YGL176C_p

Putative protein of unknown function; deletion mutant is viable and has no detectable phenotype

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL176C / YGL176C

Click on Significant Values for Screen Details ID:SGTC_34|Compound:0469-0683|FD-Score:3.49|P-value:3.78E-4 ID:SGTC_80|Compound:0159-0065|FD-Score:-3.22|P-value:8.66E-4 ID:SGTC_314|Compound:1671-0008|FD-Score:3.49|P-value:3.71E-4 ID:SGTC_344|Compound:k064-0035|FD-Score:3.28|P-value:7.62E-4 ID:SGTC_639|Compound:0833-0042|FD-Score:5.58|P-value:3.46E-8 ID:SGTC_647|Compound:0140-0236|FD-Score:3.64|P-value:2.23E-4 ID:SGTC_780|Compound:0109-0199|FD-Score:3.25|P-value:8.42E-4 ID:SGTC_792|Compound:4534-1957|FD-Score:5.70|P-value:1.73E-8 ID:SGTC_825|Compound:1988-2224|FD-Score:3.23|P-value:9.10E-4 ID:SGTC_903|Compound:1134-0042|FD-Score:3.24|P-value:8.70E-4 ID:SGTC_905|Compound:2-aminofluorene|FD-Score:5.24|P-value:2.00E-7 ID:SGTC_1027|Compound:k015-0025|FD-Score:5.56|P-value:3.80E-8 ID:SGTC_1112|Compound:tnp00069|FD-Score:3.59|P-value:2.59E-4 ID:SGTC_1192|Compound:1488-0095|FD-Score:3.29|P-value:7.58E-4 ID:SGTC_1239|Compound:0337-0584|FD-Score:3.40|P-value:5.20E-4 ID:SGTC_1280|Compound:0880-0253|FD-Score:3.42|P-value:4.85E-4 ID:SGTC_1342|Compound:1486-1464|FD-Score:3.61|P-value:2.41E-4 ID:SGTC_1451|Compound:4152-0210|FD-Score:3.56|P-value:2.94E-4 ID:SGTC_1468|Compound:k284-1086|FD-Score:4.09|P-value:3.95E-5 ID:SGTC_1567|Compound:st069303|FD-Score:-6.35|P-value:3.45E-10 ID:SGTC_1571|Compound:st070080|FD-Score:-4.98|P-value:6.31E-7 ID:SGTC_1810|Compound:st050138|FD-Score:3.28|P-value:7.71E-4 ID:SGTC_2107|Compound:5363541|FD-Score:-3.35|P-value:5.60E-4 ID:SGTC_2111|Compound:5486399|FD-Score:3.81|P-value:1.15E-4 ID:SGTC_2114|Compound:5491910|FD-Score:-4.67|P-value:2.71E-6 ID:SGTC_2326|Compound:6164455|FD-Score:3.57|P-value:2.87E-4 ID:SGTC_2329|Compound:6138490|FD-Score:-3.68|P-value:1.71E-4 ID:SGTC_2406|Compound:ethylparaben|FD-Score:-3.46|P-value:3.73E-4 ID:SGTC_2411|Compound:st077133|FD-Score:-4.46|P-value:7.04E-6 ID:SGTC_2414|Compound:st077232|FD-Score:3.61|P-value:2.44E-4 ID:SGTC_2415|Compound:st077333|FD-Score:-4.23|P-value:1.96E-5 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:4.00|P-value:5.51E-5 ID:SGTC_2592|Compound:piperlongumine|FD-Score:4.37|P-value:1.18E-5 ID:SGTC_2653|Compound:dihydrofissinolide|FD-Score:4.20|P-value:2.43E-5 ID:SGTC_2943|Compound:9068529|FD-Score:3.24|P-value:8.70E-4 ID:SGTC_2962|Compound:9082311|FD-Score:3.56|P-value:2.95E-4 ID:SGTC_3078|Compound:9116413|FD-Score:4.01|P-value:5.31E-5 ID:SGTC_3133|Compound:9127736|FD-Score:-3.78|P-value:1.18E-4 ID:SGTC_3183|Compound:9108214|FD-Score:-3.58|P-value:2.47E-4 ID:SGTC_3205|Compound:9113483|FD-Score:3.40|P-value:5.11E-4 ID:SGTC_3351|Compound:9150312|FD-Score:5.20|P-value:2.46E-7 ID:SGTC_34|Compound:0469-0683|FD-Score:3.49|P-value:3.78E-4 ID:SGTC_80|Compound:0159-0065|FD-Score:-3.22|P-value:8.66E-4 ID:SGTC_314|Compound:1671-0008|FD-Score:3.49|P-value:3.71E-4 ID:SGTC_344|Compound:k064-0035|FD-Score:3.28|P-value:7.62E-4 ID:SGTC_639|Compound:0833-0042|FD-Score:5.58|P-value:3.46E-8 ID:SGTC_647|Compound:0140-0236|FD-Score:3.64|P-value:2.23E-4 ID:SGTC_780|Compound:0109-0199|FD-Score:3.25|P-value:8.42E-4 ID:SGTC_792|Compound:4534-1957|FD-Score:5.70|P-value:1.73E-8 ID:SGTC_825|Compound:1988-2224|FD-Score:3.23|P-value:9.10E-4 ID:SGTC_903|Compound:1134-0042|FD-Score:3.24|P-value:8.70E-4 ID:SGTC_905|Compound:2-aminofluorene|FD-Score:5.24|P-value:2.00E-7 ID:SGTC_1027|Compound:k015-0025|FD-Score:5.56|P-value:3.80E-8 ID:SGTC_1112|Compound:tnp00069|FD-Score:3.59|P-value:2.59E-4 ID:SGTC_1192|Compound:1488-0095|FD-Score:3.29|P-value:7.58E-4 ID:SGTC_1239|Compound:0337-0584|FD-Score:3.40|P-value:5.20E-4 ID:SGTC_1280|Compound:0880-0253|FD-Score:3.42|P-value:4.85E-4 ID:SGTC_1342|Compound:1486-1464|FD-Score:3.61|P-value:2.41E-4 ID:SGTC_1451|Compound:4152-0210|FD-Score:3.56|P-value:2.94E-4 ID:SGTC_1468|Compound:k284-1086|FD-Score:4.09|P-value:3.95E-5 ID:SGTC_1567|Compound:st069303|FD-Score:-6.35|P-value:3.45E-10 ID:SGTC_1571|Compound:st070080|FD-Score:-4.98|P-value:6.31E-7 ID:SGTC_1810|Compound:st050138|FD-Score:3.28|P-value:7.71E-4 ID:SGTC_2107|Compound:5363541|FD-Score:-3.35|P-value:5.60E-4 ID:SGTC_2111|Compound:5486399|FD-Score:3.81|P-value:1.15E-4 ID:SGTC_2114|Compound:5491910|FD-Score:-4.67|P-value:2.71E-6 ID:SGTC_2326|Compound:6164455|FD-Score:3.57|P-value:2.87E-4 ID:SGTC_2329|Compound:6138490|FD-Score:-3.68|P-value:1.71E-4 ID:SGTC_2406|Compound:ethylparaben|FD-Score:-3.46|P-value:3.73E-4 ID:SGTC_2411|Compound:st077133|FD-Score:-4.46|P-value:7.04E-6 ID:SGTC_2414|Compound:st077232|FD-Score:3.61|P-value:2.44E-4 ID:SGTC_2415|Compound:st077333|FD-Score:-4.23|P-value:1.96E-5 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:4.00|P-value:5.51E-5 ID:SGTC_2592|Compound:piperlongumine|FD-Score:4.37|P-value:1.18E-5 ID:SGTC_2653|Compound:dihydrofissinolide|FD-Score:4.20|P-value:2.43E-5 ID:SGTC_2943|Compound:9068529|FD-Score:3.24|P-value:8.70E-4 ID:SGTC_2962|Compound:9082311|FD-Score:3.56|P-value:2.95E-4 ID:SGTC_3078|Compound:9116413|FD-Score:4.01|P-value:5.31E-5 ID:SGTC_3133|Compound:9127736|FD-Score:-3.78|P-value:1.18E-4 ID:SGTC_3183|Compound:9108214|FD-Score:-3.58|P-value:2.47E-4 ID:SGTC_3205|Compound:9113483|FD-Score:3.40|P-value:5.11E-4 ID:SGTC_3351|Compound:9150312|FD-Score:5.20|P-value:2.46E-7

Top fitness defect scores for YGL176C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_792 4534-1957 5.70 155.0 µM 1.73E-8 12 5.89E-9
2 SGTC_639 0833-0042 5.58 114.0 µM 3.46E-8 16 1.23E-8
3 SGTC_1027 k015-0025 5.56 8.7 µM 3.80E-8 6 1.36E-8
4 SGTC_905 2-aminofluorene 5.24 215.0 µM 2.00E-7 cell wall signaling 7 7.94E-8
5 SGTC_3351 9150312 5.20 21.6 µM 2.46E-7 cell wall 15 9.92E-8
6 SGTC_2592 piperlongumine 4.37 83.3 µM 1.18E-5 TSC3-RPN4 26 6.09E-6
7 SGTC_2653 dihydrofissinolide 4.20 100.0 µM 2.43E-5 2 1.31E-5
8 SGTC_1468 k284-1086 4.09 134.0 µM 3.95E-5 DNA intercalators 32 2.20E-5
9 SGTC_3078 9116413 4.01 49.5 µM 5.31E-5 unfolded protein response 35 3.02E-5
10 SGTC_2572 astragaloside iv 4.00 100.0 µM 5.51E-5 25 3.14E-5
11 SGTC_2111 5486399 3.81 200.0 µM 1.15E-4 55 6.84E-5
12 SGTC_647 0140-0236 3.64 81.0 µM 2.23E-4 16 1.39E-4
13 SGTC_1342 1486-1464 3.61 234.0 µM 2.41E-4 24 1.51E-4
14 SGTC_2414 st077232 3.61 92.9 µM 2.44E-4 35 1.52E-4
15 SGTC_1112 tnp00069 3.59 1.2 µM 2.59E-4 35 1.63E-4
16 SGTC_2326 6164455 3.57 177.6 µM 2.87E-4 mitochondrial processes 37 1.81E-4
17 SGTC_1451 4152-0210 3.56 104.0 µM 2.94E-4 38 1.86E-4
18 SGTC_2962 9082311 3.56 13.2 µM 2.95E-4 32 1.87E-4
19 SGTC_314 1671-0008 3.49 2.7 µM 3.71E-4 74 2.39E-4
20 SGTC_34 0469-0683 3.49 81.8 µM 3.78E-4 SWF1 & branched chain AA biosynthesis 39 2.43E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.092 8.17E-8 YFL032W_d YFL032W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene HAC1/YFL031W; YFL032W is not an essential gene
0.090 1.56E-7 YPR063C_p YPR063C_p hom ER-localized protein of unknown function
0.083 1.51E-6 YFL023W BUD27 hom Unconventional prefoldin protein involved in translation initiation; mutants have inappropriate expression of nutrient sensitive genes due to translational derepression of Gcn4p transcription factor; diploid mutants show random budding; ortholog of human URI/RMP
0.081 2.94E-6 YML130C ERO1 het Thiol oxidase required for oxidative protein folding in the ER; essential for maintaining proper redox balance in ER; feedback regulation of Ero1p occurs via reduction and oxidation of Ero1p regulatory bonds; reduced Pdi1p activates Ero1p by direct reduction of Ero1p regulatory bonds; depletion of thiol substrates and accumulation of oxidized Pdi1p results in inactivation of Ero1p by both Pdi1p-mediated oxidation and autonomous oxidation of Ero1p regulatory bonds
0.079 4.12E-6 YGR046W TAM41 het Mitochondrial protein required for cardiolipin biosynthesis; viability of null mutant is strain-dependent; mRNA is targeted to the bud; mutant displays defect in mitochondrial protein import, likely due to altered membrane lipid composition
0.079 5.03E-6 YEL032W MCM3 het Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex
0.078 5.78E-6 YDL069C CBS1 hom Mitochondrial translational activator of the COB mRNA; membrane protein that interacts with translating ribosomes, acts on the COB mRNA 5'-untranslated leader
0.077 7.13E-6 YIL141W_d YIL141W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.074 2.01E-5 YDL235C YPD1 het Phosphorelay intermediate protein, phosphorylated by the plasma membrane sensor Sln1p in response to osmotic stress and then in turn phosphorylates the response regulators Ssk1p in the cytosol and Skn7p in the nucleus
0.072 3.31E-5 YNL024C_p YNL024C_p hom Putative methyltransferase; has seven beta-strand methyltransferase motif; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; despite similarity to methyltransferases, null mutant does not display alterations in lysine methylation pattern
0.070 5.32E-5 YGL229C SAP4 hom Protein required for function of the Sit4p protein phosphatase, member of a family of similar proteins that form complexes with Sit4p, including Sap155p, Sap185p, and Sap190p
0.067 9.32E-5 YHR079C IRE1 hom Serine-threonine kinase and endoribonuclease; transmembrane protein that mediates the unfolded protein response (UPR) by regulating Hac1p synthesis through HAC1 mRNA splicing; Kar2p binds inactive Ire1p and releases from it upon ER stress
0.067 9.81E-5 YHR080C YHR080C hom Protein of unknown function; may interact with ribosomes, based on co-purification experiments; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YHR080C has a paralog, YSP2, that arose from the whole genome duplication
0.066 1.42E-4 YLR002C NOC3 het Component of a nuclear complex with Noc2p and pre-replicative complexes; the Noc2p-Noc3p complex binds to 66S ribosomal precursors to mediate their maturation and intranuclear transport; binds to chromatin at active replication origins, and is required for pre-RC formation and maintenance during DNA replication licensing
0.065 1.59E-4 YPL096W PNG1 hom Conserved peptide N-glycanase required for deglycosylation of misfolded glycoproteins during proteasome-dependent degradation; localizes to the cytoplasm and nucleus; activity is enhanced by interaction with Rad23p