YGL185C_p

Putative protein with sequence similarity to hydroxyacid dehydrogenases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL185C / YGL185C

Click on Significant Values for Screen Details ID:SGTC_19|Compound:0279-0214|FD-Score:3.33|P-value:9.36E-4 ID:SGTC_142|Compound:0335-0849|FD-Score:3.44|P-value:6.57E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:-3.54|P-value:2.42E-4 ID:SGTC_194|Compound:1486-1323|FD-Score:3.33|P-value:9.30E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:4.04|P-value:7.42E-5 ID:SGTC_347|Compound:4534-1311|FD-Score:3.47|P-value:5.91E-4 ID:SGTC_361|Compound:000s-0510|FD-Score:4.49|P-value:1.22E-5 ID:SGTC_380|Compound:3970-0968|FD-Score:3.78|P-value:2.04E-4 ID:SGTC_393|Compound:acivicin|FD-Score:3.32|P-value:9.75E-4 ID:SGTC_432|Compound:NS 1619|FD-Score:-3.91|P-value:5.91E-5 ID:SGTC_433|Compound:pimozide|FD-Score:7.11|P-value:8.19E-12 ID:SGTC_440|Compound:fluspirilene|FD-Score:-4.36|P-value:9.50E-6 ID:SGTC_493|Compound:zm226600|FD-Score:6.46|P-value:4.98E-10 ID:SGTC_498|Compound:2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ)|FD-Score:3.63|P-value:3.47E-4 ID:SGTC_573|Compound:3702-0553|FD-Score:-3.14|P-value:9.37E-4 ID:SGTC_632|Compound:0781-2353|FD-Score:4.30|P-value:2.65E-5 ID:SGTC_703|Compound:3875-0075|FD-Score:-3.83|P-value:8.22E-5 ID:SGTC_708|Compound:3448-5400|FD-Score:3.93|P-value:1.16E-4 ID:SGTC_724|Compound:3910-0327|FD-Score:-4.29|P-value:1.30E-5 ID:SGTC_749|Compound:1000-0129|FD-Score:3.36|P-value:8.50E-4 ID:SGTC_838|Compound:0109-0203|FD-Score:3.35|P-value:8.85E-4 ID:SGTC_843|Compound:0310-0051|FD-Score:-3.45|P-value:3.28E-4 ID:SGTC_1039|Compound:k821-0043|FD-Score:3.80|P-value:1.86E-4 ID:SGTC_1369|Compound:1866-0067|FD-Score:3.70|P-value:2.67E-4 ID:SGTC_1519|Compound:esterone|FD-Score:3.43|P-value:6.78E-4 ID:SGTC_1635|Compound:st007035|FD-Score:3.36|P-value:8.42E-4 ID:SGTC_1735|Compound:st034310|FD-Score:3.85|P-value:1.54E-4 ID:SGTC_1736|Compound:st036774|FD-Score:7.54|P-value:4.18E-13 ID:SGTC_2022|Compound:5136654|FD-Score:-3.52|P-value:2.59E-4 ID:SGTC_2023|Compound:5144124|FD-Score:-3.18|P-value:8.39E-4 ID:SGTC_2029|Compound:5175081|FD-Score:3.90|P-value:1.31E-4 ID:SGTC_2114|Compound:5491910|FD-Score:3.99|P-value:9.02E-5 ID:SGTC_2165|Compound:5727197|FD-Score:-3.39|P-value:4.12E-4 ID:SGTC_2257|Compound:7960413|FD-Score:4.06|P-value:7.08E-5 ID:SGTC_2334|Compound:9017922|FD-Score:-3.24|P-value:6.90E-4 ID:SGTC_2343|Compound:7990716|FD-Score:4.01|P-value:8.41E-5 ID:SGTC_2348|Compound:9022543|FD-Score:4.07|P-value:6.84E-5 ID:SGTC_2352|Compound:9027995|FD-Score:3.37|P-value:8.17E-4 ID:SGTC_2356|Compound:9061756|FD-Score:-4.25|P-value:1.52E-5 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:6.71|P-value:1.04E-10 ID:SGTC_2414|Compound:st077232|FD-Score:6.29|P-value:1.34E-9 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:4.41|P-value:1.70E-5 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:3.63|P-value:3.38E-4 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:3.66|P-value:3.07E-4 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:5.18|P-value:5.25E-7 ID:SGTC_2759|Compound:disulfiram|FD-Score:5.26|P-value:3.46E-7 ID:SGTC_3206|Compound:9114350|FD-Score:-4.40|P-value:8.12E-6 ID:SGTC_3223|Compound:9129970|FD-Score:-3.62|P-value:1.78E-4 ID:SGTC_19|Compound:0279-0214|FD-Score:3.33|P-value:9.36E-4 ID:SGTC_142|Compound:0335-0849|FD-Score:3.44|P-value:6.57E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:-3.54|P-value:2.42E-4 ID:SGTC_194|Compound:1486-1323|FD-Score:3.33|P-value:9.30E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:4.04|P-value:7.42E-5 ID:SGTC_347|Compound:4534-1311|FD-Score:3.47|P-value:5.91E-4 ID:SGTC_361|Compound:000s-0510|FD-Score:4.49|P-value:1.22E-5 ID:SGTC_380|Compound:3970-0968|FD-Score:3.78|P-value:2.04E-4 ID:SGTC_393|Compound:acivicin|FD-Score:3.32|P-value:9.75E-4 ID:SGTC_432|Compound:NS 1619|FD-Score:-3.91|P-value:5.91E-5 ID:SGTC_433|Compound:pimozide|FD-Score:7.11|P-value:8.19E-12 ID:SGTC_440|Compound:fluspirilene|FD-Score:-4.36|P-value:9.50E-6 ID:SGTC_493|Compound:zm226600|FD-Score:6.46|P-value:4.98E-10 ID:SGTC_498|Compound:2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ)|FD-Score:3.63|P-value:3.47E-4 ID:SGTC_573|Compound:3702-0553|FD-Score:-3.14|P-value:9.37E-4 ID:SGTC_632|Compound:0781-2353|FD-Score:4.30|P-value:2.65E-5 ID:SGTC_703|Compound:3875-0075|FD-Score:-3.83|P-value:8.22E-5 ID:SGTC_708|Compound:3448-5400|FD-Score:3.93|P-value:1.16E-4 ID:SGTC_724|Compound:3910-0327|FD-Score:-4.29|P-value:1.30E-5 ID:SGTC_749|Compound:1000-0129|FD-Score:3.36|P-value:8.50E-4 ID:SGTC_838|Compound:0109-0203|FD-Score:3.35|P-value:8.85E-4 ID:SGTC_843|Compound:0310-0051|FD-Score:-3.45|P-value:3.28E-4 ID:SGTC_1039|Compound:k821-0043|FD-Score:3.80|P-value:1.86E-4 ID:SGTC_1369|Compound:1866-0067|FD-Score:3.70|P-value:2.67E-4 ID:SGTC_1519|Compound:esterone|FD-Score:3.43|P-value:6.78E-4 ID:SGTC_1635|Compound:st007035|FD-Score:3.36|P-value:8.42E-4 ID:SGTC_1735|Compound:st034310|FD-Score:3.85|P-value:1.54E-4 ID:SGTC_1736|Compound:st036774|FD-Score:7.54|P-value:4.18E-13 ID:SGTC_2022|Compound:5136654|FD-Score:-3.52|P-value:2.59E-4 ID:SGTC_2023|Compound:5144124|FD-Score:-3.18|P-value:8.39E-4 ID:SGTC_2029|Compound:5175081|FD-Score:3.90|P-value:1.31E-4 ID:SGTC_2114|Compound:5491910|FD-Score:3.99|P-value:9.02E-5 ID:SGTC_2165|Compound:5727197|FD-Score:-3.39|P-value:4.12E-4 ID:SGTC_2257|Compound:7960413|FD-Score:4.06|P-value:7.08E-5 ID:SGTC_2334|Compound:9017922|FD-Score:-3.24|P-value:6.90E-4 ID:SGTC_2343|Compound:7990716|FD-Score:4.01|P-value:8.41E-5 ID:SGTC_2348|Compound:9022543|FD-Score:4.07|P-value:6.84E-5 ID:SGTC_2352|Compound:9027995|FD-Score:3.37|P-value:8.17E-4 ID:SGTC_2356|Compound:9061756|FD-Score:-4.25|P-value:1.52E-5 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:6.71|P-value:1.04E-10 ID:SGTC_2414|Compound:st077232|FD-Score:6.29|P-value:1.34E-9 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:4.41|P-value:1.70E-5 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:3.63|P-value:3.38E-4 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:3.66|P-value:3.07E-4 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:5.18|P-value:5.25E-7 ID:SGTC_2759|Compound:disulfiram|FD-Score:5.26|P-value:3.46E-7 ID:SGTC_3206|Compound:9114350|FD-Score:-4.40|P-value:8.12E-6 ID:SGTC_3223|Compound:9129970|FD-Score:-3.62|P-value:1.78E-4

Top fitness defect scores for YGL185C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1736 st036774 7.54 51.0 µM 4.18E-13 2 2.28E-14
2 SGTC_433 pimozide 7.11 108.0 µM 8.19E-12 2 5.94E-13
3 SGTC_2410 aloe-emodin-8-o-glycoside 6.71 46.3 µM 1.04E-10 mitochondrial processes 3 9.63E-12
4 SGTC_493 zm226600 6.46 134.0 µM 4.98E-10 mitochondrial processes 1 5.38E-11
5 SGTC_2414 st077232 6.29 92.9 µM 1.34E-9 2 1.60E-10
6 SGTC_2759 disulfiram 5.26 3.4 µM 3.46E-7 11 7.11E-8
7 SGTC_2634 4'-methoxyflavone 5.18 100.0 µM 5.25E-7 11 1.13E-7
8 SGTC_361 000s-0510 4.49 1.4 µM 1.22E-5 22 3.59E-6
9 SGTC_2573 2',4'-dihydroxychalcone 4.41 15.0 µM 1.70E-5 34 5.18E-6
10 SGTC_632 0781-2353 4.30 4.7 µM 2.65E-5 Golgi 30 8.44E-6
11 SGTC_2348 9022543 4.07 33.4 µM 6.84E-5 mitochondrial processes 25 2.40E-5
12 SGTC_2257 7960413 4.06 200.0 µM 7.08E-5 NEO1-PIK1 55 2.49E-5
13 SGTC_236 1509-0011 4.04 5.3 µM 7.42E-5 379 2.63E-5
14 SGTC_2343 7990716 4.01 14.8 µM 8.41E-5 17 3.02E-5
15 SGTC_2114 5491910 3.99 81.2 µM 9.02E-5 9 3.26E-5
16 SGTC_708 3448-5400 3.93 146.0 µM 1.16E-4 44 4.31E-5
17 SGTC_2029 5175081 3.90 200.0 µM 1.31E-4 17 4.90E-5
18 SGTC_1735 st034310 3.85 56.8 µM 1.54E-4 Golgi 30 5.88E-5
19 SGTC_1039 k821-0043 3.80 94.0 µM 1.86E-4 Golgi 28 7.22E-5
20 SGTC_380 3970-0968 3.78 6.0 µM 2.04E-4 15 8.00E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.145 4.07E-17 YNL213C RRG9 hom Protein of unknown function; null mutant lacks mitochondrial DNA and cannot grow on glycerol; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.136 2.57E-15 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.133 9.49E-15 YHR050W-A_p YHR050W-A_p hom Protein of unknown function; identified by expression profiling and mass spectrometry
0.130 3.76E-14 YGR183C QCR9 hom Subunit 9 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; required for electron transfer at the ubiquinol oxidase site of the complex
0.123 1.04E-12 YGL237C HAP2 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding
0.123 1.08E-12 YMR151W_d YIM2_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1
0.121 1.76E-12 YJR120W YJR120W hom Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p
0.121 1.93E-12 YDL140C RPO21 het RNA polymerase II largest subunit B220, part of central core; phosphorylation of C-terminal heptapeptide repeat domain regulates association with transcription and splicing factors; similar to bacterial beta-prime
0.120 3.10E-12 YDR375C BCS1 hom Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases
0.120 3.47E-12 YDR148C KGD2 hom Dihydrolipoyl transsuccinylase, component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes the oxidative decarboxylation of alpha-ketoglutarate to succinyl-CoA in the TCA cycle; phosphorylated
0.118 7.48E-12 YPL132W COX11 hom Mitochondrial inner membrane protein required for delivery of copper to the Cox1p subunit of cytochrome c oxidase; association with mitochondrial ribosomes suggests that copper delivery may occur during translation of Cox1p
0.115 2.38E-11 YKL063C_p YKL063C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the Golgi
0.114 3.13E-11 YPL013C MRPS16 hom Mitochondrial ribosomal protein of the small subunit
0.113 5.01E-11 YMR035W IMP2 hom Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
0.113 5.70E-11 YLL009C COX17 hom Copper metallochaperone that transfers copper to Sco1p and Cox11p for eventual delivery to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs