YGL180W / ATG1

Protein ser/thr kinase required for vesicle formation in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; structurally required for phagophore assembly site formation; during autophagy forms a complex with Atg13p and Atg17p

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL180W / ATG1

Click on Significant Values for Screen Details ID:SGTC_53|Compound:0973-0023|FD-Score:4.26|P-value:3.90E-6 ID:SGTC_87|Compound:0100-0052|FD-Score:4.19|P-value:5.59E-6 ID:SGTC_353|Compound:1988-1175|FD-Score:-3.71|P-value:4.58E-5 ID:SGTC_428|Compound:3448-4153|FD-Score:-3.40|P-value:1.64E-4 ID:SGTC_550|Compound:4123-0385|FD-Score:6.07|P-value:9.18E-11 ID:SGTC_970|Compound:1315-0089|FD-Score:3.28|P-value:3.00E-4 ID:SGTC_980|Compound:1473-0395|FD-Score:3.29|P-value:2.82E-4 ID:SGTC_1073|Compound:triclabendazole|FD-Score:-3.87|P-value:2.19E-5 ID:SGTC_1140|Compound:3229-1848|FD-Score:-3.53|P-value:9.73E-5 ID:SGTC_1145|Compound:3546-0597|FD-Score:2.99|P-value:8.77E-4 ID:SGTC_1152|Compound:3909-8331|FD-Score:3.67|P-value:6.02E-5 ID:SGTC_1157|Compound:4092-0394|FD-Score:-4.21|P-value:4.54E-6 ID:SGTC_1164|Compound:k060-0068|FD-Score:3.28|P-value:2.99E-4 ID:SGTC_1284|Compound:0929-0043|FD-Score:3.57|P-value:9.13E-5 ID:SGTC_1449|Compound:4112-4002|FD-Score:3.29|P-value:2.82E-4 ID:SGTC_1479|Compound:0549-0158|FD-Score:3.43|P-value:1.61E-4 ID:SGTC_1736|Compound:st036774|FD-Score:3.35|P-value:2.21E-4 ID:SGTC_1738|Compound:st035555|FD-Score:-3.59|P-value:7.71E-5 ID:SGTC_1869|Compound:3',7'-dimethoxyflavone|FD-Score:2.98|P-value:8.99E-4 ID:SGTC_2067|Compound:5224629|FD-Score:2.97|P-value:9.43E-4 ID:SGTC_2106|Compound:5357045|FD-Score:3.46|P-value:1.43E-4 ID:SGTC_2116|Compound:5511452|FD-Score:-3.00|P-value:7.68E-4 ID:SGTC_2117|Compound:5521686|FD-Score:-3.66|P-value:5.58E-5 ID:SGTC_2125|Compound:5246583|FD-Score:5.44|P-value:5.64E-9 ID:SGTC_2127|Compound:5253358|FD-Score:-3.21|P-value:3.45E-4 ID:SGTC_2132|Compound:5317594|FD-Score:3.53|P-value:1.08E-4 ID:SGTC_2282|Compound:7944268|FD-Score:3.14|P-value:5.06E-4 ID:SGTC_2287|Compound:7945887|FD-Score:3.33|P-value:2.42E-4 ID:SGTC_2336|Compound:9001819|FD-Score:-3.23|P-value:3.29E-4 ID:SGTC_2446|Compound:5162541|FD-Score:3.58|P-value:8.87E-5 ID:SGTC_2513|Compound:baicalein|FD-Score:4.73|P-value:3.46E-7 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:-3.31|P-value:2.42E-4 ID:SGTC_2610|Compound:ononetin|FD-Score:3.33|P-value:2.44E-4 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:5.23|P-value:2.07E-8 ID:SGTC_2834|Compound:9001755|FD-Score:-3.06|P-value:6.10E-4 ID:SGTC_2857|Compound:9024691|FD-Score:3.50|P-value:1.25E-4 ID:SGTC_2983|Compound:9022671|FD-Score:-3.11|P-value:5.22E-4 ID:SGTC_2988|Compound:9073640|FD-Score:5.36|P-value:9.23E-9 ID:SGTC_3138|Compound:9097216|FD-Score:2.99|P-value:8.76E-4 ID:SGTC_3190|Compound:9110366|FD-Score:-3.47|P-value:1.26E-4 ID:SGTC_3191|Compound:9110352|FD-Score:3.70|P-value:5.29E-5 ID:SGTC_3268|Compound:9137683|FD-Score:3.06|P-value:6.67E-4 ID:SGTC_3325|Compound:9138760|FD-Score:3.22|P-value:3.76E-4 ID:SGTC_53|Compound:0973-0023|FD-Score:4.26|P-value:3.90E-6 ID:SGTC_87|Compound:0100-0052|FD-Score:4.19|P-value:5.59E-6 ID:SGTC_353|Compound:1988-1175|FD-Score:-3.71|P-value:4.58E-5 ID:SGTC_428|Compound:3448-4153|FD-Score:-3.40|P-value:1.64E-4 ID:SGTC_550|Compound:4123-0385|FD-Score:6.07|P-value:9.18E-11 ID:SGTC_970|Compound:1315-0089|FD-Score:3.28|P-value:3.00E-4 ID:SGTC_980|Compound:1473-0395|FD-Score:3.29|P-value:2.82E-4 