Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YGL177W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Correlation | pval | ORF | Gene | Zygosity | Description |
---|---|---|---|---|---|
0.151 | 1.59E-18 | YGL004C | RPN14 | hom | Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasome regulatory particle (RP); null mutants accumulate ubiquitinated Gcn4p and display decreased 26S proteasome stability; interacts with Rpt5p |
0.118 | 7.38E-12 | YPL221W | FLC1 | hom | Putative FAD transporter; required for uptake of FAD into endoplasmic reticulum; involved in cell wall maintenance |
0.116 | 1.36E-11 | YHR021W-A_p | ECM12_p | hom | Putative protein of unknown function; may contribute to cell wall biosynthesis, mutants display zymolyase hypersensitivity |
0.107 | 5.30E-10 | YKL161C | KDX1 | hom | Protein kinase implicated in the Slt2p mitogen-activated (MAP) kinase signaling pathway; interacts with numerous components in the mating pheromone and CWI MAPK pathways; associates with Rlm1p |
0.103 | 2.02E-9 | YOR188W | MSB1 | hom | Protein of unknown function; may be involved in positive regulation of 1,3-beta-glucan synthesis and the Pkc1p-MAPK pathway; multicopy suppressor of temperature-sensitive mutations in CDC24 and CDC42, and of mutations in BEM4; potential Cdc28p substrate; relocalizes from bud neck to cytoplasm upon DNA replication stress |
0.097 | 1.78E-8 | YLR296W_d | YLR296W_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data |
0.093 | 7.64E-8 | YKL136W_d | YKL136W_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF APL2/YKL135C |
0.092 | 9.45E-8 | YOR190W | SPR1 | hom | Sporulation-specific exo-1,3-beta-glucanase; contributes to ascospore thermoresistance |
0.091 | 1.42E-7 | YDR024W_d | FYV1_d | hom | Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; mutation decreases survival upon exposure to K1 killer toxin |
0.089 | 2.77E-7 | YIL056W | VHR1 | hom | Transcriptional activator; required for the vitamin H-responsive element (VHRE) mediated induction of VHT1 (Vitamin H transporter) and BIO5 (biotin biosynthesis intermediate transporter) in response to low biotin concentrations; VHR1 has a paralog, VHR2, that arose from the whole genome duplication |
0.086 | 6.00E-7 | YNL149C | PGA2 | het | Essential protein required for maturation of Gas1p and Pho8p; involved in protein trafficking; GFP-fusion protein localizes to the ER and YFP-fusion protein to the nuclear envelope-ER network; null mutants have a cell separation defect |
0.084 | 1.15E-6 | YJL162C | JJJ2 | hom | Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein |
0.083 | 1.54E-6 | YDR376W | ARH1 | het | Oxidoreductase of the mitochondrial inner membrane, involved in cytoplasmic and mitochondrial iron homeostasis and required for activity of Fe-S cluster-containing enzymes; one of the few mitochondrial proteins essential for viability |
0.081 | 2.94E-6 | YJR128W_d | YJR128W_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RSF2 |
0.080 | 3.91E-6 | YGR045C_d | YGR045C_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data |