YGL196W / DSD1

D-serine dehydratase (aka D-serine ammonia-lyase); converts D-serine to pyruvate and ammonia by a reaction dependent on pyridoxal 5'-phosphate and zinc; may play a role in D-serine detoxification; L-serine is not a substrate

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL196W / DSD1

Click on Significant Values for Screen Details ID:SGTC_69|Compound:0096-0274|FD-Score:-3.14|P-value:8.89E-4 ID:SGTC_85|Compound:0868-0259|FD-Score:3.61|P-value:1.70E-4 ID:SGTC_244|Compound:nsc-207895|FD-Score:3.19|P-value:7.81E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:3.45|P-value:3.09E-4 ID:SGTC_563|Compound:tetrahydrosecaminediol|FD-Score:-3.46|P-value:2.93E-4 ID:SGTC_567|Compound:1080-0542|FD-Score:3.34|P-value:4.62E-4 ID:SGTC_712|Compound:r015-0009|FD-Score:6.20|P-value:3.78E-10 ID:SGTC_713|Compound:1488-1073|FD-Score:3.61|P-value:1.67E-4 ID:SGTC_717|Compound:1532-0246|FD-Score:3.17|P-value:8.20E-4 ID:SGTC_719|Compound:2810-4230|FD-Score:6.13|P-value:5.66E-10 ID:SGTC_730|Compound:1436-0052|FD-Score:-5.02|P-value:2.91E-7 ID:SGTC_731|Compound:3966-0296|FD-Score:-4.28|P-value:1.04E-5 ID:SGTC_784|Compound:4579-0127|FD-Score:3.64|P-value:1.53E-4 ID:SGTC_992|Compound:3909-8734|FD-Score:3.59|P-value:1.83E-4 ID:SGTC_1033|Compound:k072-0102|FD-Score:-3.83|P-value:6.96E-5 ID:SGTC_1214|Compound:0358-0031|FD-Score:3.48|P-value:2.76E-4 ID:SGTC_1281|Compound:0884-0031|FD-Score:3.16|P-value:8.53E-4 ID:SGTC_1343|Compound:1487-0095|FD-Score:3.33|P-value:4.71E-4 ID:SGTC_1352|Compound:1496-0991|FD-Score:-3.67|P-value:1.28E-4 ID:SGTC_1380|Compound:2291-0730|FD-Score:4.01|P-value:3.44E-5 ID:SGTC_1425|Compound:4048-4433|FD-Score:5.24|P-value:9.99E-8 ID:SGTC_1701|Compound:st028638|FD-Score:3.48|P-value:2.78E-4 ID:SGTC_2107|Compound:5363541|FD-Score:3.64|P-value:1.50E-4 ID:SGTC_2251|Compound:lansoprazole|FD-Score:5.09|P-value:2.15E-7 ID:SGTC_2340|Compound:7987427|FD-Score:4.36|P-value:7.57E-6 ID:SGTC_2371|Compound:9071574|FD-Score:-3.43|P-value:3.26E-4 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:3.40|P-value:3.66E-4 ID:SGTC_2461|Compound:5755302|FD-Score:4.31|P-value:9.51E-6 ID:SGTC_2480|Compound:5767542|FD-Score:3.66|P-value:1.41E-4 ID:SGTC_2484|Compound:5809818|FD-Score:-3.30|P-value:5.03E-4 ID:SGTC_2537|Compound:larixol|FD-Score:3.26|P-value:6.06E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:-3.69|P-value:1.22E-4 ID:SGTC_2693|Compound:st077581|FD-Score:5.65|P-value:1.03E-8 ID:SGTC_2746|Compound:daunorubicin|FD-Score:3.98|P-value:3.96E-5 ID:SGTC_2939|Compound:9044578|FD-Score:3.39|P-value:3.90E-4 ID:SGTC_2987|Compound:9018338|FD-Score:-3.27|P-value:5.63E-4 ID:SGTC_3205|Compound:9113483|FD-Score:3.35|P-value:4.39E-4 ID:SGTC_69|Compound:0096-0274|FD-Score:-3.14|P-value:8.89E-4 ID:SGTC_85|Compound:0868-0259|FD-Score:3.61|P-value:1.70E-4 ID:SGTC_244|Compound:nsc-207895|FD-Score:3.19|P-value:7.81E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:3.45|P-value:3.09E-4 ID:SGTC_563|Compound:tetrahydrosecaminediol|FD-Score:-3.46|P-value:2.93E-4 ID:SGTC_567|Compound:1080-0542|FD-Score:3.34|P-value:4.62E-4 ID:SGTC_712|Compound:r015-0009|FD-Score:6.20|P-value:3.78E-10 ID:SGTC_713|Compound:1488-1073|FD-Score:3.61|P-value:1.67E-4 ID:SGTC_717|Compound:1532-0246|FD-Score:3.17|P-value:8.20E-4 ID:SGTC_719|Compound:2810-4230|FD-Score:6.13|P-value:5.66E-10 ID:SGTC_730|Compound:1436-0052|FD-Score:-5.02|P-value:2.91E-7 ID:SGTC_731|Compound:3966-0296|FD-Score:-4.28|P-value:1.04E-5 ID:SGTC_784|Compound:4579-0127|FD-Score:3.64|P-value:1.53E-4 ID:SGTC_992|Compound:3909-8734|FD-Score:3.59|P-value:1.83E-4 ID:SGTC_1033|Compound:k072-0102|FD-Score:-3.83|P-value:6.96E-5 ID:SGTC_1214|Compound:0358-0031|FD-Score:3.48|P-value:2.76E-4 ID:SGTC_1281|Compound:0884-0031|FD-Score:3.16|P-value:8.53E-4 ID:SGTC_1343|Compound:1487-0095|FD-Score:3.33|P-value:4.71E-4 ID:SGTC_1352|Compound:1496-0991|FD-Score:-3.67|P-value:1.28E-4 ID:SGTC_1380|Compound:2291-0730|FD-Score:4.01|P-value:3.44E-5 ID:SGTC_1425|Compound:4048-4433|FD-Score:5.24|P-value:9.99E-8 ID:SGTC_1701|Compound:st028638|FD-Score:3.48|P-value:2.78E-4 ID:SGTC_2107|Compound:5363541|FD-Score:3.64|P-value:1.50E-4 ID:SGTC_2251|Compound:lansoprazole|FD-Score:5.09|P-value:2.15E-7 ID:SGTC_2340|Compound:7987427|FD-Score:4.36|P-value:7.57E-6 ID:SGTC_2371|Compound:9071574|FD-Score:-3.43|P-value:3.26E-4 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:3.40|P-value:3.66E-4 ID:SGTC_2461|Compound:5755302|FD-Score:4.31|P-value:9.51E-6 ID:SGTC_2480|Compound:5767542|FD-Score:3.66|P-value:1.41E-4 ID:SGTC_2484|Compound:5809818|FD-Score:-3.30|P-value:5.03E-4 ID:SGTC_2537|Compound:larixol|FD-Score:3.26|P-value:6.06E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:-3.69|P-value:1.22E-4 ID:SGTC_2693|Compound:st077581|FD-Score:5.65|P-value:1.03E-8 ID:SGTC_2746|Compound:daunorubicin|FD-Score:3.98|P-value:3.96E-5 ID:SGTC_2939|Compound:9044578|FD-Score:3.39|P-value:3.90E-4 ID:SGTC_2987|Compound:9018338|FD-Score:-3.27|P-value:5.63E-4 ID:SGTC_3205|Compound:9113483|FD-Score:3.35|P-value:4.39E-4

Top fitness defect scores for YGL196W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_712 r015-0009 6.20 80.6 µM 3.78E-10 7 2.86E-10
2 SGTC_719 2810-4230 6.13 27.3 µM 5.66E-10 1 4.31E-10
3 SGTC_2693 st077581 5.65 40.7 µM 1.03E-8 8 8.16E-9
4 SGTC_1425 4048-4433 5.24 7.3 µM 9.99E-8 copper-dependent oxidative stress 17 8.14E-8
5 SGTC_2251 lansoprazole 5.09 556.0 µM 2.15E-7 6 1.77E-7
6 SGTC_2340 7987427 4.36 183.4 µM 7.57E-6 21 6.53E-6
7 SGTC_2461 5755302 4.31 26.1 µM 9.51E-6 24 8.23E-6
8 SGTC_1380 2291-0730 4.01 164.0 µM 3.44E-5 25 3.03E-5
9 SGTC_2746 daunorubicin 3.98 9.9 µM 3.96E-5 anthracycline transcription coupled DNA repair 3 3.49E-5
10 SGTC_2480 5767542 3.66 37.2 µM 1.41E-4 14 1.27E-4
11 SGTC_2107 5363541 3.64 170.2 µM 1.50E-4 16 1.35E-4
12 SGTC_784 4579-0127 3.64 173.0 µM 1.53E-4 32 1.38E-4
13 SGTC_713 1488-1073 3.61 324.0 µM 1.67E-4 ERG2 18 1.50E-4
14 SGTC_85 0868-0259 3.61 160.1 µM 1.70E-4 60S ribosome export 16 1.53E-4
15 SGTC_992 3909-8734 3.59 162.0 µM 1.83E-4 31 1.65E-4
16 SGTC_1214 0358-0031 3.48 63.7 µM 2.76E-4 28 2.49E-4
17 SGTC_1701 st028638 3.48 40.4 µM 2.78E-4 25 2.52E-4
18 SGTC_363 0455-0021 3.45 3.1 µM 3.09E-4 azole & statin 88 2.80E-4
19 SGTC_2420 aureobasidin a 3.40 50.0 nM 3.66E-4 65 3.33E-4
20 SGTC_2939 9044578 3.39 71.4 µM 3.90E-4 57 3.54E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.160 1.15E-20 YLR060W FRS1 het Beta subunit of cytoplasmic phenylalanyl-tRNA synthetase, forms a tetramer with Frs2p to generate active enzyme; able to hydrolyze mis-aminoacylated tRNA-Phe, which could contribute to translational quality control
