YGL177W_d

Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL177W / YGL177W

Click on Significant Values for Screen Details ID:SGTC_66|Compound:0109-0187|FD-Score:-3.68|P-value:2.33E-4 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:-3.29|P-value:8.63E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:3.53|P-value:5.87E-4 ID:SGTC_553|Compound:k007-0256|FD-Score:3.56|P-value:5.36E-4 ID:SGTC_555|Compound:4296-0685|FD-Score:4.44|P-value:2.08E-5 ID:SGTC_559|Compound:1550-0661|FD-Score:-3.92|P-value:9.55E-5 ID:SGTC_565|Compound:1418-0001|FD-Score:-3.33|P-value:7.37E-4 ID:SGTC_599|Compound:1935-0052|FD-Score:3.80|P-value:2.39E-4 ID:SGTC_633|Compound:0437-0093|FD-Score:7.10|P-value:2.31E-11 ID:SGTC_652|Compound:0437-0092|FD-Score:4.05|P-value:9.55E-5 ID:SGTC_714|Compound:4296-0578|FD-Score:3.81|P-value:2.31E-4 ID:SGTC_718|Compound:1130-0073|FD-Score:-4.56|P-value:7.71E-6 ID:SGTC_823|Compound:0417-1665|FD-Score:4.59|P-value:1.13E-5 ID:SGTC_972|Compound:1319-0219|FD-Score:3.58|P-value:5.04E-4 ID:SGTC_1299|Compound:1079-1439|FD-Score:4.14|P-value:6.87E-5 ID:SGTC_1626|Compound:st003712|FD-Score:4.26|P-value:4.33E-5 ID:SGTC_1674|Compound:st016616|FD-Score:3.67|P-value:3.65E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:4.59|P-value:1.16E-5 ID:SGTC_1720|Compound:st037298|FD-Score:7.09|P-value:2.48E-11 ID:SGTC_1722|Compound:st034304|FD-Score:3.61|P-value:4.57E-4 ID:SGTC_1814|Compound:st052110|FD-Score:3.70|P-value:3.31E-4 ID:SGTC_1856|Compound:st057054|FD-Score:4.94|P-value:2.54E-6 ID:SGTC_1932|Compound:st074806|FD-Score:-3.42|P-value:5.63E-4 ID:SGTC_1935|Compound:st074532|FD-Score:-4.34|P-value:1.90E-5 ID:SGTC_2067|Compound:5224629|FD-Score:4.33|P-value:3.23E-5 ID:SGTC_2269|Compound:7935389|FD-Score:-3.61|P-value:2.97E-4 ID:SGTC_2461|Compound:5755302|FD-Score:-3.91|P-value:9.88E-5 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:4.89|P-value:3.11E-6 ID:SGTC_2759|Compound:disulfiram|FD-Score:3.57|P-value:5.17E-4 ID:SGTC_2762|Compound:leflunomide|FD-Score:4.59|P-value:1.13E-5 ID:SGTC_2809|Compound:7964133|FD-Score:3.59|P-value:4.84E-4 ID:SGTC_2886|Compound:9058944|FD-Score:-3.68|P-value:2.33E-4 ID:SGTC_2891|Compound:9063876|FD-Score:-3.73|P-value:1.93E-4 ID:SGTC_2974|Compound:9094440|FD-Score:6.37|P-value:1.80E-9 ID:SGTC_3027|Compound:9089541|FD-Score:3.39|P-value:9.31E-4 ID:SGTC_3032|Compound:9089427|FD-Score:3.97|P-value:1.26E-4 ID:SGTC_3038|Compound:9091290|FD-Score:3.61|P-value:4.49E-4 ID:SGTC_66|Compound:0109-0187|FD-Score:-3.68|P-value:2.33E-4 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:-3.29|P-value:8.63E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:3.53|P-value:5.87E-4 ID:SGTC_553|Compound:k007-0256|FD-Score:3.56|P-value:5.36E-4 ID:SGTC_555|Compound:4296-0685|FD-Score:4.44|P-value:2.08E-5 ID:SGTC_559|Compound:1550-0661|FD-Score:-3.92|P-value:9.55E-5 ID:SGTC_565|Compound:1418-0001|FD-Score:-3.33|P-value:7.37E-4 ID:SGTC_599|Compound:1935-0052|FD-Score:3.80|P-value:2.39E-4 ID:SGTC_633|Compound:0437-0093|FD-Score:7.10|P-value:2.31E-11 ID:SGTC_652|Compound:0437-0092|FD-Score:4.05|P-value:9.55E-5 ID:SGTC_714|Compound:4296-0578|FD-Score:3.81|P-value:2.31E-4 ID:SGTC_718|Compound:1130-0073|FD-Score:-4.56|P-value:7.71E-6 ID:SGTC_823|Compound:0417-1665|FD-Score:4.59|P-value:1.13E-5 ID:SGTC_972|Compound:1319-0219|FD-Score:3.58|P-value:5.04E-4 ID:SGTC_1299|Compound:1079-1439|FD-Score:4.14|P-value:6.87E-5 ID:SGTC_1626|Compound:st003712|FD-Score:4.26|P-value:4.33E-5 ID:SGTC_1674|Compound:st016616|FD-Score:3.67|P-value:3.65E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:4.59|P-value:1.16E-5 ID:SGTC_1720|Compound:st037298|FD-Score:7.09|P-value:2.48E-11 ID:SGTC_1722|Compound:st034304|FD-Score:3.61|P-value:4.57E-4 ID:SGTC_1814|Compound:st052110|FD-Score:3.70|P-value:3.31E-4 ID:SGTC_1856|Compound:st057054|FD-Score:4.94|P-value:2.54E-6 ID:SGTC_1932|Compound:st074806|FD-Score:-3.42|P-value:5.63E-4 ID:SGTC_1935|Compound:st074532|FD-Score:-4.34|P-value:1.90E-5 ID:SGTC_2067|Compound:5224629|FD-Score:4.33|P-value:3.23E-5 ID:SGTC_2269|Compound:7935389|FD-Score:-3.61|P-value:2.97E-4 ID:SGTC_2461|Compound:5755302|FD-Score:-3.91|P-value:9.88E-5 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:4.89|P-value:3.11E-6 ID:SGTC_2759|Compound:disulfiram|FD-Score:3.57|P-value:5.17E-4 ID:SGTC_2762|Compound:leflunomide|FD-Score:4.59|P-value:1.13E-5 ID:SGTC_2809|Compound:7964133|FD-Score:3.59|P-value:4.84E-4 ID:SGTC_2886|Compound:9058944|FD-Score:-3.68|P-value:2.33E-4 ID:SGTC_2891|Compound:9063876|FD-Score:-3.73|P-value:1.93E-4 ID:SGTC_2974|Compound:9094440|FD-Score:6.37|P-value:1.80E-9 ID:SGTC_3027|Compound:9089541|FD-Score:3.39|P-value:9.31E-4 ID:SGTC_3032|Compound:9089427|FD-Score:3.97|P-value:1.26E-4 ID:SGTC_3038|Compound:9091290|FD-Score:3.61|P-value:4.49E-4

Top fitness defect scores for YGL177W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_633 0437-0093 7.10 97.7 µM 2.31E-11 DNA intercalators 3 6.34E-13
2 SGTC_1720 st037298 7.09 9.5 µM 2.48E-11 7 6.89E-13
3 SGTC_2974 9094440 6.37 9.7 µM 1.80E-9 ergosterol biosynthesis 8 9.43E-11
4 SGTC_1856 st057054 4.94 55.7 µM 2.54E-6 13 3.95E-7
5 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 4.89 100.0 µM 3.11E-6 60S ribosome export 10 4.99E-7
6 SGTC_2762 leflunomide 4.59 42.1 µM 1.13E-5 13 2.21E-6
7 SGTC_823 0417-1665 4.59 178.0 µM 1.13E-5 30 2.21E-6
8 SGTC_1718 roemerine 4.59 11.9 µM 1.16E-5 redox potentiating 29 2.26E-6
9 SGTC_555 4296-0685 4.44 37.0 µM 2.08E-5 ergosterol biosynthesis 4 4.44E-6
10 SGTC_2067 5224629 4.33 34.1 µM 3.23E-5 15 7.36E-6
11 SGTC_1626 st003712 4.26 1.8 µM 4.33E-5 16 1.03E-5
12 SGTC_1299 1079-1439 4.14 3.7 µM 6.87E-5 TSC3-RPN4 10 1.75E-5
13 SGTC_652 0437-0092 4.05 114.0 µM 9.55E-5 12 2.56E-5
14 SGTC_3032 9089427 3.97 49.5 µM 1.26E-4 60S ribosome export 15 3.54E-5
15 SGTC_714 4296-0578 3.81 26.1 µM 2.31E-4 2 7.08E-5
16 SGTC_599 1935-0052 3.80 86.5 µM 2.39E-4 22 7.37E-5
17 SGTC_1814 st052110 3.70 31.5 µM 3.31E-4 RNA processing & uracil transport 14 1.07E-4
18 SGTC_1674 st016616 3.67 23.6 µM 3.65E-4 35 1.20E-4
19 SGTC_3038 9091290 3.61 49.5 µM 4.49E-4 23 1.52E-4
20 SGTC_1722 st034304 3.61 3.6 µM 4.57E-4 mitochondrial processes 42 1.55E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.151 1.59E-18 YGL004C RPN14 hom Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasome regulatory particle (RP); null mutants accumulate ubiquitinated Gcn4p and display decreased 26S proteasome stability; interacts with Rpt5p
0.118 7.38E-12 YPL221W FLC1 hom Putative FAD transporter; required for uptake of FAD into endoplasmic reticulum; involved in cell wall maintenance
0.116 1.36E-11 YHR021W-A_p ECM12_p hom Putative protein of unknown function; may contribute to cell wall biosynthesis, mutants display zymolyase hypersensitivity
0.107 5.30E-10 YKL161C KDX1 hom Protein kinase implicated in the Slt2p mitogen-activated (MAP) kinase signaling pathway; interacts with numerous components in the mating pheromone and CWI MAPK pathways; associates with Rlm1p
0.103 2.02E-9 YOR188W MSB1 hom Protein of unknown function; may be involved in positive regulation of 1,3-beta-glucan synthesis and the Pkc1p-MAPK pathway; multicopy suppressor of temperature-sensitive mutations in CDC24 and CDC42, and of mutations in BEM4; potential Cdc28p substrate; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.097 1.78E-8 YLR296W_d YLR296W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.093 7.64E-8 YKL136W_d YKL136W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF APL2/YKL135C
0.092 9.45E-8 YOR190W SPR1 hom Sporulation-specific exo-1,3-beta-glucanase; contributes to ascospore thermoresistance
0.091 1.42E-7 YDR024W_d FYV1_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; mutation decreases survival upon exposure to K1 killer toxin
0.089 2.77E-7 YIL056W VHR1 hom Transcriptional activator; required for the vitamin H-responsive element (VHRE) mediated induction of VHT1 (Vitamin H transporter) and BIO5 (biotin biosynthesis intermediate transporter) in response to low biotin concentrations; VHR1 has a paralog, VHR2, that arose from the whole genome duplication
0.086 6.00E-7 YNL149C PGA2 het Essential protein required for maturation of Gas1p and Pho8p; involved in protein trafficking; GFP-fusion protein localizes to the ER and YFP-fusion protein to the nuclear envelope-ER network; null mutants have a cell separation defect
0.084 1.15E-6 YJL162C JJJ2 hom Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
0.083 1.54E-6 YDR376W ARH1 het Oxidoreductase of the mitochondrial inner membrane, involved in cytoplasmic and mitochondrial iron homeostasis and required for activity of Fe-S cluster-containing enzymes; one of the few mitochondrial proteins essential for viability
0.081 2.94E-6 YJR128W_d YJR128W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RSF2
0.080 3.91E-6 YGR045C_d YGR045C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data