YGL168W / HUR1

Protein of unknown function; reported null mutant phenotype of hydroxyurea sensitivity may be due to effects on overlapping PMR1 gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL168W / HUR1

Click on Significant Values for Screen Details ID:SGTC_59|Compound:0330-0160|FD-Score:3.89|P-value:5.94E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:7.55|P-value:7.70E-11 ID:SGTC_73|Compound:0327-0325|FD-Score:-3.75|P-value:3.77E-4 ID:SGTC_100|Compound:0086-0128|FD-Score:4.69|P-value:4.20E-5 ID:SGTC_123|Compound:0083-0120|FD-Score:4.36|P-value:1.34E-4 ID:SGTC_217|Compound:ketoconazole|FD-Score:-5.57|P-value:3.93E-7 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:5.98|P-value:2.30E-7 ID:SGTC_242|Compound:5hr heat shock (37°C) + 5-fluorouracil|FD-Score:6.35|P-value:4.13E-8 ID:SGTC_243|Compound:5hr heat shock (37°C) + splitomicin|FD-Score:3.97|P-value:4.76E-4 ID:SGTC_255|Compound:tunicamycin|FD-Score:5.16|P-value:7.10E-6 ID:SGTC_288|Compound:1315-0019|FD-Score:3.72|P-value:9.89E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-4.62|P-value:1.85E-5 ID:SGTC_312|Compound:4092-0653|FD-Score:-4.07|P-value:1.31E-4 ID:SGTC_314|Compound:1671-0008|FD-Score:-5.25|P-value:1.54E-6 ID:SGTC_318|Compound:1488-0629|FD-Score:6.43|P-value:2.72E-8 ID:SGTC_381|Compound:3461-2219|FD-Score:3.84|P-value:7.00E-4 ID:SGTC_422|Compound:cantharidin|FD-Score:3.81|P-value:7.75E-4 ID:SGTC_446|Compound:go6976|FD-Score:5.65|P-value:9.75E-7 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:5.68|P-value:8.37E-7 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:3.96|P-value:4.91E-4 ID:SGTC_459|Compound:nigericin|FD-Score:5.06|P-value:1.08E-5 ID:SGTC_498|Compound:2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ)|FD-Score:5.47|P-value:2.03E-6 ID:SGTC_502|Compound:l-744,832|FD-Score:-3.82|P-value:3.05E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:5.14|P-value:7.85E-6 ID:SGTC_524|Compound:r073-0010|FD-Score:4.49|P-value:8.63E-5 ID:SGTC_576|Compound:1073-0113|FD-Score:4.47|P-value:9.19E-5 ID:SGTC_625|Compound:k213-0058|FD-Score:5.72|P-value:7.07E-7 ID:SGTC_626|Compound:0214-0009|FD-Score:5.84|P-value:4.26E-7 ID:SGTC_660|Compound:4031-1742|FD-Score:8.58|P-value:1.48E-13 ID:SGTC_663|Compound:1486-0733|FD-Score:5.64|P-value:1.03E-6 ID:SGTC_770|Compound:0389-1121|FD-Score:4.13|P-value:2.89E-4 ID:SGTC_913|Compound:3487-1245|FD-Score:-4.25|P-value:7.08E-5 ID:SGTC_919|Compound:tnp00227|FD-Score:4.04|P-value:3.77E-4 ID:SGTC_1000|Compound:4048-0884|FD-Score:6.54|P-value:1.63E-8 ID:SGTC_1001|Compound:4048-4355|FD-Score:8.56|P-value:1.76E-13 ID:SGTC_1098|Compound:clofazimine|FD-Score:3.88|P-value:6.16E-4 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:6.49|P-value:2.01E-8 ID:SGTC_1120|Compound:ficusin|FD-Score:-3.90|P-value:2.35E-4 ID:SGTC_1213|Compound:1315-0166|FD-Score:-3.81|P-value:3.14E-4 ID:SGTC_1228|Compound:0124-0032|FD-Score:3.95|P-value:5.05E-4 ID:SGTC_1425|Compound:4048-4433|FD-Score:4.11|P-value:3.06E-4 ID:SGTC_1522|Compound:st012842|FD-Score:-3.90|P-value:2.31E-4 ID:SGTC_1556|Compound:plumbagin|FD-Score:3.76|P-value:8.82E-4 ID:SGTC_1639|Compound:Lupinine o-methylbenzoicacid ester hydrochloride|FD-Score:-4.56|P-value:2.38E-5 ID:SGTC_1711|Compound:st032263|FD-Score:3.78|P-value:8.39E-4 ID:SGTC_1766|Compound:st045414|FD-Score:5.17|P-value:6.99E-6 