YGL160W / AIM14

NADPH oxidase localized to the perinuclear ER; produces superoxide from NADPH; overexpression causes MCA1 dependent apoptosis; likely involved in superoxide-mediated regulation of the actin cytoskeleton; member of a conserved superfamily of NADPH oxidases (NOX enzymes); has similarity to iron/copper reductases (FRE1-8), particularly Fre8p

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL160W / AIM14

Click on Significant Values for Screen Details ID:SGTC_11|Compound:0438-0307|FD-Score:3.40|P-value:2.34E-4 ID:SGTC_72|Compound:0744-0168|FD-Score:-2.96|P-value:8.95E-4 ID:SGTC_170|Compound:4197-0004|FD-Score:3.50|P-value:1.59E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:4.65|P-value:8.06E-7 ID:SGTC_181|Compound:1447-1644|FD-Score:3.28|P-value:3.76E-4 ID:SGTC_272|Compound:doxorubicin|FD-Score:3.72|P-value:6.48E-5 ID:SGTC_278|Compound:4092-0821|FD-Score:4.43|P-value:2.52E-6 ID:SGTC_367|Compound:0335-0881|FD-Score:-3.71|P-value:4.83E-5 ID:SGTC_559|Compound:1550-0661|FD-Score:4.21|P-value:7.35E-6 ID:SGTC_562|Compound:3772-2733|FD-Score:-2.96|P-value:8.96E-4 ID:SGTC_609|Compound:0986-0026|FD-Score:4.52|P-value:1.58E-6 ID:SGTC_668|Compound:1682-0499|FD-Score:3.55|P-value:1.31E-4 ID:SGTC_727|Compound:3032-0951|FD-Score:-3.01|P-value:7.53E-4 ID:SGTC_793|Compound:0488-0545|FD-Score:3.02|P-value:9.54E-4 ID:SGTC_797|Compound:k781-0471|FD-Score:3.78|P-value:5.07E-5 ID:SGTC_807|Compound:1315-0151|FD-Score:3.89|P-value:3.04E-5 ID:SGTC_867|Compound:0518-0118|FD-Score:4.02|P-value:1.70E-5 ID:SGTC_903|Compound:1134-0042|FD-Score:3.06|P-value:8.37E-4 ID:SGTC_1097|Compound:itavastatin|FD-Score:3.86|P-value:3.56E-5 ID:SGTC_1175|Compound:0741-0056|FD-Score:3.23|P-value:4.53E-4 ID:SGTC_1330|Compound:1469-0054|FD-Score:3.05|P-value:8.86E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:-3.12|P-value:5.00E-4 ID:SGTC_1501|Compound:4491-0275|FD-Score:3.75|P-value:5.67E-5 ID:SGTC_1547|Compound:harmine|FD-Score:3.77|P-value:5.21E-5 ID:SGTC_1856|Compound:st057054|FD-Score:4.62|P-value:9.47E-7 ID:SGTC_1881|Compound:5652484|FD-Score:3.10|P-value:7.27E-4 ID:SGTC_1914|Compound:st062367|FD-Score:-3.39|P-value:1.76E-4 ID:SGTC_1923|Compound:st058458|FD-Score:3.10|P-value:7.34E-4 ID:SGTC_1929|Compound:genistein trimethyl ether|FD-Score:4.53|P-value:1.47E-6 ID:SGTC_2036|Compound:5160441|FD-Score:3.61|P-value:1.03E-4 ID:SGTC_2050|Compound:5263056|FD-Score:3.15|P-value:6.17E-4 ID:SGTC_2066|Compound:5222451|FD-Score:3.11|P-value:7.04E-4 ID:SGTC_2082|Compound:5219693|FD-Score:3.13|P-value:6.58E-4 ID:SGTC_2137|Compound:5261020|FD-Score:-3.14|P-value:4.69E-4 ID:SGTC_2313|Compound:7726885|FD-Score:-3.31|P-value:2.43E-4 ID:SGTC_2397|Compound:5161689|FD-Score:6.14|P-value:1.10E-10 ID:SGTC_2404|Compound:5161160|FD-Score:5.89|P-value:5.87E-10 ID:SGTC_2611|Compound:pyromycin|FD-Score:3.24|P-value:4.34E-4 ID:SGTC_2618|Compound:avocadyne|FD-Score:3.80|P-value:4.68E-5 