YGL162W / SUT1

Transcription factor of the Zn2Cys6 family involved in sterol uptake; involved in induction of hypoxic gene expression; relocalizes from nucleus to cytoplasm upon DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL162W / SUT1

Click on Significant Values for Screen Details ID:SGTC_77|Compound:0828-0286|FD-Score:3.87|P-value:2.70E-5 ID:SGTC_105|Compound:0111-0055|FD-Score:-3.97|P-value:1.53E-5 ID:SGTC_173|Compound:1273-0061|FD-Score:-2.99|P-value:8.45E-4 ID:SGTC_179|Compound:1273-0063|FD-Score:-3.37|P-value:1.98E-4 ID:SGTC_349|Compound:k015-0014|FD-Score:2.98|P-value:9.42E-4 ID:SGTC_430|Compound:0958-0115|FD-Score:3.42|P-value:1.83E-4 ID:SGTC_518|Compound:1021-0119|FD-Score:3.89|P-value:2.49E-5 ID:SGTC_854|Compound:0422-0053|FD-Score:2.97|P-value:9.81E-4 ID:SGTC_973|Compound:1325-0077|FD-Score:3.59|P-value:9.10E-5 ID:SGTC_976|Compound:1348-1067|FD-Score:-3.46|P-value:1.43E-4 ID:SGTC_977|Compound:1348-1378|FD-Score:-3.42|P-value:1.67E-4 ID:SGTC_982|Compound:1491-0518|FD-Score:3.27|P-value:3.18E-4 ID:SGTC_1029|Compound:k015-0030|FD-Score:3.20|P-value:4.16E-4 ID:SGTC_1042|Compound:0350-0096|FD-Score:4.30|P-value:3.49E-6 ID:SGTC_1050|Compound:3232-1156|FD-Score:-3.33|P-value:2.36E-4 ID:SGTC_1179|Compound:1021-1431|FD-Score:3.57|P-value:9.57E-5 ID:SGTC_1209|Compound:2323-2347|FD-Score:3.39|P-value:2.00E-4 ID:SGTC_1250|Compound:0485-0349|FD-Score:3.08|P-value:6.61E-4 ID:SGTC_1263|Compound:0774-1208|FD-Score:5.16|P-value:3.53E-8 ID:SGTC_1345|Compound:1488-0192|FD-Score:3.09|P-value:6.25E-4 ID:SGTC_1360|Compound:1598-0022|FD-Score:3.32|P-value:2.66E-4 ID:SGTC_1456|Compound:k015-0012|FD-Score:-3.41|P-value:1.69E-4 ID:SGTC_1461|Compound:k072-0203|FD-Score:-3.49|P-value:1.23E-4 ID:SGTC_1971|Compound:st069429|FD-Score:-3.21|P-value:3.79E-4 ID:SGTC_2053|Compound:5265679|FD-Score:3.35|P-value:2.40E-4 ID:SGTC_2310|Compound:7668677|FD-Score:4.09|P-value:9.65E-6 ID:SGTC_2377|Compound:9073351|FD-Score:3.20|P-value:4.29E-4 ID:SGTC_2387|Compound:9077560|FD-Score:-3.06|P-value:6.45E-4 ID:SGTC_2418|Compound:pentamidine|FD-Score:3.34|P-value:2.48E-4 ID:SGTC_2423|Compound:st077119|FD-Score:3.02|P-value:8.11E-4 ID:SGTC_2479|Compound:5617353|FD-Score:-3.50|P-value:1.18E-4 ID:SGTC_2488|Compound:5268135|FD-Score:5.43|P-value:6.95E-9 ID:SGTC_2528|Compound:xanthyletin|FD-Score:3.16|P-value:4.89E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:-4.46|P-value:1.41E-6 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:3.98|P-value:1.60E-5 ID:SGTC_2800|Compound:7887935|FD-Score:4.18|P-value:6.27E-6 ID:SGTC_2831|Compound:7999036|FD-Score:-4.01|P-value:1.32E-5 ID:SGTC_2924|Compound:9010168|FD-Score:4.96|P-value:1.14E-7 ID:SGTC_2946|Compound:9065502|FD-Score:-3.08|P-value:6.02E-4 ID:SGTC_2952|Compound:9073731|FD-Score:6.73|P-value:1.01E-12 ID:SGTC_2992|Compound:9074591|FD-Score:3.08|P-value:6.48E-4 ID:SGTC_3268|Compound:9137683|FD-Score:3.55|P-value:1.07E-4 ID:SGTC_77|Compound:0828-0286|FD-Score:3.87|P-value:2.70E-5 ID:SGTC_105|Compound:0111-0055|FD-Score:-3.97|P-value:1.53E-5 ID:SGTC_173|Compound:1273-0061|FD-Score:-2.99|P-value:8.45E-4 ID:SGTC_179|Compound:1273-0063|FD-Score:-3.37|P-value:1.98E-4 ID:SGTC_349|Compound:k015-0014|FD-Score:2.98|P-value:9.42E-4 ID:SGTC_430|Compound:0958-0115|FD-Score:3.42|P-value:1.83E-4 ID:SGTC_518|Compound:1021-0119|FD-Score:3.89|P-value:2.49E-5 ID:SGTC_854|Compound:0422-0053|FD-Score:2.97|P-value:9.81E-4 ID:SGTC_973|Compound:1325-0077|FD-Score:3.59|P-value:9.10E-5 ID:SGTC_976|Compound:1348-1067|FD-Score:-3.46|P-value:1.43E-4 ID:SGTC_977|Compound:1348-1378|FD-Score:-3.42|P-value:1.67E-4 ID:SGTC_982|Compound:1491-0518|FD-Score:3.27|P-value:3.18E-4 ID:SGTC_1029|Compound:k015-0030|FD-Score:3.20|P-value:4.16E-4 ID:SGTC_1042|Compound:0350-0096|FD-Score:4.30|P-value:3.49E-6 ID:SGTC_1050|Compound:3232-1156|FD-Score:-3.33|P-value:2.36E-4 ID:SGTC_1179|Compound:1021-1431|FD-Score:3.57|P-value:9.57E-5 ID:SGTC_1209|Compound:2323-2347|FD-Score:3.39|P-value:2.00E-4 ID:SGTC_1250|Compound:0485-0349|FD-Score:3.08|P-value:6.61E-4 ID:SGTC_1263|Compound:0774-1208|FD-Score:5.16|P-value:3.53E-8 ID:SGTC_1345|Compound:1488-0192|FD-Score:3.09|P-value:6.25E-4 ID:SGTC_1360|Compound:1598-0022|FD-Score:3.32|P-value:2.66E-4 ID:SGTC_1456|Compound:k015-0012|FD-Score:-3.41|P-value:1.69E-4 ID:SGTC_1461|Compound:k072-0203|FD-Score:-3.49|P-value:1.23E-4 ID:SGTC_1971|Compound:st069429|FD-Score:-3.21|P-value:3.79E-4 ID:SGTC_2053|Compound:5265679|FD-Score:3.35|P-value:2.40E-4 ID:SGTC_2310|Compound:7668677|FD-Score:4.09|P-value:9.65E-6 ID:SGTC_2377|Compound:9073351|FD-Score:3.20|P-value:4.29E-4 ID:SGTC_2387|Compound:9077560|FD-Score:-3.06|P-value:6.45E-4 ID:SGTC_2418|Compound:pentamidine|FD-Score:3.34|P-value:2.48E-4 ID:SGTC_2423|Compound:st077119|FD-Score:3.02|P-value:8.11E-4 ID:SGTC_2479|Compound:5617353|FD-Score:-3.50|P-value:1.18E-4 ID:SGTC_2488|Compound:5268135|FD-Score:5.43|P-value:6.95E-9 ID:SGTC_2528|Compound:xanthyletin|FD-Score:3.16|P-value:4.89E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:-4.46|P-value:1.41E-6 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:3.98|P-value:1.60E-5 ID:SGTC_2800|Compound:7887935|FD-Score:4.18|P-value:6.27E-6 ID:SGTC_2831|Compound:7999036|FD-Score:-4.01|P-value:1.32E-5 ID:SGTC_2924|Compound:9010168|FD-Score:4.96|P-value:1.14E-7 ID:SGTC_2946|Compound:9065502|FD-Score:-3.08|P-value:6.02E-4 ID:SGTC_2952|Compound:9073731|FD-Score:6.73|P-value:1.01E-12 ID:SGTC_2992|Compound:9074591|FD-Score:3.08|P-value:6.48E-4 ID:SGTC_3268|Compound:9137683|FD-Score:3.55|P-value:1.07E-4

Top fitness defect scores for YGL162W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2952 9073731 6.73 13.8 µM 1.01E-12 tubulin folding & SWR complex 6 8.39E-12
2 SGTC_2488 5268135 5.43 45.7 µM 6.95E-9 22 2.77E-8
3 SGTC_1263 0774-1208 5.16 64.8 µM 3.53E-8 20 1.23E-7
4 SGTC_2924 9010168 4.96 62.8 µM 1.14E-7 cell wall signaling 16 3.59E-7
5 SGTC_1042 0350-0096 4.30 82.0 µM 3.49E-6 TSC3-RPN4 19 8.35E-6
6 SGTC_2800 7887935 4.18 81.8 µM 6.27E-6 RPP1 & pyrimidine depletion 28 1.43E-5
7 SGTC_2310 7668677 4.09 200.0 µM 9.65E-6 26 2.12E-5
8 SGTC_2626 ethyl orsellinate 3.98 100.0 µM 1.60E-5 35 3.38E-5
9 SGTC_518 1021-0119 3.89 62.6 µM 2.49E-5 ERG2 45 5.07E-5
10 SGTC_77 0828-0286 3.87 12.5 µM 2.70E-5 TSC3-RPN4 42 5.48E-5
11 SGTC_973 1325-0077 3.59 65.9 µM 9.10E-5 18 1.67E-4
12 SGTC_1179 1021-1431 3.57 9.3 µM 9.57E-5 62 1.75E-4
13 SGTC_3268 9137683 3.55 49.5 µM 1.07E-4 15 1.95E-4
14 SGTC_430 0958-0115 3.42 16.4 µM 1.83E-4 50 3.18E-4
15 SGTC_1209 2323-2347 3.39 50.3 µM 2.00E-4 28 3.45E-4
