YGL200C / EMP24

Component of the p24 complex; binds to GPI anchor proteins and mediates their efficient transport from the ER to the Golgi; integral membrane protein that associates with endoplasmic reticulum-derived COPII-coated vesicles

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL200C / EMP24

Click on Significant Values for Screen Details ID:SGTC_9|Compound:0092-0002|FD-Score:4.29|P-value:8.72E-6 ID:SGTC_17|Compound:0960-0276|FD-Score:6.03|P-value:7.17E-10 ID:SGTC_77|Compound:0828-0286|FD-Score:5.20|P-value:8.93E-8 ID:SGTC_85|Compound:0868-0259|FD-Score:3.77|P-value:7.88E-5 ID:SGTC_143|Compound:4032-1194|FD-Score:3.52|P-value:2.10E-4 ID:SGTC_144|Compound:4161-2749|FD-Score:5.02|P-value:2.34E-7 ID:SGTC_145|Compound:3737-0113|FD-Score:7.55|P-value:1.59E-14 ID:SGTC_181|Compound:1447-1644|FD-Score:3.22|P-value:6.36E-4 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:3.47|P-value:2.57E-4 ID:SGTC_257|Compound:daunorubicin|FD-Score:3.54|P-value:2.01E-4 ID:SGTC_264|Compound:promethazine|FD-Score:6.13|P-value:3.83E-10 ID:SGTC_330|Compound:1488-0319|FD-Score:4.13|P-value:1.79E-5 ID:SGTC_370|Compound:0180-0345|FD-Score:3.23|P-value:6.12E-4 ID:SGTC_407|Compound:eburnamonine|FD-Score:4.20|P-value:1.29E-5 ID:SGTC_470|Compound:aa-861|FD-Score:4.16|P-value:1.55E-5 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:5.02|P-value:2.33E-7 ID:SGTC_511|Compound:blebbistatin|FD-Score:3.59|P-value:1.63E-4 ID:SGTC_512|Compound:prima-1|FD-Score:3.60|P-value:1.56E-4 ID:SGTC_701|Compound:4424-0219|FD-Score:3.33|P-value:4.40E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:3.34|P-value:4.22E-4 ID:SGTC_856|Compound:0433-0016|FD-Score:-3.35|P-value:3.23E-4 ID:SGTC_867|Compound:0518-0118|FD-Score:4.14|P-value:1.68E-5 ID:SGTC_1060|Compound:3448-7350|FD-Score:4.09|P-value:2.07E-5 ID:SGTC_1243|Compound:0416-0003|FD-Score:3.46|P-value:2.71E-4 ID:SGTC_1290|Compound:0986-0249|FD-Score:5.28|P-value:5.79E-8 ID:SGTC_1299|Compound:1079-1439|FD-Score:3.14|P-value:8.55E-4 ID:SGTC_1386|Compound:3228-0095|FD-Score:-5.19|P-value:6.90E-8 ID:SGTC_1388|Compound:3346-4487|FD-Score:-3.45|P-value:2.22E-4 ID:SGTC_1396|Compound:3511-0007|FD-Score:3.51|P-value:2.21E-4 ID:SGTC_1415|Compound:3966-0071|FD-Score:4.13|P-value:1.77E-5 ID:SGTC_1418|Compound:3966-3099|FD-Score:-3.07|P-value:8.80E-4 ID:SGTC_1834|Compound:st055981|FD-Score:3.25|P-value:5.79E-4 ID:SGTC_1914|Compound:st062367|FD-Score:3.63|P-value:1.39E-4 ID:SGTC_1920|Compound:st075728|FD-Score:-3.51|P-value:1.76E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:3.62|P-value:1.43E-4 ID:SGTC_2015|Compound:5119600|FD-Score:3.47|P-value:2.56E-4 ID:SGTC_2117|Compound:5521686|FD-Score:-3.44|P-value:2.28E-4 ID:SGTC_2161|Compound:5662504|FD-Score:3.55|P-value:1.90E-4 ID:SGTC_2445|Compound:5742597|FD-Score:3.27|P-value:5.42E-4 ID:SGTC_2448|Compound:5185112|FD-Score:5.27|P-value:6.17E-8 ID:SGTC_2506|Compound:ethyl hematommate|FD-Score:-3.13|P-value:7.13E-4 ID:SGTC_2643|Compound:anethole|FD-Score:5.87|P-value:1.90E-9 ID:SGTC_2644|Compound:guaiazulene|FD-Score:3.11|P-value:9.36E-4 ID:SGTC_2645|Compound:abamectin|FD-Score:3.56|P-value:1.87E-4 ID:SGTC_2666|Compound:tannic acid|FD-Score:7.54|P-value:1.77E-14 ID:SGTC_2675|Compound:theaflavin digallate|FD-Score:3.71|P-value:1.02E-4 ID:SGTC_2780|Compound:5215298|FD-Score:3.10|P-value:9.85E-4 ID:SGTC_2868|Compound:9035608|FD-Score:-3.14|P-value:6.80E-4 ID:SGTC_2899|Compound:9053889|FD-Score:-3.10|P-value:8.01E-4 ID:SGTC_2958|Compound:9077254|FD-Score:3.72|P-value:9.70E-5 ID:SGTC_2963|Compound:9082507|FD-Score:3.12|P-value:9.01E-4 ID:SGTC_3014|Compound:9081533|FD-Score:3.10|P-value:9.59E-4 ID:SGTC_3040|Compound:9091894|FD-Score:7.53|P-value:1.87E-14 ID:SGTC_3094|Compound:9117742|FD-Score:4.29|P-value:8.48E-6 ID:SGTC_3129|Compound:9127257|FD-Score:3.73|P-value:9.48E-5 ID:SGTC_3218|Compound:9131285|FD-Score:3.46|P-value:2.74E-4 ID:SGTC_9|Compound:0092-0002|FD-Score:4.29|P-value:8.72E-6 ID:SGTC_17|Compound:0960-0276|FD-Score:6.03|P-value:7.17E-10 ID:SGTC_77|Compound:0828-0286|FD-Score:5.20|P-value:8.93E-8 ID:SGTC_85|Compound:0868-0259|FD-Score:3.77|P-value:7.88E-5 ID:SGTC_143|Compound:4032-1194|FD-Score:3.52|P-value:2.10E-4 ID:SGTC_144|Compound:4161-2749|FD-Score:5.02|P-value:2.34E-7 ID:SGTC_145|Compound:3737-0113|FD-Score:7.55|P-value:1.59E-14 ID:SGTC_181|Compound:1447-1644|FD-Score:3.22|P-value:6.36E-4 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:3.47|P-value:2.57E-4 ID:SGTC_257|Compound:daunorubicin|FD-Score:3.54|P-value:2.01E-4 ID:SGTC_264|Compound:promethazine|FD-Score:6.13|P-value:3.83E-10 ID:SGTC_330|Compound:1488-0319|FD-Score:4.13|P-value:1.79E-5 ID:SGTC_370|Compound:0180-0345|FD-Score:3.23|P-value:6.12E-4 ID:SGTC_407|Compound:eburnamonine|FD-Score:4.20|P-value:1.29E-5 ID:SGTC_470|Compound:aa-861|FD-Score:4.16|P-value:1.55E-5 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:5.02|P-value:2.33E-7 ID:SGTC_511|Compound:blebbistatin|FD-Score:3.59|P-value:1.63E-4 ID:SGTC_512|Compound:prima-1|FD-Score:3.60|P-value:1.56E-4 ID:SGTC_701|Compound:4424-0219|FD-Score:3.33|P-value:4.40E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:3.34|P-value:4.22E-4 ID:SGTC_856|Compound:0433-0016|FD-Score:-3.35|P-value:3.23E-4 ID:SGTC_867|Compound:0518-0118|FD-Score:4.14|P-value:1.68E-5 ID:SGTC_1060|Compound:3448-7350|FD-Score:4.09|P-value:2.07E-5 ID:SGTC_1243|Compound:0416-0003|FD-Score:3.46|P-value:2.71E-4 ID:SGTC_1290|Compound:0986-0249|FD-Score:5.28|P-value:5.79E-8 ID:SGTC_1299|Compound:1079-1439|FD-Score:3.14|P-value:8.55E-4 ID:SGTC_1386|Compound:3228-0095|FD-Score:-5.19|P-value:6.90E-8 ID:SGTC_1388|Compound:3346-4487|FD-Score:-3.45|P-value:2.22E-4 ID:SGTC_1396|Compound:3511-0007|FD-Score:3.51|P-value:2.21E-4 ID:SGTC_1415|Compound:3966-0071|FD-Score:4.13|P-value:1.77E-5 ID:SGTC_1418|Compound:3966-3099|FD-Score:-3.07|P-value:8.80E-4 ID:SGTC_1834|Compound:st055981|FD-Score:3.25|P-value:5.79E-4 ID:SGTC_1914|Compound:st062367|FD-Score:3.63|P-value:1.39E-4 ID:SGTC_1920|Compound:st075728|FD-Score:-3.51|P-value:1.76E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:3.62|P-value:1.43E-4 ID:SGTC_2015|Compound:5119600|FD-Score:3.47|P-value:2.56E-4 ID:SGTC_2117|Compound:5521686|FD-Score:-3.44|P-value:2.28E-4 ID:SGTC_2161|Compound:5662504|FD-Score:3.55|P-value:1.90E-4 ID:SGTC_2445|Compound:5742597|FD-Score:3.27|P-value:5.42E-4 ID:SGTC_2448|Compound:5185112|FD-Score:5.27|P-value:6.17E-8 ID:SGTC_2506|Compound:ethyl hematommate|FD-Score:-3.13|P-value:7.13E-4 ID:SGTC_2643|Compound:anethole|FD-Score:5.87|P-value:1.90E-9 ID:SGTC_2644|Compound:guaiazulene|FD-Score:3.11|P-value:9.36E-4 ID:SGTC_2645|Compound:abamectin|FD-Score:3.56|P-value:1.87E-4 ID:SGTC_2666|Compound:tannic acid|FD-Score:7.54|P-value:1.77E-14 ID:SGTC_2675|Compound:theaflavin digallate|FD-Score:3.71|P-value:1.02E-4 ID:SGTC_2780|Compound:5215298|FD-Score:3.10|P-value:9.85E-4 ID:SGTC_2868|Compound:9035608|FD-Score:-3.14|P-value:6.80E-4 ID:SGTC_2899|Compound:9053889|FD-Score:-3.10|P-value:8.01E-4 ID:SGTC_2958|Compound:9077254|FD-Score:3.72|P-value:9.70E-5 ID:SGTC_2963|Compound:9082507|FD-Score:3.12|P-value:9.01E-4 ID:SGTC_3014|Compound:9081533|FD-Score:3.10|P-value:9.59E-4 ID:SGTC_3040|Compound:9091894|FD-Score:7.53|P-value:1.87E-14 ID:SGTC_3094|Compound:9117742|FD-Score:4.29|P-value:8.48E-6 ID:SGTC_3129|Compound:9127257|FD-Score:3.73|P-value:9.48E-5 ID:SGTC_3218|Compound:9131285|FD-Score:3.46|P-value:2.74E-4

Top fitness defect scores for YGL200C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_145 3737-0113 7.55 38.4 µM 1.59E-14 DNA intercalators 11 2.15E-14
2 SGTC_2666 tannic acid 7.54 100.0 µM 1.77E-14 iron homeostasis 5 2.39E-14
3 SGTC_3040 9091894 7.53 49.5 µM 1.87E-14 DNA intercalators 3 2.53E-14
4 SGTC_264 promethazine 6.13 12.5 mM 3.83E-10 DNA intercalators 18 4.51E-10
5 SGTC_17 0960-0276 6.03 49.8 µM 7.17E-10 4 8.38E-10
6 SGTC_2643 anethole 5.87 100.0 µM 1.90E-9 3 2.19E-9
7 SGTC_1290 0986-0249 5.28 10.2 µM 5.79E-8 DNA intercalators 7 6.40E-8
8 SGTC_2448 5185112 5.27 27.2 µM 6.17E-8 5 6.81E-8
9 SGTC_77 0828-0286 5.20 12.5 µM 8.93E-8 TSC3-RPN4 9 9.81E-8
10 SGTC_471 1-acyl-paf 5.02 4.0 µM 2.33E-7 DNA intercalators 13 2.53E-7
11 SGTC_144 4161-2749 5.02 112.4 µM 2.34E-7 DNA intercalators 10 2.54E-7
12 SGTC_3094 9117742 4.29 49.5 µM 8.48E-6 14 8.83E-6
13 SGTC_9 0092-0002 4.29 10.4 µM 8.72E-6 22 9.09E-6
14 SGTC_407 eburnamonine 4.20 100.0 µM 1.29E-5 9 1.34E-5
15 SGTC_470 aa-861 4.16 153.0 µM 1.55E-5 sphingolipid biosynthesis & PDR1 47 1.60E-5
16 SGTC_867 0518-0118 4.14 155.0 µM 1.68E-5 DNA intercalators 17 1.74E-5
17 SGTC_1415 3966-0071 4.13 78.1 µM 1.77E-5 DNA intercalators 9 1.83E-5
18 SGTC_330 1488-0319 4.13 80.1 µM 1.79E-5 RPP1 & pyrimidine depletion 8 1.85E-5
19 SGTC_1060 3448-7350 4.09 82.0 µM 2.07E-5 Golgi 32 2.14E-5
20 SGTC_85 0868-0259 3.77 160.1 µM 7.88E-5 60S ribosome export 12 8.01E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.413 3.29E-138 YHL039W EFM1 hom Lysine methyltransferase involved in the monomethylation of eEF1A (Tef1p/Tef2p); SET-domain family member; predicted involvement in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.392 4.86E-123 YMR166C_p YMR166C_p hom Predicted transporter of the mitochondrial inner membrane; has similarity to human mitochondrial ATP-Mg/Pi carriers; YMR166C is not an essential gene
0.366 9.02E-107 YOR133W EFT1 hom Elongation factor 2 (EF-2), also encoded by EFT2; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin; EFT1 has a paralog, EFT2, that arose from the whole genome duplication
0.364 1.78E-105 YDL223C HBT1 hom Substrate of the Hub1p ubiquitin-like protein that localizes to the shmoo tip (mating projection); mutants are defective for mating projection formation, thereby implicating Hbt1p in polarized cell morphogenesis
0.360 3.22E-103 YMR168C CEP3 het Essential kinetochore protein, component of the CBF3 complex that binds the CDEIII region of the centromere; contains an N-terminal Zn2Cys6 type zinc finger domain, a C-terminal acidic domain, and a putative coiled coil dimerization domain
0.358 6.52E-102 YMR289W ABZ2 hom Aminodeoxychorismate lyase (4-amino-4-deoxychorismate lyase), catalyzes the third step in para-aminobenzoic acid biosynthesis; involved in folic acid biosynthesis
0.332 9.00E-87 YPL157W TGS1 hom Trimethyl guanosine synthase, conserved nucleolar methyl transferase that converts the m(7)G cap structure of snRNAs, snoRNAs, and telomerase TLC1 RNA to m(2,2,7)G; also required for nucleolar assembly and splicing of meiotic pre-mRNAs
0.321 3.96E-81 YDL058W USO1 het Essential protein involved in the vesicle-mediated ER to Golgi transport step of secretion; binds membranes and functions during vesicle docking to the Golgi; required for assembly of the ER-to-Golgi SNARE complex
0.306 1.41E-73 YGR065C VHT1 het High-affinity plasma membrane H+-biotin (vitamin H) symporter; mutation results in fatty acid auxotrophy; 12 transmembrane domain containing major facilitator subfamily member; mRNA levels negatively regulated by iron deprivation and biotin
0.304 1.37E-72 YGL118C_d YGL118C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.297 2.34E-69 YHR172W SPC97 het Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex; interacts with Spc110p at the spindle pole body (SPB) inner plaque and with Spc72p at the SPB outer plaque
0.285 1.87E-63 YJL025W RRN7 het Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p
0.282 2.11E-62 YGR156W PTI1 het Essential protein that is a component of CPF (cleavage and polyadenylation factor); involved in 3' end formation of snoRNA and mRNA; interacts directly with Pta1p; has similarity to mammalian Cleavage-Stimulation Factor CstF-64
0.257 1.71E-51 YDR458C HEH2 hom Inner nuclear membrane (INM) protein; contains helix-extension-helix (HEH) motif, nuclear localization signal sequence; targeting to the INM requires the Srp1p-Kap95p karyopherins and the Ran cycle
0.253 3.16E-50 YMR208W ERG12 het Mevalonate kinase, acts in the biosynthesis of isoprenoids and sterols, including ergosterol, from mevalonate