YGL178W / MPT5

mRNA-binding protein of the PUF family; binds to the 3' UTR of specific mRNAs, including those involved in mating type switching, cell wall integrity, chronological lifespan, chromatin modification, and spindle pole body architecture; recruits the CCR4-NOT deadenylase complex to mRNAs along with Dhh1p and Dcp1p to promote deadenylation, decapping, and decay; also interacts with the Caf20p translational initiation repressor, affecting its mRNA target specificity

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL178W / MPT5

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:5.83|P-value:5.50E-11 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:2.85|P-value:7.98E-4 ID:SGTC_304|Compound:1310-0298|FD-Score:2.82|P-value:8.85E-4 ID:SGTC_380|Compound:3970-0968|FD-Score:-2.96|P-value:5.31E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:4.43|P-value:4.72E-7 ID:SGTC_702|Compound:1488-0190|FD-Score:3.39|P-value:8.61E-5 ID:SGTC_738|Compound:1315-0003|FD-Score:5.01|P-value:1.45E-8 ID:SGTC_752|Compound:1896-0090|FD-Score:-3.11|P-value:2.91E-4 ID:SGTC_878|Compound:0828-0289|FD-Score:2.80|P-value:9.65E-4 ID:SGTC_894|Compound:0960-0238|FD-Score:4.17|P-value:1.96E-6 ID:SGTC_958|Compound:1222-0007|FD-Score:2.86|P-value:7.86E-4 ID:SGTC_994|Compound:3910-0338|FD-Score:3.14|P-value:2.51E-4 ID:SGTC_1004|Compound:4084-0029|FD-Score:4.27|P-value:1.15E-6 ID:SGTC_1167|Compound:k781-0610|FD-Score:3.61|P-value:3.28E-5 ID:SGTC_1259|Compound:0671-0132|FD-Score:2.99|P-value:4.65E-4 ID:SGTC_1523|Compound:st012844|FD-Score:2.94|P-value:5.78E-4 ID:SGTC_1528|Compound:arabinosylhypoxanthine|FD-Score:2.94|P-value:5.60E-4 ID:SGTC_1596|Compound:piperlongumine|FD-Score:-3.75|P-value:1.70E-5 ID:SGTC_1632|Compound:st005650|FD-Score:3.46|P-value:6.46E-5 ID:SGTC_1635|Compound:st007035|FD-Score:3.60|P-value:3.46E-5 ID:SGTC_1996|Compound:st072960|FD-Score:3.10|P-value:3.03E-4 ID:SGTC_2083|Compound:5306046|FD-Score:4.33|P-value:8.33E-7 ID:SGTC_2096|Compound:5468907|FD-Score:3.06|P-value:3.57E-4 ID:SGTC_2123|Compound:5259487|FD-Score:3.52|P-value:4.99E-5 ID:SGTC_2141|Compound:5621638|FD-Score:4.26|P-value:1.19E-6 ID:SGTC_2147|Compound:5545932|FD-Score:-3.55|P-value:4.27E-5 ID:SGTC_2153|Compound:5569715|FD-Score:-3.78|P-value:1.43E-5 ID:SGTC_2293|Compound:7624732|FD-Score:-2.83|P-value:8.56E-4 ID:SGTC_2323|Compound:6148992|FD-Score:-2.87|P-value:7.38E-4 ID:SGTC_2327|Compound:6189656|FD-Score:3.96|P-value:5.90E-6 ID:SGTC_2417|Compound:cerulenin|FD-Score:-5.02|P-value:1.36E-8 ID:SGTC_2488|Compound:5268135|FD-Score:3.31|P-value:1.26E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:13.10|P-value:1.11E-47 ID:SGTC_2583|Compound:asiatic acid|FD-Score:3.53|P-value:4.74E-5 ID:SGTC_2584|Compound:androsterone|FD-Score:4.20|P-value:1.65E-6 ID:SGTC_2640|Compound:pentamidine|FD-Score:3.99|P-value:5.03E-6 ID:SGTC_2645|Compound:abamectin|FD-Score:3.44|P-value:6.90E-5 ID:SGTC_2705|Compound:st078069|FD-Score:3.26|P-value:1.55E-4 ID:SGTC_2707|Compound:st078556|FD-Score:6.35|P-value:1.08E-12 ID:SGTC_2711|Compound:st079103|FD-Score:2.80|P-value:9.64E-4 ID:SGTC_2717|Compound:st081029|FD-Score:3.22|P-value:1.83E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:3.52|P-value:4.82E-5 ID:SGTC_2802|Compound:7925815|FD-Score:4.99|P-value:1.66E-8 ID:SGTC_2925|Compound:9010536|FD-Score:-2.86|P-value:7.77E-4 ID:SGTC_2927|Compound:9011802|FD-Score:5.22|P-value:3.89E-9 ID:SGTC_3010|Compound:9080089|FD-Score:4.81|P-value:5.18E-8 ID:SGTC_3011|Compound:9081274|FD-Score:3.56|P-value:4.09E-5 ID:SGTC_3013|Compound:9080133|FD-Score:4.17|P-value:1.94E-6 ID:SGTC_3028|Compound:9087778|FD-Score:-3.64|P-value:2.86E-5 ID:SGTC_3045|Compound:9092950|FD-Score:3.03|P-value:3.94E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:5.83|P-value:5.50E-11 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:2.85|P-value:7.98E-4 ID:SGTC_304|Compound:1310-0298|FD-Score:2.82|P-value:8.85E-4 ID:SGTC_380|Compound:3970-0968|FD-Score:-2.96|P-value:5.31E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:4.43|P-value:4.72E-7 ID:SGTC_702|Compound:1488-0190|FD-Score:3.39|P-value:8.61E-5 ID:SGTC_738|Compound:1315-0003|FD-Score:5.01|P-value:1.45E-8 ID:SGTC_752|Compound:1896-0090|FD-Score:-3.11|P-value:2.91E-4 ID:SGTC_878|Compound:0828-0289|FD-Score:2.80|P-value:9.65E-4 ID:SGTC_894|Compound:0960-0238|FD-Score:4.17|P-value:1.96E-6 ID:SGTC_958|Compound:1222-0007|FD-Score:2.86|P-value:7.86E-4 ID:SGTC_994|Compound:3910-0338|FD-Score:3.14|P-value:2.51E-4 ID:SGTC_1004|Compound:4084-0029|FD-Score:4.27|P-value:1.15E-6 ID:SGTC_1167|Compound:k781-0610|FD-Score:3.61|P-value:3.28E-5 ID:SGTC_1259|Compound:0671-0132|FD-Score:2.99|P-value:4.65E-4 ID:SGTC_1523|Compound:st012844|FD-Score:2.94|P-value:5.78E-4 ID:SGTC_1528|Compound:arabinosylhypoxanthine|FD-Score:2.94|P-value:5.60E-4 ID:SGTC_1596|Compound:piperlongumine|FD-Score:-3.75|P-value:1.70E-5 ID:SGTC_1632|Compound:st005650|FD-Score:3.46|P-value:6.46E-5 ID:SGTC_1635|Compound:st007035|FD-Score:3.60|P-value:3.46E-5 ID:SGTC_1996|Compound:st072960|FD-Score:3.10|P-value:3.03E-4 ID:SGTC_2083|Compound:5306046|FD-Score:4.33|P-value:8.33E-7 ID:SGTC_2096|Compound:5468907|FD-Score:3.06|P-value:3.57E-4 ID:SGTC_2123|Compound:5259487|FD-Score:3.52|P-value:4.99E-5 ID:SGTC_2141|Compound:5621638|FD-Score:4.26|P-value:1.19E-6 ID:SGTC_2147|Compound:5545932|FD-Score:-3.55|P-value:4.27E-5 ID:SGTC_2153|Compound:5569715|FD-Score:-3.78|P-value:1.43E-5 ID:SGTC_2293|Compound:7624732|FD-Score:-2.83|P-value:8.56E-4 ID:SGTC_2323|Compound:6148992|FD-Score:-2.87|P-value:7.38E-4 ID:SGTC_2327|Compound:6189656|FD-Score:3.96|P-value:5.90E-6 ID:SGTC_2417|Compound:cerulenin|FD-Score:-5.02|P-value:1.36E-8 ID:SGTC_2488|Compound:5268135|FD-Score:3.31|P-value:1.26E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:13.10|P-value:1.11E-47 