YGL169W / SUA5

Single-stranded telomeric DNA-binding protein, required for normal telomere length; null mutant lacks N6-threonylcarbamoyl adenosine (t6A) modification in the anticodon loop of ANN-decoding tRNA; member of conserved YrdC/Sua5 family

Zygosity: Heterozygous strain
fixedexpanded
Profile for YGL169W / SUA5

Click on Significant Values for Screen Details ID:SGTC_47|Compound:0149-0135|FD-Score:3.96|P-value:6.90E-5 ID:SGTC_126|Compound:0417-1624|FD-Score:3.79|P-value:1.29E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:3.28|P-value:7.88E-4 ID:SGTC_227|Compound:fluconazole|FD-Score:8.70|P-value:2.62E-17 ID:SGTC_259|Compound:usnic acid|FD-Score:4.34|P-value:1.47E-5 ID:SGTC_313|Compound:3474-0040|FD-Score:3.36|P-value:5.98E-4 ID:SGTC_374|Compound:0880-0231|FD-Score:-3.73|P-value:1.61E-4 ID:SGTC_384|Compound:k007-0144|FD-Score:-3.34|P-value:6.52E-4 ID:SGTC_393|Compound:acivicin|FD-Score:-4.51|P-value:7.05E-6 ID:SGTC_445|Compound:e6 berbamine|FD-Score:7.85|P-value:1.98E-14 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:4.27|P-value:1.92E-5 ID:SGTC_600|Compound:1495-0418|FD-Score:3.52|P-value:3.52E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:3.35|P-value:6.15E-4 ID:SGTC_660|Compound:4031-1742|FD-Score:-3.35|P-value:6.13E-4 ID:SGTC_737|Compound:1950-0117|FD-Score:4.61|P-value:4.52E-6 ID:SGTC_740|Compound:k014-0057|FD-Score:3.47|P-value:4.12E-4 ID:SGTC_742|Compound:0kpi-0133|FD-Score:3.96|P-value:6.90E-5 ID:SGTC_760|Compound:0568-0725|FD-Score:3.71|P-value:1.74E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:5.84|P-value:8.97E-9 ID:SGTC_803|Compound:4488-1585|FD-Score:3.45|P-value:4.39E-4 ID:SGTC_884|Compound:0851-0618|FD-Score:3.59|P-value:2.72E-4 ID:SGTC_900|Compound:1112-0045|FD-Score:3.51|P-value:3.63E-4 ID:SGTC_903|Compound:1134-0042|FD-Score:3.31|P-value:7.13E-4 ID:SGTC_952|Compound:1185-0122|FD-Score:3.49|P-value:3.89E-4 ID:SGTC_1129|Compound:3453-1384|FD-Score:4.43|P-value:9.98E-6 ID:SGTC_1732|Compound:st034308|FD-Score:3.95|P-value:7.01E-5 ID:SGTC_1749|Compound:st037932|FD-Score:-3.28|P-value:7.86E-4 ID:SGTC_1754|Compound:st042065|FD-Score:3.43|P-value:4.80E-4 ID:SGTC_1797|Compound:st048695|FD-Score:-3.27|P-value:8.00E-4 ID:SGTC_1800|Compound:st050079|FD-Score:3.35|P-value:6.14E-4 ID:SGTC_1901|Compound:st060216|FD-Score:4.11|P-value:3.75E-5 ID:SGTC_1949|Compound:st076024|FD-Score:4.64|P-value:3.96E-6 ID:SGTC_2057|Compound:5236571|FD-Score:-4.44|P-value:9.28E-6 ID:SGTC_2058|Compound:5236698|FD-Score:5.54|P-value:4.75E-8 ID:SGTC_2163|Compound:5671233|FD-Score:3.24|P-value:9.00E-4 ID:SGTC_2179|Compound:6298986|FD-Score:-3.55|P-value:3.06E-4 ID:SGTC_2240|Compound:6690706|FD-Score:3.32|P-value:7.01E-4 ID:SGTC_2266|Compound:7929956|FD-Score:3.69|P-value:1.86E-4 ID:SGTC_2274|Compound:7947094|FD-Score:4.43|P-value:9.79E-6 ID:SGTC_2276|Compound:7947513|FD-Score:5.22|P-value:2.46E-7 ID:SGTC_2303|Compound:7774051|FD-Score:-3.43|P-value:4.73E-4 ID:SGTC_2323|Compound:6148992|FD-Score:4.69|P-value:3.05E-6 ID:SGTC_2326|Compound:6164455|FD-Score:-4.20|P-value:2.62E-5 ID:SGTC_2344|Compound:7990960|FD-Score:-3.74|P-value:1.56E-4 ID:SGTC_2348|Compound:9022543|FD-Score:-3.42|P-value:4.98E-4 ID:SGTC_2406|Compound:ethylparaben|FD-Score:4.67|P-value:3.45E-6 ID:SGTC_2487|Compound:5918373|FD-Score:3.86|P-value:1.02E-4 ID:SGTC_2507|Compound:purpurin|FD-Score:5.12|P-value:3.95E-7 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:10.30|P-value:1.05E-23 ID:SGTC_2584|Compound:androsterone|FD-Score:-4.08|P-value:4.28E-5 ID:SGTC_2730|Compound:imipramine|FD-Score:3.94|P-value:7.36E-5 ID:SGTC_2739|Compound:tacrine|FD-Score:-4.41|P-value:1.09E-5 ID:SGTC_2845|Compound:9003024|FD-Score:3.84|P-value:1.10E-4 ID:SGTC_2854|Compound:9024559|FD-Score:-4.63|P-value:4.04E-6 ID:SGTC_2865|Compound:9030313|FD-Score:3.99|P-value:6.06E-5 ID:SGTC_2930|Compound:9013230|FD-Score:-3.69|P-value:1.89E-4 ID:SGTC_3024|Compound:9090631|FD-Score:3.68|P-value:1.95E-4 ID:SGTC_3124|Compound:9127567|FD-Score:3.36|P-value:6.05E-4 ID:SGTC_3126|Compound:9127922|FD-Score:3.80|P-value:1.24E-4 ID:SGTC_3141|Compound:9094609|FD-Score:-5.62|P-value:3.11E-8 ID:SGTC_3142|Compound:9086498|FD-Score:-4.46|P-value:8.76E-6 ID:SGTC_3304|Compound:9125678|FD-Score:5.91|P-value:6.33E-9 ID:SGTC_47|Compound:0149-0135|FD-Score:3.96|P-value:6.90E-5 ID:SGTC_126|Compound:0417-1624|FD-Score:3.79|P-value:1.29E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:3.28|P-value:7.88E-4 ID:SGTC_227|Compound:fluconazole|FD-Score:8.70|P-value:2.62E-17 ID:SGTC_259|Compound:usnic acid|FD-Score:4.34|P-value:1.47E-5 ID:SGTC_313|Compound:3474-0040|FD-Score:3.36|P-value:5.98E-4 ID:SGTC_374|Compound:0880-0231|FD-Score:-3.73|P-value:1.61E-4 ID:SGTC_384|Compound:k007-0144|FD-Score:-3.34|P-value:6.52E-4 ID:SGTC_393|Compound:acivicin|FD-Score:-4.51|P-value:7.05E-6 ID:SGTC_445|Compound:e6 berbamine|FD-Score:7.85|P-value:1.98E-14 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:4.27|P-value:1.92E-5 ID:SGTC_600|Compound:1495-0418|FD-Score:3.52|P-value:3.52E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:3.35|P-value:6.15E-4 ID:SGTC_660|Compound:4031-1742|FD-Score:-3.35|P-value:6.13E-4 ID:SGTC_737|Compound:1950-0117|FD-Score:4.61|P-value:4.52E-6 ID:SGTC_740|Compound:k014-0057|FD-Score:3.47|P-value:4.12E-4 ID:SGTC_742|Compound:0kpi-0133|FD-Score:3.96|P-value:6.90E-5 ID:SGTC_760|Compound:0568-0725|FD-Score:3.71|P-value:1.74E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:5.84|P-value:8.97E-9 ID:SGTC_803|Compound:4488-1585|FD-Score:3.45|P-value:4.39E-4 ID:SGTC_884|Compound:0851-0618|FD-Score:3.59|P-value:2.72E-4 ID:SGTC_900|Compound:1112-0045|FD-Score:3.51|P-value:3.63E-4 ID:SGTC_903|Compound:1134-0042|FD-Score:3.31|P-value:7.13E-4 ID:SGTC_952|Compound:1185-0122|FD-Score:3.49|P-value:3.89E-4 ID:SGTC_1129|Compound:3453-1384|FD-Score:4.43|P-value:9.98E-6 ID:SGTC_1732|Compound:st034308|FD-Score:3.95|P-value:7.01E-5 ID:SGTC_1749|Compound:st037932|FD-Score:-3.28|P-value:7.86E-4 ID:SGTC_1754|Compound:st042065|FD-Score:3.43|P-value:4.80E-4 ID:SGTC_1797|Compound:st048695|FD-Score:-3.27|P-value:8.00E-4 ID:SGTC_1800|Compound:st050079|FD-Score:3.35|P-value:6.14E-4 ID:SGTC_1901|Compound:st060216|FD-Score:4.11|P-value:3.75E-5 ID:SGTC_1949|Compound:st076024|FD-Score:4.64|P-value:3.96E-6 ID:SGTC_2057|Compound:5236571|FD-Score:-4.44|P-value:9.28E-6 ID:SGTC_2058|Compound:5236698|FD-Score:5.54|P-value:4.75E-8 ID:SGTC_2163|Compound:5671233|FD-Score:3.24|P-value:9.00E-4 ID:SGTC_2179|Compound:6298986|FD-Score:-3.55|P-value:3.06E-4 ID:SGTC_2240|Compound:6690706|FD-Score:3.32|P-value:7.01E-4 ID:SGTC_2266|Compound:7929956|FD-Score:3.69|P-value:1.86E-4 ID:SGTC_2274|Compound:7947094|FD-Score:4.43|P-value:9.79E-6 ID:SGTC_2276|Compound:7947513|FD-Score:5.22|P-value:2.46E-7 ID:SGTC_2303|Compound:7774051|FD-Score:-3.43|P-value:4.73E-4 ID:SGTC_2323|Compound:6148992|FD-Score:4.69|P-value:3.05E-6 ID:SGTC_2326|Compound:6164455|FD-Score:-4.20|P-value:2.62E-5 ID:SGTC_2344|Compound:7990960|FD-Score:-3.74|P-value:1.56E-4 ID:SGTC_2348|Compound:9022543|FD-Score:-3.42|P-value:4.98E-4 ID:SGTC_2406|Compound:ethylparaben|FD-Score:4.67|P-value:3.45E-6 ID:SGTC_2487|Compound:5918373|FD-Score:3.86|P-value:1.02E-4 ID:SGTC_2507|Compound:purpurin|FD-Score:5.12|P-value:3.95E-7 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:10.30|P-value:1.05E-23 ID:SGTC_2584|Compound:androsterone|FD-Score:-4.08|P-value:4.28E-5 ID:SGTC_2730|Compound:imipramine|FD-Score:3.94|P-value:7.36E-5 ID:SGTC_2739|Compound:tacrine|FD-Score:-4.41|P-value:1.09E-5 ID:SGTC_2845|Compound:9003024|FD-Score:3.84|P-value:1.10E-4 ID:SGTC_2854|Compound:9024559|FD-Score:-4.63|P-value:4.04E-6 ID:SGTC_2865|Compound:9030313|FD-Score:3.99|P-value:6.06E-5 ID:SGTC_2930|Compound:9013230|FD-Score:-3.69|P-value:1.89E-4 ID:SGTC_3024|Compound:9090631|FD-Score:3.68|P-value:1.95E-4 ID:SGTC_3124|Compound:9127567|FD-Score:3.36|P-value:6.05E-4 ID:SGTC_3126|Compound:9127922|FD-Score:3.80|P-value:1.24E-4 ID:SGTC_3141|Compound:9094609|FD-Score:-5.62|P-value:3.11E-8 ID:SGTC_3142|Compound:9086498|FD-Score:-4.46|P-value:8.76E-6 ID:SGTC_3304|Compound:9125678|FD-Score:5.91|P-value:6.33E-9

Top fitness defect scores for YGL169W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2567 aureobasidin a 10.30 60.0 nM 1.05E-23 13 2.20E-25 1.24
2 SGTC_227 fluconazole 8.70 33.5 µM 2.62E-17 azole & statin 16 1.69E-18 0.15
3 SGTC_445 e6 berbamine 7.85 66.0 µM 1.98E-14 NEO1-PIK1 6 2.11E-15 0.26
4 SGTC_3304 9125678 5.91 46.1 µM 6.33E-9 21 1.75E-9 0.09
5 SGTC_800 3448-7362 5.84 155.0 µM 8.97E-9 translation 24 2.55E-9 0.05
6 SGTC_2058 5236698 5.54 133.0 µM 4.75E-8 1 1.53E-8 1.23
7 SGTC_2276 7947513 5.22 42.1 µM 2.46E-7 1 8.94E-8 0.85
8 SGTC_2507 purpurin 5.12 79.7 µM 3.95E-7 copper-dependent oxidative stress 7 1.49E-7 0.36
9 SGTC_2323 6148992 4.69 148.3 µM 3.05E-6 9 1.34E-6 0.23
10 SGTC_2406 ethylparaben 4.67 405.7 µM 3.45E-6 6 1.53E-6 0.49
11 SGTC_1949 st076024 4.64 69.1 µM 3.96E-6 4 1.77E-6 0.40
12 SGTC_737 1950-0117 4.61 57.9 µM 4.52E-6 2 2.04E-6 0.83
13 SGTC_2274 7947094 4.43 46.1 µM 9.79E-6 4 4.68E-6 0.07
14 SGTC_1129 3453-1384 4.43 223.0 µM 9.98E-6 13 4.78E-6 0.29
15 SGTC_259 usnic acid 4.34 108.9 µM 1.47E-5 5 7.25E-6 0.31
16 SGTC_471 1-acyl-paf 4.27 4.0 µM 1.92E-5 DNA intercalators 14 9.65E-6 0.10
17 SGTC_1901 st060216 4.11 58.6 µM 3.75E-5 3 1.98E-5 0.15
18 SGTC_2865 9030313 3.99 52.0 µM 6.06E-5 1 3.31E-5 0.57
19 SGTC_47 0149-0135 3.96 24.2 µM 6.90E-5 TSC3-RPN4 5 3.80E-5 0.42
20 SGTC_742 0kpi-0133 3.96 140.0 µM 6.90E-5 ERG2 5 3.81E-5 0.30

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.265 6.04E-55 YKL004W AUR1 het Phosphatidylinositol:ceramide phosphoinositol transferase (IPC synthase), required for sphingolipid synthesis; can mutate to confer aureobasidin A resistance
0.181 4.75E-26 YDR367W KEI1 het Component of inositol phosphorylceramide (IPC) synthase; forms a complex with Aur1p and regulates its activity; required for IPC synthase complex localization to the Golgi; post-translationally processed by Kex2p; KEI1 is an essential gene
0.151 1.49E-18 YMR211W DML1 het Essential protein involved in mtDNA inheritance, may also function in the partitioning of the mitochondrial organelle or in the segregation of chromosomes, exhibits regions similar to members of a GTPase family
0.147 1.15E-17 YDL192W ARF1 hom ADP-ribosylation factor; GTPase of the Ras superfamily involved in regulation of coated vesicle formation in intracellular trafficking within the Golgi; ARF1 has a paralog, ARF2, that arose from the whole genome duplication
0.135 4.61E-15 YPL062W_d YPL062W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YPL062W is not an essential gene; homozygous diploid mutant shows a decrease in glycogen accumulation
0.130 4.23E-14 YJL195C_d YJL195C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL194W/CDC6
0.114 3.75E-11 YPR034W ARP7 het Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation
0.114 4.49E-11 YDR281C PHM6 hom Protein of unknown function, expression is regulated by phosphate levels
0.110 1.57E-10 YBR110W ALG1 het Mannosyltransferase, involved in asparagine-linked glycosylation in the endoplasmic reticulum (ER); essential for viability, mutation is functionally complemented by human ortholog
0.110 2.04E-10 YKL019W RAM2 het Alpha subunit of both the farnesyltransferase and type I geranylgeranyltransferase that catalyze prenylation of proteins containing a CAAX consensus motif; essential protein required for membrane localization of Ras proteins and a-factor
0.108 3.73E-10 YBL092W RPL32 het Ribosomal 60S subunit protein L32; overexpression disrupts telomeric silencing; homologous to mammalian ribosomal protein L32, no bacterial homolog
0.108 3.97E-10 YHR108W GGA2 hom Protein that interacts with and regulates Arf1p and Arf2p in a GTP-dependent manner to facilitate traffic through the late Golgi; binds phosphatidylinositol 4-phosphate, which plays a role in TGN localization; has homology to gamma-adaptin
0.107 6.06E-10 YPL238C_d YPL238C_d het Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps 5' end of the verified essential gene SUI3/YPL237W
0.106 7.80E-10 YOR357C SNX3 hom Sorting nexin required to maintain late-Golgi resident enzymes in their proper location by recycling molecules from the prevacuolar compartment; contains a PX domain and sequence similarity to human Snx3p
0.106 8.49E-10 YGL155W CDC43 het Beta subunit of geranylgeranyltransferase type I, catalyzes geranylgeranylation to the cysteine residue in proteins containing a C-terminal CaaX sequence ending in Leu or Phe; has substrates important for morphogenesis