YGL188C-A_p

Putative protein of unknown function

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL188C-A / YGL188C-A

Click on Significant Values for Screen Details ID:SGTC_39|Compound:0986-0283|FD-Score:6.01|P-value:9.14E-8 ID:SGTC_87|Compound:0100-0052|FD-Score:4.50|P-value:4.40E-5 ID:SGTC_95|Compound:0471-0001|FD-Score:4.98|P-value:7.29E-6 ID:SGTC_129|Compound:0088-0017|FD-Score:4.92|P-value:9.33E-6 ID:SGTC_146|Compound:3448-8650|FD-Score:5.29|P-value:2.14E-6 ID:SGTC_187|Compound:1488-2104|FD-Score:6.79|P-value:2.03E-9 ID:SGTC_295|Compound:k015-0027|FD-Score:3.69|P-value:6.16E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:-6.90|P-value:3.00E-9 ID:SGTC_301|Compound:4119-0100|FD-Score:4.71|P-value:2.05E-5 ID:SGTC_304|Compound:1310-0298|FD-Score:-5.06|P-value:1.12E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:-9.34|P-value:1.35E-15 ID:SGTC_352|Compound:k048-0007|FD-Score:4.04|P-value:2.09E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:-8.21|P-value:2.06E-12 ID:SGTC_445|Compound:e6 berbamine|FD-Score:3.96|P-value:2.68E-4 ID:SGTC_446|Compound:go6976|FD-Score:4.21|P-value:1.18E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-6.36|P-value:4.30E-8 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:-3.83|P-value:7.11E-4 ID:SGTC_582|Compound:0987-0078|FD-Score:5.74|P-value:3.19E-7 ID:SGTC_710|Compound:3448-4187|FD-Score:9.35|P-value:3.60E-16 ID:SGTC_762|Compound:1165-0429|FD-Score:-4.05|P-value:3.57E-4 ID:SGTC_772|Compound:k072-0172|FD-Score:4.84|P-value:1.25E-5 ID:SGTC_866|Compound:0495-0101|FD-Score:-4.33|P-value:1.48E-4 ID:SGTC_874|Compound:0599-0792|FD-Score:-3.76|P-value:8.75E-4 ID:SGTC_881|Compound:0833-0569|FD-Score:3.78|P-value:4.66E-4 ID:SGTC_927|Compound:2425-1185|FD-Score:6.68|P-value:3.59E-9 ID:SGTC_934|Compound:2950-0684|FD-Score:4.12|P-value:1.62E-4 ID:SGTC_953|Compound:1188-0045|FD-Score:5.07|P-value:5.15E-6 ID:SGTC_975|Compound:1335-0046|FD-Score:-3.86|P-value:6.37E-4 ID:SGTC_999|Compound:4022-0066|FD-Score:3.82|P-value:4.09E-4 ID:SGTC_1004|Compound:4084-0029|FD-Score:4.44|P-value:5.49E-5 ID:SGTC_1272|Compound:0839-0021|FD-Score:7.34|P-value:1.11E-10 ID:SGTC_1304|Compound:1165-0502|FD-Score:3.60|P-value:7.94E-4 ID:SGTC_1347|Compound:1493-0251|FD-Score:-3.82|P-value:7.14E-4 ID:SGTC_1445|Compound:4239-0156|FD-Score:4.83|P-value:1.30E-5 ID:SGTC_1446|Compound:4239-0190|FD-Score:5.82|P-value:2.16E-7 ID:SGTC_1564|Compound:D-Arginine|FD-Score:5.63|P-value:5.15E-7 ID:SGTC_1574|Compound:spiramycin|FD-Score:4.47|P-value:4.83E-5 ID:SGTC_1627|Compound:st003713|FD-Score:3.97|P-value:2.56E-4 ID:SGTC_1694|Compound:st024011|FD-Score:4.05|P-value:2.02E-4 ID:SGTC_1742|Compound:st038235|FD-Score:-3.94|P-value:5.00E-4 ID:SGTC_1745|Compound:st081495|FD-Score:3.87|P-value:3.54E-4 ID:SGTC_1749|Compound:st037932|FD-Score:-5.40|P-value:2.91E-6 ID:SGTC_1750|Compound:st081859|FD-Score:4.96|P-value:8.08E-6 ID:SGTC_1781|Compound:st038725|FD-Score:8.45|P-value:1.42E-13 ID:SGTC_1786|Compound:berberine|FD-Score:-3.74|P-value:9.25E-4 ID:SGTC_1797|Compound:st048695|FD-Score:4.44|P-value:5.43E-5 ID:SGTC_1844|Compound:rapamycin|FD-Score:7.69|P-value:1.48E-11 ID:SGTC_1953|Compound:st076800|FD-Score:4.11|P-value:1.65E-4 ID:SGTC_2064|Compound:5220758|FD-Score:5.61|P-value:5.43E-7 ID:SGTC_2106|Compound:5357045|FD-Score:-4.33|P-value:1.45E-4 ID:SGTC_2127|Compound:5253358|FD-Score:5.07|P-value:5.13E-6 ID:SGTC_2258|Compound:7960471|FD-Score:4.50|P-value:4.35E-5 ID:SGTC_2264|Compound:7948757|FD-Score:-5.01|P-value:1.34E-5 ID:SGTC_2265|Compound:7929201|FD-Score:4.85|P-value:1.22E-5 ID:SGTC_2268|Compound:7933382|FD-Score:5.26|P-value:2.44E-6 ID:SGTC_2306|Compound:7482397|FD-Score:4.22|P-value:1.14E-4 ID:SGTC_2320|Compound:7373003|FD-Score:4.62|P-value:2.88E-5 ID:SGTC_2325|Compound:6158266|FD-Score:3.75|P-value:5.07E-4 ID:SGTC_2376|Compound:9072922|FD-Score:4.04|P-value:2.09E-4 ID:SGTC_2402|Compound:5553605|FD-Score:4.66|P-value:2.49E-5 ID:SGTC_2431|Compound:5490079|FD-Score:-4.14|P-value:2.72E-4 ID:SGTC_2458|Compound:5808907|FD-Score:3.57|P-value:8.68E-4 ID:SGTC_2502|Compound:avocadyne acetate|FD-Score:3.56|P-value:8.98E-4 ID:SGTC_2625|Compound:euphol|FD-Score:3.62|P-value:7.58E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:4.04|P-value:2.09E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:4.46|P-value:5.03E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.64|P-value:7.07E-4 ID:SGTC_2709|Compound:st078560|FD-Score:-3.81|P-value:7.54E-4 ID:SGTC_2717|Compound:st081029|FD-Score:4.11|P-value:1.64E-4 ID:SGTC_2831|Compound:7999036|FD-Score:5.43|P-value:1.20E-6 ID:SGTC_2873|Compound:9040596|FD-Score:4.12|P-value:1.60E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-3.71|P-value:9.84E-4 ID:SGTC_2897|Compound:9048598|FD-Score:3.56|P-value:9.14E-4 ID:SGTC_2908|Compound:7930301|FD-Score:3.59|P-value:8.36E-4 ID:SGTC_2977|Compound:9011197|FD-Score:3.79|P-value:4.54E-4 ID:SGTC_3056|Compound:9094900|FD-Score:4.68|P-value:2.28E-5 ID:SGTC_3094|Compound:9117742|FD-Score:3.53|P-value:9.96E-4 ID:SGTC_3141|Compound:9094609|FD-Score:-3.90|P-value:5.73E-4 ID:SGTC_3180|Compound:9109287|FD-Score:4.03|P-value:2.12E-4 ID:SGTC_3269|Compound:9137823|FD-Score:4.66|P-value:2.48E-5 ID:SGTC_3324|Compound:9138759|FD-Score:3.63|P-value:7.37E-4 ID:SGTC_3347|Compound:9188721|FD-Score:4.50|P-value:4.32E-5 ID:SGTC_39|Compound:0986-0283|FD-Score:6.01|P-value:9.14E-8 ID:SGTC_87|Compound:0100-0052|FD-Score:4.50|P-value:4.40E-5 ID:SGTC_95|Compound:0471-0001|FD-Score:4.98|P-value:7.29E-6 ID:SGTC_129|Compound:0088-0017|FD-Score:4.92|P-value:9.33E-6 ID:SGTC_146|Compound:3448-8650|FD-Score:5.29|P-value:2.14E-6 ID:SGTC_187|Compound:1488-2104|FD-Score:6.79|P-value:2.03E-9 ID:SGTC_295|Compound:k015-0027|FD-Score:3.69|P-value:6.16E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:-6.90|P-value:3.00E-9 ID:SGTC_301|Compound:4119-0100|FD-Score:4.71|P-value:2.05E-5 ID:SGTC_304|Compound:1310-0298|FD-Score:-5.06|P-value:1.12E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:-9.34|P-value:1.35E-15 ID:SGTC_352|Compound:k048-0007|FD-Score:4.04|P-value:2.09E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:-8.21|P-value:2.06E-12 ID:SGTC_445|Compound:e6 berbamine|FD-Score:3.96|P-value:2.68E-4 ID:SGTC_446|Compound:go6976|FD-Score:4.21|P-value:1.18E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-6.36|P-value:4.30E-8 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:-3.83|P-value:7.11E-4 ID:SGTC_582|Compound:0987-0078|FD-Score:5.74|P-value:3.19E-7 ID:SGTC_710|Compound:3448-4187|FD-Score:9.35|P-value:3.60E-16 ID:SGTC_762|Compound:1165-0429|FD-Score:-4.05|P-value:3.57E-4 ID:SGTC_772|Compound:k072-0172|FD-Score:4.84|P-value:1.25E-5 ID:SGTC_866|Compound:0495-0101|FD-Score:-4.33|P-value:1.48E-4 ID:SGTC_874|Compound:0599-0792|FD-Score:-3.76|P-value:8.75E-4 ID:SGTC_881|Compound:0833-0569|FD-Score:3.78|P-value:4.66E-4 ID:SGTC_927|Compound:2425-1185|FD-Score:6.68|P-value:3.59E-9 ID:SGTC_934|Compound:2950-0684|FD-Score:4.12|P-value:1.62E-4 ID:SGTC_953|Compound:1188-0045|FD-Score:5.07|P-value:5.15E-6 ID:SGTC_975|Compound:1335-0046|FD-Score:-3.86|P-value:6.37E-4 ID:SGTC_999|Compound:4022-0066|FD-Score:3.82|P-value:4.09E-4 ID:SGTC_1004|Compound:4084-0029|FD-Score:4.44|P-value:5.49E-5 ID:SGTC_1272|Compound:0839-0021|FD-Score:7.34|P-value:1.11E-10 ID:SGTC_1304|Compound:1165-0502|FD-Score:3.60|P-value:7.94E-4 ID:SGTC_1347|Compound:1493-0251|FD-Score:-3.82|P-value:7.14E-4 ID:SGTC_1445|Compound:4239-0156|FD-Score:4.83|P-value:1.30E-5 ID:SGTC_1446|Compound:4239-0190|FD-Score:5.82|P-value:2.16E-7 ID:SGTC_1564|Compound:D-Arginine|FD-Score:5.63|P-value:5.15E-7 ID:SGTC_1574|Compound:spiramycin|FD-Score:4.47|P-value:4.83E-5 ID:SGTC_1627|Compound:st003713|FD-Score:3.97|P-value:2.56E-4 ID:SGTC_1694|Compound:st024011|FD-Score:4.05|P-value:2.02E-4 ID:SGTC_1742|Compound:st038235|FD-Score:-3.94|P-value:5.00E-4 ID:SGTC_1745|Compound:st081495|FD-Score:3.87|P-value:3.54E-4 ID:SGTC_1749|Compound:st037932|FD-Score:-5.40|P-value:2.91E-6 ID:SGTC_1750|Compound:st081859|FD-Score:4.96|P-value:8.08E-6 ID:SGTC_1781|Compound:st038725|FD-Score:8.45|P-value:1.42E-13 ID:SGTC_1786|Compound:berberine|FD-Score:-3.74|P-value:9.25E-4 ID:SGTC_1797|Compound:st048695|FD-Score:4.44|P-value:5.43E-5 ID:SGTC_1844|Compound:rapamycin|FD-Score:7.69|P-value:1.48E-11 ID:SGTC_1953|Compound:st076800|FD-Score:4.11|P-value:1.65E-4 ID:SGTC_2064|Compound:5220758|FD-Score:5.61|P-value:5.43E-7 ID:SGTC_2106|Compound:5357045|FD-Score:-4.33|P-value:1.45E-4 ID:SGTC_2127|Compound:5253358|FD-Score:5.07|P-value:5.13E-6 ID:SGTC_2258|Compound:7960471|FD-Score:4.50|P-value:4.35E-5 ID:SGTC_2264|Compound:7948757|FD-Score:-5.01|P-value:1.34E-5 ID:SGTC_2265|Compound:7929201|FD-Score:4.85|P-value:1.22E-5 ID:SGTC_2268|Compound:7933382|FD-Score:5.26|P-value:2.44E-6 ID:SGTC_2306|Compound:7482397|FD-Score:4.22|P-value:1.14E-4 ID:SGTC_2320|Compound:7373003|FD-Score:4.62|P-value:2.88E-5 ID:SGTC_2325|Compound:6158266|FD-Score:3.75|P-value:5.07E-4 ID:SGTC_2376|Compound:9072922|FD-Score:4.04|P-value:2.09E-4 ID:SGTC_2402|Compound:5553605|FD-Score:4.66|P-value:2.49E-5 ID:SGTC_2431|Compound:5490079|FD-Score:-4.14|P-value:2.72E-4 ID:SGTC_2458|Compound:5808907|FD-Score:3.57|P-value:8.68E-4 ID:SGTC_2502|Compound:avocadyne acetate|FD-Score:3.56|P-value:8.98E-4 ID:SGTC_2625|Compound:euphol|FD-Score:3.62|P-value:7.58E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:4.04|P-value:2.09E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:4.46|P-value:5.03E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.64|P-value:7.07E-4 ID:SGTC_2709|Compound:st078560|FD-Score:-3.81|P-value:7.54E-4 ID:SGTC_2717|Compound:st081029|FD-Score:4.11|P-value:1.64E-4 ID:SGTC_2831|Compound:7999036|FD-Score:5.43|P-value:1.20E-6 ID:SGTC_2873|Compound:9040596|FD-Score:4.12|P-value:1.60E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-3.71|P-value:9.84E-4 ID:SGTC_2897|Compound:9048598|FD-Score:3.56|P-value:9.14E-4 ID:SGTC_2908|Compound:7930301|FD-Score:3.59|P-value:8.36E-4 ID:SGTC_2977|Compound:9011197|FD-Score:3.79|P-value:4.54E-4 ID:SGTC_3056|Compound:9094900|FD-Score:4.68|P-value:2.28E-5 ID:SGTC_3094|Compound:9117742|FD-Score:3.53|P-value:9.96E-4 ID:SGTC_3141|Compound:9094609|FD-Score:-3.90|P-value:5.73E-4 ID:SGTC_3180|Compound:9109287|FD-Score:4.03|P-value:2.12E-4 ID:SGTC_3269|Compound:9137823|FD-Score:4.66|P-value:2.48E-5 ID:SGTC_3324|Compound:9138759|FD-Score:3.63|P-value:7.37E-4 ID:SGTC_3347|Compound:9188721|FD-Score:4.50|P-value:4.32E-5

Top fitness defect scores for YGL188C-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_710 3448-4187 9.35 58.0 µM 3.60E-16 fatty acid desaturase (OLE1) 4 4.37E-21
2 SGTC_1781 st038725 8.45 66.3 µM 1.42E-13 NEO1 29 1.41E-17
3 SGTC_1844 rapamycin 7.69 4.0 nM 1.48E-11 61 7.34E-15
4 SGTC_1272 0839-0021 7.34 27.0 µM 1.11E-10 2 1.11E-13
5 SGTC_187 1488-2104 6.79 32.7 µM 2.03E-9 calcium & mitochondrial duress 11 5.50E-12
6 SGTC_927 2425-1185 6.68 123.0 µM 3.59E-9 3 1.18E-11
7 SGTC_39 0986-0283 6.01 58.4 µM 9.14E-8 calcium & mitochondrial duress 4 9.10E-10
8 SGTC_1446 4239-0190 5.82 62.0 µM 2.16E-7 8 2.88E-9
9 SGTC_582 0987-0078 5.74 156.0 µM 3.19E-7 calcium & mitochondrial duress 23 4.84E-9
10 SGTC_1564 D-Arginine 5.63 115.0 µM 5.15E-7 10 9.19E-9
11 SGTC_2064 5220758 5.61 200.0 µM 5.43E-7 10 9.87E-9
12 SGTC_2831 7999036 5.43 19.5 µM 1.20E-6 11 2.83E-8
13 SGTC_146 3448-8650 5.29 53.1 µM 2.14E-6 NEO1-PIK1 70 6.14E-8
14 SGTC_2268 7933382 5.26 153.8 µM 2.44E-6 15 7.34E-8
15 SGTC_2127 5253358 5.07 187.9 µM 5.13E-6 6 1.97E-7
16 SGTC_953 1188-0045 5.07 9.7 µM 5.15E-6 60S ribosome export 7 1.98E-7
17 SGTC_95 0471-0001 4.98 561.1 µM 7.29E-6 10 3.15E-7
18 SGTC_1750 st081859 4.96 2.4 µM 8.08E-6 endomembrane recycling 140 3.61E-7
19 SGTC_129 0088-0017 4.92 176.6 µM 9.33E-6 49 4.37E-7
20 SGTC_2265 7929201 4.85 200.0 µM 1.22E-5 12 6.27E-7

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.205 4.67E-33 YJR063W RPA12 hom RNA polymerase I subunit A12.2; contains two zinc binding domains, and the N terminal domain is responsible for anchoring to the RNA pol I complex
0.203 1.73E-32 YDR378C LSM6 hom Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA
0.198 5.61E-31 YGR159C NSR1 hom Nucleolar protein that binds nuclear localization sequences, required for pre-rRNA processing and ribosome biogenesis
0.198 6.71E-31 YBR189W RPS9B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S9 and bacterial S4; RPS9B has a paralog, RPS9A, that arose from the whole genome duplication
0.187 9.84E-28 YDR417C_d YDR417C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RPL12B/YDR418W
0.186 1.99E-27 YOR293W RPS10A hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S10, no bacterial homolog; RPS10A has a paralog, RPS10B, that arose from the whole genome duplication
0.175 1.31E-24 YKL176C LST4 hom Protein possibly involved in a post-Golgi secretory pathway; required for the transport of nitrogen-regulated amino acid permease Gap1p from the Golgi to the cell surface
0.173 6.07E-24 YJR066W TOR1 hom PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that controls growth in response to nutrients by regulating translation, transcription, ribosome biogenesis, nutrient transport and autophagy; involved in meiosis; TOR1 has a paralog, TOR2, that arose from the whole genome duplication
0.172 1.09E-23 YGR163W GTR2 hom Putative GTP binding protein that negatively regulates Ran/Tc4 GTPase cycle; activates transcription; subunit of EGO and GSE complexes; required for sorting of Gap1p; localizes to cytoplasm and to chromatin; homolog of human RagC and RagD
0.171 2.69E-23 YML036W CGI121 hom Component of the EKC/KEOPS complex with Bud32p, Kae1p, Pcc1p, and Gon7p; EKC/KEOPS complex is required for t6A tRNA modification and may have roles in telomere maintenance and transcription; Cgi121p is dispensable for tRNA modification
0.165 6.36E-22 YDR159W SAC3 hom Nuclear pore-associated protein; required for biogenesis of the small ribosomal subunit; component of TREX-2 complex (Sac3p-Thp1p-Sus1p-Cdc31p) involved in transcription elongation and mRNA export from the nucleus; involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP; similar to the human germinal center-associated nuclear protein (GANP)
0.164 1.06E-21 YIL052C RPL34B hom Ribosomal 60S subunit protein L34B; homologous to mammalian ribosomal protein L34, no bacterial homolog; RPL34B has a paralog, RPL34A, that arose from the whole genome duplication
0.163 2.78E-21 YJL136C RPS21B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S21, no bacterial homolog; RPS21B has a paralog, RPS21A, that arose from the whole genome duplication
0.162 3.48E-21 YGL019W CKB1 hom Beta regulatory subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases
0.159 2.03E-20 YCR077C PAT1 hom Deadenylation-dependent mRNA-decapping factor; also required for faithful chromosome transmission, maintenance of rDNA locus stability, and protection of mRNA 3'-UTRs from trimming; associated with topoisomerase II; functionally linked to Pab1p; forms cytoplasmic foci upon DNA replication stress