ID:SGTC_2628|Compound:lathosterol|FD-Score:-5.97|P-value:2.00E-10 ID:SGTC_2757|Compound:clomiphene|FD-Score:3.08|P-value:7.97E-4 ID:SGTC_2919|Compound:7978188|FD-Score:3.02|P-value:9.54E-4 ID:SGTC_2925|Compound:9010536|FD-Score:3.30|P-value:3.44E-4 ID:SGTC_2958|Compound:9077254|FD-Score:3.07|P-value:8.04E-4 ID:SGTC_2963|Compound:9082507|FD-Score:-3.14|P-value:4.70E-4 ID:SGTC_2974|Compound:9094440|FD-Score:6.62|P-value:3.95E-12 ID:SGTC_3181|Compound:9108277|FD-Score:4.33|P-value:3.96E-6 ID:SGTC_3232|Compound:9132874|FD-Score:3.17|P-value:5.71E-4 ID:SGTC_3233|Compound:9132340|FD-Score:7.80|P-value:3.41E-16 ID:SGTC_3265|Compound:9137266|FD-Score:-2.99|P-value:7.96E-4 ID:SGTC_3274|Compound:9138298|FD-Score:-3.38|P-value:1.84E-4 ID:SGTC_11|Compound:0438-0307|FD-Score:3.40|P-value:2.34E-4 ID:SGTC_72|Compound:0744-0168|FD-Score:-2.96|P-value:8.95E-4 ID:SGTC_170|Compound:4197-0004|FD-Score:3.50|P-value:1.59E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:4.65|P-value:8.06E-7 ID:SGTC_181|Compound:1447-1644|FD-Score:3.28|P-value:3.76E-4 ID:SGTC_272|Compound:doxorubicin|FD-Score:3.72|P-value:6.48E-5 ID:SGTC_278|Compound:4092-0821|FD-Score:4.43|P-value:2.52E-6 ID:SGTC_367|Compound:0335-0881|FD-Score:-3.71|P-value:4.83E-5 ID:SGTC_559|Compound:1550-0661|FD-Score:4.21|P-value:7.35E-6 ID:SGTC_562|Compound:3772-2733|FD-Score:-2.96|P-value:8.96E-4 ID:SGTC_609|Compound:0986-0026|FD-Score:4.52|P-value:1.58E-6 ID:SGTC_668|Compound:1682-0499|FD-Score:3.55|P-value:1.31E-4 ID:SGTC_727|Compound:3032-0951|FD-Score:-3.01|P-value:7.53E-4 ID:SGTC_793|Compound:0488-0545|FD-Score:3.02|P-value:9.54E-4 ID:SGTC_797|Compound:k781-0471|FD-Score:3.78|P-value:5.07E-5 ID:SGTC_807|Compound:1315-0151|FD-Score:3.89|P-value:3.04E-5 ID:SGTC_867|Compound:0518-0118|FD-Score:4.02|P-value:1.70E-5 ID:SGTC_903|Compound:1134-0042|FD-Score:3.06|P-value:8.37E-4 ID:SGTC_1097|Compound:itavastatin|FD-Score:3.86|P-value:3.56E-5 ID:SGTC_1175|Compound:0741-0056|FD-Score:3.23|P-value:4.53E-4 ID:SGTC_1330|Compound:1469-0054|FD-Score:3.05|P-value:8.86E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:-3.12|P-value:5.00E-4 ID:SGTC_1501|Compound:4491-0275|FD-Score:3.75|P-value:5.67E-5 ID:SGTC_1547|Compound:harmine|FD-Score:3.77|P-value:5.21E-5 ID:SGTC_1856|Compound:st057054|FD-Score:4.62|P-value:9.47E-7 ID:SGTC_1881|Compound:5652484|FD-Score:3.10|P-value:7.27E-4 ID:SGTC_1914|Compound:st062367|FD-Score:-3.39|P-value:1.76E-4 ID:SGTC_1923|Compound:st058458|FD-Score:3.10|P-value:7.34E-4 ID:SGTC_1929|Compound:genistein trimethyl ether|FD-Score:4.53|P-value:1.47E-6 ID:SGTC_2036|Compound:5160441|FD-Score:3.61|P-value:1.03E-4 ID:SGTC_2050|Compound:5263056|FD-Score:3.15|P-value:6.17E-4 ID:SGTC_2066|Compound:5222451|FD-Score:3.11|P-value:7.04E-4 ID:SGTC_2082|Compound:5219693|FD-Score:3.13|P-value:6.58E-4 ID:SGTC_2137|Compound:5261020|FD-Score:-3.14|P-value:4.69E-4 ID:SGTC_2313|Compound:7726885|FD-Score:-3.31|P-value:2.43E-4 