ID:SGTC_1073|Compound:triclabendazole|FD-Score:-3.87|P-value:2.19E-5 ID:SGTC_1140|Compound:3229-1848|FD-Score:-3.53|P-value:9.73E-5 ID:SGTC_1145|Compound:3546-0597|FD-Score:2.99|P-value:8.77E-4 ID:SGTC_1152|Compound:3909-8331|FD-Score:3.67|P-value:6.02E-5 ID:SGTC_1157|Compound:4092-0394|FD-Score:-4.21|P-value:4.54E-6 ID:SGTC_1164|Compound:k060-0068|FD-Score:3.28|P-value:2.99E-4 ID:SGTC_1284|Compound:0929-0043|FD-Score:3.57|P-value:9.13E-5 ID:SGTC_1449|Compound:4112-4002|FD-Score:3.29|P-value:2.82E-4 ID:SGTC_1479|Compound:0549-0158|FD-Score:3.43|P-value:1.61E-4 ID:SGTC_1736|Compound:st036774|FD-Score:3.35|P-value:2.21E-4 ID:SGTC_1738|Compound:st035555|FD-Score:-3.59|P-value:7.71E-5 ID:SGTC_1869|Compound:3',7'-dimethoxyflavone|FD-Score:2.98|P-value:8.99E-4 ID:SGTC_2067|Compound:5224629|FD-Score:2.97|P-value:9.43E-4 ID:SGTC_2106|Compound:5357045|FD-Score:3.46|P-value:1.43E-4 ID:SGTC_2116|Compound:5511452|FD-Score:-3.00|P-value:7.68E-4 ID:SGTC_2117|Compound:5521686|FD-Score:-3.66|P-value:5.58E-5 ID:SGTC_2125|Compound:5246583|FD-Score:5.44|P-value:5.64E-9 ID:SGTC_2127|Compound:5253358|FD-Score:-3.21|P-value:3.45E-4 ID:SGTC_2132|Compound:5317594|FD-Score:3.53|P-value:1.08E-4 ID:SGTC_2282|Compound:7944268|FD-Score:3.14|P-value:5.06E-4 ID:SGTC_2287|Compound:7945887|FD-Score:3.33|P-value:2.42E-4 ID:SGTC_2336|Compound:9001819|FD-Score:-3.23|P-value:3.29E-4 ID:SGTC_2446|Compound:5162541|FD-Score:3.58|P-value:8.87E-5 ID:SGTC_2513|Compound:baicalein|FD-Score:4.73|P-value:3.46E-7 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:-3.31|P-value:2.42E-4 ID:SGTC_2610|Compound:ononetin|FD-Score:3.33|P-value:2.44E-4 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:5.23|P-value:2.07E-8 ID:SGTC_2834|Compound:9001755|FD-Score:-3.06|P-value:6.10E-4 ID:SGTC_2857|Compound:9024691|FD-Score:3.50|P-value:1.25E-4 ID:SGTC_2983|Compound:9022671|FD-Score:-3.11|P-value:5.22E-4 ID:SGTC_2988|Compound:9073640|FD-Score:5.36|P-value:9.23E-9 ID:SGTC_3138|Compound:9097216|FD-Score:2.99|P-value:8.76E-4 ID:SGTC_3190|Compound:9110366|FD-Score:-3.47|P-value:1.26E-4 ID:SGTC_3191|Compound:9110352|FD-Score:3.70|P-value:5.29E-5 ID:SGTC_3268|Compound:9137683|FD-Score:3.06|P-value:6.67E-4 ID:SGTC_3325|Compound:9138760|FD-Score:3.22|P-value:3.76E-4

Top fitness defect scores for YGL180W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_550 4123-0385 6.07 25.7 µM 9.18E-11 TSC3-RPN4 5 6.22E-10
2 SGTC_2125 5246583 5.44 200.0 µM 5.64E-9 tubulin folding & SWR complex 20 2.62E-8
3 SGTC_2988 9073640 5.36 71.4 µM 9.23E-9 8 4.11E-8
4 SGTC_2615 purpurogallin-4-carboxylic acid 5.23 100.0 µM 2.07E-8 redox potentiating 37 8.56E-8
5 SGTC_2513 baicalein 4.73 25.6 µM 3.46E-7 calcium & mitochondrial duress 14 1.11E-6
6 SGTC_53 0973-0023 4.26 40.0 µM 3.90E-6 RNA processing & uracil transport 11 1.00E-5
7 SGTC_87 0100-0052 4.19 35.5 µM 5.59E-6 95 1.39E-5
8 SGTC_3191 9110352 3.70 49.5 µM 5.29E-5 15 1.08E-4
9 SGTC_1152 3909-8331 3.67 15.9 µM 6.02E-5 15 1.22E-4
10 SGTC_2446 5162541 3.58 200.0 µM 8.87E-5 18 1.73E-4
11 SGTC_1284 0929-0043 3.57 16.0 µM 9.13E-5 36 1.78E-4
12 SGTC_2132 5317594 3.53 122.7 µM 1.08E-4 SWF1 & branched chain AA biosynthesis 34 2.08E-4
13 SGTC_2857 9024691 3.50 58.4 µM 1.25E-4 37 2.36E-4
14 SGTC_2106 5357045 3.46 167.3 µM 1.43E-4 32 2.68E-4
15 SGTC_1479 0549-0158 3.43 134.0 µM 1.61E-4 51 2.98E-4
16 SGTC_1736 st036774 3.35 51.0 µM 2.21E-4 58 3.98E-4
17 SGTC_2287 7945887 3.33 168.8 µM 2.42E-4 16 4.33E-4
18 SGTC_2610 ononetin 3.33 44.2 µM 2.44E-4 72 4.37E-4
19 SGTC_980 1473-0395 3.29 201.0 µM 2.82E-4 27 4.98E-4
20 SGTC_1449 4112-4002 3.29 201.0 µM 2.82E-4 RPP1 & pyrimidine depletion 30 4.99E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.134 7.17E-15 YGR197C SNG1 hom Protein involved in resistance to nitrosoguanidine (MNNG) and 6-azauracil (6-AU); expression is regulated by transcription factors involved in multidrug resistance
0.128 8.52E-14 YBR157C ICS2 hom Protein of unknown function; null mutation does not confer any obvious defects in growth, spore germination, viability, or carbohydrate utilization
0.111 1.11E-10 YOR162C YRR1 hom Zn2-Cys6 zinc-finger transcription factor; activates genes involved in multidrug resistance; paralog of Yrm1p, acting on an overlapping set of target genes; YRR1 has a paralog, PDR8, that arose from the whole genome duplication
0.103 2.30E-9 YKL066W_d YKL066W_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified gene YNK1
0.099 9.64E-9 YOR164C GET4 hom Protein with a role in insertion of tail-anchored proteins into the ER membrane; forms a complex with Mdy2p; highly conserved across species and homologous to human gene C7orf20
0.098 1.51E-8 YNL134C YNL134C hom Protein of unknown function; similar to dehydrogenases from other model organisms; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus; protein abundance increases in response to DNA replication stress
0.094 4.75E-8 YLL013C PUF3 hom Protein of the mitochondrial outer surface, links the Arp2/3 complex with the mitochore during anterograde mitochondrial movement; also binds to and promotes degradation of mRNAs for select nuclear-encoded mitochondrial proteins
0.094 5.54E-8 YBL059W_p YBL059W_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YBL059W has a paralog, YER093C-A, that arose from the whole genome duplication
0.093 7.25E-8 YDR315C IPK1 hom Inositol 1,3,4,5,6-pentakisphosphate 2-kinase, nuclear protein required for synthesis of 1,2,3,4,5,6-hexakisphosphate (phytate), which is integral to cell function; has 2 motifs conserved in other fungi; ipk1 gle1 double mutant is inviable
0.092 8.02E-8 YLR304C ACO1 hom Aconitase, required for the tricarboxylic acid (TCA) cycle and also independently required for mitochondrial genome maintenance; phosphorylated; component of the mitochondrial nucleoid; mutation leads to glutamate auxotrophy
0.089 2.74E-7 YJL051W IRC8 hom Bud tip localized protein of unknown function; mRNA is targeted to the bud by a She2p dependent transport system; mRNA is cell cycle regulated via Fkh2p, peaking in G2/M phase; null mutant displays increased levels of spontaneous Rad52p foc
0.088 3.39E-7 YOL078W AVO1 het Component of a membrane-bound complex containing the Tor2p kinase and other proteins, which may have a role in regulation of cell growth
0.086 5.22E-7 YOR382W FIT2 hom Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall
0.086 5.25E-7 YPR183W DPM1 het Dolichol phosphate mannose (Dol-P-Man) synthase of the ER membrane, catalyzes the formation of Dol-P-Man from Dol-P and GDP-Man; required for glycosyl phosphatidylinositol membrane anchoring, O mannosylation, and protein glycosylation
0.085 9.15E-7 YIL104C SHQ1 het Chaperone protein required for the assembly of box H/ACA snoRNPs and thus for pre-rRNA processing, forms a complex with Naf1p and interacts with H/ACA snoRNP components Nhp2p and Cbf5p; homology with known Hsp90p cochaperones