_1048|Compound:3161-0300|FD-Score:-4.43|P-value:1.50E-5 ID:SGTC_1065|Compound:prochlorperazine maleate|FD-Score:4.48|P-value:1.28E-5 ID:SGTC_1121|Compound:fusaric acid|FD-Score:8.10|P-value:1.38E-14 ID:SGTC_1123|Compound:mangostin|FD-Score:-3.64|P-value:3.07E-4 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:-4.51|P-value:1.09E-5 ID:SGTC_1143|Compound:3454-2408|FD-Score:3.49|P-value:5.31E-4 ID:SGTC_1153|Compound:4055-0057|FD-Score:3.78|P-value:1.91E-4 ID:SGTC_1201|Compound:1889-3372|FD-Score:-4.08|P-value:6.05E-5 ID:SGTC_1259|Compound:0671-0132|FD-Score:4.57|P-value:8.76E-6 ID:SGTC_1269|Compound:0831-0796|FD-Score:7.52|P-value:8.14E-13 ID:SGTC_1414|Compound:3917-0015|FD-Score:5.50|P-value:1.22E-7 ID:SGTC_1437|Compound:4092-1038|FD-Score:4.32|P-value:2.51E-5 ID:SGTC_1506|Compound:4226-2149|FD-Score:-3.51|P-value:4.71E-4 ID:SGTC_1510|Compound:1123-0200|FD-Score:6.19|P-value:2.97E-9 ID:SGTC_1513|Compound:0337-0559|FD-Score:4.05|P-value:7.23E-5 ID:SGTC_1746|Compound:st038117|FD-Score:-3.40|P-value:6.74E-4 ID:SGTC_1750|Compound:st081859|FD-Score:-3.43|P-value:6.23E-4 ID:SGTC_1764|Compound:st044502|FD-Score:-3.43|P-value:6.18E-4 ID:SGTC_1888|Compound:azatryptophan|FD-Score:3.95|P-value:1.03E-4 ID:SGTC_1916|Compound:st067606|FD-Score:5.60|P-value:7.07E-8 ID:SGTC_1948|Compound:st076329|FD-Score:3.59|P-value:3.78E-4 ID:SGTC_1958|Compound:st076513|FD-Score:3.36|P-value:8.17E-4 ID:SGTC_1968|Compound:st069590|FD-Score:3.32|P-value:9.08E-4 ID:SGTC_2075|Compound:5212009|FD-Score:3.40|P-value:7.16E-4 ID:SGTC_2159|Compound:5658611|FD-Score:3.32|P-value:9.04E-4 ID:SGTC_2329|Compound:6138490|FD-Score:-5.16|P-value:5.95E-7 ID:SGTC_2339|Compound:9000433|FD-Score:5.05|P-value:1.03E-6 ID:SGTC_2343|Compound:7990716|FD-Score:5.64|P-value:5.77E-8 ID:SGTC_2357|Compound:9067248|FD-Score:3.32|P-value:9.26E-4 ID:SGTC_2362|Compound:9071156|FD-Score:-3.84|P-value:1.50E-4 ID:SGTC_2368|Compound:9071271|FD-Score:4.19|P-value:4.19E-5 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:4.31|P-value:2.56E-5 ID:SGTC_2555|Compound:cholic acid|FD-Score:-3.74|P-value:2.10E-4 ID:SGTC_2665|Compound:lovastatin|FD-Score:3.38|P-value:7.44E-4 ID:SGTC_2882|Compound:9058044|FD-Score:-3.29|P-value:9.59E-4 ID:SGTC_2930|Compound:9013230|FD-Score:3.89|P-value:1.29E-4 ID:SGTC_2952|Compound:9073731|FD-Score:3.56|P-value:4.11E-4 ID:SGTC_2993|Compound:9054257|FD-Score:4.64|P-value:6.67E-6 ID:SGTC_2995|Compound:9067767|FD-Score:-5.31|P-value:2.83E-7 ID:SGTC_3052|Compound:9092717|FD-Score:-3.49|P-value:5.04E-4 ID:SGTC_3053|Compound:9095903|FD-Score:3.61|P-value:3.57E-4 ID:SGTC_3232|Compound:9132874|FD-Score:3.50|P-value:5.16E-4 ID:SGTC_72|Compound:0744-0168|FD-Score:-3.55|P-value:4.09E-4 ID:SGTC_300|Compound:r073-0011|FD-Score:4.12|P-value:5.50E-5 ID:SGTC_315|Compound:k915-0449|FD-Score:3.34|P-value:8.59E-4 ID:SGTC_345|Compound:1362-0200|FD-Score:3.44|P-value:6.19E-4 ID:SGTC_526|Compound:4469-0568|FD-Score:3.52|P-value:4.74E-4 ID:SGTC_535|Compound:2293-4129|FD-Score:-4.55|P-value:9.18E-6 ID:SGTC_557|Compound:1315-0110|FD-Score:-3.58|P-value:3.72E-4 ID:SGTC_651|Compound:3253-0966|FD-Score:4.26|P-value:3.23E-5 ID:SGTC_757|Compound:1066-0008|FD-Score:3.52|P-value:4.72E-4 ID:SGTC_1040|Compound:k898-0338|FD-Score:5.06|P-value:1.02E-6 ID:SGTC_1045|Compound:1348-1485|FD-Score:-4.06|P-value:6.54E-5 ID:SGTC_1048|Compound:3161-0300|FD-Score:-4.43|P-value:1.50E-5 ID:SGTC_1065|Compound:prochlorperazine maleate|FD-Score:4.48|P-value:1.28E-5 ID:SGTC_1121|Compound:fusaric acid|FD-Score:8.10|P-value:1.38E-14 ID:SGTC_1123|Compound:mangostin|FD-Score:-3.64|P-value:3.07E-4 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:-4.51|P-value:1.09E-5 ID:SGTC_1143|Compound:3454-2408|FD-Score:3.49|P-value:5.31E-4 ID:SGTC_1153|Compound:4055-0057|FD-Score:3.78|P-value:1.91E-4 ID:SGTC_1201|Compound:1889-3372|FD-Score:-4.08|P-value:6.05E-5 ID:SGTC_1259|Compound:0671-0132|FD-Score:4.57|P-value:8.76E-6 ID:SGTC_1269|Compound:0831-0796|FD-Score:7.52|P-value:8.14E-13 ID:SGTC_1414|Compound:3917-0015|FD-Score:5.50|P-value:1.22E-7 ID:SGTC_1437|Compound:4092-1038|FD-Score:4.32|P-value:2.51E-5 ID:SGTC_1506|Compound:4226-2149|FD-Score:-3.51|P-value:4.71E-4 ID:SGTC_1510|Compound:1123-0200|FD-Score:6.19|P-value:2.97E-9 ID:SGTC_1513|Compound:0337-0559|FD-Score:4.05|P-value:7.23E-5 ID:SGTC_1746|Compound:st038117|FD-Score:-3.40|P-value:6.74E-4 ID:SGTC_1750|Compound:st081859|FD-Score:-3.43|P-value:6.23E-4 ID:SGTC_1764|Compound:st044502|FD-Score:-3.43|P-value:6.18E-4 ID:SGTC_1888|Compound:azatryptophan|FD-Score:3.95|P-value:1.03E-4 ID:SGTC_1916|Compound:st067606|FD-Score:5.60|P-value:7.07E-8 ID:SGTC_1948|Compound:st076329|FD-Score:3.59|P-value:3.78E-4 ID:SGTC_1958|Compound:st076513|FD-Score:3.36|P-value:8.17E-4 ID:SGTC_1968|Compound:st069590|FD-Score:3.32|P-value:9.08E-4 ID:SGTC_2075|Compound:5212009|FD-Score:3.40|P-value:7.16E-4 ID:SGTC_2159|Compound:5658611|FD-Score:3.32|P-value:9.04E-4 ID:SGTC_2329|Compound:6138490|FD-Score:-5.16|P-value:5.95E-7 ID:SGTC_2339|Compound:9000433|FD-Score:5.05|P-value:1.03E-6 ID:SGTC_2343|Compound:7990716|FD-Score:5.64|P-value:5.77E-8 ID:SGTC_2357|Compound:9067248|FD-Score:3.32|P-value:9.26E-4 ID:SGTC_2362|Compound:9071156|FD-Score:-3.84|P-value:1.50E-4 ID:SGTC_2368|Compound:9071271|FD-Score:4.19|P-value:4.19E-5 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:4.31|P-value:2.56E-5 ID:SGTC_2555|Compound:cholic acid|FD-Score:-3.74|P-value:2.10E-4 ID:SGTC_2665|Compound:lovastatin|FD-Score:3.38|P-value:7.44E-4 ID:SGTC_2882|Compound:9058044|FD-Score:-3.29|P-value:9.59E-4 ID:SGTC_2930|Compound:9013230|FD-Score:3.89|P-value:1.29E-4 ID:SGTC_2952|Compound:9073731|FD-Score:3.56|P-value:4.11E-4 ID:SGTC_2993|Compound:9054257|FD-Score:4.64|P-value:6.67E-6 ID:SGTC_2995|Compound:9067767|FD-Score:-5.31|P-value:2.83E-7 ID:SGTC_3052|Compound:9092717|FD-Score:-3.49|P-value:5.04E-4 ID:SGTC_3053|Compound:9095903|FD-Score:3.61|P-value:3.57E-4 ID:SGTC_3232|Compound:9132874|FD-Score:3.50|P-value:5.16E-4

Top fitness defect scores for YGL159W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1121 fusaric acid 8.10 630.5 nM 1.38E-14 6 2.79E-16
2 SGTC_1269 0831-0796 7.52 3.0 µM 8.14E-13 60S ribosome export 1 2.80E-14
3 SGTC_1510 1123-0200 6.19 71.5 µM 2.97E-9 15 2.93E-10
4 SGTC_2343 7990716 5.64 14.8 µM 5.77E-8 2 8.36E-9
5 SGTC_1916 st067606 5.60 49.2 µM 7.07E-8 10 1.05E-8
6 SGTC_1414 3917-0015 5.50 5.4 µM 1.22E-7 1 1.95E-8
7 SGTC_1040 k898-0338 5.06 155.0 µM 1.02E-6 8 2.12E-7
8 SGTC_2339 9000433 5.05 200.0 µM 1.03E-6 11 2.16E-7
9 SGTC_2993 9054257 4.64 71.4 µM 6.67E-6 fatty acid desaturase (OLE1) 26 1.77E-6
10 SGTC_1259 0671-0132 4.57 43.0 µM 8.76E-6 11 2.40E-6
11 SGTC_1065 prochlorperazine maleate 4.48 2.5 µM 1.28E-5 7 3.70E-6
12 SGTC_1437 4092-1038 4.32 11.6 µM 2.51E-5 14 7.85E-6
13 SGTC_2541 muurolladie-3-one 4.31 83.1 µM 2.56E-5 excess fatty acid 20 8.06E-6