ID:SGTC_2397|Compound:5161689|FD-Score:6.14|P-value:1.10E-10 ID:SGTC_2404|Compound:5161160|FD-Score:5.89|P-value:5.87E-10 ID:SGTC_2611|Compound:pyromycin|FD-Score:3.24|P-value:4.34E-4 ID:SGTC_2618|Compound:avocadyne|FD-Score:3.80|P-value:4.68E-5 ID:SGTC_2628|Compound:lathosterol|FD-Score:-5.97|P-value:2.00E-10 ID:SGTC_2757|Compound:clomiphene|FD-Score:3.08|P-value:7.97E-4 ID:SGTC_2919|Compound:7978188|FD-Score:3.02|P-value:9.54E-4 ID:SGTC_2925|Compound:9010536|FD-Score:3.30|P-value:3.44E-4 ID:SGTC_2958|Compound:9077254|FD-Score:3.07|P-value:8.04E-4 ID:SGTC_2963|Compound:9082507|FD-Score:-3.14|P-value:4.70E-4 ID:SGTC_2974|Compound:9094440|FD-Score:6.62|P-value:3.95E-12 ID:SGTC_3181|Compound:9108277|FD-Score:4.33|P-value:3.96E-6 ID:SGTC_3232|Compound:9132874|FD-Score:3.17|P-value:5.71E-4 ID:SGTC_3233|Compound:9132340|FD-Score:7.80|P-value:3.41E-16 ID:SGTC_3265|Compound:9137266|FD-Score:-2.99|P-value:7.96E-4 ID:SGTC_3274|Compound:9138298|FD-Score:-3.38|P-value:1.84E-4

Top fitness defect scores for YGL160W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3233 9132340 7.80 49.5 µM 3.41E-16 1 3.09E-15
2 SGTC_2974 9094440 6.62 9.7 µM 3.95E-12 ergosterol biosynthesis 6 1.86E-11
3 SGTC_2397 5161689 6.14 200.0 µM 1.10E-10 4 4.12E-10
4 SGTC_2404 5161160 5.89 200.0 µM 5.87E-10 4 1.96E-9
5 SGTC_178 4092-0806 4.65 87.5 µM 8.06E-7 ergosterol depletion effects on membrane 65 1.65E-6
6 SGTC_1856 st057054 4.62 55.7 µM 9.47E-7 17 1.92E-6
7 SGTC_1929 genistein trimethyl ether 4.53 50.5 µM 1.47E-6 8 2.89E-6
8 SGTC_609 0986-0026 4.52 86.3 µM 1.58E-6 calcium & mitochondrial duress 19 3.09E-6
9 SGTC_278 4092-0821 4.43 23.9 µM 2.52E-6 plasma membrane duress 30 4.79E-6
10 SGTC_3181 9108277 4.33 49.5 µM 3.96E-6 iron homeostasis 8 7.31E-6
11 SGTC_559 1550-0661 4.21 158.0 µM 7.35E-6 4 1.30E-5
12 SGTC_867 0518-0118 4.02 155.0 µM 1.70E-5 DNA intercalators 19 2.85E-5
13 SGTC_807 1315-0151 3.89 48.0 µM 3.04E-5 31 4.92E-5
14 SGTC_1097 itavastatin 3.86 7.2 µM 3.56E-5 azole & statin 24 5.71E-5
15 SGTC_2618 avocadyne 3.80 43.4 µM 4.68E-5 32 7.36E-5
16 SGTC_797 k781-0471 3.78 270.0 µM 5.07E-5 RPP1 & pyrimidine depletion 25 7.94E-5
17 SGTC_1547 harmine 3.77 94.2 µM 5.21E-5 ergosterol biosynthesis 54 8.14E-5
18 SGTC_1501 4491-0275 3.75 38.4 µM 5.67E-5 14 8.82E-5
19 SGTC_272 doxorubicin 3.72 8.1 µM 6.48E-5 anthracycline transcription coupled DNA repair 27 1.00E-4
20 SGTC_2036 5160441 3.61 105.0 µM 1.03E-4 NEO1 92 1.54E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.129 6.67E-14 YLR349W_d YLR349W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified ORF DIC1/YLR348C
0.100 7.71E-9 YIL056W VHR1 hom Transcriptional activator; required for the vitamin H-responsive element (VHRE) mediated induction of VHT1 (Vitamin H transporter) and BIO5 (biotin biosynthesis intermediate transporter) in response to low biotin concentrations; VHR1 has a paralog, VHR2, that arose from the whole genome duplication
