YGL184C / STR3

Peroxisomal cystathionine beta-lyase, converts cystathionine into homocysteine; may be redox regulated by Gto1p

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL184C / STR3

Click on Significant Values for Screen Details ID:SGTC_49|Compound:0717-0965|FD-Score:4.28|P-value:7.74E-6 ID:SGTC_280|Compound:3448-3607|FD-Score:4.20|P-value:1.12E-5 ID:SGTC_284|Compound:0988-0104|FD-Score:3.66|P-value:1.15E-4 ID:SGTC_292|Compound:k038-0015|FD-Score:3.45|P-value:2.63E-4 ID:SGTC_430|Compound:0958-0115|FD-Score:3.42|P-value:2.95E-4 ID:SGTC_604|Compound:1000-0114|FD-Score:3.98|P-value:3.00E-5 ID:SGTC_669|Compound:0108-0021|FD-Score:-3.38|P-value:2.08E-4 ID:SGTC_810|Compound:3825-7150|FD-Score:3.42|P-value:2.87E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:3.82|P-value:5.99E-5 ID:SGTC_926|Compound:2268-1401|FD-Score:4.43|P-value:3.77E-6 ID:SGTC_941|Compound:3237-0776|FD-Score:4.20|P-value:1.10E-5 ID:SGTC_943|Compound:3253-1379|FD-Score:3.49|P-value:2.20E-4 ID:SGTC_1113|Compound:artemisinin|FD-Score:4.06|P-value:2.12E-5 ID:SGTC_1129|Compound:3453-1384|FD-Score:4.16|P-value:1.34E-5 ID:SGTC_1237|Compound:0330-0133|FD-Score:3.19|P-value:6.71E-4 ID:SGTC_1320|Compound:1313-0481|FD-Score:3.37|P-value:3.54E-4 ID:SGTC_1515|Compound:3460-0031|FD-Score:-4.90|P-value:1.83E-7 ID:SGTC_1623|Compound:st003709|FD-Score:4.07|P-value:1.99E-5 ID:SGTC_1635|Compound:st007035|FD-Score:3.90|P-value:4.17E-5 ID:SGTC_1642|Compound:st009582|FD-Score:3.28|P-value:4.95E-4 ID:SGTC_1788|Compound:fluconazole|FD-Score:-3.58|P-value:9.48E-5 ID:SGTC_1826|Compound:st055655|FD-Score:3.34|P-value:3.98E-4 ID:SGTC_2131|Compound:toluylene red|FD-Score:3.51|P-value:2.02E-4 ID:SGTC_2158|Compound:5657123|FD-Score:3.43|P-value:2.81E-4 ID:SGTC_2532|Compound:xanthone|FD-Score:4.11|P-value:1.67E-5 ID:SGTC_2549|Compound:cedrol|FD-Score:3.62|P-value:1.33E-4 ID:SGTC_2570|Compound:licareol|FD-Score:-3.72|P-value:5.17E-5 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:-3.49|P-value:1.35E-4 ID:SGTC_2575|Compound:plumbagin|FD-Score:-2.99|P-value:8.78E-4 ID:SGTC_2630|Compound:antimycin a|FD-Score:3.79|P-value:6.81E-5 ID:SGTC_2836|Compound:9010338|FD-Score:4.28|P-value:7.86E-6 ID:SGTC_2839|Compound:9003951|FD-Score:-3.03|P-value:7.53E-4 ID:SGTC_3017|Compound:9080681|FD-Score:4.89|P-value:3.86E-7 ID:SGTC_3154|Compound:9100113|FD-Score:3.45|P-value:2.64E-4 ID:SGTC_3213|Compound:9129884|FD-Score:-3.01|P-value:8.05E-4 ID:SGTC_3264|Compound:9137442|FD-Score:-3.70|P-value:5.74E-5 ID:SGTC_3276|Compound:9139060|FD-Score:3.67|P-value:1.09E-4 ID:SGTC_49|Compound:0717-0965|FD-Score:4.28|P-value:7.74E-6 ID:SGTC_280|Compound:3448-3607|FD-Score:4.20|P-value:1.12E-5 ID:SGTC_284|Compound:0988-0104|FD-Score:3.66|P-value:1.15E-4 ID:SGTC_292|Compound:k038-0015|FD-Score:3.45|P-value:2.63E-4 ID:SGTC_430|Compound:0958-0115|FD-Score:3.42|P-value:2.95E-4 ID:SGTC_604|Compound:1000-0114|FD-Score:3.98|P-value:3.00E-5 ID:SGTC_669|Compound:0108-0021|FD-Score:-3.38|P-value:2.08E-4 ID:SGTC_810|Compound:3825-7150|FD-Score:3.42|P-value:2.87E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:3.82|P-value:5.99E-5 ID:SGTC_926|Compound:2268-1401|FD-Score:4.43|P-value:3.77E-6 ID:SGTC_941|Compound:3237-0776|FD-Score:4.20|P-value:1.10E-5 ID:SGTC_943|Compound:3253-1379|FD-Score:3.49|P-value:2.20E-4 ID:SGTC_1113|Compound:artemisinin|FD-Score:4.06|P-value:2.12E-5 ID:SGTC_1129|Compound:3453-1384|FD-Score:4.16|P-value:1.34E-5 ID:SGTC_1237|Compound:0330-0133|FD-Score:3.19|P-value:6.71E-4 ID:SGTC_1320|Compound:1313-0481|FD-Score:3.37|P-value:3.54E-4 ID:SGTC_1515|Compound:3460-0031|FD-Score:-4.90|P-value:1.83E-7 ID:SGTC_1623|Compound:st003709|FD-Score:4.07|P-value:1.99E-5 ID:SGTC_1635|Compound:st007035|FD-Score:3.90|P-value:4.17E-5 ID:SGTC_1642|Compound:st009582|FD-Score:3.28|P-value:4.95E-4 ID:SGTC_1788|Compound:fluconazole|FD-Score:-3.58|P-value:9.48E-5 ID:SGTC_1826|Compound:st055655|FD-Score:3.34|P-value:3.98E-4 ID:SGTC_2131|Compound:toluylene red|FD-Score:3.51|P-value:2.02E-4 ID:SGTC_2158|Compound:5657123|FD-Score:3.43|P-value:2.81E-4 ID:SGTC_2532|Compound:xanthone|FD-Score:4.11|P-value:1.67E-5 ID:SGTC_2549|Compound:cedrol|FD-Score:3.62|P-value:1.33E-4 ID:SGTC_2570|Compound:licareol|FD-Score:-3.72|P-value:5.17E-5 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:-3.49|P-value:1.35E-4 ID:SGTC_2575|Compound:plumbagin|FD-Score:-2.99|P-value:8.78E-4 ID:SGTC_2630|Compound:antimycin a|FD-Score:3.79|P-value:6.81E-5 ID:SGTC_2836|Compound:9010338|FD-Score:4.28|P-value:7.86E-6 ID:SGTC_2839|Compound:9003951|FD-Score:-3.03|P-value:7.53E-4 ID:SGTC_3017|Compound:9080681|FD-Score:4.89|P-value:3.86E-7 ID:SGTC_3154|Compound:9100113|FD-Score:3.45|P-value:2.64E-4 ID:SGTC_3213|Compound:9129884|FD-Score:-3.01|P-value:8.05E-4 ID:SGTC_3264|Compound:9137442|FD-Score:-3.70|P-value:5.74E-5 ID:SGTC_3276|Compound:9139060|FD-Score:3.67|P-value:1.09E-4

Top fitness defect scores for YGL184C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3017 9080681 4.89 49.5 µM 3.86E-7 6 5.16E-7
2 SGTC_926 2268-1401 4.43 59.4 µM 3.77E-6 TSC3-RPN4 24 4.66E-6
3 SGTC_49 0717-0965 4.28 32.1 µM 7.74E-6 60S ribosome export 15 9.34E-6
4 SGTC_2836 9010338 4.28 19.5 µM 7.86E-6 RPP1 & pyrimidine depletion 18 9.48E-6
5 SGTC_941 3237-0776 4.20 460.0 µM 1.10E-5 10 1.32E-5
6 SGTC_280 3448-3607 4.20 3.0 µM 1.12E-5 60S ribosome export 4 1.34E-5
7 SGTC_1129 3453-1384 4.16 223.0 µM 1.34E-5 33 1.59E-5
8 SGTC_2532 xanthone 4.11 78.9 µM 1.67E-5 23 1.97E-5
9 SGTC_1623 st003709 4.07 20.3 µM 1.99E-5 calcium & mitochondrial duress 66 2.33E-5
10 SGTC_1113 artemisinin 4.06 1.2 µM 2.12E-5 heme biosynthesis & mitochondrial translocase 13 2.48E-5
11 SGTC_604 1000-0114 3.98 314.0 µM 3.00E-5 20 3.46E-5
12 SGTC_1635 st007035 3.90 42.4 µM 4.17E-5 214 4.77E-5
13 SGTC_922 1866-0035 3.82 480.0 µM 5.99E-5 excess fatty acid 65 6.77E-5
14 SGTC_2630 antimycin a 3.79 100.0 µM 6.81E-5 mitochondrial processes 44 7.66E-5
15 SGTC_3276 9139060 3.67 49.5 µM 1.09E-4 60S ribosome export 7 1.21E-4
16 SGTC_284 0988-0104 3.66 32.6 µM 1.15E-4 heme requiring 16 1.27E-4
17 SGTC_2549 cedrol 3.62 20.9 µM 1.33E-4 20 1.47E-4
18 SGTC_2131 toluylene red 3.51 5.3 µM 2.02E-4 60S ribosome export 36 2.20E-4
19 SGTC_943 3253-1379 3.49 105.0 µM 2.20E-4 42 2.39E-4
20 SGTC_292 k038-0015 3.45 474.0 µM 2.63E-4 11 2.84E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.150 2.73E-18 YOR007C SGT2 hom Glutamine-rich cytoplasmic cochaperone; serves as a scaffold bringing together Get4, Get5p, and other TRC complex members that are required to mediate posttranslational insertion of tail-anchored proteins into the ER membrane; interacts with the prion domain of Sup35p; amyloid sensor; plays a role in targeting chaperones to prion aggregates; has similarity to human cochaperone SGT; forms cytoplasmic foci upon DNA replication stress
0.140 3.59E-16 YNR018W RCF2 hom Cytochrome c oxidase subunit; has a role in assembly of respiratory supercomplexes; similar to Rcf1p, and either Rcf1p or Rcf2p is required for late-stage assembly of the Cox12p and Cox13p subunits and for cytochrome c oxidase activity; associates with the cytochrome c oxidase - cytochrome bc1 supercomplex; null mutant accumulates reactive oxygen species; member of the conserved hypoxia induced gene family; C. elegans homolog is functional in yeast
0.133 1.15E-14 YBR234C ARC40 het Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches
0.128 1.20E-13 YMR151W_d YIM2_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1
0.122 1.42E-12 YGL191W COX13 hom Subunit VIa of cytochrome c oxidase; present in a subclass of cytochrome c oxidase complexes that may have a role in mimimizing generation of reactive oxygen species; not essential for cytochrome c oxidase activity but may modulate activity in response to ATP; required for assembly of Rcf2p into cytochrome c oxidase - cytochrome bc1 supercomplexes
0.118 6.37E-12 YEL059C-A SOM1 hom Subunit of the mitochondrial inner membrane peptidase, which is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates; contains twin cysteine-x9-cysteine motifs
0.117 1.11E-11 YLL009C COX17 hom Copper metallochaperone that transfers copper to Sco1p and Cox11p for eventual delivery to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs
0.113 5.16E-11 YPL189C-A COA2 hom Cytochrome oxidase assembly factor; null mutation results in respiratory deficiency with specific loss of cytochrome oxidase activity; functions downstream of assembly factors Mss51p and Coa1p and interacts with assembly factor Shy1p
0.104 1.77E-9 YPL070W MUK1 hom Cytoplasmic protein of unknown function containing a Vps9 domain; computational analysis of large-scale protein-protein interaction data suggests a possible role in transcriptional regulation
0.097 1.90E-8 YGR183C QCR9 hom Subunit 9 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; required for electron transfer at the ubiquinol oxidase site of the complex
0.094 4.40E-8 YKL155C RSM22 hom Mitochondrial ribosomal protein of the small subunit; also predicted to be an S-adenosylmethionine-dependent methyltransferase
0.092 8.79E-8 YGL260W_p YGL260W_p hom Putative protein of unknown function; transcription is significantly increased in a NAP1 deletion background; deletion mutant has increased accumulation of nickel and selenium
0.091 1.30E-7 YNL001W DOM34 hom Protein that facilitates ribosomal subunit dissociation; acts when translation is stalled, with binding partner Hbs1p; required for RNA cleavage in no-go decay, but reports conflict on endonuclease activity; Pelota ortholog; protein abundance increases in response to DNA replication stress; DOM34 has a paralog, YCL001W-B, that arose from the whole genome duplication
0.091 1.49E-7 YPL013C MRPS16 hom Mitochondrial ribosomal protein of the small subunit
0.090 1.62E-7 YEL062W NPR2 hom Subunit of SEA (Seh1-associated), Npr2/3, and Iml1p complexes; Npr2/3 complex mediates downregulation of TORC1 activity upon amino acid limitation; SEA complex is a coatomer-related complex that associates dynamically with the vacuole; Iml1p complex (Iml1p-Npr2p-Npr3p) is required for non-nitrogen-starvation (NNS)-induced autophagy; Iml1p interacts primarily with phosphorylated Npr2p; homolog of human NPRL2; target of Grr1p; required for growth on urea and proline