YGL170C / SPO74

Component of the meiotic outer plaque of the spindle pole body, involved in modifying the meiotic outer plaque that is required prior to prospore membrane formation

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL170C / SPO74

Click on Significant Values for Screen Details ID:SGTC_521|Compound:r062-0005|FD-Score:4.41|P-value:7.14E-6 ID:SGTC_741|Compound:4582-0002|FD-Score:3.58|P-value:2.12E-4 ID:SGTC_757|Compound:1066-0008|FD-Score:4.63|P-value:2.53E-6 ID:SGTC_766|Compound:1391-0721|FD-Score:-3.44|P-value:3.51E-4 ID:SGTC_809|Compound:3998-0021|FD-Score:4.15|P-value:2.15E-5 ID:SGTC_1071|Compound:trifluoperazine|FD-Score:3.58|P-value:2.14E-4 ID:SGTC_1081|Compound:sertraline|FD-Score:3.45|P-value:3.34E-4 ID:SGTC_1087|Compound:pterostilbene|FD-Score:4.87|P-value:8.11E-7 ID:SGTC_1121|Compound:fusaric acid|FD-Score:3.84|P-value:7.87E-5 ID:SGTC_1164|Compound:k060-0068|FD-Score:-3.70|P-value:1.38E-4 ID:SGTC_1239|Compound:0337-0584|FD-Score:4.77|P-value:1.33E-6 ID:SGTC_1241|Compound:0364-0022|FD-Score:4.51|P-value:4.38E-6 ID:SGTC_1242|Compound:0402-0103|FD-Score:-4.78|P-value:1.29E-6 ID:SGTC_1243|Compound:0416-0003|FD-Score:6.62|P-value:3.52E-11 ID:SGTC_1350|Compound:1495-0454|FD-Score:4.40|P-value:7.41E-6 ID:SGTC_1452|Compound:4194-0072|FD-Score:3.97|P-value:4.66E-5 ID:SGTC_1459|Compound:k035-0031|FD-Score:-3.27|P-value:6.50E-4 ID:SGTC_1603|Compound:st002045|FD-Score:3.53|P-value:2.55E-4 ID:SGTC_1777|Compound:st045864|FD-Score:3.77|P-value:1.04E-4 ID:SGTC_1779|Compound:st039427|FD-Score:4.92|P-value:6.31E-7 ID:SGTC_1783|Compound:st039459|FD-Score:4.32|P-value:1.03E-5 ID:SGTC_1790|Compound:st045711|FD-Score:3.83|P-value:8.06E-5 ID:SGTC_1862|Compound:st057513|FD-Score:-3.38|P-value:4.43E-4 ID:SGTC_2152|Compound:5568786|FD-Score:3.43|P-value:3.62E-4 ID:SGTC_2214|Compound:7179297|FD-Score:3.27|P-value:6.33E-4 ID:SGTC_2427|Compound:5545055|FD-Score:3.18|P-value:8.76E-4 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:-3.15|P-value:9.62E-4 ID:SGTC_2849|Compound:9019321|FD-Score:3.87|P-value:7.02E-5 ID:SGTC_2877|Compound:9040724|FD-Score:3.55|P-value:2.40E-4 ID:SGTC_2997|Compound:9067075|FD-Score:3.74|P-value:1.14E-4 ID:SGTC_3046|Compound:9092212|FD-Score:3.55|P-value:2.39E-4 ID:SGTC_521|Compound:r062-0005|FD-Score:4.41|P-value:7.14E-6 ID:SGTC_741|Compound:4582-0002|FD-Score:3.58|P-value:2.12E-4 ID:SGTC_757|Compound:1066-0008|FD-Score:4.63|P-value:2.53E-6 ID:SGTC_766|Compound:1391-0721|FD-Score:-3.44|P-value:3.51E-4 ID:SGTC_809|Compound:3998-0021|FD-Score:4.15|P-value:2.15E-5 ID:SGTC_1071|Compound:trifluoperazine|FD-Score:3.58|P-value:2.14E-4 ID:SGTC_1081|Compound:sertraline|FD-Score:3.45|P-value:3.34E-4 ID:SGTC_1087|Compound:pterostilbene|FD-Score:4.87|P-value:8.11E-7 ID:SGTC_1121|Compound:fusaric acid|FD-Score:3.84|P-value:7.87E-5 ID:SGTC_1164|Compound:k060-0068|FD-Score:-3.70|P-value:1.38E-4 ID:SGTC_1239|Compound:0337-0584|FD-Score:4.77|P-value:1.33E-6 ID:SGTC_1241|Compound:0364-0022|FD-Score:4.51|P-value:4.38E-6 ID:SGTC_1242|Compound:0402-0103|FD-Score:-4.78|P-value:1.29E-6 ID:SGTC_1243|Compound:0416-0003|FD-Score:6.62|P-value:3.52E-11 ID:SGTC_1350|Compound:1495-0454|FD-Score:4.40|P-value:7.41E-6 ID:SGTC_1452|Compound:4194-0072|FD-Score:3.97|P-value:4.66E-5 ID:SGTC_1459|Compound:k035-0031|FD-Score:-3.27|P-value:6.50E-4 ID:SGTC_1603|Compound:st002045|FD-Score:3.53|P-value:2.55E-4 ID:SGTC_1777|Compound:st045864|FD-Score:3.77|P-value:1.04E-4 ID:SGTC_1779|Compound:st039427|FD-Score:4.92|P-value:6.31E-7 ID:SGTC_1783|Compound:st039459|FD-Score:4.32|P-value:1.03E-5 ID:SGTC_1790|Compound:st045711|FD-Score:3.83|P-value:8.06E-5 ID:SGTC_1862|Compound:st057513|FD-Score:-3.38|P-value:4.43E-4 ID:SGTC_2152|Compound:5568786|FD-Score:3.43|P-value:3.62E-4 ID:SGTC_2214|Compound:7179297|FD-Score:3.27|P-value:6.33E-4 ID:SGTC_2427|Compound:5545055|FD-Score:3.18|P-value:8.76E-4 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:-3.15|P-value:9.62E-4 ID:SGTC_2849|Compound:9019321|FD-Score:3.87|P-value:7.02E-5 ID:SGTC_2877|Compound:9040724|FD-Score:3.55|P-value:2.40E-4 ID:SGTC_2997|Compound:9067075|FD-Score:3.74|P-value:1.14E-4 ID:SGTC_3046|Compound:9092212|FD-Score:3.55|P-value:2.39E-4

Top fitness defect scores for YGL170C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1243 0416-0003 6.62 5.7 µM 3.52E-11 PDR1 4 1.78E-11
2 SGTC_1779 st039427 4.92 55.0 µM 6.31E-7 8 4.31E-7
3 SGTC_1087 pterostilbene 4.87 9.1 µM 8.11E-7 8 5.58E-7
4 SGTC_1239 0337-0584 4.77 35.4 µM 1.33E-6 unfolded protein response 31 9.29E-7
5 SGTC_757 1066-0008 4.63 322.0 µM 2.53E-6 Golgi 11 1.81E-6
6 SGTC_1241 0364-0022 4.51 50.8 µM 4.38E-6 ERG2 21 3.18E-6
7 SGTC_521 r062-0005 4.41 13.8 µM 7.14E-6 10 5.25E-6
8 SGTC_1350 1495-0454 4.40 146.0 µM 7.41E-6 16 5.46E-6
9 SGTC_1783 st039459 4.32 87.5 µM 1.03E-5 Golgi 18 7.66E-6
10 SGTC_809 3998-0021 4.15 90.0 µM 2.15E-5 RNA processing & uracil transport 11 1.63E-5
11 SGTC_1452 4194-0072 3.97 190.0 µM 4.66E-5 12 3.62E-5
12 SGTC_2849 9019321 3.87 13.0 µM 7.02E-5 32 5.53E-5
13 SGTC_1121 fusaric acid 3.84 630.5 nM 7.87E-5 38 6.22E-5
14 SGTC_1790 st045711 3.83 43.5 µM 8.06E-5 15 6.37E-5
15 SGTC_1777 st045864 3.77 34.8 µM 1.04E-4 12 8.25E-5
16 SGTC_2997 9067075 3.74 71.4 µM 1.14E-4 unfolded protein response 58 9.13E-5
17 SGTC_741 4582-0002 3.58 126.0 µM 2.12E-4 17 1.73E-4
18 SGTC_1071 trifluoperazine 3.58 6.3 µM 2.14E-4 38 1.74E-4
19 SGTC_3046 9092212 3.55 49.5 µM 2.39E-4 13 1.95E-4
20 SGTC_2877 9040724 3.55 71.4 µM 2.40E-4 18 1.96E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.153 4.72E-19 YFL032W_d YFL032W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene HAC1/YFL031W; YFL032W is not an essential gene
0.148 5.88E-18 YML130C ERO1 het Thiol oxidase required for oxidative protein folding in the ER; essential for maintaining proper redox balance in ER; feedback regulation of Ero1p occurs via reduction and oxidation of Ero1p regulatory bonds; reduced Pdi1p activates Ero1p by direct reduction of Ero1p regulatory bonds; depletion of thiol substrates and accumulation of oxidized Pdi1p results in inactivation of Ero1p by both Pdi1p-mediated oxidation and autonomous oxidation of Ero1p regulatory bonds
0.123 1.11E-12 YDR095C_d YDR095C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.110 1.61E-10 YLL062C MHT1 hom S-methylmethionine-homocysteine methyltransferase, functions along with Sam4p in the conversion of S-adenosylmethionine (AdoMet) to methionine to control the methionine/AdoMet ratio
0.108 3.85E-10 YGR205W TDA10 hom ATP-binding protein of unknown function; crystal structure resembles that of E.coli pantothenate kinase and other small kinases; null mutant is sensitive to expression of the top1-T722A allele
0.103 1.96E-9 YGR234W YHB1 hom Nitric oxide oxidoreductase; flavohemoglobin involved in nitric oxide detoxification; plays a role in the oxidative and nitrosative stress responses; protein increases in abundance and relocalizes from nucleus to cytoplasmic foci upon DNA replication stress
0.099 1.00E-8 YML052W SUR7 hom Plasma membrane protein that localizes to furrow-like invaginations (MCC patches); component of eisosomes; associated with endocytosis, along with Pil1p and Lsp1p; sporulation and plasma membrane sphingolipid content are altered in mutants
0.098 1.25E-8 YHR079C IRE1 hom Serine-threonine kinase and endoribonuclease; transmembrane protein that mediates the unfolded protein response (UPR) by regulating Hac1p synthesis through HAC1 mRNA splicing; Kar2p binds inactive Ire1p and releases from it upon ER stress
0.098 1.40E-8 YDR315C IPK1 hom Inositol 1,3,4,5,6-pentakisphosphate 2-kinase, nuclear protein required for synthesis of 1,2,3,4,5,6-hexakisphosphate (phytate), which is integral to cell function; has 2 motifs conserved in other fungi; ipk1 gle1 double mutant is inviable
0.093 6.16E-8 YLR132C USB1 het Putative phosphodiesterase specific for U6 snRNA 3' end modification; trims the 3' poly(u) tract to leave a terminal 3' phosphate; human homolog, hUSB1 (aka C16orf57) produces a 2',3' cyclic phosphate; mutations in hUSB1 are associated with a rare skin condition (OMIM 604173); essential protein that localizes to the nucleus and mitochondria; overexpression suppresses the respiratory defects of oxa1 and mtf2 mutants
0.092 8.31E-8 YLR241W_p YLR241W_p hom Putative protein of unknown function, may be involved in detoxification
0.087 4.27E-7 YGL202W ARO8 hom Aromatic aminotransferase I, expression is regulated by general control of amino acid biosynthesis
0.086 5.28E-7 YGR099W TEL2 het Subunit of the ASTRA complex, involved in chromatin remodeling; subunit of the telomere cap complex DNA-binding protein specific to single-stranded yeast telomeric DNA repeats, required for telomere length regulation and telomere position effect; involved in the stability or biogenesis of PIKKs such as TORC1
0.083 1.63E-6 YDR181C SAS4 hom Subunit of the SAS complex (Sas2p, Sas4p, Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; required for the HAT activity of Sas2p
0.081 2.71E-6 YKL221W MCH2 hom Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport