YGL165C_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CUP2/YGL166W

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL165C / YGL165C

Click on Significant Values for Screen Details ID:SGTC_37|Compound:0566-0070|FD-Score:3.50|P-value:7.69E-5 ID:SGTC_392|Compound:N-ethylmaleimide|FD-Score:-3.47|P-value:7.22E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:2.91|P-value:8.29E-4 ID:SGTC_757|Compound:1066-0008|FD-Score:2.93|P-value:7.75E-4 ID:SGTC_911|Compound:3456-4043|FD-Score:-2.83|P-value:9.56E-4 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:4.34|P-value:1.33E-6 ID:SGTC_947|Compound:3447-0010|FD-Score:4.02|P-value:6.96E-6 ID:SGTC_949|Compound:1165-0505|FD-Score:3.21|P-value:2.64E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:6.80|P-value:8.37E-14 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.93|P-value:3.66E-8 ID:SGTC_1128|Compound:3448-9350|FD-Score:-3.49|P-value:6.59E-5 ID:SGTC_1254|Compound:0550-0035|FD-Score:-3.19|P-value:2.38E-4 ID:SGTC_1373|Compound:2887-0003|FD-Score:2.87|P-value:9.84E-4 ID:SGTC_1521|Compound:st012942|FD-Score:-3.05|P-value:4.15E-4 ID:SGTC_1546|Compound:5-methoxyflavanone|FD-Score:2.96|P-value:6.89E-4 ID:SGTC_1753|Compound:st043925|FD-Score:4.07|P-value:5.38E-6 ID:SGTC_1913|Compound:st060213|FD-Score:3.08|P-value:4.43E-4 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:2.99|P-value:6.25E-4 ID:SGTC_2014|Compound:4013930|FD-Score:3.76|P-value:2.36E-5 ID:SGTC_2356|Compound:9061756|FD-Score:3.68|P-value:3.39E-5 ID:SGTC_2359|Compound:9039622|FD-Score:3.57|P-value:5.78E-5 ID:SGTC_2367|Compound:9070478|FD-Score:3.40|P-value:1.17E-4 ID:SGTC_2419|Compound:paclitaxel|FD-Score:5.08|P-value:1.86E-8 ID:SGTC_2700|Compound:st077718|FD-Score:-3.07|P-value:3.82E-4 ID:SGTC_2701|Compound:st077767|FD-Score:-3.38|P-value:1.08E-4 ID:SGTC_2717|Compound:st081029|FD-Score:-3.57|P-value:4.81E-5 ID:SGTC_2859|Compound:9028643|FD-Score:-2.88|P-value:7.98E-4 ID:SGTC_2957|Compound:9076800|FD-Score:3.64|P-value:4.07E-5 ID:SGTC_2978|Compound:9011784|FD-Score:2.88|P-value:9.46E-4 ID:SGTC_3050|Compound:9093513|FD-Score:-2.96|P-value:5.87E-4 ID:SGTC_3063|Compound:1327-0034|FD-Score:2.88|P-value:9.21E-4 ID:SGTC_3153|Compound:9100258|FD-Score:-2.84|P-value:9.33E-4 ID:SGTC_3160|Compound:9100216|FD-Score:4.24|P-value:2.29E-6 ID:SGTC_3165|Compound:9101544|FD-Score:3.41|P-value:1.12E-4 ID:SGTC_3216|Compound:9129716|FD-Score:-2.82|P-value:9.92E-4 ID:SGTC_3283|Compound:9109332|FD-Score:-3.67|P-value:2.93E-5 ID:SGTC_37|Compound:0566-0070|FD-Score:3.50|P-value:7.69E-5 ID:SGTC_392|Compound:N-ethylmaleimide|FD-Score:-3.47|P-value:7.22E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:2.91|P-value:8.29E-4 ID:SGTC_757|Compound:1066-0008|FD-Score:2.93|P-value:7.75E-4 ID:SGTC_911|Compound:3456-4043|FD-Score:-2.83|P-value:9.56E-4 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:4.34|P-value:1.33E-6 ID:SGTC_947|Compound:3447-0010|FD-Score:4.02|P-value:6.96E-6 ID:SGTC_949|Compound:1165-0505|FD-Score:3.21|P-value:2.64E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:6.80|P-value:8.37E-14 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.93|P-value:3.66E-8 ID:SGTC_1128|Compound:3448-9350|FD-Score:-3.49|P-value:6.59E-5 ID:SGTC_1254|Compound:0550-0035|FD-Score:-3.19|P-value:2.38E-4 ID:SGTC_1373|Compound:2887-0003|FD-Score:2.87|P-value:9.84E-4 ID:SGTC_1521|Compound:st012942|FD-Score:-3.05|P-value:4.15E-4 ID:SGTC_1546|Compound:5-methoxyflavanone|FD-Score:2.96|P-value:6.89E-4 ID:SGTC_1753|Compound:st043925|FD-Score:4.07|P-value:5.38E-6 ID:SGTC_1913|Compound:st060213|FD-Score:3.08|P-value:4.43E-4 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:2.99|P-value:6.25E-4 ID:SGTC_2014|Compound:4013930|FD-Score:3.76|P-value:2.36E-5 ID:SGTC_2356|Compound:9061756|FD-Score:3.68|P-value:3.39E-5 ID:SGTC_2359|Compound:9039622|FD-Score:3.57|P-value:5.78E-5 ID:SGTC_2367|Compound:9070478|FD-Score:3.40|P-value:1.17E-4 ID:SGTC_2419|Compound:paclitaxel|FD-Score:5.08|P-value:1.86E-8 ID:SGTC_2700|Compound:st077718|FD-Score:-3.07|P-value:3.82E-4 ID:SGTC_2701|Compound:st077767|FD-Score:-3.38|P-value:1.08E-4 ID:SGTC_2717|Compound:st081029|FD-Score:-3.57|P-value:4.81E-5 ID:SGTC_2859|Compound:9028643|FD-Score:-2.88|P-value:7.98E-4 ID:SGTC_2957|Compound:9076800|FD-Score:3.64|P-value:4.07E-5 ID:SGTC_2978|Compound:9011784|FD-Score:2.88|P-value:9.46E-4 ID:SGTC_3050|Compound:9093513|FD-Score:-2.96|P-value:5.87E-4 ID:SGTC_3063|Compound:1327-0034|FD-Score:2.88|P-value:9.21E-4 ID:SGTC_3153|Compound:9100258|FD-Score:-2.84|P-value:9.33E-4 ID:SGTC_3160|Compound:9100216|FD-Score:4.24|P-value:2.29E-6 ID:SGTC_3165|Compound:9101544|FD-Score:3.41|P-value:1.12E-4 ID:SGTC_3216|Compound:9129716|FD-Score:-2.82|P-value:9.92E-4 ID:SGTC_3283|Compound:9109332|FD-Score:-3.67|P-value:2.93E-5

Top fitness defect scores for YGL165C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1083 didemethylchlorpromazine sulfoxide 6.80 707.4 nM 8.37E-14 redox potentiating 18 5.24E-12
2 SGTC_2419 paclitaxel 5.08 166.5 µM 1.86E-8 13 1.87E-7
3 SGTC_915 methyl methanesulfonate (MMS) 4.34 110.0 mM 1.33E-6 DNA damage response 33 7.21E-6
4 SGTC_3160 9100216 4.24 49.5 µM 2.29E-6 2 1.14E-5
5 SGTC_1753 st043925 4.07 64.0 µM 5.38E-6 7 2.38E-5
6 SGTC_947 3447-0010 4.02 211.0 µM 6.96E-6 11 2.96E-5
7 SGTC_2014 4013930 3.76 200.0 µM 2.36E-5 38 8.42E-5
8 SGTC_2356 9061756 3.68 189.0 µM 3.39E-5 14 1.15E-4
9 SGTC_2957 9076800 3.64 11.5 µM 4.07E-5 27 1.34E-4
10 SGTC_2359 9039622 3.57 200.0 µM 5.78E-5 endomembrane recycling 31 1.81E-4
11 SGTC_37 0566-0070 3.50 1.6 µM 7.69E-5 42 2.32E-4
12 SGTC_3165 9101544 3.41 49.5 µM 1.12E-4 19 3.21E-4
13 SGTC_2367 9070478 3.40 135.4 µM 1.17E-4 cell wall 62 3.32E-4
14 SGTC_949 1165-0505 3.21 146.0 µM 2.64E-4 54 6.70E-4
15 SGTC_1913 st060213 3.08 96.1 µM 4.43E-4 81 0.00104
16 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 2.99 70.1 µM 6.25E-4 90 0.00140
17 SGTC_1546 5-methoxyflavanone 2.96 78.7 µM 6.89E-4 41 0.00153
18 SGTC_757 1066-0008 2.93 322.0 µM 7.75E-4 Golgi 64 0.00169
19 SGTC_453 enantio-paf c16 2.91 10.0 µM 8.29E-4 262 0.00179
20 SGTC_3063 1327-0034 2.88 4.0 µM 9.21E-4 85 0.00196

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.319 1.97E-80 YPL251W_d YPL251W_d het Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps 5' end of the verified, essential gene YAH1/YPL252C
0.267 6.28E-56 YPL252C YAH1 het Ferredoxin of the mitochondrial matrix required for formation of cellular iron-sulfur proteins; involved in heme A biosynthesis; homologous to human adrenodoxin
0.239 1.01E-44 YDR431W_d YDR431W_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.218 1.86E-37 YDL049C KNH1 hom Protein with similarity to Kre9p, which is involved in cell wall beta 1,6-glucan synthesis; overproduction suppresses growth defects of a kre9 null mutant; required for propionic acid resistance
0.209 1.46E-34 YKL030W_d YKL030W_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified gene MAE1
0.208 5.61E-34 YGR025W_d YGR025W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.199 2.61E-31 YDR376W ARH1 het Oxidoreductase of the mitochondrial inner membrane, involved in cytoplasmic and mitochondrial iron homeostasis and required for activity of Fe-S cluster-containing enzymes; one of the few mitochondrial proteins essential for viability
0.197 1.01E-30 YLL012W YEH1 hom Steryl ester hydrolase, one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes
0.196 2.72E-30 YKL051W SFK1 hom Plasma membrane protein that may act together with or upstream of Stt4p to generate normal levels of the essential phospholipid PI4P, at least partially mediates proper localization of Stt4p to the plasma membrane
0.193 1.22E-29 YDR201W SPC19 het Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; also localized to nuclear side of spindle pole body
0.193 1.87E-29 YKL202W_d YKL202W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.174 2.93E-24 YLR385C SWC7 hom Protein of unknown function, component of the Swr1p complex that incorporates Htz1p into chromatin
0.171 1.86E-23 YCL035C GRX1 hom Glutathione-dependent disulfide oxidoreductase; hydroperoxide and superoxide-radical responsive, heat-stable, with active site cysteine pair; protects cells from oxidative damage; GRX1 has a paralog, GRX2, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.170 2.88E-23 YAL054C ACS1 hom Acetyl-coA synthetase isoform which, along with Acs2p, is the nuclear source of acetyl-coA for histone acetylation; expressed during growth on nonfermentable carbon sources and under aerobic conditions
0.164 9.57E-22 YNR013C PHO91 hom Low-affinity phosphate transporter of the vacuolar membrane; deletion of pho84, pho87, pho89, pho90, and pho91 causes synthetic lethality; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth