YGL198W / YIP4

Protein that interacts with Rab GTPases, localized to late Golgi vesicles; computational analysis of large-scale protein-protein interaction data suggests a possible role in vesicle-mediated transport

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL198W / YIP4

Click on Significant Values for Screen Details ID:SGTC_15|Compound:0266-0086|FD-Score:4.83|P-value:2.39E-6 ID:SGTC_42|Compound:0133-0086|FD-Score:4.68|P-value:4.63E-6 ID:SGTC_64|Compound:000l-0018|FD-Score:-3.52|P-value:4.21E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:5.93|P-value:9.82E-9 ID:SGTC_76|Compound:0433-0009|FD-Score:-4.48|P-value:1.04E-5 ID:SGTC_85|Compound:0868-0259|FD-Score:3.28|P-value:9.53E-4 ID:SGTC_106|Compound:0092-0003|FD-Score:4.68|P-value:4.78E-6 ID:SGTC_113|Compound:0099-0221|FD-Score:6.41|P-value:6.41E-10 ID:SGTC_115|Compound:0527-0192|FD-Score:3.89|P-value:1.17E-4 ID:SGTC_125|Compound:0133-0007|FD-Score:4.09|P-value:5.36E-5 ID:SGTC_126|Compound:0417-1624|FD-Score:5.42|P-value:1.44E-7 ID:SGTC_131|Compound:0141-0277|FD-Score:4.68|P-value:4.78E-6 ID:SGTC_181|Compound:1447-1644|FD-Score:8.28|P-value:2.14E-15 ID:SGTC_184|Compound:1494-0393|FD-Score:3.64|P-value:2.81E-4 ID:SGTC_203|Compound:k066-0004|FD-Score:4.81|P-value:2.62E-6 ID:SGTC_205|Compound:1486-1330|FD-Score:4.16|P-value:4.18E-5 ID:SGTC_221|Compound:trifluoperazine|FD-Score:5.07|P-value:7.91E-7 ID:SGTC_247|Compound:mechlorethamine|FD-Score:3.82|P-value:1.48E-4 ID:SGTC_308|Compound:4092-1169|FD-Score:3.40|P-value:6.46E-4 ID:SGTC_313|Compound:3474-0040|FD-Score:12.00|P-value:1.80E-30 ID:SGTC_315|Compound:k915-0449|FD-Score:4.57|P-value:7.46E-6 ID:SGTC_405|Compound:ebelactone b|FD-Score:4.51|P-value:9.83E-6 ID:SGTC_424|Compound:splitomicin|FD-Score:5.11|P-value:6.63E-7 ID:SGTC_425|Compound:3825-7017|FD-Score:5.26|P-value:3.19E-7 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:5.84|P-value:1.63E-8 ID:SGTC_521|Compound:r062-0005|FD-Score:-3.65|P-value:2.61E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:3.89|P-value:1.15E-4 ID:SGTC_649|Compound:1123-0311|FD-Score:3.56|P-value:3.75E-4 ID:SGTC_716|Compound:1683-5115|FD-Score:4.11|P-value:5.03E-5 ID:SGTC_769|Compound:0302-0231|FD-Score:5.19|P-value:4.55E-7 ID:SGTC_788|Compound:1182-0090|FD-Score:5.96|P-value:8.10E-9 ID:SGTC_822|Compound:1487-0950|FD-Score:3.43|P-value:5.95E-4 ID:SGTC_890|Compound:0929-0006|FD-Score:-4.72|P-value:3.68E-6 ID:SGTC_945|Compound:3381-0768|FD-Score:3.29|P-value:9.36E-4 ID:SGTC_955|Compound:1216-0110|FD-Score:4.36|P-value:1.86E-5 ID:SGTC_967|Compound:1306-0166|FD-Score:3.34|P-value:7.90E-4 ID:SGTC_1008|Compound:4106-0037|FD-Score:3.71|P-value:2.25E-4 ID:SGTC_1080|Compound:nisoldipine|FD-Score:-4.31|P-value:2.13E-5 ID:SGTC_1130|Compound:3454-2858|FD-Score:8.76|P-value:5.15E-17 ID:SGTC_1247|Compound:0448-0043|FD-Score:-4.11|P-value:4.86E-5 ID:SGTC_1248|Compound:0469-0687|FD-Score:5.10|P-value:6.78E-7 ID:SGTC_1282|Compound:0886-0010|FD-Score:3.79|P-value:1.64E-4 ID:SGTC_1334|Compound:1486-0610|FD-Score:3.70|P-value:2.29E-4 ID:SGTC_1454|Compound:4239-0054|FD-Score:-3.26|P-value:9.89E-4 ID:SGTC_1465|Compound:k213-0056|FD-Score:4.10|P-value:5.30E-5 ID:SGTC_1470|Compound:k295-0292|FD-Score:4.32|P-value:2.19E-5 ID:SGTC_1488|Compound:4013-0813|FD-Score:4.08|P-value:5.71E-5 ID:SGTC_1493|Compound:4348-0038|FD-Score:5.15|P-value:5.31E-7 ID:SGTC_1547|Compound:harmine|FD-Score:3.59|P-value:3.41E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:-3.36|P-value:7.01E-4 ID:SGTC_1621|Compound:st003705|FD-Score:-3.40|P-value:6.20E-4 ID:SGTC_1672|Compound:st016598|FD-Score:8.67|P-value:1.06E-16 ID:SGTC_1679|Compound:4130-1276|FD-Score:3.54|P-value:3.97E-4 ID:SGTC_1724|Compound:st037281|FD-Score:-3.52|P-value:4.19E-4 ID:SGTC_1732|Compound:st034308|FD-Score:3.48|P-value:4.94E-4 ID:SGTC_1754|Compound:st042065|FD-Score:4.89|P-value:1.81E-6 ID:SGTC_1760|Compound:st045453|FD-Score:6.52|P-value:3.37E-10 ID:SGTC_1797|Compound:st048695|FD-Score:7.52|P-value:5.25E-13 ID:SGTC_1800|Compound:st050079|FD-Score:3.27|P-value:9.80E-4 ID:SGTC_1801|Compound:st050089|FD-Score:6.68|P-value:1.24E-10 ID:SGTC_1803|Compound:st050068|FD-Score:8.41|P-value:8.35E-16 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:5.22|P-value:3.78E-7 ID:SGTC_2006|Compound:4011487|FD-Score:5.34|P-value:2.13E-7 ID:SGTC_2021|Compound:4019055|FD-Score:3.52|P-value:4.36E-4 ID:SGTC_2036|Compound:5160441|FD-Score:7.77|P-value:9.16E-14 ID:SGTC_2052|Compound:5265182|FD-Score:4.06|P-value:6.13E-5 ID:SGTC_2257|Compound:7960413|FD-Score:7.41|P-value:1.10E-12 ID:SGTC_2287|Compound:7945887|FD-Score:-3.26|P-value:9.71E-4 ID:SGTC_2304|Compound:7443016|FD-Score:-4.06|P-value:5.86E-5 ID:SGTC_2314|Compound:7727897|FD-Score:-3.52|P-value:4.16E-4 ID:SGTC_2414|Compound:st077232|FD-Score:-4.01|P-value:6.95E-5 ID:SGTC_2576|Compound:guaiol|FD-Score:4.08|P-value:5.67E-5 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:5.61|P-value:5.44E-8 ID:SGTC_2783|Compound:7738165|FD-Score:-3.72|P-value:2.04E-4 ID:SGTC_2789|Compound:5281112|FD-Score:-3.80|P-value:1.54E-4 ID:SGTC_2790|Compound:5423970|FD-Score:4.45|P-value:1.24E-5 ID:SGTC_2791|Compound:5663188|FD-Score:3.44|P-value:5.65E-4 ID:SGTC_2813|Compound:7971799|FD-Score:-3.54|P-value:3.83E-4 ID:SGTC_2896|Compound:9052656|FD-Score:4.69|P-value:4.56E-6 ID:SGTC_3212|Compound:9128307|FD-Score:-3.91|P-value:1.02E-4 ID:SGTC_3331|Compound:9141060|FD-Score:-3.30|P-value:8.74E-4 ID:SGTC_15|Compound:0266-0086|FD-Score:4.83|P-value:2.39E-6 ID:SGTC_42|Compound:0133-0086|FD-Score:4.68|P-value:4.63E-6 ID:SGTC_64|Compound:000l-0018|FD-Score:-3.52|P-value:4.21E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:5.93|P-value:9.82E-9 ID:SGTC_76|Compound:0433-0009|FD-Score:-4.48|P-value:1.04E-5 ID:SGTC_85|Compound:0868-0259|FD-Score:3.28|P-value:9.53E-4 ID:SGTC_106|Compound:0092-0003|FD-Score:4.68|P-value:4.78E-6 ID:SGTC_113|Compound:0099-0221|FD-Score:6.41|P-value:6.41E-10 ID:SGTC_115|Compound:0527-0192|FD-Score:3.89|P-value:1.17E-4 ID:SGTC_125|Compound:0133-0007|FD-Score:4.09|P-value:5.36E-5 ID:SGTC_126|Compound:0417-1624|FD-Score:5.42|P-value:1.44E-7 ID:SGTC_131|Compound:0141-0277|FD-Score:4.68|P-value:4.78E-6 ID:SGTC_181|Compound:1447-1644|FD-Score:8.28|P-value:2.14E-15 ID:SGTC_184|Compound:1494-0393|FD-Score:3.64|P-value:2.81E-4 ID:SGTC_203|Compound:k066-0004|FD-Score:4.81|P-value:2.62E-6 ID:SGTC_205|Compound:1486-1330|FD-Score:4.16|P-value:4.18E-5 ID:SGTC_221|Compound:trifluoperazine|FD-Score:5.07|P-value:7.91E-7 ID:SGTC_247|Compound:mechlorethamine|FD-Score:3.82|P-value:1.48E-4 ID:SGTC_308|Compound:4092-1169|FD-Score:3.40|P-value:6.46E-4 ID:SGTC_313|Compound:3474-0040|FD-Score:12.00|P-value:1.80E-30 ID:SGTC_315|Compound:k915-0449|FD-Score:4.57|P-value:7.46E-6 ID:SGTC_405|Compound:ebelactone b|FD-Score:4.51|P-value:9.83E-6 ID:SGTC_424|Compound:splitomicin|FD-Score:5.11|P-value:6.63E-7 ID:SGTC_425|Compound:3825-7017|FD-Score:5.26|P-value:3.19E-7 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:5.84|P-value:1.63E-8 ID:SGTC_521|Compound:r062-0005|FD-Score:-3.65|P-value:2.61E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:3.89|P-value:1.15E-4 ID:SGTC_649|Compound:1123-0311|FD-Score:3.56|P-value:3.75E-4 ID:SGTC_716|Compound:1683-5115|FD-Score:4.11|P-value:5.03E-5 ID:SGTC_769|Compound:0302-0231|FD-Score:5.19|P-value:4.55E-7 ID:SGTC_788|Compound:1182-0090|FD-Score:5.96|P-value:8.10E-9 ID:SGTC_822|Compound:1487-0950|FD-Score:3.43|P-value:5.95E-4 ID:SGTC_890|Compound:0929-0006|FD-Score:-4.72|P-value:3.68E-6 ID:SGTC_945|Compound:3381-0768|FD-Score:3.29|P-value:9.36E-4 ID:SGTC_955|Compound:1216-0110|FD-Score:4.36|P-value:1.86E-5 ID:SGTC_967|Compound:1306-0166|FD-Score:3.34|P-value:7.90E-4 ID:SGTC_1008|Compound:4106-0037|FD-Score:3.71|P-value:2.25E-4 ID:SGTC_1080|Compound:nisoldipine|FD-Score:-4.31|P-value:2.13E-5 ID:SGTC_1130|Compound:3454-2858|FD-Score:8.76|P-value:5.15E-17 ID:SGTC_1247|Compound:0448-0043|FD-Score:-4.11|P-value:4.86E-5 ID:SGTC_1248|Compound:0469-0687|FD-Score:5.10|P-value:6.78E-7 ID:SGTC_1282|Compound:0886-0010|FD-Score:3.79|P-value:1.64E-4 ID:SGTC_1334|Compound:1486-0610|FD-Score:3.70|P-value:2.29E-4 ID:SGTC_1454|Compound:4239-0054|FD-Score:-3.26|P-value:9.89E-4 ID:SGTC_1465|Compound:k213-0056|FD-Score:4.10|P-value:5.30E-5 ID:SGTC_1470|Compound:k295-0292|FD-Score:4.32|P-value:2.19E-5 ID:SGTC_1488|Compound:4013-0813|FD-Score:4.08|P-value:5.71E-5 ID:SGTC_1493|Compound:4348-0038|FD-Score:5.15|P-value:5.31E-7 ID:SGTC_1547|Compound:harmine|FD-Score:3.59|P-value:3.41E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:-3.36|P-value:7.01E-4 ID:SGTC_1621|Compound:st003705|FD-Score:-3.40|P-value:6.20E-4 ID:SGTC_1672|Compound:st016598|FD-Score:8.67|P-value:1.06E-16 ID:SGTC_1679|Compound:4130-1276|FD-Score:3.54|P-value:3.97E-4 ID:SGTC_1724|Compound:st037281|FD-Score:-3.52|P-value:4.19E-4 ID:SGTC_1732|Compound:st034308|FD-Score:3.48|P-value:4.94E-4 ID:SGTC_1754|Compound:st042065|FD-Score:4.89|P-value:1.81E-6 ID:SGTC_1760|Compound:st045453|FD-Score:6.52|P-value:3.37E-10 ID:SGTC_1797|Compound:st048695|FD-Score:7.52|P-value:5.25E-13 ID:SGTC_1800|Compound:st050079|FD-Score:3.27|P-value:9.80E-4 ID:SGTC_1801|Compound:st050089|FD-Score:6.68|P-value:1.24E-10 ID:SGTC_1803|Compound:st050068|FD-Score:8.41|P-value:8.35E-16 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:5.22|P-value:3.78E-7 ID:SGTC_2006|Compound:4011487|FD-Score:5.34|P-value:2.13E-7 ID:SGTC_2021|Compound:4019055|FD-Score:3.52|P-value:4.36E-4 ID:SGTC_2036|Compound:5160441|FD-Score:7.77|P-value:9.16E-14 ID:SGTC_2052|Compound:5265182|FD-Score:4.06|P-value:6.13E-5 ID:SGTC_2257|Compound:7960413|FD-Score:7.41|P-value:1.10E-12 ID:SGTC_2287|Compound:7945887|FD-Score:-3.26|P-value:9.71E-4 ID:SGTC_2304|Compound:7443016|FD-Score:-4.06|P-value:5.86E-5 ID:SGTC_2314|Compound:7727897|FD-Score:-3.52|P-value:4.16E-4 ID:SGTC_2414|Compound:st077232|FD-Score:-4.01|P-value:6.95E-5 ID:SGTC_2576|Compound:guaiol|FD-Score:4.08|P-value:5.67E-5 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:5.61|P-value:5.44E-8 ID:SGTC_2783|Compound:7738165|FD-Score:-3.72|P-value:2.04E-4 ID:SGTC_2789|Compound:5281112|FD-Score:-3.80|P-value:1.54E-4 ID:SGTC_2790|Compound:5423970|FD-Score:4.45|P-value:1.24E-5 ID:SGTC_2791|Compound:5663188|FD-Score:3.44|P-value:5.65E-4 ID:SGTC_2813|Compound:7971799|FD-Score:-3.54|P-value:3.83E-4 ID:SGTC_2896|Compound:9052656|FD-Score:4.69|P-value:4.56E-6 ID:SGTC_3212|Compound:9128307|FD-Score:-3.91|P-value:1.02E-4 ID:SGTC_3331|Compound:9141060|FD-Score:-3.30|P-value:8.74E-4

Top fitness defect scores for YGL198W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_313 3474-0040 12.00 5.0 µM 1.80E-30 NEO1-PIK1 2 1.03E-33
2 SGTC_1130 3454-2858 8.76 15.9 µM 5.15E-17 NEO1 19 9.55E-19
3 SGTC_1672 st016598 8.67 6.5 µM 1.06E-16 endomembrane recycling 15 2.13E-18
4 SGTC_1803 st050068 8.41 52.4 µM 8.35E-16 NEO1-PIK1 33 2.11E-17
5 SGTC_181 1447-1644 8.28 8.1 µM 2.14E-15 endomembrane recycling 7 6.01E-17
6 SGTC_2036 5160441 7.77 105.0 µM 9.16E-14 NEO1 31 3.92E-15
7 SGTC_1797 st048695 7.52 56.8 µM 5.25E-13 NEO1 23 2.73E-14
8 SGTC_2257 7960413 7.41 200.0 µM 1.10E-12 NEO1-PIK1 6 6.19E-14
9 SGTC_1801 st050089 6.68 28.4 µM 1.24E-10 NEO1-PIK1 41 1.19E-11
10 SGTC_1760 st045453 6.52 10.4 µM 3.37E-10 NEO1-PIK1 73 3.59E-11
11 SGTC_113 0099-0221 6.41 2.5 µM 6.41E-10 1 7.35E-11
12 SGTC_788 1182-0090 5.96 188.0 µM 8.10E-9 endomembrane recycling 36 1.23E-9
13 SGTC_70 0141-0289 5.93 43.3 µM 9.82E-9 mitochondrial stress 83 1.52E-9
14 SGTC_453 enantio-paf c16 5.84 10.0 µM 1.63E-8 57 2.68E-9
15 SGTC_2697 mebhydrolin 5.61 72.4 µM 5.44E-8 NEO1 36 1.02E-8
16 SGTC_126 0417-1624 5.42 672.5 µM 1.44E-7 DNA intercalators 5 3.00E-8
17 SGTC_2006 4011487 5.34 200.0 µM 2.13E-7 endomembrane recycling 54 4.64E-8
18 SGTC_425 3825-7017 5.26 13.1 µM 3.19E-7 11 7.27E-8
19 SGTC_1926 methyl fluorone black 5.22 53.6 µM 3.78E-7 DNA intercalators 31 8.78E-8
20 SGTC_769 0302-0231 5.19 76.0 µM 4.55E-7 15 1.08E-7

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.508 9.01E-220 YGL199C_d YGL199C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YIP4/YGL198W
0.450 2.03E-166 YNL267W PIK1 het Phosphatidylinositol 4-kinase; catalyzes first step in the biosynthesis of phosphatidylinositol-4,5-biphosphate; may control cytokinesis through the actin cytoskeleton
0.440 1.98E-158 YDR084C TVP23 hom Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
0.355 1.36E-99 YDL090C RAM1 hom Beta subunit of the CAAX farnesyltransferase (FTase) that prenylates the a-factor mating pheromone and Ras proteins; required for the membrane localization of Ras proteins and a-factor; homolog of the mammalian FTase beta subunit
0.349 3.10E-96 YGL019W CKB1 hom Beta regulatory subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases
0.344 1.65E-93 YGL161C YIP5 hom Protein that interacts with Rab GTPases, localized to late Golgi vesicles; computational analysis of large-scale protein-protein interaction data suggests a possible role in vesicle-mediated transport
0.340 2.44E-91 YML037C_p YML037C_p hom Putative protein of unknown function with some characteristics of a transcriptional activator; may be a target of Dbf2p-Mob1p kinase; GFP-fusion protein co-localizes with clathrin-coated vesicles; YML037C is not an essential gene
0.324 9.10E-83 YOR115C TRS33 hom One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic
0.307 4.76E-74 YJL207C LAA1 hom AP-1 accessory protein; colocalizes with clathrin to the late-Golgi apparatus; involved in TGN-endosome transport; physically interacts with AP-1; similar to the mammalian p200; may interact with ribosomes; YJL207C is a non-essential gene
0.294 5.19E-68 YHR108W GGA2 hom Protein that interacts with and regulates Arf1p and Arf2p in a GTP-dependent manner to facilitate traffic through the late Golgi; binds phosphatidylinositol 4-phosphate, which plays a role in TGN localization; has homology to gamma-adaptin
0.284 4.02E-63 YIL048W NEO1 het Putative aminophospholipid translocase (flippase) involved in endocytosis and vacuolar biogenesis; localizes to endosomes and the Golgi aparatus
0.277 4.54E-60 YOR039W CKB2 hom Beta' regulatory subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerase
0.273 2.49E-58 YPR091C NVJ2 hom Lipid-binding ER protein, enriched at nucleus-vacuolar junctions (NVJ); may be involved in sterol metabolism or signaling at the NVJ; contains a synaptotagmin-like-mitochondrial- lipid binding protein (SMP) domain; binds phosphatidylinositols and other lipids in a large-scale study; may interact with ribosomes, based on co-purification experiments
0.265 9.88E-55 YGR166W TRS65 hom Subunit of TRAPPII, a multimeric guanine nucleotide-exchange factor for Ypt1p; involved in intra-Golgi traffic and the retrograde pathway from the endosome to Golgi; role in cell wall beta-glucan biosynthesis and the stress response
0.256 3.34E-51 YFL034W_p YFL034W_p hom Putative integral membrane protein that interacts with Rpp0p, which is a component of the ribosomal stalk