16 SGTC_2053 5265679 3.35 138.0 µM 2.40E-4 46 4.08E-4
17 SGTC_2418 pentamidine 3.34 31.7 µM 2.48E-4 mitochondrial processes 74 4.20E-4
18 SGTC_1360 1598-0022 3.32 39.8 µM 2.66E-4 ERG2 58 4.49E-4
19 SGTC_982 1491-0518 3.27 27.5 µM 3.18E-4 38 5.29E-4
20 SGTC_1029 k015-0030 3.20 64.7 µM 4.16E-4 70 6.77E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.109 2.30E-10 YOR272W YTM1 het Constituent of 66S pre-ribosomal particles, forms a complex with Nop7p and Erb1p that is required for maturation of the large ribosomal subunit; has seven C-terminal WD repeats
0.090 1.90E-7 YKR018C YKR018C hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; protein abundance increases in response to DNA replication stress; YKR018C has a paralog, IML2, that arose from the whole genome duplication
0.090 1.94E-7 YBR199W KTR4 hom Putative mannosyltransferase involved in protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family
0.088 3.76E-7 YOR350C MNE1 hom Mitochondrial matrix protein involved in splicing Group I aI5-beta intron from COX1 mRNA
0.087 5.18E-7 YCR012W PGK1 het 3-phosphoglycerate kinase, catalyzes transfer of high-energy phosphoryl groups from the acyl phosphate of 1,3-bisphosphoglycerate to ADP to produce ATP; key enzyme in glycolysis and gluconeogenesis
0.081 2.41E-6 YDR483W KRE2 hom Alpha1,2-mannosyltransferase of the Golgi; involved in protein mannosylation; KRE2 has a paralog, KTR6, that arose from the whole genome duplication
0.078 6.61E-6 YPR012W_d YPR012W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YPR012W is not an essential gene
0.076 9.92E-6 YGR177C ATF2 hom Alcohol acetyltransferase, may play a role in steroid detoxification; forms volatile esters during fermentation, which is important for brewing and winemaking
0.075 1.32E-5 YLR375W STP3 hom Zinc-finger protein of unknown function, possibly involved in pre-tRNA splicing and in uptake of branched-chain amino acids
0.075 1.41E-5 YJL045W YJL045W hom Minor succinate dehydrogenase isozyme; homologous to Sdh1p, the major isozyme reponsible for the oxidation of succinate and transfer of electrons to ubiquinone; induced during the diauxic shift in a Cat8p-dependent manner
0.074 1.59E-5 YDR182W-A_p YDR182W-A_p hom Putative protein of unknown function; identified by fungal homology and RT-PCR
0.074 1.74E-5 YOR062C_p YOR062C_p hom Protein of unknown function; similar to YKR075Cp and Reg1p; expression regulated by glucose and Rgt1p; GFP-fusion protein is induced in response to the DNA-damaging agent MMS
0.072 2.63E-5 YKR077W MSA2 hom Putative transcriptional activator, that interacts with G1-specific transcription factor, MBF and G1-specific promoters; ortholog of Msa2p, an MBF and SBF activator that regulates G1-specific transcription and cell cycle initiation
0.072 3.00E-5 YNL088W TOP2 het Topoisomerase II, relieves torsional strain in DNA by cleaving and re-sealing the phosphodiester backbone of both positively and negatively supercoiled DNA; cleaves complementary strands; localizes to axial cores in meiosis; required for replication slow zone (RSZ) breakage following Mec1p inactivation
0.071 4.02E-5 YEL057C_p YEL057C_p hom Protein of unknown function involved in telomere maintenance; target of UME6 regulation