YGL194C / HOS2

Histone deacetylase and subunit of Set3 and Rpd3L complexes; required for gene activation via specific deacetylation of lysines in H3 and H4 histone tails; subunit of the Set3 complex, a meiotic-specific repressor of sporulation specific genes that contains deacetylase activity; co-localizes with Cmr1p in nuclear foci in response to DNA damage by MMS

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL194C / HOS2

Click on Significant Values for Screen Details ID:SGTC_178|Compound:4092-0806|FD-Score:5.35|P-value:2.43E-8 ID:SGTC_266|Compound:formosanin C|FD-Score:4.19|P-value:9.32E-6 ID:SGTC_278|Compound:4092-0821|FD-Score:3.53|P-value:1.53E-4 ID:SGTC_279|Compound:1273-0055|FD-Score:8.07|P-value:9.95E-17 ID:SGTC_293|Compound:4049-0273|FD-Score:3.34|P-value:3.17E-4 ID:SGTC_294|Compound:k038-0071|FD-Score:6.12|P-value:2.16E-10 ID:SGTC_424|Compound:splitomicin|FD-Score:-5.15|P-value:9.88E-8 ID:SGTC_431|Compound:k089-0097|FD-Score:-5.74|P-value:3.43E-9 ID:SGTC_562|Compound:3772-2733|FD-Score:3.59|P-value:1.22E-4 ID:SGTC_623|Compound:k072-0108|FD-Score:3.49|P-value:1.81E-4 ID:SGTC_628|Compound:1636-0253|FD-Score:6.24|P-value:1.00E-10 ID:SGTC_664|Compound:1222-0054|FD-Score:3.44|P-value:2.19E-4 ID:SGTC_710|Compound:3448-4187|FD-Score:3.43|P-value:2.23E-4 ID:SGTC_819|Compound:1013-0258|FD-Score:4.67|P-value:9.50E-7 ID:SGTC_830|Compound:4076-0286|FD-Score:-4.07|P-value:2.01E-5 ID:SGTC_836|Compound:0330-0104|FD-Score:3.14|P-value:6.55E-4 ID:SGTC_852|Compound:0418-0143|FD-Score:3.82|P-value:4.70E-5 ID:SGTC_939|Compound:1165-0479|FD-Score:3.10|P-value:7.37E-4 ID:SGTC_940|Compound:3232-1287|FD-Score:3.38|P-value:2.72E-4 ID:SGTC_945|Compound:3381-0768|FD-Score:3.07|P-value:8.41E-4 ID:SGTC_947|Compound:3447-0010|FD-Score:-5.13|P-value:1.13E-7 ID:SGTC_955|Compound:1216-0110|FD-Score:5.63|P-value:4.78E-9 ID:SGTC_996|Compound:3970-0799|FD-Score:3.42|P-value:2.36E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:5.13|P-value:8.22E-8 ID:SGTC_1180|Compound:1193-0155|FD-Score:3.25|P-value:4.42E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:-3.23|P-value:5.83E-4 ID:SGTC_1251|Compound:0490-5699|FD-Score:4.30|P-value:5.69E-6 ID:SGTC_1317|Compound:1273-0028|FD-Score:3.99|P-value:2.30E-5 ID:SGTC_1388|Compound:3346-4487|FD-Score:6.23|P-value:1.09E-10 ID:SGTC_1495|Compound:4469-0029|FD-Score:3.69|P-value:7.91E-5 ID:SGTC_1527|Compound:coumarin|FD-Score:4.25|P-value:7.15E-6 ID:SGTC_1562|Compound:morin hydrate|FD-Score:4.36|P-value:4.12E-6 ID:SGTC_1574|Compound:spiramycin|FD-Score:-3.14|P-value:7.81E-4 ID:SGTC_1687|Compound:st020778|FD-Score:8.21|P-value:3.14E-17 ID:SGTC_1691|Compound:st019933|FD-Score:4.56|P-value:1.64E-6 ID:SGTC_1694|Compound:st024011|FD-Score:7.76|P-value:1.38E-15 ID:SGTC_1707|Compound:st032323|FD-Score:-3.12|P-value:8.38E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:3.70|P-value:7.58E-5 ID:SGTC_1728|Compound:st035614|FD-Score:3.29|P-value:3.76E-4 ID:SGTC_1941|Compound:st076221|FD-Score:7.26|P-value:6.91E-14 ID:SGTC_2125|Compound:5246583|FD-Score:3.35|P-value:3.04E-4 ID:SGTC_2162|Compound:5663267|FD-Score:4.12|P-value:1.27E-5 ID:SGTC_2364|Compound:9055074|FD-Score:-3.65|P-value:1.19E-4 ID:SGTC_2375|Compound:9072683|FD-Score:3.78|P-value:5.45E-5 ID:SGTC_2389|Compound:9091542|FD-Score:-3.53|P-value:1.90E-4 ID:SGTC_2393|Compound:9031399|FD-Score:3.26|P-value:4.30E-4 ID:SGTC_2481|Compound:5478948|FD-Score:3.05|P-value:8.79E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:5.54|P-value:7.72E-9 ID:SGTC_2625|Compound:euphol|FD-Score:3.15|P-value:6.38E-4 ID:SGTC_2715|Compound:st079500|FD-Score:-4.06|P-value:2.16E-5 ID:SGTC_2716|Compound:st080858|FD-Score:3.04|P-value:9.10E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:3.05|P-value:8.83E-4 ID:SGTC_2780|Compound:5215298|FD-Score:5.68|P-value:3.42E-9 ID:SGTC_2784|Compound:7567673|FD-Score:-3.30|P-value:4.45E-4 ID:SGTC_2785|Compound:7756463|FD-Score:-3.24|P-value:5.62E-4 ID:SGTC_2790|Compound:5423970|FD-Score:4.99|P-value:1.78E-7 ID:SGTC_2808|Compound:7946468|FD-Score:3.06|P-value:8.56E-4 ID:SGTC_2809|Compound:7964133|FD-Score:3.87|P-value:3.87E-5 ID:SGTC_2812|Compound:7970281|FD-Score:4.53|P-value:1.88E-6 ID:SGTC_2858|Compound:9025781|FD-Score:4.24|P-value:7.40E-6 ID:SGTC_3286|Compound:9117135|FD-Score:-3.15|P-value:7.59E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:5.35|P-value:2.43E-8 ID:SGTC_266|Compound:formosanin C|FD-Score:4.19|P-value:9.32E-6 ID:SGTC_278|Compound:4092-0821|FD-Score:3.53|P-value:1.53E-4 ID:SGTC_279|Compound:1273-0055|FD-Score:8.07|P-value:9.95E-17 ID:SGTC_293|Compound:4049-0273|FD-Score:3.34|P-value:3.17E-4 ID:SGTC_294|Compound:k038-0071|FD-Score:6.12|P-value:2.16E-10 ID:SGTC_424|Compound:splitomicin|FD-Score:-5.15|P-value:9.88E-8 ID:SGTC_431|Compound:k089-0097|FD-Score:-5.74|P-value:3.43E-9 ID:SGTC_562|Compound:3772-2733|FD-Score:3.59|P-value:1.22E-4 ID:SGTC_623|Compound:k072-0108|FD-Score:3.49|P-value:1.81E-4 ID:SGTC_628|Compound:1636-0253|FD-Score:6.24|P-value:1.00E-10 ID:SGTC_664|Compound:1222-0054|FD-Score:3.44|P-value:2.19E-4 ID:SGTC_710|Compound:3448-4187|FD-Score:3.43|P-value:2.23E-4 ID:SGTC_819|Compound:1013-0258|FD-Score:4.67|P-value:9.50E-7 ID:SGTC_830|Compound:4076-0286|FD-Score:-4.07|P-value:2.01E-5 ID:SGTC_836|Compound:0330-0104|FD-Score:3.14|P-value:6.55E-4 ID:SGTC_852|Compound:0418-0143|FD-Score:3.82|P-value:4.70E-5 ID:SGTC_939|Compound:1165-0479|FD-Score:3.10|P-value:7.37E-4 ID:SGTC_940|Compound:3232-1287|FD-Score:3.38|P-value:2.72E-4 ID:SGTC_945|Compound:3381-0768|FD-Score:3.07|P-value:8.41E-4 ID:SGTC_947|Compound:3447-0010|FD-Score:-5.13|P-value:1.13E-7 ID:SGTC_955|Compound:1216-0110|FD-Score:5.63|P-value:4.78E-9 ID:SGTC_996|Compound:3970-0799|FD-Score:3.42|P-value:2.36E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:5.13|P-value:8.22E-8 ID:SGTC_1180|Compound:1193-0155|FD-Score:3.25|P-value:4.42E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:-3.23|P-value:5.83E-4 ID:SGTC_1251|Compound:0490-5699|FD-Score:4.30|P-value:5.69E-6 ID:SGTC_1317|Compound:1273-0028|FD-Score:3.99|P-value:2.30E-5 ID:SGTC_1388|Compound:3346-4487|FD-Score:6.23|P-value:1.09E-10 ID:SGTC_1495|Compound:4469-0029|FD-Score:3.69|P-value:7.91E-5 ID:SGTC_1527|Compound:coumarin|FD-Score:4.25|P-value:7.15E-6 ID:SGTC_1562|Compound:morin hydrate|FD-Score:4.36|P-value:4.12E-6 ID:SGTC_1574|Compound:spiramycin|FD-Score:-3.14|P-value:7.81E-4 ID:SGTC_1687|Compound:st020778|FD-Score:8.21|P-value:3.14E-17 ID:SGTC_1691|Compound:st019933|FD-Score:4.56|P-value:1.64E-6 ID:SGTC_1694|Compound:st024011|FD-Score:7.76|P-value:1.38E-15 ID:SGTC_1707|Compound:st032323|FD-Score:-3.12|P-value:8.38E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:3.70|P-value:7.58E-5 ID:SGTC_1728|Compound:st035614|FD-Score:3.29|P-value:3.76E-4 ID:SGTC_1941|Compound:st076221|FD-Score:7.26|P-value:6.91E-14 ID:SGTC_2125|Compound:5246583|FD-Score:3.35|P-value:3.04E-4 ID:SGTC_2162|Compound:5663267|FD-Score:4.12|P-value:1.27E-5 ID:SGTC_2364|Compound:9055074|FD-Score:-3.65|P-value:1.19E-4 ID:SGTC_2375|Compound:9072683|FD-Score:3.78|P-value:5.45E-5 ID:SGTC_2389|Compound:9091542|FD-Score:-3.53|P-value:1.90E-4 ID:SGTC_2393|Compound:9031399|FD-Score:3.26|P-value:4.30E-4 ID:SGTC_2481|Compound:5478948|FD-Score:3.05|P-value:8.79E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:5.54|P-value:7.72E-9 ID:SGTC_2625|Compound:euphol|FD-Score:3.15|P-value:6.38E-4 ID:SGTC_2715|Compound:st079500|FD-Score:-4.06|P-value:2.16E-5 ID:SGTC_2716|Compound:st080858|FD-Score:3.04|P-value:9.10E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:3.05|P-value:8.83E-4 ID:SGTC_2780|Compound:5215298|FD-Score:5.68|P-value:3.42E-9 ID:SGTC_2784|Compound:7567673|FD-Score:-3.30|P-value:4.45E-4 ID:SGTC_2785|Compound:7756463|FD-Score:-3.24|P-value:5.62E-4 ID:SGTC_2790|Compound:5423970|FD-Score:4.99|P-value:1.78E-7 ID:SGTC_2808|Compound:7946468|FD-Score:3.06|P-value:8.56E-4 ID:SGTC_2809|Compound:7964133|FD-Score:3.87|P-value:3.87E-5 ID:SGTC_2812|Compound:7970281|FD-Score:4.53|P-value:1.88E-6 ID:SGTC_2858|Compound:9025781|FD-Score:4.24|P-value:7.40E-6 ID:SGTC_3286|Compound:9117135|FD-Score:-3.15|P-value:7.59E-4

Top fitness defect scores for YGL194C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1687 st020778 8.21 55.4 µM 3.14E-17 66 1.13E-16
2 SGTC_279 1273-0055 8.07 2.9 µM 9.95E-17 azole & statin 4 3.44E-16
3 SGTC_1694 st024011 7.76 44.9 µM 1.38E-15 ERG2 8 4.39E-15
4 SGTC_1941 st076221 7.26 61.8 µM 6.91E-14 sphingolipid biosynthesis & PDR1 24 1.93E-13
5 SGTC_628 1636-0253 6.24 16.0 µM 1.00E-10 sphingolipid biosynthesis & PDR1 8 2.21E-10
6 SGTC_1388 3346-4487 6.23 254.0 µM 1.09E-10 1 2.41E-10
7 SGTC_294 k038-0071 6.12 157.0 µM 2.16E-10 ubiquinone biosynthesis & proteasome 13 4.64E-10
8 SGTC_2780 5215298 5.68 71.4 µM 3.42E-9 10 6.71E-9
9 SGTC_955 1216-0110 5.63 33.0 µM 4.78E-9 sphingolipid biosynthesis & PDR1 36 9.27E-9
10 SGTC_2582 agaric acid 5.54 100.0 µM 7.72E-9 redox potentiating 185 1.47E-8
11 SGTC_178 4092-0806 5.35 87.5 µM 2.43E-8 ergosterol depletion effects on membrane 48 4.47E-8
12 SGTC_1083 didemethylchlorpromazine sulfoxide 5.13 707.4 nM 8.22E-8 redox potentiating 45 1.45E-7
13 SGTC_2790 5423970 4.99 71.4 µM 1.78E-7 endomembrane recycling 37 3.06E-7
14 SGTC_819 1013-0258 4.67 27.7 µM 9.50E-7 24 1.54E-6
15 SGTC_1691 st019933 4.56 84.6 µM 1.64E-6 7 2.62E-6
16 SGTC_2812 7970281 4.53 58.4 µM 1.88E-6 12 2.99E-6
17 SGTC_1562 morin hydrate 4.36 59.1 µM 4.12E-6 10 6.36E-6
18 SGTC_1251 0490-5699 4.30 265.0 µM 5.69E-6 25 8.69E-6
19 SGTC_1527 coumarin 4.25 137.0 µM 7.15E-6 17 1.09E-5
20 SGTC_2858 9025781 4.24 9.0 µM 7.40E-6 sphingolipid biosynthesis & PDR1 85 1.12E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.318 1.48E-79 YCR033W SNT1 hom Subunit of the Set3C deacetylase complex that interacts directly with the Set3C subunit, Sif2p; putative DNA-binding protein; mutant has increased aneuploidy tolerance
0.277 3.54E-60 YOL050C_d YOL050C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps verified gene GAL11; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)
0.269 1.47E-56 YKR029C SET3 hom Defining member of the SET3 histone deacetylase complex which is a meiosis-specific repressor of sporulation genes; necessary for efficient transcription by RNAPII; one of two yeast proteins that contains both SET and PHD domains; SET3 has a paralog, SET4, that arose from the whole genome duplication
0.230 2.27E-41 YBR103W SIF2 hom WD40 repeat-containing subunit of the Set3C histone deacetylase complex, which represses early/middle sporulation genes; antagonizes telomeric silencing; binds specifically to the Sir4p N-terminus
0.221 1.86E-38 YPL057C SUR1 hom Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit; forms a complex with regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Csh1p; SUR1 has a paralog, CSH1, that arose from the whole genome duplication
0.205 2.98E-33 YLR055C SPT8 hom Subunit of the SAGA transcriptional regulatory complex but not present in SAGA-like complex SLIK/SALSA, required for SAGA-mediated inhibition at some promoters
0.185 2.81E-27 YDR392W SPT3 hom Subunit of the SAGA and SAGA-like transcriptional regulatory complexes, interacts with Spt15p to activate transcription of some RNA polymerase II-dependent genes, also functions to inhibit transcription at some promoters
0.177 3.67E-25 YMR102C_p YMR102C_p hom Protein of unknown function; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance; mutant shows increased resistance to azoles; YMR102C is not an essential gene
0.173 5.57E-24 YDR326C YSP2 hom Protein involved in programmed cell death; mutant shows resistance to cell death induced by amiodarone or intracellular acidification; YSP2 has a paralog, YHR080C, that arose from the whole genome duplication
0.168 8.98E-23 YDR072C IPT1 hom Inositolphosphotransferase, involved in synthesis of mannose-(inositol-P)2-ceramide (M(IP)2C), the most abundant sphingolipid; can mutate to resistance to the antifungals syringomycin E and DmAMP1 and to K. lactis zymocin
0.167 2.20E-22 YDR376W ARH1 het Oxidoreductase of the mitochondrial inner membrane, involved in cytoplasmic and mitochondrial iron homeostasis and required for activity of Fe-S cluster-containing enzymes; one of the few mitochondrial proteins essential for viability
0.167 2.22E-22 YPL252C YAH1 het Ferredoxin of the mitochondrial matrix required for formation of cellular iron-sulfur proteins; involved in heme A biosynthesis; homologous to human adrenodoxin
0.167 2.70E-22 YBL079W NUP170 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC assembly and nucleocytoplasmic transport; both Nup170p and NUP157p are similar to human Nup155p; NUP170 has a paralog, NUP157, that arose from the whole genome duplication
0.161 6.73E-21 YNL229C URE2 hom Nitrogen catabolite repression transcriptional regulator that acts by inhibition of GLN3 transcription in good nitrogen source; has glutathione peroxidase activity and can mutate to acquire GST activity; altered form creates [URE3] prion
0.152 8.72E-19 YKR093W PTR2 hom Integral membrane peptide transporter, mediates transport of di- and tri-peptides; conserved protein that contains 12 transmembrane domains; PTR2 expression is regulated by the N-end rule pathway via repression by Cup9p