YGL164C / YRB30

RanGTP-binding protein, inhibits RanGAP1 (Rna1p)-mediated GTP hydrolysis of RanGTP (Gsp1p); shares similarity to proteins in other fungi but not in higher eukaryotes

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL164C / YRB30

Click on Significant Values for Screen Details ID:SGTC_41|Compound:0478-0632|FD-Score:-3.15|P-value:5.88E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:4.03|P-value:1.84E-5 ID:SGTC_361|Compound:000s-0510|FD-Score:-3.24|P-value:4.29E-4 ID:SGTC_383|Compound:2324-0395|FD-Score:-3.12|P-value:6.64E-4 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:3.57|P-value:1.28E-4 ID:SGTC_530|Compound:4358-1714|FD-Score:3.16|P-value:6.11E-4 ID:SGTC_668|Compound:1682-0499|FD-Score:3.48|P-value:1.85E-4 ID:SGTC_697|Compound:0508-1955|FD-Score:-3.10|P-value:7.14E-4 ID:SGTC_914|Compound:3820-6779|FD-Score:3.14|P-value:6.46E-4 ID:SGTC_986|Compound:1493-0483|FD-Score:3.04|P-value:9.23E-4 ID:SGTC_1105|Compound:epirubicin|FD-Score:-3.90|P-value:3.01E-5 ID:SGTC_1150|Compound:3909-7983|FD-Score:3.16|P-value:6.11E-4 ID:SGTC_1261|Compound:0712-0010|FD-Score:-3.07|P-value:7.91E-4 ID:SGTC_1313|Compound:1220-0047|FD-Score:3.76|P-value:5.86E-5 ID:SGTC_1359|Compound:1582-0056|FD-Score:3.08|P-value:8.22E-4 ID:SGTC_1365|Compound:1672-3266|FD-Score:-3.07|P-value:7.78E-4 ID:SGTC_1368|Compound:1852-0141|FD-Score:4.83|P-value:3.80E-7 ID:SGTC_1373|Compound:2887-0003|FD-Score:4.21|P-value:8.22E-6 ID:SGTC_1380|Compound:2291-0730|FD-Score:3.62|P-value:1.06E-4 ID:SGTC_1468|Compound:k284-1086|FD-Score:-3.08|P-value:7.43E-4 ID:SGTC_1746|Compound:st038117|FD-Score:4.00|P-value:2.11E-5 ID:SGTC_1768|Compound:st044301|FD-Score:3.16|P-value:6.21E-4 ID:SGTC_2033|Compound:5192550|FD-Score:3.37|P-value:2.82E-4 ID:SGTC_2127|Compound:5253358|FD-Score:-3.56|P-value:1.23E-4 ID:SGTC_2133|Compound:5320837|FD-Score:-3.79|P-value:4.79E-5 ID:SGTC_2285|Compound:7945142|FD-Score:-4.45|P-value:2.28E-6 ID:SGTC_2415|Compound:st077333|FD-Score:3.19|P-value:5.45E-4 ID:SGTC_2432|Compound:5630864|FD-Score:3.47|P-value:1.91E-4 ID:SGTC_2435|Compound:5706476|FD-Score:3.19|P-value:5.53E-4 ID:SGTC_2581|Compound:avocatin a|FD-Score:7.09|P-value:1.87E-13 ID:SGTC_2610|Compound:ononetin|FD-Score:-3.93|P-value:2.63E-5 ID:SGTC_2611|Compound:pyromycin|FD-Score:3.16|P-value:6.10E-4 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:3.03|P-value:9.53E-4 ID:SGTC_2698|Compound:st077697|FD-Score:3.02|P-value:9.92E-4 ID:SGTC_2769|Compound:toremifene|FD-Score:3.45|P-value:2.04E-4 ID:SGTC_2792|Compound:7535235|FD-Score:-5.20|P-value:4.49E-8 ID:SGTC_2793|Compound:7325131|FD-Score:-4.10|P-value:1.19E-5 ID:SGTC_2795|Compound:7780010|FD-Score:-4.54|P-value:1.48E-6 ID:SGTC_2894|Compound:9048625|FD-Score:-3.16|P-value:5.68E-4 ID:SGTC_2932|Compound:9016711|FD-Score:3.26|P-value:4.20E-4 ID:SGTC_2978|Compound:9011784|FD-Score:3.07|P-value:8.40E-4 ID:SGTC_3048|Compound:9093155|FD-Score:3.07|P-value:8.47E-4 ID:SGTC_3300|Compound:9124615|FD-Score:3.59|P-value:1.17E-4 ID:SGTC_3308|Compound:9128332|FD-Score:-3.69|P-value:7.18E-5 ID:SGTC_3344|Compound:9148862|FD-Score:-4.04|P-value:1.62E-5 ID:SGTC_3348|Compound:9149464|FD-Score:4.29|P-value:5.55E-6 ID:SGTC_41|Compound:0478-0632|FD-Score:-3.15|P-value:5.88E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:4.03|P-value:1.84E-5 ID:SGTC_361|Compound:000s-0510|FD-Score:-3.24|P-value:4.29E-4 ID:SGTC_383|Compound:2324-0395|FD-Score:-3.12|P-value:6.64E-4 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:3.57|P-value:1.28E-4 ID:SGTC_530|Compound:4358-1714|FD-Score:3.16|P-value:6.11E-4 ID:SGTC_668|Compound:1682-0499|FD-Score:3.48|P-value:1.85E-4 ID:SGTC_697|Compound:0508-1955|FD-Score:-3.10|P-value:7.14E-4 ID:SGTC_914|Compound:3820-6779|FD-Score:3.14|P-value:6.46E-4 ID:SGTC_986|Compound:1493-0483|FD-Score:3.04|P-value:9.23E-4 ID:SGTC_1105|Compound:epirubicin|FD-Score:-3.90|P-value:3.01E-5 ID:SGTC_1150|Compound:3909-7983|FD-Score:3.16|P-value:6.11E-4 ID:SGTC_1261|Compound:0712-0010|FD-Score:-3.07|P-value:7.91E-4 ID:SGTC_1313|Compound:1220-0047|FD-Score:3.76|P-value:5.86E-5 ID:SGTC_1359|Compound:1582-0056|FD-Score:3.08|P-value:8.22E-4 ID:SGTC_1365|Compound:1672-3266|FD-Score:-3.07|P-value:7.78E-4 ID:SGTC_1368|Compound:1852-0141|FD-Score:4.83|P-value:3.80E-7 ID:SGTC_1373|Compound:2887-0003|FD-Score:4.21|P-value:8.22E-6 ID:SGTC_1380|Compound:2291-0730|FD-Score:3.62|P-value:1.06E-4 ID:SGTC_1468|Compound:k284-1086|FD-Score:-3.08|P-value:7.43E-4 ID:SGTC_1746|Compound:st038117|FD-Score:4.00|P-value:2.11E-5 ID:SGTC_1768|Compound:st044301|FD-Score:3.16|P-value:6.21E-4 ID:SGTC_2033|Compound:5192550|FD-Score:3.37|P-value:2.82E-4 ID:SGTC_2127|Compound:5253358|FD-Score:-3.56|P-value:1.23E-4 ID:SGTC_2133|Compound:5320837|FD-Score:-3.79|P-value:4.79E-5 ID:SGTC_2285|Compound:7945142|FD-Score:-4.45|P-value:2.28E-6 ID:SGTC_2415|Compound:st077333|FD-Score:3.19|P-value:5.45E-4 ID:SGTC_2432|Compound:5630864|FD-Score:3.47|P-value:1.91E-4 ID:SGTC_2435|Compound:5706476|FD-Score:3.19|P-value:5.53E-4 ID:SGTC_2581|Compound:avocatin a|FD-Score:7.09|P-value:1.87E-13 ID:SGTC_2610|Compound:ononetin|FD-Score:-3.93|P-value:2.63E-5 ID:SGTC_2611|Compound:pyromycin|FD-Score:3.16|P-value:6.10E-4 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:3.03|P-value:9.53E-4 ID:SGTC_2698|Compound:st077697|FD-Score:3.02|P-value:9.92E-4 ID:SGTC_2769|Compound:toremifene|FD-Score:3.45|P-value:2.04E-4 ID:SGTC_2792|Compound:7535235|FD-Score:-5.20|P-value:4.49E-8 ID:SGTC_2793|Compound:7325131|FD-Score:-4.10|P-value:1.19E-5 ID:SGTC_2795|Compound:7780010|FD-Score:-4.54|P-value:1.48E-6 ID:SGTC_2894|Compound:9048625|FD-Score:-3.16|P-value:5.68E-4 ID:SGTC_2932|Compound:9016711|FD-Score:3.26|P-value:4.20E-4 ID:SGTC_2978|Compound:9011784|FD-Score:3.07|P-value:8.40E-4 ID:SGTC_3048|Compound:9093155|FD-Score:3.07|P-value:8.47E-4 ID:SGTC_3300|Compound:9124615|FD-Score:3.59|P-value:1.17E-4 ID:SGTC_3308|Compound:9128332|FD-Score:-3.69|P-value:7.18E-5 ID:SGTC_3344|Compound:9148862|FD-Score:-4.04|P-value:1.62E-5 ID:SGTC_3348|Compound:9149464|FD-Score:4.29|P-value:5.55E-6

Top fitness defect scores for YGL164C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2581 avocatin a 7.09 64.0 µM 1.87E-13 sphingolipid biosynthesis & PDR1 10 6.88E-13
2 SGTC_1368 1852-0141 4.83 284.0 µM 3.80E-7 ERG2 23 6.91E-7
3 SGTC_3348 9149464 4.29 3.5 µM 5.55E-6 10 8.89E-6
4 SGTC_1373 2887-0003 4.21 58.5 µM 8.22E-6 Golgi 16 1.29E-5
5 SGTC_163 1327-0036 4.03 7.5 µM 1.84E-5 99 2.79E-5
6 SGTC_1746 st038117 4.00 42.0 µM 2.11E-5 33 3.17E-5
7 SGTC_1313 1220-0047 3.76 237.0 µM 5.86E-5 47 8.41E-5
8 SGTC_1380 2291-0730 3.62 164.0 µM 1.06E-4 36 1.48E-4
9 SGTC_3300 9124615 3.59 50.5 µM 1.17E-4 28 1.63E-4
10 SGTC_423 5-fluorouracil 3.57 457.0 µM 1.28E-4 exosome 34 1.78E-4
11 SGTC_668 1682-0499 3.48 62.6 µM 1.85E-4 42 2.51E-4
12 SGTC_2432 5630864 3.47 12.2 µM 1.91E-4 44 2.60E-4
13 SGTC_2769 toremifene 3.45 3.7 µM 2.04E-4 36 2.76E-4
14 SGTC_2033 5192550 3.37 145.0 µM 2.82E-4 29 3.77E-4
15 SGTC_2932 9016711 3.26 44.5 µM 4.20E-4 77 5.51E-4
16 SGTC_2415 st077333 3.19 57.7 µM 5.45E-4 96 7.07E-4
17 SGTC_2435 5706476 3.19 10.6 µM 5.53E-4 54 7.16E-4
18 SGTC_2611 pyromycin 3.16 23.9 µM 6.10E-4 74 7.86E-4
19 SGTC_530 4358-1714 3.16 28.0 µM 6.11E-4 79 7.88E-4
20 SGTC_1150 3909-7983 3.16 10.9 µM 6.11E-4 59 7.88E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.175 1.38E-24 YDR146C SWI5 hom Transcription factor that recruits Mediator and Swi/Snf complexes; activates transcription of genes expressed at the M/G1 phase boundary and in G1 phase; required for expression of the HO gene controlling mating type switching; localization to nucleus occurs during G1 and appears to be regulated by phosphorylation by Cdc28p kinase; SWI5 has a paralog, ACE2, that arose from the whole genome duplication
0.155 1.78E-19 YDR006C SOK1 hom Protein whose overexpression suppresses the growth defect of mutants lacking protein kinase A activity; involved in cAMP-mediated signaling; localized to the nucleus; similar to the mouse testis-specific protein PBS13
0.139 6.68E-16 YOL017W ESC8 hom Protein involved in telomeric and mating-type locus silencing; interacts with Sir2p and also interacts with Gal11p, which is a component of the RNA pol II mediator complex; ESC8 has a paralog, IOC3, that arose from the whole genome duplication
0.119 4.16E-12 YLR089C ALT1 hom Alanine transaminase (glutamic pyruvic transaminase); involved in alanine biosynthetic and catabolic processes; expression is induced in the presence of alanine; repression is mediated by Nrg1p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; paralogous gene ALT2 is catalytically inactive
0.118 6.34E-12 YOR084W LPX1 hom Oleic acid-inducible, peroxisomal matrix localized lipase; transcriptionally activated by Yrm1p along with genes involved in multidrug resistance; peroxisomal import is dependent on the PTS1 receptor, Pex5p and on self-interaction
0.117 1.24E-11 YBR228W SLX1 hom Subunit of a complex, with Slx4p, that hydrolyzes 5' branches from duplex DNA in response to stalled or converging replication forks; function overlaps with that of Sgs1p-Top3p
0.115 2.06E-11 YDR359C EAF1 hom Component of the NuA4 histone acetyltransferase complex; acts as a platform for assembly of NuA4 subunits into the native complex; required for initiation of pre-meiotic DNA replication, likely due to its requirement for expression of IME1
0.112 6.99E-11 YGR017W_p YGR017W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the cytoplasm
0.104 1.31E-9 YNL239W LAP3 hom Cysteine aminopeptidase with homocysteine-thiolactonase activity; protects cells against homocysteine toxicity; has bleomycin hydrolase activity in vitro; transcription is regulated by galactose via Gal4p; orthologous to human BLMH
0.104 1.59E-9 YIR008C PRI1 het Subunit of DNA primase, which is required for DNA synthesis and double-strand break repair
0.096 2.81E-8 YGR193C PDX1 hom Dihydrolipoamide dehydrogenase (E3)-binding protein (E3BP) of the mitochondrial pyruvate dehydrogenase (PDH) complex, plays a structural role in the complex by binding and positioning E3 to the dihydrolipoamide acetyltransferase (E2) core
0.093 5.87E-8 YLR191W PEX13 hom Integral peroxisomal membrane protein required for translocation of peroxisomal matrix proteins, interacts with the PTS1 signal recognition factor Pex5p and the PTS2 signal recognition factor Pex7p, forms a complex with Pex14p and Pex17p
0.092 8.97E-8 YJR013W GPI14 het Glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I, involved in GPI anchor biosynthesis, requires Pbn1p for function; homolog of mammalian PIG-M
0.091 1.47E-7 YLR272C YCS4 het Subunit of the condensin complex; required for establishment and maintenance of chromosome condensation, chromosome segregation, chromatin binding of condensin, tRNA gene clustering at the nucleolus, and silencing at the mating type locus; required for replication slow zone (RSZ) breakage following Mec1p inactivation
0.090 1.76E-7 YDR510W SMT3 het Ubiquitin-like protein of the SUMO family, conjugated to lysine residues of target proteins; regulates chromatid cohesion, chromosome segregation, APC-mediated proteolysis, DNA replication and septin ring dynamics; phosphorylated at Ser2