YGL172W / NUP49

FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier; found in stable complex with Nic96p and two other FG-nucleoproteins (Nsp1p and Nup57p)

Zygosity: Heterozygous strain
fixedexpanded
Profile for YGL172W / NUP49

Click on Significant Values for Screen Details ID:SGTC_17|Compound:0960-0276|FD-Score:3.73|P-value:7.74E-4 ID:SGTC_23|Compound:0213-0011|FD-Score:3.73|P-value:7.66E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:5.96|P-value:1.95E-7 ID:SGTC_223|Compound:busulfan|FD-Score:3.92|P-value:4.35E-4 ID:SGTC_302|Compound:1094-0063|FD-Score:4.79|P-value:2.30E-5 ID:SGTC_422|Compound:cantharidin|FD-Score:4.73|P-value:2.82E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-4.10|P-value:2.18E-4 ID:SGTC_480|Compound:am 92016|FD-Score:-3.99|P-value:3.12E-4 ID:SGTC_485|Compound:niflumic acid|FD-Score:3.81|P-value:6.09E-4 ID:SGTC_569|Compound:4130-2812|FD-Score:-3.73|P-value:6.79E-4 ID:SGTC_585|Compound:0kpi-0023|FD-Score:-3.78|P-value:5.88E-4 ID:SGTC_676|Compound:falcarinol|FD-Score:-5.91|P-value:2.07E-7 ID:SGTC_685|Compound:1278-0033|FD-Score:-4.86|P-value:1.56E-5 ID:SGTC_778|Compound:3456-2434|FD-Score:4.64|P-value:4.02E-5 ID:SGTC_907|Compound:3448-6986|FD-Score:5.86|P-value:3.08E-7 ID:SGTC_914|Compound:3820-6779|FD-Score:5.26|P-value:3.80E-6 ID:SGTC_988|Compound:1497-1057|FD-Score:4.20|P-value:1.79E-4 ID:SGTC_1276|Compound:0871-0068|FD-Score:4.20|P-value:1.77E-4 ID:SGTC_1374|Compound:2889-5571|FD-Score:5.07|P-value:8.11E-6 ID:SGTC_1469|Compound:k284-2957|FD-Score:4.17|P-value:1.99E-4 ID:SGTC_1531|Compound:st059297|FD-Score:4.01|P-value:3.22E-4 ID:SGTC_1539|Compound:benzyladenosine|FD-Score:3.69|P-value:8.52E-4 ID:SGTC_1554|Compound:st069299|FD-Score:-3.68|P-value:7.87E-4 ID:SGTC_1582|Compound:3',3',6'-trihydroxyflavone|FD-Score:6.74|P-value:4.67E-9 ID:SGTC_1583|Compound:clindamycin|FD-Score:4.57|P-value:5.12E-5 ID:SGTC_1591|Compound:genipin|FD-Score:3.94|P-value:4.05E-4 ID:SGTC_1599|Compound:8-chlro-1-tetrahydronorharmanone|FD-Score:7.04|P-value:9.93E-10 ID:SGTC_1724|Compound:st037281|FD-Score:-3.88|P-value:4.30E-4 ID:SGTC_1769|Compound:st044406|FD-Score:4.16|P-value:2.04E-4 ID:SGTC_1809|Compound:st050081|FD-Score:3.86|P-value:5.14E-4 ID:SGTC_1846|Compound:st056244|FD-Score:4.01|P-value:3.21E-4 ID:SGTC_2041|Compound:5107442|FD-Score:4.43|P-value:8.23E-5 ID:SGTC_2049|Compound:5262831|FD-Score:-3.75|P-value:6.55E-4 ID:SGTC_2107|Compound:5363541|FD-Score:5.12|P-value:6.48E-6 ID:SGTC_2140|Compound:5586273|FD-Score:7.13|P-value:6.39E-10 ID:SGTC_2259|Compound:7964009|FD-Score:4.20|P-value:1.79E-4 ID:SGTC_2283|Compound:7944793|FD-Score:7.88|P-value:9.72E-12 ID:SGTC_2285|Compound:7945142|FD-Score:3.77|P-value:6.74E-4 ID:SGTC_2286|Compound:7945697|FD-Score:-5.95|P-value:1.71E-7 ID:SGTC_2290|Compound:7904846|FD-Score:12.10|P-value:2.86E-25 ID:SGTC_2318|Compound:6029776|FD-Score:-4.16|P-value:1.82E-4 ID:SGTC_2322|Compound:7413319|FD-Score:6.42|P-value:2.31E-8 ID:SGTC_2328|Compound:6201408|FD-Score:-5.20|P-value:4.17E-6 ID:SGTC_2370|Compound:9071495|FD-Score:3.89|P-value:4.72E-4 ID:SGTC_2395|Compound:5646831|FD-Score:5.59|P-value:9.94E-7 ID:SGTC_2403|Compound:6032726|FD-Score:5.78|P-value:4.29E-7 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:3.80|P-value:6.25E-4 ID:SGTC_2463|Compound:5473429|FD-Score:3.85|P-value:5.28E-4 ID:SGTC_2559|Compound:tetrahydrosappanone a trimethyl ether|FD-Score:3.72|P-value:7.75E-4 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:-4.85|P-value:1.60E-5 ID:SGTC_2606|Compound:farnesol|FD-Score:4.58|P-value:4.92E-5 ID:SGTC_2701|Compound:st077767|FD-Score:-4.20|P-value:1.60E-4 ID:SGTC_2704|Compound:st078022|FD-Score:-5.28|P-value:3.00E-6 ID:SGTC_2726|Compound:cimetidine|FD-Score:4.22|P-value:1.69E-4 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:4.18|P-value:1.89E-4 ID:SGTC_2841|Compound:9004761|FD-Score:3.75|P-value:7.22E-4 ID:SGTC_2853|Compound:9015042|FD-Score:5.70|P-value:6.04E-7 ID:SGTC_2905|Compound:7799065|FD-Score:6.04|P-value:1.37E-7 ID:SGTC_2980|Compound:9014342|FD-Score:-4.28|P-value:1.19E-4 ID:SGTC_2996|Compound:9066192|FD-Score:5.23|P-value:4.35E-6 ID:SGTC_2998|Compound:9066762|FD-Score:4.38|P-value:9.94E-5 ID:SGTC_3263|Compound:9137018|FD-Score:4.66|P-value:3.69E-5 ID:SGTC_3286|Compound:9117135|FD-Score:4.04|P-value:2.98E-4 ID:SGTC_3309|Compound:9129340|FD-Score:3.92|P-value:4.29E-4 ID:SGTC_17|Compound:0960-0276|FD-Score:3.73|P-value:7.74E-4 ID:SGTC_23|Compound:0213-0011|FD-Score:3.73|P-value:7.66E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:5.96|P-value:1.95E-7 ID:SGTC_223|Compound:busulfan|FD-Score:3.92|P-value:4.35E-4 ID:SGTC_302|Compound:1094-0063|FD-Score:4.79|P-value:2.30E-5 ID:SGTC_422|Compound:cantharidin|FD-Score:4.73|P-value:2.82E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-4.10|P-value:2.18E-4 ID:SGTC_480|Compound:am 92016|FD-Score:-3.99|P-value:3.12E-4 ID:SGTC_485|Compound:niflumic acid|FD-Score:3.81|P-value:6.09E-4 ID:SGTC_569|Compound:4130-2812|FD-Score:-3.73|P-value:6.79E-4 ID:SGTC_585|Compound:0kpi-0023|FD-Score:-3.78|P-value:5.88E-4 ID:SGTC_676|Compound:falcarinol|FD-Score:-5.91|P-value:2.07E-7 ID:SGTC_685|Compound:1278-0033|FD-Score:-4.86|P-value:1.56E-5 ID:SGTC_778|Compound:3456-2434|FD-Score:4.64|P-value:4.02E-5 ID:SGTC_907|Compound:3448-6986|FD-Score:5.86|P-value:3.08E-7 ID:SGTC_914|Compound:3820-6779|FD-Score:5.26|P-value:3.80E-6 ID:SGTC_988|Compound:1497-1057|FD-Score:4.20|P-value:1.79E-4 ID:SGTC_1276|Compound:0871-0068|FD-Score:4.20|P-value:1.77E-4 ID:SGTC_1374|Compound:2889-5571|FD-Score:5.07|P-value:8.11E-6 ID:SGTC_1469|Compound:k284-2957|FD-Score:4.17|P-value:1.99E-4 ID:SGTC_1531|Compound:st059297|FD-Score:4.01|P-value:3.22E-4 ID:SGTC_1539|Compound:benzyladenosine|FD-Score:3.69|P-value:8.52E-4 ID:SGTC_1554|Compound:st069299|FD-Score:-3.68|P-value:7.87E-4 ID:SGTC_1582|Compound:3',3',6'-trihydroxyflavone|FD-Score:6.74|P-value:4.67E-9 ID:SGTC_1583|Compound:clindamycin|FD-Score:4.57|P-value:5.12E-5 ID:SGTC_1591|Compound:genipin|FD-Score:3.94|P-value:4.05E-4 ID:SGTC_1599|Compound:8-chlro-1-tetrahydronorharmanone|FD-Score:7.04|P-value:9.93E-10 ID:SGTC_1724|Compound:st037281|FD-Score:-3.88|P-value:4.30E-4 ID:SGTC_1769|Compound:st044406|FD-Score:4.16|P-value:2.04E-4 ID:SGTC_1809|Compound:st050081|FD-Score:3.86|P-value:5.14E-4 ID:SGTC_1846|Compound:st056244|FD-Score:4.01|P-value:3.21E-4 ID:SGTC_2041|Compound:5107442|FD-Score:4.43|P-value:8.23E-5 ID:SGTC_2049|Compound:5262831|FD-Score:-3.75|P-value:6.55E-4 ID:SGTC_2107|Compound:5363541|FD-Score:5.12|P-value:6.48E-6 ID:SGTC_2140|Compound:5586273|FD-Score:7.13|P-value:6.39E-10 ID:SGTC_2259|Compound:7964009|FD-Score:4.20|P-value:1.79E-4 ID:SGTC_2283|Compound:7944793|FD-Score:7.88|P-value:9.72E-12 ID:SGTC_2285|Compound:7945142|FD-Score:3.77|P-value:6.74E-4 ID:SGTC_2286|Compound:7945697|FD-Score:-5.95|P-value:1.71E-7 ID:SGTC_2290|Compound:7904846|FD-Score:12.10|P-value:2.86E-25 ID:SGTC_2318|Compound:6029776|FD-Score:-4.16|P-value:1.82E-4 ID:SGTC_2322|Compound:7413319|FD-Score:6.42|P-value:2.31E-8 ID:SGTC_2328|Compound:6201408|FD-Score:-5.20|P-value:4.17E-6 ID:SGTC_2370|Compound:9071495|FD-Score:3.89|P-value:4.72E-4 ID:SGTC_2395|Compound:5646831|FD-Score:5.59|P-value:9.94E-7 ID:SGTC_2403|Compound:6032726|FD-Score:5.78|P-value:4.29E-7 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:3.80|P-value:6.25E-4 ID:SGTC_2463|Compound:5473429|FD-Score:3.85|P-value:5.28E-4 ID:SGTC_2559|Compound:tetrahydrosappanone a trimethyl ether|FD-Score:3.72|P-value:7.75E-4 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:-4.85|P-value:1.60E-5 ID:SGTC_2606|Compound:farnesol|FD-Score:4.58|P-value:4.92E-5 ID:SGTC_2701|Compound:st077767|FD-Score:-4.20|P-value:1.60E-4 ID:SGTC_2704|Compound:st078022|FD-Score:-5.28|P-value:3.00E-6 ID:SGTC_2726|Compound:cimetidine|FD-Score:4.22|P-value:1.69E-4 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:4.18|P-value:1.89E-4 ID:SGTC_2841|Compound:9004761|FD-Score:3.75|P-value:7.22E-4 ID:SGTC_2853|Compound:9015042|FD-Score:5.70|P-value:6.04E-7 ID:SGTC_2905|Compound:7799065|FD-Score:6.04|P-value:1.37E-7 ID:SGTC_2980|Compound:9014342|FD-Score:-4.28|P-value:1.19E-4 ID:SGTC_2996|Compound:9066192|FD-Score:5.23|P-value:4.35E-6 ID:SGTC_2998|Compound:9066762|FD-Score:4.38|P-value:9.94E-5 ID:SGTC_3263|Compound:9137018|FD-Score:4.66|P-value:3.69E-5 ID:SGTC_3286|Compound:9117135|FD-Score:4.04|P-value:2.98E-4 ID:SGTC_3309|Compound:9129340|FD-Score:3.92|P-value:4.29E-4

Top fitness defect scores for YGL172W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2290 7904846 12.10 200.0 µM 2.86E-25 1 5.07E-34 3.90
2 SGTC_2283 7944793 7.88 200.0 µM 9.72E-12 2 1.69E-15 2.03
3 SGTC_2140 5586273 7.13 200.0 µM 6.39E-10 RSC complex & mRNA processing 1 5.14E-13 0.64
4 SGTC_1599 8-chlro-1-tetrahydronorharmanone 7.04 90.6 µM 9.93E-10 1 9.39E-13 1.09
5 SGTC_1582 3',3',6'-trihydroxyflavone 6.74 74.0 µM 4.67E-9 1 7.78E-12 1.86
6 SGTC_2322 7413319 6.42 38.2 µM 2.31E-8 ERAD & cell cycle 9 6.89E-11 0.25
7 SGTC_2905 7799065 6.04 20.1 µM 1.37E-7 2 7.81E-10 0.88
8 SGTC_103 0844-0104 5.96 51.8 µM 1.95E-7 ERAD & cell cycle 25 1.27E-9 0.03
9 SGTC_907 3448-6986 5.86 75.5 µM 3.08E-7 2 2.35E-9 1.16
10 SGTC_2403 6032726 5.78 181.2 µM 4.29E-7 2 3.69E-9 1.14
11 SGTC_2853 9015042 5.70 58.4 µM 6.04E-7 1 5.89E-9 0.96
12 SGTC_2395 5646831 5.59 180.2 µM 9.94E-7 1 1.16E-8 1.63
13 SGTC_914 3820-6779 5.26 408.0 µM 3.80E-6 2 7.21E-8 1.07
14 SGTC_2996 9066192 5.23 71.4 µM 4.35E-6 2 8.66E-8 0.60
15 SGTC_2107 5363541 5.12 170.2 µM 6.48E-6 1 1.49E-7 0.32
16 SGTC_1374 2889-5571 5.07 141.0 µM 8.11E-6 RSC complex & mRNA processing 27 2.02E-7 0.06
17 SGTC_302 1094-0063 4.79 18.9 µM 2.30E-5 10 8.33E-7 0.11
18 SGTC_422 cantharidin 4.73 155.0 µM 2.82E-5 cell wall signaling 4 1.10E-6 0.06
19 SGTC_3263 9137018 4.66 49.5 µM 3.69E-5 2 1.58E-6 0.87
20 SGTC_778 3456-2434 4.64 196.0 µM 4.02E-5 mitochondrial response to ROS 5 1.78E-6 0.59

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.137 1.42E-15 YGR119C NUP57 het FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier; found in stable complex with Nic96p and two other FG-nucleoproteins (Nsp1p and Nup49p)
0.098 1.48E-8 YJR105W ADO1 hom Adenosine kinase, required for the utilization of S-adenosylmethionine (AdoMet); may be involved in recycling adenosine produced through the methyl cycle
0.095 3.03E-8 YNL141W AAH1 hom Adenine deaminase (adenine aminohydrolase), converts adenine to hypoxanthine; involved in purine salvage; transcriptionally regulated by nutrient levels and growth phase; Aah1p degraded upon entry into quiescence via SCF and the proteasome
0.094 5.20E-8 YML127W RSC9 het Component of the RSC chromatin remodeling complex; DNA-binding protein involved in the synthesis of rRNA and in transcriptional repression and activation of genes regulated by the Target of Rapamycin (TOR) pathway
0.092 1.06E-7 YKL186C MTR2 het mRNA transport regulator, essential nuclear protein; Mex67p and Mtr2p form a mRNA export complex which binds to RNA
0.091 1.37E-7 YHR196W UTP9 het Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
0.088 2.97E-7 YMR170C ALD2 hom Cytoplasmic aldehyde dehydrogenase, involved in ethanol oxidation and beta-alanine biosynthesis; uses NAD+ as the preferred coenzyme; expression is stress induced and glucose repressed; very similar to Ald3p
0.087 4.80E-7 YPL169C MEX67 het Poly(A)RNA binding protein involved in nuclear mRNA export, component of the nuclear pore; ortholog of human TAP
0.078 5.92E-6 YLR344W RPL26A hom Ribosomal 60S subunit protein L26A; binds to 5.8S rRNA; homologous to mammalian ribosomal protein L26 and bacterial L24; RPL26A has a paralog, RPL26B, that arose from the whole genome duplication
0.078 6.20E-6 YGR159C NSR1 hom Nucleolar protein that binds nuclear localization sequences, required for pre-rRNA processing and ribosome biogenesis
0.077 8.61E-6 YDL148C NOP14 het Nucleolar protein, forms a complex with Noc4p that mediates maturation and nuclear export of 40S ribosomal subunits; also present in the small subunit processome complex, which is required for processing of pre-18S rRNA
0.074 1.99E-5 YIL126W STH1 het ATPase component of the RSC chromatin remodeling complex; required for expression of early meiotic genes; essential helicase-related protein homologous to Snf2p
0.074 2.04E-5 YBL092W RPL32 het Ribosomal 60S subunit protein L32; overexpression disrupts telomeric silencing; homologous to mammalian ribosomal protein L32, no bacterial homolog
0.073 2.12E-5 YOR201C MRM1 hom Ribose methyltransferase that modifies a functionally critical, conserved nucleotide in mitochondrial 21S rRNA
0.073 2.62E-5 YCR086W CSM1 hom Nucleolar protein that forms a complex with Lrs4p and then Mam1p at kinetochores during meiosis I to mediate accurate homolog segregation; required for condensin recruitment to the replication fork barrier site and rDNA repeat segregation