YGL192W / IME4

Probable mRNA N6-adenosine methyltransferase required for entry into meiosis; transcribed in diploid cells; haploids repress IME4 transcription via production of antisense IME4 transcripts; antisense transcription is repressed in diploids

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL192W / IME4

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:9.46|P-value:2.75E-18 ID:SGTC_70|Compound:0141-0289|FD-Score:4.67|P-value:1.01E-5 ID:SGTC_236|Compound:1509-0011|FD-Score:4.36|P-value:3.54E-5 ID:SGTC_331|Compound:k048-0133|FD-Score:4.41|P-value:2.93E-5 ID:SGTC_495|Compound:decylubiquinone|FD-Score:4.83|P-value:5.16E-6 ID:SGTC_515|Compound:4092-1064|FD-Score:3.43|P-value:8.93E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:3.67|P-value:4.12E-4 ID:SGTC_529|Compound:4076-0302|FD-Score:3.70|P-value:3.70E-4 ID:SGTC_533|Compound:1222-0222|FD-Score:4.05|P-value:1.11E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:6.46|P-value:1.84E-9 ID:SGTC_703|Compound:3875-0075|FD-Score:3.50|P-value:7.06E-4 ID:SGTC_928|Compound:2764-0428|FD-Score:3.85|P-value:2.23E-4 ID:SGTC_1048|Compound:3161-0300|FD-Score:3.57|P-value:5.78E-4 ID:SGTC_1112|Compound:tnp00069|FD-Score:3.67|P-value:4.07E-4 ID:SGTC_1257|Compound:0669-0121|FD-Score:-4.00|P-value:1.21E-4 ID:SGTC_1262|Compound:0737-0114|FD-Score:3.65|P-value:4.45E-4 ID:SGTC_1264|Compound:0783-0040|FD-Score:-3.92|P-value:1.58E-4 ID:SGTC_1313|Compound:1220-0047|FD-Score:4.02|P-value:1.23E-4 ID:SGTC_1329|Compound:1447-1697|FD-Score:4.42|P-value:2.81E-5 ID:SGTC_1635|Compound:st007035|FD-Score:7.15|P-value:3.22E-11 ID:SGTC_1682|Compound:st012968|FD-Score:4.11|P-value:9.08E-5 ID:SGTC_1817|Compound:st052116|FD-Score:3.55|P-value:6.04E-4 ID:SGTC_2008|Compound:4012253|FD-Score:3.70|P-value:3.78E-4 ID:SGTC_2067|Compound:5224629|FD-Score:-3.55|P-value:5.57E-4 ID:SGTC_2112|Compound:5488546|FD-Score:3.48|P-value:7.54E-4 ID:SGTC_2154|Compound:5570129|FD-Score:-3.37|P-value:9.90E-4 ID:SGTC_2156|Compound:5649887|FD-Score:-3.68|P-value:3.64E-4 ID:SGTC_2174|Compound:5790901|FD-Score:-4.06|P-value:9.54E-5 ID:SGTC_2317|Compound:5986382|FD-Score:4.01|P-value:1.28E-4 ID:SGTC_2330|Compound:7979373|FD-Score:3.95|P-value:1.59E-4 ID:SGTC_2331|Compound:7980721|FD-Score:3.61|P-value:4.98E-4 ID:SGTC_2355|Compound:9061122|FD-Score:5.11|P-value:1.57E-6 ID:SGTC_2416|Compound:tofa|FD-Score:3.82|P-value:2.51E-4 ID:SGTC_2450|Compound:5739737|FD-Score:3.64|P-value:4.49E-4 ID:SGTC_2480|Compound:5767542|FD-Score:-3.57|P-value:5.12E-4 ID:SGTC_2529|Compound:gangaleoidin|FD-Score:11.50|P-value:5.67E-26 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:-6.64|P-value:5.83E-10 ID:SGTC_2533|Compound:agelasine|FD-Score:5.88|P-value:4.01E-8 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:9.55|P-value:1.29E-18 ID:SGTC_2561|Compound:acetosyringone|FD-Score:3.45|P-value:8.33E-4 ID:SGTC_2581|Compound:avocatin a|FD-Score:3.95|P-value:1.57E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:3.85|P-value:2.28E-4 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:-4.51|P-value:1.76E-5 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:3.45|P-value:8.23E-4 ID:SGTC_2632|Compound:3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone|FD-Score:5.80|P-value:6.00E-8 ID:SGTC_2635|Compound:hydroquinidine|FD-Score:3.87|P-value:2.12E-4 ID:SGTC_2929|Compound:9013348|FD-Score:4.86|P-value:4.63E-6 ID:SGTC_3034|Compound:9090421|FD-Score:-3.47|P-value:7.16E-4 ID:SGTC_3130|Compound:9127414|FD-Score:5.37|P-value:4.86E-7 ID:SGTC_3133|Compound:9127736|FD-Score:-5.07|P-value:1.63E-6 ID:SGTC_3134|Compound:9127454|FD-Score:5.35|P-value:5.36E-7 ID:SGTC_3142|Compound:9086498|FD-Score:-3.46|P-value:7.39E-4 ID:SGTC_3143|Compound:9086658|FD-Score:4.40|P-value:2.97E-5 ID:SGTC_3220|Compound:9131269|FD-Score:6.68|P-value:5.20E-10 ID:SGTC_58|Compound:0957-0393|FD-Score:9.46|P-value:2.75E-18 ID:SGTC_70|Compound:0141-0289|FD-Score:4.67|P-value:1.01E-5 ID:SGTC_236|Compound:1509-0011|FD-Score:4.36|P-value:3.54E-5 ID:SGTC_331|Compound:k048-0133|FD-Score:4.41|P-value:2.93E-5 ID:SGTC_495|Compound:decylubiquinone|FD-Score:4.83|P-value:5.16E-6 ID:SGTC_515|Compound:4092-1064|FD-Score:3.43|P-value:8.93E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:3.67|P-value:4.12E-4 ID:SGTC_529|Compound:4076-0302|FD-Score:3.70|P-value:3.70E-4 ID:SGTC_533|Compound:1222-0222|FD-Score:4.05|P-value:1.11E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:6.46|P-value:1.84E-9 ID:SGTC_703|Compound:3875-0075|FD-Score:3.50|P-value:7.06E-4 ID:SGTC_928|Compound:2764-0428|FD-Score:3.85|P-value:2.23E-4 ID:SGTC_1048|Compound:3161-0300|FD-Score:3.57|P-value:5.78E-4 ID:SGTC_1112|Compound:tnp00069|FD-Score:3.67|P-value:4.07E-4 ID:SGTC_1257|Compound:0669-0121|FD-Score:-4.00|P-value:1.21E-4 ID:SGTC_1262|Compound:0737-0114|FD-Score:3.65|P-value:4.45E-4 ID:SGTC_1264|Compound:0783-0040|FD-Score:-3.92|P-value:1.58E-4 ID:SGTC_1313|Compound:1220-0047|FD-Score:4.02|P-value:1.23E-4 ID:SGTC_1329|Compound:1447-1697|FD-Score:4.42|P-value:2.81E-5 ID:SGTC_1635|Compound:st007035|FD-Score:7.15|P-value:3.22E-11 ID:SGTC_1682|Compound:st012968|FD-Score:4.11|P-value:9.08E-5 ID:SGTC_1817|Compound:st052116|FD-Score:3.55|P-value:6.04E-4 ID:SGTC_2008|Compound:4012253|FD-Score:3.70|P-value:3.78E-4 ID:SGTC_2067|Compound:5224629|FD-Score:-3.55|P-value:5.57E-4 ID:SGTC_2112|Compound:5488546|FD-Score:3.48|P-value:7.54E-4 ID:SGTC_2154|Compound:5570129|FD-Score:-3.37|P-value:9.90E-4 ID:SGTC_2156|Compound:5649887|FD-Score:-3.68|P-value:3.64E-4 ID:SGTC_2174|Compound:5790901|FD-Score:-4.06|P-value:9.54E-5 ID:SGTC_2317|Compound:5986382|FD-Score:4.01|P-value:1.28E-4 ID:SGTC_2330|Compound:7979373|FD-Score:3.95|P-value:1.59E-4 ID:SGTC_2331|Compound:7980721|FD-Score:3.61|P-value:4.98E-4 ID:SGTC_2355|Compound:9061122|FD-Score:5.11|P-value:1.57E-6 ID:SGTC_2416|Compound:tofa|FD-Score:3.82|P-value:2.51E-4 ID:SGTC_2450|Compound:5739737|FD-Score:3.64|P-value:4.49E-4 ID:SGTC_2480|Compound:5767542|FD-Score:-3.57|P-value:5.12E-4 ID:SGTC_2529|Compound:gangaleoidin|FD-Score:11.50|P-value:5.67E-26 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:-6.64|P-value:5.83E-10 ID:SGTC_2533|Compound:agelasine|FD-Score:5.88|P-value:4.01E-8 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:9.55|P-value:1.29E-18 ID:SGTC_2561|Compound:acetosyringone|FD-Score:3.45|P-value:8.33E-4 ID:SGTC_2581|Compound:avocatin a|FD-Score:3.95|P-value:1.57E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:3.85|P-value:2.28E-4 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:-4.51|P-value:1.76E-5 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:3.45|P-value:8.23E-4 ID:SGTC_2632|Compound:3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone|FD-Score:5.80|P-value:6.00E-8 ID:SGTC_2635|Compound:hydroquinidine|FD-Score:3.87|P-value:2.12E-4 ID:SGTC_2929|Compound:9013348|FD-Score:4.86|P-value:4.63E-6 ID:SGTC_3034|Compound:9090421|FD-Score:-3.47|P-value:7.16E-4 ID:SGTC_3130|Compound:9127414|FD-Score:5.37|P-value:4.86E-7 ID:SGTC_3133|Compound:9127736|FD-Score:-5.07|P-value:1.63E-6 ID:SGTC_3134|Compound:9127454|FD-Score:5.35|P-value:5.36E-7 ID:SGTC_3142|Compound:9086498|FD-Score:-3.46|P-value:7.39E-4 ID:SGTC_3143|Compound:9086658|FD-Score:4.40|P-value:2.97E-5 ID:SGTC_3220|Compound:9131269|FD-Score:6.68|P-value:5.20E-10

Top fitness defect scores for YGL192W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2529 gangaleoidin 11.50 93.6 µM 5.67E-26 1 1.04E-30
2 SGTC_2538 3',7'-epoxycaryophyllan-6-one 9.55 100.0 µM 1.29E-18 1 6.27E-22
3 SGTC_58 0957-0393 9.46 9.0 µM 2.75E-18 cell wall 90 1.55E-21
4 SGTC_1635 st007035 7.15 42.4 µM 3.22E-11 111 4.22E-13
5 SGTC_3220 9131269 6.68 49.5 µM 5.20E-10 2 1.16E-11
6 SGTC_690 glyoxal 6.46 20.3 µM 1.84E-9 38 5.26E-11
7 SGTC_2533 agelasine 5.88 13.7 µM 4.01E-8 ERG2 13 2.06E-9
8 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 5.80 100.0 µM 6.00E-8 4 3.33E-9
9 SGTC_3130 9127414 5.37 49.5 µM 4.86E-7 7 4.02E-8
10 SGTC_3134 9127454 5.35 49.5 µM 5.36E-7 5 4.51E-8
11 SGTC_2355 9061122 5.11 103.1 µM 1.57E-6 4 1.62E-7
12 SGTC_2929 9013348 4.86 24.6 µM 4.63E-6 7 5.88E-7
13 SGTC_495 decylubiquinone 4.83 155.0 µM 5.16E-6 copper-dependent oxidative stress 7 6.69E-7
14 SGTC_70 0141-0289 4.67 43.3 µM 1.01E-5 mitochondrial stress 127 1.48E-6
15 SGTC_1329 1447-1697 4.42 50.6 µM 2.81E-5 10 5.01E-6
16 SGTC_331 k048-0133 4.41 24.5 µM 2.93E-5 RSC & ERG11 5 5.27E-6
17 SGTC_3143 9086658 4.40 49.5 µM 2.97E-5 31 5.35E-6
18 SGTC_236 1509-0011 4.36 5.3 µM 3.54E-5 363 6.60E-6
19 SGTC_1682 st012968 4.11 530.0 nM 9.08E-5 13 2.02E-5
20 SGTC_533 1222-0222 4.05 6.7 µM 1.11E-4 PDR1 25 2.56E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.201 6.38E-32 YLL009C COX17 hom Copper metallochaperone that transfers copper to Sco1p and Cox11p for eventual delivery to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs
0.184 7.23E-27 YMR151W_d YIM2_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1
0.179 1.19E-25 YNL314W DAL82 hom Positive regulator of allophanate inducible genes; binds a dodecanucleotide sequence upstream of all genes that are induced by allophanate; contains an UISALL DNA-binding, a transcriptional activation, and a coiled-coil domain
0.178 2.58E-25 YKL076C_d PSY1_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 69% of ORF overlaps the uncharacterized ORF YKL075C
0.177 4.07E-25 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.169 5.65E-23 YJR054W KCH1 hom Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate
0.168 1.16E-22 YPL013C MRPS16 hom Mitochondrial ribosomal protein of the small subunit
0.168 1.66E-22 YDR375C BCS1 hom Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases
0.167 1.87E-22 YCL005W LDB16 hom Protein of unknown function; null mutants have decreased net negative cell surface charge; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; native protein is detected in purified mitochondria
0.167 2.05E-22 YKL033W-A_p YKL033W-A_p hom Putative protein of unknown function; similar to uncharacterized proteins from other fungi
0.163 1.82E-21 YGL191W COX13 hom Subunit VIa of cytochrome c oxidase; present in a subclass of cytochrome c oxidase complexes that may have a role in mimimizing generation of reactive oxygen species; not essential for cytochrome c oxidase activity but may modulate activity in response to ATP; required for assembly of Rcf2p into cytochrome c oxidase - cytochrome bc1 supercomplexes
0.163 2.67E-21 YEL059C-A SOM1 hom Subunit of the mitochondrial inner membrane peptidase, which is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates; contains twin cysteine-x9-cysteine motifs
0.160 1.53E-20 YGL107C RMD9 hom Mitochondrial protein required for respiratory growth; mutant phenotype and genetic interactions suggest a role in delivering mt mRNAs to ribosomes; located on matrix face of the inner membrane and loosely associated with mitoribosomes
0.158 3.07E-20 YDR205W MSC2 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
0.158 4.23E-20 YGR183C QCR9 hom Subunit 9 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; required for electron transfer at the ubiquinol oxidase site of the complex