RNA-dependent ATPase; involved in pre-rRNA processing at sites A0, A1, and A2, and in control of cell cycle progression; contains two upstream open reading frames (uORFs) in 5' untranslated region which regulate translation
Zygosity: Heterozygous strain
fixedexpanded
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Top fitness defect scores for YGL171W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Correlation | pval | ORF | Gene | Zygosity | Description |
---|---|---|---|---|---|
0.109 | 2.21E-10 | YPR157W_p | TDA6_p | hom | Putative protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation; null mutant is sensitive to expression of the top1-T722A allele |
0.095 | 3.96E-8 | YNL151C | RPC31 | het | RNA polymerase III subunit C31 |
0.088 | 2.91E-7 | YFL042C_p | YFL042C_p | hom | Putative protein of unknown function; YFL042C is not an essential gene |
0.083 | 1.31E-6 | YDR062W | LCB2 | het | Component of serine palmitoyltransferase, responsible along with Lcb1p for the first committed step in sphingolipid synthesis, which is the condensation of serine with palmitoyl-CoA to form 3-ketosphinganine |
0.081 | 2.72E-6 | YHR065C | RRP3 | het | Protein involved in rRNA processing; required for maturation of the 35S primary transcript of pre-rRNA and for cleavage leading to mature 18S rRNA; homologous to eIF-4a, which is a DEAD box RNA-dependent ATPase with helicase activity |
0.080 | 3.50E-6 | YBL074C | AAR2 | het | Component of the U5 snRNP, required for splicing of U3 precursors; originally described as a splicing factor specifically required for splicing pre-mRNA of the MATa1 cistron |
0.078 | 6.88E-6 | YAR014C | BUD14 | hom | Protein involved in bud-site selection; Bud14p-Glc7p complex is a cortical regulator of dynein; inhibitor of the actin assembly factor Bnr1p (formin); diploid mutants display a random budding pattern instead of the wild-type bipolar pattern; relative distribution to the nucleus increases upon DNA replication stress |
0.077 | 7.64E-6 | YPR113W | PIS1 | het | Phosphatidylinositol synthase, required for biosynthesis of phosphatidylinositol, which is a precursor for polyphosphoinositides, sphingolipids, and glycolipid anchors for some of the plasma membrane proteins |
0.077 | 8.47E-6 | YGL210W | YPT32 | hom | Rab family GTPase involved in the exocytic pathway; mediates intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi; protein abundance increases in response to DNA replication stress; YPT32 has a paralog, YPT31, that arose from the whole genome duplication |
0.076 | 9.20E-6 | YMR065W | KAR5 | hom | Protein required for nuclear membrane fusion during karyogamy, localizes to the membrane with a soluble portion in the endoplasmic reticulum lumen, may form a complex with Jem1p and Kar2p; expression of the gene is regulated by pheromone |
0.074 | 1.76E-5 | YCR101C_p | YCR101C_p | hom | Putative protein of unknown function; localizes to the membrane fraction; YCR101C is not an essential gene |
0.074 | 1.82E-5 | YDR043C | NRG1 | hom | Transcriptional repressor; recruits the Cyc8p-Tup1p complex to promoters; mediates glucose repression and negatively regulates a variety of processes including filamentous growth and alkaline pH response; NRG1 has a paralog, NRG2, that arose from the whole genome duplication |
0.073 | 2.25E-5 | YOR032C | HMS1 | hom | Basic helix-loop-helix (bHLH) protein with similarity to myc-family transcription factors; overexpression confers hyperfilamentous growth and suppresses the pseudohyphal filamentation defect of a diploid mep1 mep2 homozygous null mutant |
0.073 | 2.50E-5 | YHR195W | NVJ1 | hom | Nuclear envelope protein, anchored to the nuclear inner membrane, that interacts with the vacuolar membrane protein Vac8p to promote formation of nucleus-vacuole junctions during piecemeal microautophagy of the nucleus (PMN) |
0.071 | 3.44E-5 | YBL008W-A_p | YBL008W-A_p | hom | Putative protein of unknown function; identified by fungal homology and RT-PCR |