YGL181W / GTS1

Protein involved in Arf3p regulation and in transcription regulation; localizes to the nucleus and to endocytic patches; contains an N-terminal Zn-finger and ArfGAP homology domain, a C-terminal glutamine-rich region, and a UBA (ubiquitin associated) domain; gts1 mutations affect budding, cell size, heat tolerance, sporulation, life span, ultradian rhythms, endocytosis; expression oscillates in a pattern similar to metabolic oscillations

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL181W / GTS1

Click on Significant Values for Screen Details ID:SGTC_42|Compound:0133-0086|FD-Score:-5.70|P-value:4.99E-9 ID:SGTC_61|Compound:0978-8327|FD-Score:-3.67|P-value:1.09E-4 ID:SGTC_66|Compound:0109-0187|FD-Score:-4.12|P-value:1.65E-5 ID:SGTC_711|Compound:k292-0785|FD-Score:-3.59|P-value:1.47E-4 ID:SGTC_938|Compound:3126-1755|FD-Score:-3.20|P-value:6.37E-4 ID:SGTC_1217|Compound:1183-1422|FD-Score:-4.73|P-value:9.58E-7 ID:SGTC_1220|Compound:1838-0075|FD-Score:-6.07|P-value:5.20E-10 ID:SGTC_1344|Compound:1488-0097|FD-Score:3.44|P-value:2.96E-4 ID:SGTC_1521|Compound:st012942|FD-Score:-3.43|P-value:2.74E-4 ID:SGTC_1625|Compound:st003711|FD-Score:3.36|P-value:3.98E-4 ID:SGTC_1753|Compound:st043925|FD-Score:4.37|P-value:6.43E-6 ID:SGTC_1765|Compound:st044815|FD-Score:3.63|P-value:1.45E-4 ID:SGTC_1894|Compound:3',6'-dihydroxyflavone|FD-Score:-5.21|P-value:7.88E-8 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.13|P-value:7.99E-4 ID:SGTC_1969|Compound:st069479|FD-Score:-3.12|P-value:8.17E-4 ID:SGTC_1971|Compound:st069429|FD-Score:-3.51|P-value:2.04E-4 ID:SGTC_1974|Compound:st069448|FD-Score:-3.39|P-value:3.17E-4 ID:SGTC_2072|Compound:5231554|FD-Score:5.82|P-value:3.05E-9 ID:SGTC_2081|Compound:5214970|FD-Score:3.88|P-value:5.33E-5 ID:SGTC_2287|Compound:7945887|FD-Score:4.87|P-value:5.81E-7 ID:SGTC_2291|Compound:7917025|FD-Score:3.31|P-value:4.78E-4 ID:SGTC_2425|Compound:5628681|FD-Score:4.92|P-value:4.35E-7 ID:SGTC_2426|Compound:5582046|FD-Score:-3.70|P-value:9.77E-5 ID:SGTC_2436|Compound:5633522|FD-Score:3.57|P-value:1.84E-4 ID:SGTC_2485|Compound:5633444|FD-Score:3.79|P-value:7.76E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:3.25|P-value:6.02E-4 ID:SGTC_2707|Compound:st078556|FD-Score:-3.60|P-value:1.43E-4 ID:SGTC_2711|Compound:st079103|FD-Score:-3.52|P-value:1.97E-4 ID:SGTC_2712|Compound:st079126|FD-Score:3.16|P-value:8.03E-4 ID:SGTC_3040|Compound:9091894|FD-Score:-3.18|P-value:6.73E-4 ID:SGTC_3119|Compound:9125183|FD-Score:-3.11|P-value:8.51E-4 ID:SGTC_3141|Compound:9094609|FD-Score:3.24|P-value:6.20E-4 ID:SGTC_3142|Compound:9086498|FD-Score:-3.12|P-value:8.19E-4 ID:SGTC_3145|Compound:9085516|FD-Score:3.35|P-value:4.11E-4 ID:SGTC_3308|Compound:9128332|FD-Score:-4.80|P-value:6.94E-7 ID:SGTC_42|Compound:0133-0086|FD-Score:-5.70|P-value:4.99E-9 ID:SGTC_61|Compound:0978-8327|FD-Score:-3.67|P-value:1.09E-4 ID:SGTC_66|Compound:0109-0187|FD-Score:-4.12|P-value:1.65E-5 ID:SGTC_711|Compound:k292-0785|FD-Score:-3.59|P-value:1.47E-4 ID:SGTC_938|Compound:3126-1755|FD-Score:-3.20|P-value:6.37E-4 ID:SGTC_1217|Compound:1183-1422|FD-Score:-4.73|P-value:9.58E-7 ID:SGTC_1220|Compound:1838-0075|FD-Score:-6.07|P-value:5.20E-10 ID:SGTC_1344|Compound:1488-0097|FD-Score:3.44|P-value:2.96E-4 ID:SGTC_1521|Compound:st012942|FD-Score:-3.43|P-value:2.74E-4 ID:SGTC_1625|Compound:st003711|FD-Score:3.36|P-value:3.98E-4 ID:SGTC_1753|Compound:st043925|FD-Score:4.37|P-value:6.43E-6 ID:SGTC_1765|Compound:st044815|FD-Score:3.63|P-value:1.45E-4 ID:SGTC_1894|Compound:3',6'-dihydroxyflavone|FD-Score:-5.21|P-value:7.88E-8 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.13|P-value:7.99E-4 ID:SGTC_1969|Compound:st069479|FD-Score:-3.12|P-value:8.17E-4 ID:SGTC_1971|Compound:st069429|FD-Score:-3.51|P-value:2.04E-4 ID:SGTC_1974|Compound:st069448|FD-Score:-3.39|P-value:3.17E-4 ID:SGTC_2072|Compound:5231554|FD-Score:5.82|P-value:3.05E-9 ID:SGTC_2081|Compound:5214970|FD-Score:3.88|P-value:5.33E-5 ID:SGTC_2287|Compound:7945887|FD-Score:4.87|P-value:5.81E-7 ID:SGTC_2291|Compound:7917025|FD-Score:3.31|P-value:4.78E-4 ID:SGTC_2425|Compound:5628681|FD-Score:4.92|P-value:4.35E-7 ID:SGTC_2426|Compound:5582046|FD-Score:-3.70|P-value:9.77E-5 ID:SGTC_2436|Compound:5633522|FD-Score:3.57|P-value:1.84E-4 ID:SGTC_2485|Compound:5633444|FD-Score:3.79|P-value:7.76E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:3.25|P-value:6.02E-4 ID:SGTC_2707|Compound:st078556|FD-Score:-3.60|P-value:1.43E-4 ID:SGTC_2711|Compound:st079103|FD-Score:-3.52|P-value:1.97E-4 ID:SGTC_2712|Compound:st079126|FD-Score:3.16|P-value:8.03E-4 ID:SGTC_3040|Compound:9091894|FD-Score:-3.18|P-value:6.73E-4 ID:SGTC_3119|Compound:9125183|FD-Score:-3.11|P-value:8.51E-4 ID:SGTC_3141|Compound:9094609|FD-Score:3.24|P-value:6.20E-4 ID:SGTC_3142|Compound:9086498|FD-Score:-3.12|P-value:8.19E-4 ID:SGTC_3145|Compound:9085516|FD-Score:3.35|P-value:4.11E-4 ID:SGTC_3308|Compound:9128332|FD-Score:-4.80|P-value:6.94E-7

Top fitness defect scores for YGL181W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2072 5231554 5.82 129.0 µM 3.05E-9 1 2.99E-9
2 SGTC_2425 5628681 4.92 7.8 µM 4.35E-7 5 4.23E-7
3 SGTC_2287 7945887 4.87 168.8 µM 5.81E-7 3 5.65E-7
4 SGTC_1753 st043925 4.37 64.0 µM 6.43E-6 4 6.24E-6
5 SGTC_2081 5214970 3.88 32.3 µM 5.33E-5 27 5.16E-5
6 SGTC_2485 5633444 3.79 17.8 µM 7.76E-5 redox potentiating 51 7.52E-5
7 SGTC_1765 st044815 3.63 90.4 µM 1.45E-4 32 1.41E-4
8 SGTC_2436 5633522 3.57 8.1 µM 1.84E-4 27 1.78E-4
9 SGTC_1344 1488-0097 3.44 29.1 µM 2.96E-4 28 2.87E-4
10 SGTC_1625 st003711 3.36 30.1 µM 3.98E-4 calcium & mitochondrial duress 61 3.85E-4
11 SGTC_3145 9085516 3.35 49.5 µM 4.11E-4 fatty acid desaturase (OLE1) 50 3.98E-4
12 SGTC_2291 7917025 3.31 104.3 µM 4.78E-4 iron homeostasis 80 4.62E-4
13 SGTC_2582 agaric acid 3.25 100.0 µM 6.02E-4 redox potentiating 396 5.83E-4
14 SGTC_3141 9094609 3.24 49.5 µM 6.20E-4 iron homeostasis 64 6.00E-4
15 SGTC_2712 st079126 3.16 47.7 µM 8.03E-4 45 7.77E-4
16 SGTC_2942 9052777 3.02 62.2 µM 0.00129 81 0.00125
17 SGTC_392 N-ethylmaleimide 3.01 8.3 µM 0.00134 RNA pol III & RNase P/MRP 42 0.00130
18 SGTC_992 3909-8734 2.97 162.0 µM 0.00151 60 0.00147
19 SGTC_2762 leflunomide 2.97 42.1 µM 0.00154 80 0.00149
20 SGTC_2062 5245942 2.96 200.0 µM 0.00157 59 0.00152

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.195 4.91E-30 YGR097W ASK10 hom Component of RNA polymerase II holoenzyme; phosphorylated in response to oxidative stress; has a role in destruction of Ssn8p; proposed to function in activation of the glycerol channel Fps1p; ASK10 has a paralog, RGC1, that arose from the whole genome duplication
0.156 9.16E-20 YDR051C DET1 hom Acid phosphatase involved in the non-vesicular transport of sterols in both directions between the endoplasmic reticulum and plasma membrane; deletion confers sensitivity to nickel
0.145 3.82E-17 YNL097C-B_p YNL097C-B_p hom Putative protein of unknown function
0.144 6.11E-17 YLR414C PUN1 hom Plasma membrane protein with a role in cell wall integrity; co-localizes with Sur7p in punctate membrane patches; null mutant displays decreased thermotolerance; transcription induced upon cell wall damage and metal ion stress
0.139 5.06E-16 YMR041C ARA2 hom NAD-dependent arabinose dehydrogenase, involved in biosynthesis of dehydro-D-arabinono-1,4-lactone; similar to plant L-galactose dehydrogenase
0.138 1.06E-15 YGR025W_d YGR025W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.136 2.31E-15 YBL028C YBL028C hom Protein of unknown function that may interact with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; predicted to be involved in ribosome biogenesis
0.133 9.93E-15 YML084W_d YML084W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.128 9.97E-14 YDR244W PEX5 hom Peroxisomal membrane signal receptor for the C-terminal tripeptide signal sequence (PTS1) of peroxisomal matrix proteins, required for peroxisomal matrix protein import; also proposed to have PTS1-receptor independent functions
0.123 9.76E-13 YEL040W UTR2 hom Chitin transglycosylase that functions in the transfer of chitin to beta(1-6) and beta(1-3) glucans in the cell wall; similar to and functionally redundant with Crh1; glycosylphosphatidylinositol (GPI)-anchored protein localized to bud neck
0.122 1.22E-12 YJL161W_p FMP33_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.119 5.51E-12 YGR008C STF2 hom Protein involved in resistance to dessication stress; Stf2p exhibits antioxidant properties, and its overexpression prevents ROS accumulation and apoptosis; binds to the F0 sector of mitochondrial F1F0 ATPase in vitro and is proposed to modulate the inhibitory action of Inh1p and Stf1p; protein abundance increases in response to DNA replication stress
0.115 2.38E-11 YLR206W ENT2 hom Epsin-like protein required for endocytosis and actin patch assembly and functionally redundant with Ent1p; contains clathrin-binding motif at C-terminus
0.113 5.63E-11 YDR252W BTT1 hom Beta3 subunit of the heterotrimeric nascent polypeptide-associated complex which binds ribosomes via its beta-subunits in close proximity to nascent polypeptides; interacts with Caf130p of the CCR4-NOT complex; similar to human BTF3
0.106 7.97E-10 YMR109W MYO5 hom One of two type I myosins; contains proline-rich tail homology 2 (TH2) and SH3 domains; MYO5 deletion has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization