YGL167C / PMR1

High affinity Ca2+/Mn2+ P-type ATPase required for Ca2+ and Mn2+ transport into Golgi; involved in Ca2+ dependent protein sorting and processing; mutations in human homolog ATP2C1 cause acantholytic skin condition Hailey-Hailey disease

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL167C / PMR1

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:-3.87|P-value:5.70E-4 ID:SGTC_100|Compound:0086-0128|FD-Score:5.04|P-value:1.33E-5 ID:SGTC_106|Compound:0092-0003|FD-Score:5.23|P-value:6.53E-6 ID:SGTC_123|Compound:0083-0120|FD-Score:4.58|P-value:6.75E-5 ID:SGTC_129|Compound:0088-0017|FD-Score:7.82|P-value:3.44E-11 ID:SGTC_195|Compound:4234-0266|FD-Score:4.29|P-value:1.76E-4 ID:SGTC_206|Compound:4546-0025|FD-Score:3.83|P-value:7.11E-4 ID:SGTC_207|Compound:4185-0010|FD-Score:4.33|P-value:1.56E-4 ID:SGTC_217|Compound:ketoconazole|FD-Score:-3.98|P-value:4.05E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:-3.77|P-value:7.63E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-6.01|P-value:2.21E-7 ID:SGTC_318|Compound:1488-0629|FD-Score:4.65|P-value:5.39E-5 ID:SGTC_351|Compound:caspofungin|FD-Score:10.50|P-value:1.17E-18 ID:SGTC_362|Compound:0310-0100|FD-Score:5.03|P-value:1.39E-5 ID:SGTC_381|Compound:3461-2219|FD-Score:5.68|P-value:1.10E-6 ID:SGTC_498|Compound:2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ)|FD-Score:6.65|P-value:1.47E-8 ID:SGTC_513|Compound:4245-1575|FD-Score:7.58|P-value:1.24E-10 ID:SGTC_514|Compound:4466-0038|FD-Score:-4.42|P-value:1.01E-4 ID:SGTC_524|Compound:r073-0010|FD-Score:5.81|P-value:6.52E-7 ID:SGTC_612|Compound:0302-0167|FD-Score:8.25|P-value:2.92E-12 ID:SGTC_625|Compound:k213-0058|FD-Score:6.89|P-value:4.48E-9 ID:SGTC_626|Compound:0214-0009|FD-Score:6.83|P-value:6.18E-9 ID:SGTC_637|Compound:1181-0519|FD-Score:3.93|P-value:5.39E-4 ID:SGTC_660|Compound:4031-1742|FD-Score:4.10|P-value:3.26E-4 ID:SGTC_795|Compound:0685-0265|FD-Score:-4.06|P-value:3.21E-4 ID:SGTC_796|Compound:1234-0020|FD-Score:4.29|P-value:1.77E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:7.34|P-value:4.66E-10 ID:SGTC_805|Compound:3852-0218|FD-Score:3.73|P-value:9.47E-4 ID:SGTC_857|Compound:0438-0306|FD-Score:7.10|P-value:1.60E-9 ID:SGTC_859|Compound:0439-0102|FD-Score:7.43|P-value:2.84E-10 ID:SGTC_918|Compound:glabranin|FD-Score:4.29|P-value:1.79E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:5.64|P-value:1.29E-6 ID:SGTC_1159|Compound:4092-0538|FD-Score:4.49|P-value:9.14E-5 ID:SGTC_1227|Compound:3909-8010|FD-Score:-3.72|P-value:8.62E-4 ID:SGTC_1239|Compound:0337-0584|FD-Score:4.46|P-value:1.03E-4 ID:SGTC_1364|Compound:1653-0028|FD-Score:3.85|P-value:6.81E-4 ID:SGTC_1568|Compound:digitonin|FD-Score:3.81|P-value:7.71E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:6.69|P-value:1.20E-8 ID:SGTC_1723|Compound:st034307|FD-Score:4.65|P-value:5.32E-5 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:5.66|P-value:1.21E-6 ID:SGTC_1787|Compound:fluconazole|FD-Score:-3.69|P-value:9.38E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:-6.00|P-value:2.34E-7 ID:SGTC_1884|Compound:5633444|FD-Score:4.06|P-value:3.70E-4 ID:SGTC_2080|Compound:5212524|FD-Score:4.24|P-value:2.06E-4 ID:SGTC_2259|Compound:7964009|FD-Score:5.26|P-value:5.90E-6 ID:SGTC_2399|Compound:5884133|FD-Score:5.18|P-value:7.99E-6 ID:SGTC_2485|Compound:5633444|FD-Score:9.48|P-value:1.23E-15 ID:SGTC_2504|Compound:purpurogallin|FD-Score:5.39|P-value:3.53E-6 ID:SGTC_2507|Compound:purpurin|FD-Score:6.23|P-value:1.04E-7 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:3.72|P-value:9.90E-4 ID:SGTC_2575|Compound:plumbagin|FD-Score:4.67|P-value:5.05E-5 ID:SGTC_2584|Compound:androsterone|FD-Score:-4.07|P-value:3.14E-4 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:5.64|P-value:1.31E-6 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:7.17|P-value:1.11E-9 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:4.60|P-value:6.41E-5 ID:SGTC_2671|Compound:danthron|FD-Score:3.89|P-value:6.05E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:-4.61|P-value:5.24E-5 ID:SGTC_2681|Compound:menadione|FD-Score:4.57|P-value:7.05E-5 ID:SGTC_2781|Compound:5567276|FD-Score:13.20|P-value:1.38E-28 ID:SGTC_2784|Compound:7567673|FD-Score:3.72|P-value:9.73E-4 ID:SGTC_2942|Compound:9052777|FD-Score:3.93|P-value:5.44E-4 ID:SGTC_3018|Compound:9082602|FD-Score:-4.38|P-value:1.17E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.87|P-value:5.70E-4 ID:SGTC_100|Compound:0086-0128|FD-Score:5.04|P-value:1.33E-5 ID:SGTC_106|Compound:0092-0003|FD-Score:5.23|P-value:6.53E-6 ID:SGTC_123|Compound:0083-0120|FD-Score:4.58|P-value:6.75E-5 ID:SGTC_129|Compound:0088-0017|FD-Score:7.82|P-value:3.44E-11 ID:SGTC_195|Compound:4234-0266|FD-Score:4.29|P-value:1.76E-4 ID:SGTC_206|Compound:4546-0025|FD-Score:3.83|P-value:7.11E-4 ID:SGTC_207|Compound:4185-0010|FD-Score:4.33|P-value:1.56E-4 ID:SGTC_217|Compound:ketoconazole|FD-Score:-3.98|P-value:4.05E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:-3.77|P-value:7.63E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-6.01|P-value:2.21E-7 ID:SGTC_318|Compound:1488-0629|FD-Score:4.65|P-value:5.39E-5 ID:SGTC_351|Compound:caspofungin|FD-Score:10.50|P-value:1.17E-18 ID:SGTC_362|Compound:0310-0100|FD-Score:5.03|P-value:1.39E-5 ID:SGTC_381|Compound:3461-2219|FD-Score:5.68|P-value:1.10E-6 ID:SGTC_498|Compound:2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ)|FD-Score:6.65|P-value:1.47E-8 ID:SGTC_513|Compound:4245-1575|FD-Score:7.58|P-value:1.24E-10 ID:SGTC_514|Compound:4466-0038|FD-Score:-4.42|P-value:1.01E-4 ID:SGTC_524|Compound:r073-0010|FD-Score:5.81|P-value:6.52E-7 ID:SGTC_612|Compound:0302-0167|FD-Score:8.25|P-value:2.92E-12 ID:SGTC_625|Compound:k213-0058|FD-Score:6.89|P-value:4.48E-9 ID:SGTC_626|Compound:0214-0009|FD-Score:6.83|P-value:6.18E-9 ID:SGTC_637|Compound:1181-0519|FD-Score:3.93|P-value:5.39E-4 ID:SGTC_660|Compound:4031-1742|FD-Score:4.10|P-value:3.26E-4 ID:SGTC_795|Compound:0685-0265|FD-Score:-4.06|P-value:3.21E-4 ID:SGTC_796|Compound:1234-0020|FD-Score:4.29|P-value:1.77E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:7.34|P-value:4.66E-10 ID:SGTC_805|Compound:3852-0218|FD-Score:3.73|P-value:9.47E-4 ID:SGTC_857|Compound:0438-0306|FD-Score:7.10|P-value:1.60E-9 ID:SGTC_859|Compound:0439-0102|FD-Score:7.43|P-value:2.84E-10 ID:SGTC_918|Compound:glabranin|FD-Score:4.29|P-value:1.79E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:5.64|P-value:1.29E-6 ID:SGTC_1159|Compound:4092-0538|FD-Score:4.49|P-value:9.14E-5 ID:SGTC_1227|Compound:3909-8010|FD-Score:-3.72|P-value:8.62E-4 ID:SGTC_1239|Compound:0337-0584|FD-Score:4.46|P-value:1.03E-4 ID:SGTC_1364|Compound:1653-0028|FD-Score:3.85|P-value:6.81E-4 ID:SGTC_1568|Compound:digitonin|FD-Score:3.81|P-value:7.71E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:6.69|P-value:1.20E-8 ID:SGTC_1723|Compound:st034307|FD-Score:4.65|P-value:5.32E-5 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:5.66|P-value:1.21E-6 ID:SGTC_1787|Compound:fluconazole|FD-Score:-3.69|P-value:9.38E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:-6.00|P-value:2.34E-7 ID:SGTC_1884|Compound:5633444|FD-Score:4.06|P-value:3.70E-4 ID:SGTC_2080|Compound:5212524|FD-Score:4.24|P-value:2.06E-4 ID:SGTC_2259|Compound:7964009|FD-Score:5.26|P-value:5.90E-6 ID:SGTC_2399|Compound:5884133|FD-Score:5.18|P-value:7.99E-6 ID:SGTC_2485|Compound:5633444|FD-Score:9.48|P-value:1.23E-15 ID:SGTC_2504|Compound:purpurogallin|FD-Score:5.39|P-value:3.53E-6 ID:SGTC_2507|Compound:purpurin|FD-Score:6.23|P-value:1.04E-7 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:3.72|P-value:9.90E-4 ID:SGTC_2575|Compound:plumbagin|FD-Score:4.67|P-value:5.05E-5 ID:SGTC_2584|Compound:androsterone|FD-Score:-4.07|P-value:3.14E-4 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:5.64|P-value:1.31E-6 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:7.17|P-value:1.11E-9 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:4.60|P-value:6.41E-5 ID:SGTC_2671|Compound:danthron|FD-Score:3.89|P-value:6.05E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:-4.61|P-value:5.24E-5 ID:SGTC_2681|Compound:menadione|FD-Score:4.57|P-value:7.05E-5 ID:SGTC_2781|Compound:5567276|FD-Score:13.20|P-value:1.38E-28 ID:SGTC_2784|Compound:7567673|FD-Score:3.72|P-value:9.73E-4 ID:SGTC_2942|Compound:9052777|FD-Score:3.93|P-value:5.44E-4 ID:SGTC_3018|Compound:9082602|FD-Score:-4.38|P-value:1.17E-4

Top fitness defect scores for YGL167C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2781 5567276 13.20 71.4 µM 1.38E-28 3 4.19E-40
2 SGTC_351 caspofungin 10.50 25.0 nM 1.17E-18 cell wall 8 6.12E-26
3 SGTC_2485 5633444 9.48 17.8 µM 1.23E-15 redox potentiating 4 1.24E-21
4 SGTC_612 0302-0167 8.25 22.4 µM 2.92E-12 copper-dependent oxidative stress 6 8.03E-17
5 SGTC_129 0088-0017 7.82 176.6 µM 3.44E-11 18 2.69E-15
6 SGTC_513 4245-1575 7.58 41.7 µM 1.24E-10 unfolded protein response 30 1.67E-14
7 SGTC_859 0439-0102 7.43 54.6 µM 2.84E-10 redox potentiating 3 5.40E-14
8 SGTC_800 3448-7362 7.34 155.0 µM 4.66E-10 translation 20 1.09E-13
9 SGTC_2615 purpurogallin-4-carboxylic acid 7.17 100.0 µM 1.11E-9 redox potentiating 21 3.74E-13
10 SGTC_857 0438-0306 7.10 1.4 µM 1.60E-9 copper-dependent oxidative stress 1 6.31E-13
11 SGTC_625 k213-0058 6.89 121.0 µM 4.48E-9 translation 23 2.72E-12
12 SGTC_626 0214-0009 6.83 33.0 µM 6.18E-9 copper-dependent oxidative stress 2 4.31E-12
13 SGTC_1718 roemerine 6.69 11.9 µM 1.20E-8 redox potentiating 13 1.11E-11
14 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 6.65 150.0 µM 1.47E-8 Golgi 15 1.47E-11
15 SGTC_2507 purpurin 6.23 79.7 µM 1.04E-7 copper-dependent oxidative stress 9 2.37E-10
16 SGTC_524 r073-0010 5.81 27.8 µM 6.52E-7 17 3.21E-9
17 SGTC_381 3461-2219 5.68 42.7 µM 1.10E-6 copper-dependent oxidative stress 6 6.72E-9
18 SGTC_1785 bathophenanthroline 5.66 24.0 µM 1.21E-6 heme requiring 11 7.69E-9
19 SGTC_1083 didemethylchlorpromazine sulfoxide 5.64 707.4 nM 1.29E-6 redox potentiating 33 8.49E-9
20 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 5.64 70.0 µM 1.31E-6 redox potentiating 30 8.68E-9

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.379 2.56E-115 YGL168W HUR1 hom Protein of unknown function; reported null mutant phenotype of hydroxyurea sensitivity may be due to effects on overlapping PMR1 gene
0.298 5.24E-70 YPR124W CTR1 hom High-affinity copper transporter of the plasma membrane; mediates nearly all copper uptake under low copper conditions; transcriptionally induced at low copper levels and degraded at high copper levels; protein increases in abundance and relocalizes from nucleus to plasma membrane upon DNA replication stress
0.274 7.10E-59 YPR123C_d YPR123C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially/completely overlaps the verified ORF CTR
0.258 9.63E-52 YMR038C CCS1 hom Copper chaperone for superoxide dismutase Sod1p; involved in oxidative stress protection; Met-X-Cys-X2-Cys motif within the N-terminal portion is involved in insertion of copper into Sod1p under conditions of copper deprivation; protein abundance increases in response to DNA replication stress
0.227 1.46E-40 YJR104C SOD1 hom Cytosolic copper-zinc superoxide dismutase; some mutations are analogous to those that cause ALS (amyotrophic lateral sclerosis) in humans; protein abundance increases in response to DNA replication stress and in response to prolonged exposure to boric acid
0.215 2.58E-36 YMR021C MAC1 hom Copper-sensing transcription factor involved in regulation of genes required for high affinity copper transport
0.176 9.72E-25 YLR417W VPS36 hom Component of the ESCRT-II complex; contains the GLUE (GRAM Like Ubiquitin binding in EAP45) domain which is involved in interactions with ESCRT-I and ubiquitin-dependent sorting of proteins into the endosome
0.167 2.16E-22 YML007W YAP1 hom Basic leucine zipper (bZIP) transcription factor; required for oxidative stress tolerance; activated by H2O2 through the multistep formation of disulfide bonds and transit from the cytoplasm to the nucleus; Yap1p is degraded in the nucleus after the oxidative stress has passed; mediates resistance to cadmium; YAP1 has a paralog, CAD1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.165 6.32E-22 YHR008C SOD2 hom Mitochondrial manganese superoxide dismutase, protects cells against oxygen toxicity; phosphorylated
0.160 1.22E-20 YIL039W TED1 hom Conserved phosphoesterase domain-containing protein that acts together with Emp24p/Erv25p in cargo exit from the ER; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)
0.157 6.83E-20 YPR074C TKL1 hom Transketolase; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids; TKL1 has a paralog, TKL2, that arose from the whole genome duplication
0.149 4.15E-18 YDR376W ARH1 het Oxidoreductase of the mitochondrial inner membrane, involved in cytoplasmic and mitochondrial iron homeostasis and required for activity of Fe-S cluster-containing enzymes; one of the few mitochondrial proteins essential for viability
0.145 3.70E-17 YMR073C IRC21 hom Putative protein of unknown function; may be involved in resistance to carboplatin and cisplatin; null mutant displays increase in spontaneous Rad52p foci; contains a lipid-binding domain and binds cardiolipin in a large-scale study
0.137 1.61E-15 YPL252C YAH1 het Ferredoxin of the mitochondrial matrix required for formation of cellular iron-sulfur proteins; involved in heme A biosynthesis; homologous to human adrenodoxin
0.135 3.81E-15 YJL120W_d YJL120W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL121C/RPE1; deletion confers sensitivity to GSAO