YGL201C / MCM6

Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex; forms a subcomplex with Mcm4p and Mcm7p

Zygosity: Heterozygous strain
fixedexpanded
Profile for YGL201C / MCM6

Click on Significant Values for Screen Details ID:SGTC_82|Compound:0054-0107|FD-Score:5.19|P-value:1.57E-7 ID:SGTC_358|Compound:0075-0058|FD-Score:-8.07|P-value:8.49E-16 ID:SGTC_373|Compound:0844-0104|FD-Score:-3.74|P-value:1.12E-4 ID:SGTC_377|Compound:3970-0964|FD-Score:-3.26|P-value:6.41E-4 ID:SGTC_430|Compound:0958-0115|FD-Score:3.16|P-value:9.49E-4 ID:SGTC_560|Compound:2332-1943|FD-Score:3.54|P-value:2.48E-4 ID:SGTC_737|Compound:1950-0117|FD-Score:-3.23|P-value:7.19E-4 ID:SGTC_740|Compound:k014-0057|FD-Score:-3.26|P-value:6.46E-4 ID:SGTC_783|Compound:0848-0141|FD-Score:3.23|P-value:7.34E-4 ID:SGTC_792|Compound:4534-1957|FD-Score:3.35|P-value:4.95E-4 ID:SGTC_796|Compound:1234-0020|FD-Score:3.48|P-value:3.12E-4 ID:SGTC_1065|Compound:prochlorperazine maleate|FD-Score:3.90|P-value:6.20E-5 ID:SGTC_1076|Compound:itraconazole|FD-Score:3.37|P-value:4.58E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:4.79|P-value:1.18E-6 ID:SGTC_1084|Compound:voriconazole|FD-Score:-3.15|P-value:9.30E-4 ID:SGTC_1132|Compound:3456-3614|FD-Score:-3.56|P-value:2.23E-4 ID:SGTC_1735|Compound:st034310|FD-Score:-3.97|P-value:4.52E-5 ID:SGTC_1743|Compound:st037606|FD-Score:3.51|P-value:2.75E-4 ID:SGTC_1832|Compound:st054113|FD-Score:4.15|P-value:2.22E-5 ID:SGTC_1838|Compound:st055369|FD-Score:3.28|P-value:6.33E-4 ID:SGTC_1842|Compound:st055362|FD-Score:4.12|P-value:2.54E-5 ID:SGTC_1843|Compound:st055809|FD-Score:3.77|P-value:1.03E-4 ID:SGTC_1846|Compound:st056244|FD-Score:-3.22|P-value:7.25E-4 ID:SGTC_1857|Compound:st056007|FD-Score:3.32|P-value:5.49E-4 ID:SGTC_1908|Compound:st060353|FD-Score:-3.18|P-value:8.55E-4 ID:SGTC_1965|Compound:Pectolinarigenin|FD-Score:3.15|P-value:9.83E-4 ID:SGTC_2084|Compound:5306078|FD-Score:-3.50|P-value:2.76E-4 ID:SGTC_2095|Compound:5432005|FD-Score:3.41|P-value:3.93E-4 ID:SGTC_2124|Compound:5246320|FD-Score:3.40|P-value:4.16E-4 ID:SGTC_2298|Compound:7976326|FD-Score:-3.38|P-value:4.29E-4 ID:SGTC_2316|Compound:5844804|FD-Score:3.18|P-value:8.87E-4 ID:SGTC_2486|Compound:5283202|FD-Score:3.53|P-value:2.59E-4 ID:SGTC_2568|Compound:diosmetin|FD-Score:4.62|P-value:2.76E-6 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:-5.04|P-value:3.23E-7 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:8.22|P-value:2.83E-16 ID:SGTC_2623|Compound:humulene|FD-Score:3.47|P-value:3.15E-4 ID:SGTC_2915|Compound:7971052|FD-Score:-3.24|P-value:6.87E-4 ID:SGTC_2917|Compound:7979103|FD-Score:4.25|P-value:1.43E-5 ID:SGTC_2948|Compound:9070189|FD-Score:7.00|P-value:2.76E-12 ID:SGTC_2949|Compound:9072542|FD-Score:-3.53|P-value:2.44E-4 ID:SGTC_3146|Compound:9095609|FD-Score:3.40|P-value:4.03E-4 ID:SGTC_3217|Compound:9129673|FD-Score:3.25|P-value:7.03E-4 ID:SGTC_3344|Compound:9148862|FD-Score:3.49|P-value:3.02E-4 ID:SGTC_82|Compound:0054-0107|FD-Score:5.19|P-value:1.57E-7 ID:SGTC_358|Compound:0075-0058|FD-Score:-8.07|P-value:8.49E-16 ID:SGTC_373|Compound:0844-0104|FD-Score:-3.74|P-value:1.12E-4 ID:SGTC_377|Compound:3970-0964|FD-Score:-3.26|P-value:6.41E-4 ID:SGTC_430|Compound:0958-0115|FD-Score:3.16|P-value:9.49E-4 ID:SGTC_560|Compound:2332-1943|FD-Score:3.54|P-value:2.48E-4 ID:SGTC_737|Compound:1950-0117|FD-Score:-3.23|P-value:7.19E-4 ID:SGTC_740|Compound:k014-0057|FD-Score:-3.26|P-value:6.46E-4 ID:SGTC_783|Compound:0848-0141|FD-Score:3.23|P-value:7.34E-4 ID:SGTC_792|Compound:4534-1957|FD-Score:3.35|P-value:4.95E-4 ID:SGTC_796|Compound:1234-0020|FD-Score:3.48|P-value:3.12E-4 ID:SGTC_1065|Compound:prochlorperazine maleate|FD-Score:3.90|P-value:6.20E-5 ID:SGTC_1076|Compound:itraconazole|FD-Score:3.37|P-value:4.58E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:4.79|P-value:1.18E-6 ID:SGTC_1084|Compound:voriconazole|FD-Score:-3.15|P-value:9.30E-4 ID:SGTC_1132|Compound:3456-3614|FD-Score:-3.56|P-value:2.23E-4 ID:SGTC_1735|Compound:st034310|FD-Score:-3.97|P-value:4.52E-5 ID:SGTC_1743|Compound:st037606|FD-Score:3.51|P-value:2.75E-4 ID:SGTC_1832|Compound:st054113|FD-Score:4.15|P-value:2.22E-5 ID:SGTC_1838|Compound:st055369|FD-Score:3.28|P-value:6.33E-4 ID:SGTC_1842|Compound:st055362|FD-Score:4.12|P-value:2.54E-5 ID:SGTC_1843|Compound:st055809|FD-Score:3.77|P-value:1.03E-4 ID:SGTC_1846|Compound:st056244|FD-Score:-3.22|P-value:7.25E-4 ID:SGTC_1857|Compound:st056007|FD-Score:3.32|P-value:5.49E-4 ID:SGTC_1908|Compound:st060353|FD-Score:-3.18|P-value:8.55E-4 ID:SGTC_1965|Compound:Pectolinarigenin|FD-Score:3.15|P-value:9.83E-4 ID:SGTC_2084|Compound:5306078|FD-Score:-3.50|P-value:2.76E-4 ID:SGTC_2095|Compound:5432005|FD-Score:3.41|P-value:3.93E-4 ID:SGTC_2124|Compound:5246320|FD-Score:3.40|P-value:4.16E-4 ID:SGTC_2298|Compound:7976326|FD-Score:-3.38|P-value:4.29E-4 ID:SGTC_2316|Compound:5844804|FD-Score:3.18|P-value:8.87E-4 ID:SGTC_2486|Compound:5283202|FD-Score:3.53|P-value:2.59E-4 ID:SGTC_2568|Compound:diosmetin|FD-Score:4.62|P-value:2.76E-6 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:-5.04|P-value:3.23E-7 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:8.22|P-value:2.83E-16 ID:SGTC_2623|Compound:humulene|FD-Score:3.47|P-value:3.15E-4 ID:SGTC_2915|Compound:7971052|FD-Score:-3.24|P-value:6.87E-4 ID:SGTC_2917|Compound:7979103|FD-Score:4.25|P-value:1.43E-5 ID:SGTC_2948|Compound:9070189|FD-Score:7.00|P-value:2.76E-12 ID:SGTC_2949|Compound:9072542|FD-Score:-3.53|P-value:2.44E-4 ID:SGTC_3146|Compound:9095609|FD-Score:3.40|P-value:4.03E-4 ID:SGTC_3217|Compound:9129673|FD-Score:3.25|P-value:7.03E-4 ID:SGTC_3344|Compound:9148862|FD-Score:3.49|P-value:3.02E-4

Top fitness defect scores for YGL201C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 8.22 15.3 µM 2.83E-16 1 1.03E-16 3.75
2 SGTC_2948 9070189 7.00 9.4 µM 2.76E-12 plasma membrane duress 3 1.31E-12 1.46
3 SGTC_82 0054-0107 5.19 293.8 µM 1.57E-7 1 1.03E-7 0.87
4 SGTC_1082 camptothecin 4.79 424.9 nM 1.18E-6 DNA damage response 11 8.19E-7 0.03
5 SGTC_2568 diosmetin 4.62 100.0 µM 2.76E-6 3 1.96E-6 0.29
6 SGTC_2917 7979103 4.25 53.8 µM 1.43E-5 6 1.06E-5 0.28
7 SGTC_1832 st054113 4.15 55.0 µM 2.22E-5 3 1.68E-5 0.64
8 SGTC_1842 st055362 4.12 61.2 µM 2.54E-5 2 1.92E-5 0.06
9 SGTC_1065 prochlorperazine maleate 3.90 2.5 µM 6.20E-5 7 4.83E-5 0.38
10 SGTC_1843 st055809 3.77 45.5 µM 1.03E-4 8 8.14E-5 0.03
11 SGTC_560 2332-1943 3.54 155.0 µM 2.48E-4 6 2.01E-4 0.19
12 SGTC_2486 5283202 3.53 22.4 µM 2.59E-4 5 2.10E-4 0.29
13 SGTC_1743 st037606 3.51 46.4 µM 2.75E-4 13 2.24E-4 0.14
14 SGTC_3344 9148862 3.49 3.9 µM 3.02E-4 4 2.46E-4 0.01
15 SGTC_796 1234-0020 3.48 70.7 µM 3.12E-4 SWF1 & branched chain AA biosynthesis 12 2.54E-4 0.24
16 SGTC_2623 humulene 3.47 100.0 µM 3.15E-4 4 2.57E-4 0.06
17 SGTC_2095 5432005 3.41 200.0 µM 3.93E-4 7 3.23E-4 0.01
18 SGTC_3146 9095609 3.40 49.5 µM 4.03E-4 8 3.31E-4 0.09
19 SGTC_2124 5246320 3.40 200.0 µM 4.16E-4 heme biosynthesis & mitochondrial translocase 37 3.42E-4 0.06
20 SGTC_1076 itraconazole 3.37 331.0 nM 4.58E-4 10 3.77E-4 0.10

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.124 4.92E-13 YGL263W COS12 hom Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins
0.089 2.43E-7 YGL015C_p YGL015C_p hom Putative protein of unknown function; null mutants accumulate cargo in the Golgi
0.089 2.44E-7 YDR386W MUS81 hom Subunit of the structure-specific Mms4p-Mus81p endonuclease that cleaves branched DNA; involved in DNA repair, replication fork stability, and joint molecule formation/resolution during meiotic recombination; helix-hairpin-helix protein; phosphorylation of the non-catalytic subunit Mms4p by Cdc28p and Cdcp during mitotic cell cycle activates the function of Mms4p-Mus81p
0.088 3.31E-7 YDR387C_p YDR387C_p hom Putative transporter, member of the sugar porter family; YDR387C is not an essential gene
0.088 3.73E-7 YGR145W ENP2 het Essential nucleolar protein, required for biogenesis of the small ribosomal subunit; contains WD repeats, interacts with Mpp10p and Bfr2p, and has homology to Spb1p
0.086 7.01E-7 YDR234W LYS4 hom Homoaconitase, catalyzes the conversion of homocitrate to homoisocitrate, which is a step in the lysine biosynthesis pathway
0.085 7.47E-7 YKL106C-A_p YKL106C-A_p hom Putative protein of unknown function; identified by homology to uncharacterized proteins in other fungi
0.085 7.89E-7 YDR253C MET32 hom Zinc-finger DNA-binding transcription factor; involved in transcriptional regulation of the methionine biosynthetic genes; MET32 has a paralog, MET31, that arose from the whole genome duplication
0.083 1.29E-6 YNR073C_p YNR073C_p hom Putative mannitol dehydrogenase; identical in amino acid sequence to Dsf1p
0.082 1.74E-6 YGL075C MPS2 het Essential membrane protein localized at the nuclear envelope and spindle pole body (SPB), required for insertion of the newly duplicated SPB into the nuclear envelope; potentially phosphorylated by Cdc28p
0.082 1.95E-6 YBR099C_d YBR099C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene MMS4
0.081 2.67E-6 YMR181C_p YMR181C_p hom Protein of unknown function; mRNA transcribed as part of a bicistronic transcript with a predicted transcriptional repressor RGM1/YMR182C; mRNA is destroyed by nonsense-mediated decay (NMD); not an essential gene; YMR181C has a paralog, YPL229W, that arose from the whole genome duplication
0.079 5.12E-6 YGL242C_p YGL242C_p hom Putative protein of unknown function; deletion mutant is viable
0.075 1.31E-5 YGR021W_p YGR021W_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.073 2.09E-5 YAL062W GDH3 hom NADP(+)-dependent glutamate dehydrogenase; synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh1p; expression regulated by nitrogen and carbon sources; GDH3 has a paralog, GDH1, that arose from the whole genome duplication