0.096 2.81E-8 YHR072W ERG7 het Lanosterol synthase, an essential enzyme that catalyzes the cyclization of squalene 2,3-epoxide, a step in ergosterol biosynthesis
0.089 2.20E-7 YNL202W SPS19 hom Peroxisomal 2,4-dienoyl-CoA reductase, auxiliary enzyme of fatty acid beta-oxidation; homodimeric enzyme required for growth and sporulation on petroselineate medium; expression induced during late sporulation and in the presence of oleate
0.088 3.63E-7 YKR083C DAD2 het Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis
0.084 9.81E-7 YIL143C SSL2 het Component of RNA polymerase transcription factor TFIIH holoenzyme; has DNA-dependent ATPase/helicase activity and is required, with Rad3p, for unwinding promoter DNA; interacts functionally with TFIIB and has roles in transcription start site selection and in gene looping to juxtapose initiation and termination regions; involved in DNA repair; homolog of human ERCC3
0.084 1.08E-6 YDL182W LYS20 hom Homocitrate synthase isozyme; catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate to form homocitrate, which is the first step in the lysine biosynthesis pathway; LYS20 has a paralog, LYS21, that arose from the whole genome duplication
0.083 1.39E-6 YML037C_p YML037C_p hom Putative protein of unknown function with some characteristics of a transcriptional activator; may be a target of Dbf2p-Mob1p kinase; GFP-fusion protein co-localizes with clathrin-coated vesicles; YML037C is not an essential gene
0.082 1.78E-6 YGL152C_d YGL152C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF PEX14/YGL153W
0.081 2.76E-6 YDR331W GPI8 het ER membrane glycoprotein subunit of the glycosylphosphatidylinositol transamidase complex that adds glycosylphosphatidylinositol (GPI) anchors to newly synthesized proteins; human PIG-K protein is a functional homolog
0.080 3.30E-6 YLR166C SEC10 het Essential 100kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane prior to SNARE-mediated fusion
0.079 5.15E-6 YOR194C TOA1 het TFIIA large subunit; involved in transcriptional activation, acts as antirepressor or as coactivator; homologous to largest and second largest subunits of human and Drosophila TFIIA
0.078 5.33E-6 YMR043W MCM1 het Transcription factor involved in cell-type-specific transcription and pheromone response; plays a central role in the formation of both repressor and activator complexes
0.077 7.10E-6 YGR186W TFG1 het TFIIF (Transcription Factor II) largest subunit; involved in both transcription initiation and elongation of RNA polymerase II; homologous to human RAP74
0.076 1.13E-5 YKR102W FLO10 hom Member of the FLO family of cell wall flocculation proteins; not expressed in most lab strains; overproduction induces flocculation that can be inhibited by mannose, sucrose, or glucose; overproduction also promotes haploid invasive growth and diploid filamentous growth