14 SGTC_651 3253-0966 4.26 34.4 µM 3.23E-5 calcium & mitochondrial duress 24 1.04E-5
15 SGTC_2368 9071271 4.19 200.0 µM 4.19E-5 26 1.40E-5
16 SGTC_300 r073-0011 4.12 5.0 µM 5.50E-5 21 1.90E-5
17 SGTC_1513 0337-0559 4.05 19.0 µM 7.23E-5 16 2.59E-5
18 SGTC_1888 azatryptophan 3.95 97.5 µM 1.03E-4 15 3.87E-5
19 SGTC_2930 9013230 3.89 14.9 µM 1.29E-4 heme biosynthesis & mitochondrial translocase 39 4.97E-5
20 SGTC_1153 4055-0057 3.78 267.0 µM 1.91E-4 31 7.71E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.159 2.46E-20 YDR315C IPK1 hom Inositol 1,3,4,5,6-pentakisphosphate 2-kinase, nuclear protein required for synthesis of 1,2,3,4,5,6-hexakisphosphate (phytate), which is integral to cell function; has 2 motifs conserved in other fungi; ipk1 gle1 double mutant is inviable
0.155 1.38E-19 YDR181C SAS4 hom Subunit of the SAS complex (Sas2p, Sas4p, Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; required for the HAT activity of Sas2p
0.144 5.25E-17 YKL221W MCH2 hom Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport
0.125 4.13E-13 YKL222C YKL222C hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments; similar to transcriptional regulators from the zinc cluster (binuclear cluster) family; null mutant is sensitive to caffeine
0.116 1.50E-11 YNL150W_d YNL150W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; extensive overlap with PGA2/YNL149C, an uncharacterized gene with a proposed role in protein trafficking
0.116 1.87E-11 YNL149C PGA2 het Essential protein required for maturation of Gas1p and Pho8p; involved in protein trafficking; GFP-fusion protein localizes to the ER and YFP-fusion protein to the nuclear envelope-ER network; null mutants have a cell separation defect
0.100 6.58E-9 YMR127C SAS2 hom Histone acetyltransferase (HAT) catalytic subunit of the SAS complex (Sas2p-Sas4p-Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; member of the MYSTacetyltransferase family
0.099 1.08E-8 YPR097W YPR097W hom Protein that contains a Phox homology (PX) domain and binds phosphoinositides; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.084 1.23E-6 YPR078C_p YPR078C_p hom Putative protein of unknown function; possible role in DNA metabolism and/or in genome stability; expression is heat-inducible
0.082 1.77E-6 YLR079W SIC1 hom Cyclin-dependent kinase inhibitor (CKI); inhibitor of Cdc28-Clb kinase complexes that controls G1/S phase transition, preventing premature S phase and ensuring genomic integrity; phosphorylation targets Sic1p for SCF(CDC4)-dependent turnover; functional homolog of mammalian Kip1
0.081 2.74E-6 YJR094C IME1 hom Master regulator of meiosis that is active only during meiotic events, activates transcription of early meiotic genes through interaction with Ume6p, degraded by the 26S proteasome following phosphorylation by Ime2p
0.081 2.83E-6 YOR213C SAS5 hom Subunit of the SAS complex (Sas2p, Sas4p, Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; stimulates Sas2p HAT activity
0.081 3.05E-6 YKL156W RPS27A hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S27, no bacterial homolog; RPS27A has a paralog, RPS27B, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.079 4.48E-6 YKL090W CUE2 hom Protein of unknown function; has two CUE domains that bind ubiquitin, which may facilitate intramolecular monoubiquitination
0.076 1.01E-5 YJL172W CPS1 hom Vacuolar carboxypeptidase yscS; expression is induced under low-nitrogen conditions