ID:SGTC_2583|Compound:asiatic acid|FD-Score:3.53|P-value:4.74E-5 ID:SGTC_2584|Compound:androsterone|FD-Score:4.20|P-value:1.65E-6 ID:SGTC_2640|Compound:pentamidine|FD-Score:3.99|P-value:5.03E-6 ID:SGTC_2645|Compound:abamectin|FD-Score:3.44|P-value:6.90E-5 ID:SGTC_2705|Compound:st078069|FD-Score:3.26|P-value:1.55E-4 ID:SGTC_2707|Compound:st078556|FD-Score:6.35|P-value:1.08E-12 ID:SGTC_2711|Compound:st079103|FD-Score:2.80|P-value:9.64E-4 ID:SGTC_2717|Compound:st081029|FD-Score:3.22|P-value:1.83E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:3.52|P-value:4.82E-5 ID:SGTC_2802|Compound:7925815|FD-Score:4.99|P-value:1.66E-8 ID:SGTC_2925|Compound:9010536|FD-Score:-2.86|P-value:7.77E-4 ID:SGTC_2927|Compound:9011802|FD-Score:5.22|P-value:3.89E-9 ID:SGTC_3010|Compound:9080089|FD-Score:4.81|P-value:5.18E-8 ID:SGTC_3011|Compound:9081274|FD-Score:3.56|P-value:4.09E-5 ID:SGTC_3013|Compound:9080133|FD-Score:4.17|P-value:1.94E-6 ID:SGTC_3028|Compound:9087778|FD-Score:-3.64|P-value:2.86E-5 ID:SGTC_3045|Compound:9092950|FD-Score:3.03|P-value:3.94E-4

Top fitness defect scores for YGL178W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2582 agaric acid 13.10 100.0 µM 1.11E-47 redox potentiating 27 2.62E-39
2 SGTC_2707 st078556 6.35 66.6 µM 1.08E-12 1 1.10E-10
3 SGTC_58 0957-0393 5.83 9.0 µM 5.50E-11 cell wall 220 2.77E-9
4 SGTC_2927 9011802 5.22 47.9 µM 3.89E-9 9 9.13E-8
5 SGTC_738 1315-0003 5.01 72.4 µM 1.45E-8 8 2.69E-7
6 SGTC_2802 7925815 4.99 54.5 µM 1.66E-8 17 3.01E-7
7 SGTC_3010 9080089 4.81 71.4 µM 5.18E-8 3 7.66E-7
8 SGTC_453 enantio-paf c16 4.43 10.0 µM 4.72E-7 112 4.72E-6
9 SGTC_2083 5306046 4.33 65.9 µM 8.33E-7 18 7.53E-6
10 SGTC_1004 4084-0029 4.27 199.0 µM 1.15E-6 10 9.79E-6
11 SGTC_2141 5621638 4.26 7.7 µM 1.19E-6 tubulin folding & SWR complex 30 1.01E-5
12 SGTC_2584 androsterone 4.20 48.7 µM 1.65E-6 cell wall 116 1.32E-5
13 SGTC_3013 9080133 4.17 71.4 µM 1.94E-6 17 1.51E-5
14 SGTC_894 0960-0238 4.17 55.9 µM 1.96E-6 7 1.52E-5
15 SGTC_2640 pentamidine 3.99 10.4 µM 5.03E-6 mitochondrial processes 33 3.31E-5
16 SGTC_2327 6189656 3.96 200.0 µM 5.90E-6 24 3.78E-5
17 SGTC_1167 k781-0610 3.61 148.0 µM 3.28E-5 RNA processing & uracil transport 39 1.55E-4
18 SGTC_1635 st007035 3.60 42.4 µM 3.46E-5 240 1.62E-4
19 SGTC_3011 9081274 3.56 71.4 µM 4.09E-5 28 1.86E-4
20 SGTC_2583 asiatic acid 3.53 100.0 µM 4.74E-5 50 2.10E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.373 2.58E-111 YNL106C INP52 hom Polyphosphatidylinositol phosphatase, dephosphorylates a number of phosphatidylinositols (PIs) to PI; involved in endocytosis; hyperosmotic stress causes translocation to actin patches; synaptojanin-like protein with a Sac1 domain
0.367 1.02E-107 YML103C NUP188 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188