0.098 1.12E-8 YBR207W FTH1 hom Putative high affinity iron transporter; involved in transport of intravacuolar stores of iron; forms complex with Fet5p; expression is regulated by iron; proposed to play indirect role in endocytosis; protein abundance increases in response to DNA replication stress
0.095 4.18E-8 YDR428C BNA7 hom Formylkynurenine formamidase, involved in the de novo biosynthesis of NAD from tryptophan via kynurenine
0.094 4.99E-8 YBL066C SEF1 hom Putative transcription factor, has homolog in Kluyveromyces lactis
0.088 3.12E-7 YGR149W_p YGR149W_p hom Putative protein of unknown function; predicted to be an integal membrane protein
0.087 4.92E-7 YDR246W TRS23 het One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic; human homolog is TRAPPC4
0.087 5.28E-7 YPL183C RTT10 hom WD40 domain-containing protein involved in endosomal recycling; forms a complex with Rrt2p that functions in the retromer-mediated pathway for recycling internalized cell-surface proteins; evidence it interacts with Trm7p for 2'-O-methylation of N34 of substrate tRNAs; has a role in regulation of Ty1 transposition; human ortholog is WDR6
0.086 5.54E-7 YGL056C SDS23 hom One of two S. cerevisiae homologs (Sds23p and Sds24p) of the S. pombe Sds23 protein, which is implicated in APC/cyclosome regulation; involved in cell separation during budding; SDS23 has a paralog, SDS24, that arose from the whole genome duplication
0.086 5.55E-7 YOR152C_p YOR152C_p hom Putative protein of unknown function; YOR152C is not an essential gene
0.084 9.82E-7 YBR085W AAC3 hom Mitochondrial inner membrane ADP/ATP translocator; exchanges cytosolic ADP for mitochondrially synthesized ATP; expressed under anaerobic conditions; similar to Aac1p; has roles in maintenance of viability and in respiration; AAC3 has a paralog, PET9, that arose from the whole genome duplication
0.083 1.63E-6 YDR248C_p YDR248C_p hom Putative gluconokinase; sequence similarity to bacterial and human gluconokinase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; upregulated by deletion of the RNAP-II associated factor, PAF1
0.082 1.80E-6 YDR386W MUS81 hom Subunit of the structure-specific Mms4p-Mus81p endonuclease that cleaves branched DNA; involved in DNA repair, replication fork stability, and joint molecule formation/resolution during meiotic recombination; helix-hairpin-helix protein; phosphorylation of the non-catalytic subunit Mms4p by Cdc28p and Cdcp during mitotic cell cycle activates the function of Mms4p-Mus81p
0.082 1.83E-6 YML116W ATR1 hom Multidrug efflux pump of the major facilitator superfamily; required for resistance to aminotriazole and 4-nitroquinoline-N-oxide; ATR1 has a paralog, YMR279C, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.082 1.98E-6 YER001W MNN1 hom Alpha-1,3-mannosyltransferase, integral membrane glycoprotein of the Golgi complex, required for addition of alpha1,3-mannose linkages to N-linked and O-linked oligosaccharides, one of five S. cerevisiae proteins of the MNN1 family
0.078 6.78E-6 YPL074W YTA6 hom Putative ATPase of the CDC48/PAS1/SEC18 (AAA) family; localized to the cortex of mother cells but not to daughter cells; relocalizes from cytoplasm to plasma membrane foci upon DNA replication stress