ID:SGTC_1789|Compound:tunicamycin|FD-Score:4.00|P-value:4.32E-4 ID:SGTC_1834|Compound:st055981|FD-Score:5.07|P-value:1.03E-5 ID:SGTC_1884|Compound:5633444|FD-Score:6.24|P-value:6.93E-8 ID:SGTC_1933|Compound:st074711|FD-Score:-3.83|P-value:2.96E-4 ID:SGTC_1934|Compound:st074720|FD-Score:-3.75|P-value:3.74E-4 ID:SGTC_1962|Compound:st076595|FD-Score:3.92|P-value:5.49E-4 ID:SGTC_2007|Compound:4011539|FD-Score:4.94|P-value:1.68E-5 ID:SGTC_2009|Compound:4012297|FD-Score:5.62|P-value:1.09E-6 ID:SGTC_2090|Compound:5301565|FD-Score:7.89|P-value:1.08E-11 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:4.54|P-value:7.19E-5 ID:SGTC_2255|Compound:7941087|FD-Score:-3.89|P-value:2.44E-4 ID:SGTC_2342|Compound:7990637|FD-Score:-4.11|P-value:1.15E-4 ID:SGTC_2385|Compound:9074692|FD-Score:4.17|P-value:2.52E-4 ID:SGTC_2399|Compound:5884133|FD-Score:5.21|P-value:6.06E-6 ID:SGTC_2526|Compound:patulin|FD-Score:3.89|P-value:6.02E-4 ID:SGTC_2533|Compound:agelasine|FD-Score:-3.99|P-value:1.73E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:13.10|P-value:1.45E-29 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:-5.05|P-value:3.58E-6 ID:SGTC_2575|Compound:plumbagin|FD-Score:7.11|P-value:8.53E-10 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:11.40|P-value:8.22E-23 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:13.90|P-value:6.14E-33 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:7.40|P-value:1.73E-10 ID:SGTC_2671|Compound:danthron|FD-Score:4.33|P-value:1.48E-4 ID:SGTC_2682|Compound:pyrogallin|FD-Score:5.70|P-value:7.93E-7 ID:SGTC_2726|Compound:cimetidine|FD-Score:4.18|P-value:2.42E-4 ID:SGTC_2778|Compound:tioconazole|FD-Score:-3.93|P-value:2.15E-4 ID:SGTC_2836|Compound:9010338|FD-Score:6.39|P-value:3.32E-8 ID:SGTC_2844|Compound:9010103|FD-Score:-5.62|P-value:3.06E-7 ID:SGTC_2867|Compound:9039098|FD-Score:6.89|P-value:2.71E-9 ID:SGTC_2916|Compound:7875993|FD-Score:-4.04|P-value:1.49E-4 ID:SGTC_2980|Compound:9014342|FD-Score:4.85|P-value:2.38E-5 ID:SGTC_3018|Compound:9082602|FD-Score:-5.35|P-value:9.93E-7 ID:SGTC_3043|Compound:9092303|FD-Score:3.80|P-value:7.94E-4 ID:SGTC_3110|Compound:9122132|FD-Score:3.86|P-value:6.56E-4 ID:SGTC_3141|Compound:9094609|FD-Score:5.26|P-value:4.94E-6 ID:SGTC_3152|Compound:9099253|FD-Score:-4.47|P-value:3.31E-5 ID:SGTC_3211|Compound:9128781|FD-Score:6.02|P-value:1.88E-7 ID:SGTC_3266|Compound:9136860|FD-Score:-5.67|P-value:2.41E-7 ID:SGTC_59|Compound:0330-0160|FD-Score:3.89|P-value:5.94E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:7.55|P-value:7.70E-11 ID:SGTC_73|Compound:0327-0325|FD-Score:-3.75|P-value:3.77E-4 ID:SGTC_100|Compound:0086-0128|FD-Score:4.69|P-value:4.20E-5 ID:SGTC_123|Compound:0083-0120|FD-Score:4.36|P-value:1.34E-4 ID:SGTC_217|Compound:ketoconazole|FD-Score:-5.57|P-value:3.93E-7 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:5.98|P-value:2.30E-7 ID:SGTC_242|Compound:5hr heat shock (37°C) + 5-fluorouracil|FD-Score:6.35|P-value:4.13E-8 ID:SGTC_243|Compound:5hr heat shock (37°C) + splitomicin|FD-Score:3.97|P-value:4.76E-4 ID:SGTC_255|Compound:tunicamycin|FD-Score:5.16|P-value:7.10E-6 ID:SGTC_288|Compound:1315-0019|FD-Score:3.72|P-value:9.89E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-4.62|P-value:1.85E-5 ID:SGTC_312|Compound:4092-0653|FD-Score:-4.07|P-value:1.31E-4 ID:SGTC_314|Compound:1671-0008|FD-Score:-5.25|P-value:1.54E-6 ID:SGTC_318|Compound:1488-0629|FD-Score:6.43|P-value:2.72E-8 ID:SGTC_381|Compound:3461-2219|FD-Score:3.84|P-value:7.00E-4 ID:SGTC_422|Compound:cantharidin|FD-Score:3.81|P-value:7.75E-4 ID:SGTC_446|Compound:go6976|FD-Score:5.65|P-value:9.75E-7 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:5.68|P-value:8.37E-7 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:3.96|P-value:4.91E-4 ID:SGTC_459|Compound:nigericin|FD-Score:5.06|P-value:1.08E-5 ID:SGTC_498|Compound:2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ)|FD-Score:5.47|P-value:2.03E-6 ID:SGTC_502|Compound:l-744,832|FD-Score:-3.82|P-value:3.05E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:5.14|P-value:7.85E-6 ID:SGTC_524|Compound:r073-0010|FD-Score:4.49|P-value:8.63E-5 ID:SGTC_576|Compound:1073-0113|FD-Score:4.47|P-value:9.19E-5 ID:SGTC_625|Compound:k213-0058|FD-Score:5.72|P-value:7.07E-7 ID:SGTC_626|Compound:0214-0009|FD-Score:5.84|P-value:4.26E-7 ID:SGTC_660|Compound:4031-1742|FD-Score:8.58|P-value:1.48E-13 ID:SGTC_663|Compound:1486-0733|FD-Score:5.64|P-value:1.03E-6 ID:SGTC_770|Compound:0389-1121|FD-Score:4.13|P-value:2.89E-4 ID:SGTC_913|Compound:3487-1245|FD-Score:-4.25|P-value:7.08E-5 ID:SGTC_919|Compound:tnp00227|FD-Score:4.04|P-value:3.77E-4 ID:SGTC_1000|Compound:4048-0884|FD-Score:6.54|P-value:1.63E-8 ID:SGTC_1001|Compound:4048-4355|FD-Score:8.56|P-value:1.76E-13 ID:SGTC_1098|Compound:clofazimine|FD-Score:3.88|P-value:6.16E-4 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:6.49|P-value:2.01E-8 ID:SGTC_1120|Compound:ficusin|FD-Score:-3.90|P-value:2.35E-4 ID:SGTC_1213|Compound:1315-0166|FD-Score:-3.81|P-value:3.14E-4 ID:SGTC_1228|Compound:0124-0032|FD-Score:3.95|P-value:5.05E-4 ID:SGTC_1425|Compound:4048-4433|FD-Score:4.11|P-value:3.06E-4 ID:SGTC_1522|Compound:st012842|FD-Score:-3.90|P-value:2.31E-4 ID:SGTC_1556|Compound:plumbagin|FD-Score:3.76|P-value:8.82E-4 ID:SGTC_1639|Compound:Lupinine o-methylbenzoicacid ester hydrochloride|FD-Score:-4.56|P-value:2.38E-5 ID:SGTC_1711|Compound:st032263|FD-Score:3.78|P-value:8.39E-4 ID:SGTC_1766|Compound:st045414|FD-Score:5.17|P-value:6.99E-6 ID:SGTC_1789|Compound:tunicamycin|FD-Score:4.00|P-value:4.32E-4 ID:SGTC_1834|Compound:st055981|FD-Score:5.07|P-value:1.03E-5 ID:SGTC_1884|Compound:5633444|FD-Score:6.24|P-value:6.93E-8 ID:SGTC_1933|Compound:st074711|FD-Score:-3.83|P-value:2.96E-4 ID:SGTC_1934|Compound:st074720|FD-Score:-3.75|P-value:3.74E-4 ID:SGTC_1962|Compound:st076595|FD-Score:3.92|P-value:5.49E-4 ID:SGTC_2007|Compound:4011539|FD-Score:4.94|P-value:1.68E-5 ID:SGTC_2009|Compound:4012297|FD-Score:5.62|P-value:1.09E-6 ID:SGTC_2090|Compound:5301565|FD-Score:7.89|P-value:1.08E-11 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:4.54|P-value:7.19E-5 ID:SGTC_2255|Compound:7941087|FD-Score:-3.89|P-value:2.44E-4 ID:SGTC_2342|Compound:7990637|FD-Score:-4.11|P-value:1.15E-4 ID:SGTC_2385|Compound:9074692|FD-Score:4.17|P-value:2.52E-4 ID:SGTC_2399|Compound:5884133|FD-Score:5.21|P-value:6.06E-6 ID:SGTC_2526|Compound:patulin|FD-Score:3.89|P-value:6.02E-4 ID:SGTC_2533|Compound:agelasine|FD-Score:-3.99|P-value:1.73E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:13.10|P-value:1.45E-29 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:-5.05|P-value:3.58E-6 ID:SGTC_2575|Compound:plumbagin|FD-Score:7.11|P-value:8.53E-10 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:11.40|P-value:8.22E-23 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:13.90|P-value:6.14E-33 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:7.40|P-value:1.73E-10 ID:SGTC_2671|Compound:danthron|FD-Score:4.33|P-value:1.48E-4 ID:SGTC_2682|Compound:pyrogallin|FD-Score:5.70|P-value:7.93E-7 ID:SGTC_2726|Compound:cimetidine|FD-Score:4.18|P-value:2.42E-4 ID:SGTC_2778|Compound:tioconazole|FD-Score:-3.93|P-value:2.15E-4 ID:SGTC_2836|Compound:9010338|FD-Score:6.39|P-value:3.32E-8 ID:SGTC_2844|Compound:9010103|FD-Score:-5.62|P-value:3.06E-7 ID:SGTC_2867|Compound:9039098|FD-Score:6.89|P-value:2.71E-9 ID:SGTC_2916|Compound:7875993|FD-Score:-4.04|P-value:1.49E-4 ID:SGTC_2980|Compound:9014342|FD-Score:4.85|P-value:2.38E-5 ID:SGTC_3018|Compound:9082602|FD-Score:-5.35|P-value:9.93E-7 ID:SGTC_3043|Compound:9092303|FD-Score:3.80|P-value:7.94E-4 ID:SGTC_3110|Compound:9122132|FD-Score:3.86|P-value:6.56E-4 ID:SGTC_3141|Compound:9094609|FD-Score:5.26|P-value:4.94E-6 ID:SGTC_3152|Compound:9099253|FD-Score:-4.47|P-value:3.31E-5 ID:SGTC_3211|Compound:9128781|FD-Score:6.02|P-value:1.88E-7 ID:SGTC_3266|Compound:9136860|FD-Score:-5.67|P-value:2.41E-7

Top fitness defect scores for YGL168W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2615 purpurogallin-4-carboxylic acid 13.90 100.0 µM 6.14E-33 redox potentiating 4 3.05E-44
2 SGTC_2567 aureobasidin a 13.10 60.0 nM 1.45E-29 7 1.08E-39
3 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 11.40 70.0 µM 8.22E-23 redox potentiating 5 1.42E-30
4 SGTC_660 4031-1742 8.58 102.0 µM 1.48E-13 redox potentiating 6 4.62E-18
5 SGTC_1001 4048-4355 8.56 44.4 µM 1.76E-13 copper-dependent oxidative stress 5 5.85E-18
6 SGTC_2090 5301565 7.89 104.5 µM 1.08E-11 TSC3-RPN4 10 1.54E-15
7 SGTC_70 0141-0289 7.55 43.3 µM 7.70E-11 mitochondrial stress 46 2.21E-14
8 SGTC_2617 dihydrotanshinone i 7.40 20.8 µM 1.73E-10 copper-dependent oxidative stress 7 6.63E-14
9 SGTC_2575 plumbagin 7.11 510.0 nM 8.53E-10 superoxide 11 5.76E-13
10 SGTC_2867 9039098 6.89 71.4 µM 2.71E-9 iron homeostasis 4 2.76E-12
11 SGTC_1000 4048-0884 6.54 8.7 µM 1.63E-8 copper-dependent oxidative stress 7 3.16E-11
12 SGTC_1110 3-hydroxy-3'-methoxyflavone 6.49 1.2 µM 2.01E-8 iron homeostasis 10 4.19E-11
13 SGTC_318 1488-0629 6.43 67.2 µM 2.72E-8 copper-dependent oxidative stress 11 6.29E-11
14 SGTC_2836 9010338 6.39 19.5 µM 3.32E-8 RPP1 & pyrimidine depletion 3 8.25E-11
15 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 6.35 4.6 µM 4.13E-8 heat shock/prefoldin 12 1.11E-10
16 SGTC_1884 5633444 6.24 25.0 µM 6.93E-8 redox potentiating 27 2.24E-10
17 SGTC_3211 9128781 6.02 49.5 µM 1.88E-7 20 8.71E-10
18 SGTC_241 5hr heat shock (37°C) + cantharidin 5.98 155.4 µM 2.30E-7 cell wall signaling 30 1.14E-9
19 SGTC_626 0214-0009 5.84 33.0 µM 4.26E-7 copper-dependent oxidative stress 6 2.63E-9
20 SGTC_625 k213-0058 5.72 121.0 µM 7.07E-7 translation 39 5.25E-9

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.379 2.56E-115 YGL167C PMR1 hom High affinity Ca2+/Mn2+ P-type ATPase required for Ca2+ and Mn2+ transport into Golgi; involved in Ca2+ dependent protein sorting and processing; mutations in human homolog ATP2C1 cause acantholytic skin condition Hailey-Hailey disease
0.221 3.37E-38 YMR038C CCS1 hom Copper chaperone for superoxide dismutase Sod1p; involved in oxidative stress protection; Met-X-Cys-X2-Cys motif within the N-terminal portion is involved in insertion of copper into Sod1p under conditions of copper deprivation; protein abundance increases in response to DNA replication stress
0.213 7.26E-36 YKL004W AUR1 het Phosphatidylinositol:ceramide phosphoinositol transferase (IPC synthase), required for sphingolipid synthesis; can mutate to confer aureobasidin A resistance
0.189 2.29E-28 YDR323C PEP7 hom Multivalent adaptor protein that facilitates vesicle-mediated vacuolar protein sorting by ensuring high-fidelity vesicle docking and fusion, which are essential for targeting of vesicles to the endosome; required for vacuole inheritance
0.182 2.35E-26 YOR008C SLG1 hom Sensor-transducer of the stress-activated PKC1-MPK1 kinase pathway; involved in maintenance of cell wall integrity; required for mitophagy; involved in organization of the actin cytoskeleton; secretory pathway Wsc1p is required for the arrest of secretion response
0.175 1.64E-24 YDR414C ERD1 hom Predicted membrane protein required for the retention of lumenal endoplasmic reticulum proteins; mutants secrete the endogenous ER protein, BiP (Kar2p)
0.173 5.03E-24 YPR124W CTR1 hom High-affinity copper transporter of the plasma membrane; mediates nearly all copper uptake under low copper conditions; transcriptionally induced at low copper levels and degraded at high copper levels; protein increases in abundance and relocalizes from nucleus to plasma membrane upon DNA replication stress
0.169 7.05E-23 YLR417W VPS36 hom Component of the ESCRT-II complex; contains the GLUE (GRAM Like Ubiquitin binding in EAP45) domain which is involved in interactions with ESCRT-I and ubiquitin-dependent sorting of proteins into the endosome
0.169 6.83E-23 YOR089C VPS21 hom Rab family GTPase; required for endocytic transport and for sorting of vacuolar hydrolases; localized in endocytic intermediates; detected in mitochondria; geranylgeranylation required for membrane association; mammalian Rab5 homolog; protein abundance increases in response to DNA replication stress; VPS21 has a paralog, YPT53, that arose from the whole genome duplication
0.169 6.88E-23 YMR211W DML1 het Essential protein involved in mtDNA inheritance, may also function in the partitioning of the mitochondrial organelle or in the segregation of chromosomes, exhibits regions similar to members of a GTPase family
0.169 8.15E-23 YPR123C_d YPR123C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially/completely overlaps the verified ORF CTR
0.167 1.87E-22 YLR027C AAT2 hom Cytosolic aspartate aminotransferase, involved in nitrogen metabolism; localizes to peroxisomes in oleate-grown cells
0.162 3.28E-21 YMR021C MAC1 hom Copper-sensing transcription factor involved in regulation of genes required for high affinity copper transport
0.162 3.73E-21 YGL025C PGD1 hom Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for basal and activated transcription; direct target of Cyc8p-Tup1p transcriptional corepressor
0.161 6.02E-21 YGR196C FYV8 hom Protein of unknown function, required for survival upon exposure to K1 killer toxin