0.318 1.30E-79 YML101C-A_d YML101C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.314 1.29E-77 YEL007W MIT1 hom Transcriptional regulator of pseudohyphal growth; protein with sequence similarity to S. pombe gti1+ (gluconate transport inducer 1) and C. albicans Wor1
0.305 2.60E-73 YOR049C RSB1 hom Suppressor of sphingoid long chain base (LCB) sensitivity of an LCB-lyase mutation; putative integral membrane transporter or flippase that may transport LCBs from the cytoplasmic side toward the extracytoplasmic side of the membrane
0.295 3.03E-68 YOR050C_d YOR050C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutation is viable
0.294 7.25E-68 YMR109W MYO5 hom One of two type I myosins; contains proline-rich tail homology 2 (TH2) and SH3 domains; MYO5 deletion has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization
0.291 1.84E-66 YML102W CAC2 hom Subunit of chromatin assembly factor I (CAF-1), with Rlf2p and Msi1p; chromatin assembly by CAF-1 is important for multiple processes including silencing at telomeres, mating type loci, and rDNA; maintenance of kinetochore structure; deactivation of the DNA damage checkpoint after DNA repair; and chromatin dynamics during transcription
0.286 2.22E-64 YNL027W CRZ1 hom Transcription factor, activates transcription of stress response genes; nuclear localization is positively regulated by calcineurin-mediated dephosphorylation; rapidly localizes to the nucleus under blue light stress
0.278 2.52E-60 YNL215W IES2 hom Protein that associates with the INO80 chromatin remodeling complex; associates with the INO80 complex under low-salt conditions; essential for growth under anaerobic conditions; protein abundance increases in response to DNA replication stress
0.269 8.36E-57 YBR134W_d YBR134W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.253 3.85E-50 YOL003C PFA4 hom Palmitoyltransferase with autoacylation activity, required for palmitoylation of amino acid permeases containing a C-terminal Phe-Trp-Cys site; required for modification of Chs3p; member of the DHHC family of putative palmitoyltransferases
0.248 4.44E-48 YIL111W COX5B hom Subunit Vb of cytochrome c oxidase; cytochrome c oxidase is the terminal member of the mitochondrial inner membrane electron transport chain; Cox5Bp is predominantly expressed during anaerobic growth while its isoform Va (Cox5Ap) is expressed during aerobic growth; COX5B has a paralog, COX5A, that arose from the whole genome duplication
0.246 2.72E-47 YMR214W SCJ1 hom One of several homologs of bacterial chaperone DnaJ, located in the ER lumen where it cooperates with Kar2p to mediate maturation of proteins
0.245 3.52E-47 YML052W SUR7 hom Plasma membrane protein that localizes to furrow-like invaginations (MCC patches); component of eisosomes; associated with endocytosis, along with Pil1p and Lsp1p; sporulation and plasma membrane sphingolipid content are altered in mutants