YGL202W / ARO8

Aromatic aminotransferase I, expression is regulated by general control of amino acid biosynthesis

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL202W / ARO8

Click on Significant Values for Screen Details ID:SGTC_55|Compound:0767-0285|FD-Score:-2.86|P-value:6.94E-4 ID:SGTC_132|Compound:0417-1715|FD-Score:2.90|P-value:6.60E-4 ID:SGTC_185|Compound:k048-0037|FD-Score:-3.13|P-value:2.38E-4 ID:SGTC_375|Compound:3970-0961|FD-Score:2.85|P-value:8.18E-4 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:2.85|P-value:8.18E-4 ID:SGTC_428|Compound:3448-4153|FD-Score:-3.44|P-value:6.23E-5 ID:SGTC_463|Compound:ikarugamyin|FD-Score:3.08|P-value:3.29E-4 ID:SGTC_483|Compound:fpl-64176|FD-Score:2.80|P-value:9.70E-4 ID:SGTC_488|Compound:nitrendipine|FD-Score:2.92|P-value:6.19E-4 ID:SGTC_622|Compound:1348-1566|FD-Score:-3.39|P-value:7.89E-5 ID:SGTC_816|Compound:0325-0417|FD-Score:2.87|P-value:7.60E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:-2.98|P-value:4.35E-4 ID:SGTC_1063|Compound:disulfiram|FD-Score:-3.12|P-value:2.51E-4 ID:SGTC_1072|Compound:oxiconazole|FD-Score:2.88|P-value:7.35E-4 ID:SGTC_1089|Compound:terbinafine|FD-Score:2.94|P-value:5.80E-4 ID:SGTC_1172|Compound:0370-0043|FD-Score:2.85|P-value:8.14E-4 ID:SGTC_1241|Compound:0364-0022|FD-Score:5.12|P-value:6.82E-9 ID:SGTC_1245|Compound:0418-0076|FD-Score:4.54|P-value:2.51E-7 ID:SGTC_1249|Compound:0481-0015|FD-Score:4.19|P-value:1.71E-6 ID:SGTC_1253|Compound:0550-0034|FD-Score:2.89|P-value:6.85E-4 ID:SGTC_1319|Compound:1306-0155|FD-Score:-5.61|P-value:2.04E-10 ID:SGTC_1371|Compound:2421-0008|FD-Score:-2.83|P-value:7.79E-4 ID:SGTC_1439|Compound:4092-1168|FD-Score:2.80|P-value:9.96E-4 ID:SGTC_1449|Compound:4112-4002|FD-Score:-2.92|P-value:5.63E-4 ID:SGTC_1452|Compound:4194-0072|FD-Score:3.28|P-value:1.44E-4 ID:SGTC_1604|Compound:st002052|FD-Score:3.40|P-value:8.26E-5 ID:SGTC_1625|Compound:st003711|FD-Score:2.83|P-value:8.70E-4 ID:SGTC_1635|Compound:st007035|FD-Score:-3.12|P-value:2.51E-4 ID:SGTC_1691|Compound:st019933|FD-Score:2.90|P-value:6.77E-4 ID:SGTC_1940|Compound:st075990|FD-Score:3.02|P-value:4.25E-4 ID:SGTC_2316|Compound:5844804|FD-Score:3.07|P-value:3.46E-4 ID:SGTC_2326|Compound:6164455|FD-Score:3.07|P-value:3.35E-4 ID:SGTC_2349|Compound:9023730|FD-Score:3.08|P-value:3.32E-4 ID:SGTC_2386|Compound:9075165|FD-Score:2.98|P-value:4.86E-4 ID:SGTC_2587|Compound:piperic acid|FD-Score:4.53|P-value:2.54E-7 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:-2.85|P-value:7.17E-4 ID:SGTC_2701|Compound:st077767|FD-Score:-3.08|P-value:2.89E-4 ID:SGTC_2824|Compound:7998404|FD-Score:-2.83|P-value:7.79E-4 ID:SGTC_2835|Compound:9006588|FD-Score:-2.78|P-value:9.57E-4 ID:SGTC_2841|Compound:9004761|FD-Score:3.38|P-value:9.26E-5 ID:SGTC_2898|Compound:9056270|FD-Score:2.86|P-value:7.73E-4 ID:SGTC_2950|Compound:9072895|FD-Score:-3.50|P-value:4.60E-5 ID:SGTC_2960|Compound:9079389|FD-Score:6.30|P-value:1.40E-12 ID:SGTC_2962|Compound:9082311|FD-Score:3.09|P-value:3.14E-4 ID:SGTC_3025|Compound:9087895|FD-Score:2.83|P-value:8.61E-4 ID:SGTC_3042|Compound:9091578|FD-Score:2.82|P-value:9.23E-4 ID:SGTC_3043|Compound:9092303|FD-Score:-2.93|P-value:5.35E-4 ID:SGTC_3155|Compound:9099265|FD-Score:-4.14|P-value:1.93E-6 ID:SGTC_3212|Compound:9128307|FD-Score:-3.45|P-value:5.84E-5 ID:SGTC_3236|Compound:9132701|FD-Score:-3.09|P-value:2.82E-4 ID:SGTC_3266|Compound:9136860|FD-Score:2.88|P-value:7.32E-4 ID:SGTC_3272|Compound:9137413|FD-Score:-3.16|P-value:2.13E-4 ID:SGTC_3340|Compound:9146634|FD-Score:3.11|P-value:2.92E-4 ID:SGTC_3354|Compound:9151612|FD-Score:3.31|P-value:1.26E-4 ID:SGTC_55|Compound:0767-0285|FD-Score:-2.86|P-value:6.94E-4 ID:SGTC_132|Compound:0417-1715|FD-Score:2.90|P-value:6.60E-4 ID:SGTC_185|Compound:k048-0037|FD-Score:-3.13|P-value:2.38E-4 ID:SGTC_375|Compound:3970-0961|FD-Score:2.85|P-value:8.18E-4 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:2.85|P-value:8.18E-4 ID:SGTC_428|Compound:3448-4153|FD-Score:-3.44|P-value:6.23E-5 ID:SGTC_463|Compound:ikarugamyin|FD-Score:3.08|P-value:3.29E-4 ID:SGTC_483|Compound:fpl-64176|FD-Score:2.80|P-value:9.70E-4 ID:SGTC_488|Compound:nitrendipine|FD-Score:2.92|P-value:6.19E-4 ID:SGTC_622|Compound:1348-1566|FD-Score:-3.39|P-value:7.89E-5 ID:SGTC_816|Compound:0325-0417|FD-Score:2.87|P-value:7.60E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:-2.98|P-value:4.35E-4 ID:SGTC_1063|Compound:disulfiram|FD-Score:-3.12|P-value:2.51E-4 ID:SGTC_1072|Compound:oxiconazole|FD-Score:2.88|P-value:7.35E-4 ID:SGTC_1089|Compound:terbinafine|FD-Score:2.94|P-value:5.80E-4 ID:SGTC_1172|Compound:0370-0043|FD-Score:2.85|P-value:8.14E-4 ID:SGTC_1241|Compound:0364-0022|FD-Score:5.12|P-value:6.82E-9 ID:SGTC_1245|Compound:0418-0076|FD-Score:4.54|P-value:2.51E-7 ID:SGTC_1249|Compound:0481-0015|FD-Score:4.19|P-value:1.71E-6 ID:SGTC_1253|Compound:0550-0034|FD-Score:2.89|P-value:6.85E-4 ID:SGTC_1319|Compound:1306-0155|FD-Score:-5.61|P-value:2.04E-10 ID:SGTC_1371|Compound:2421-0008|FD-Score:-2.83|P-value:7.79E-4 ID:SGTC_1439|Compound:4092-1168|FD-Score:2.80|P-value:9.96E-4 ID:SGTC_1449|Compound:4112-4002|FD-Score:-2.92|P-value:5.63E-4 ID:SGTC_1452|Compound:4194-0072|FD-Score:3.28|P-value:1.44E-4 ID:SGTC_1604|Compound:st002052|FD-Score:3.40|P-value:8.26E-5 ID:SGTC_1625|Compound:st003711|FD-Score:2.83|P-value:8.70E-4 ID:SGTC_1635|Compound:st007035|FD-Score:-3.12|P-value:2.51E-4 ID:SGTC_1691|Compound:st019933|FD-Score:2.90|P-value:6.77E-4 ID:SGTC_1940|Compound:st075990|FD-Score:3.02|P-value:4.25E-4 ID:SGTC_2316|Compound:5844804|FD-Score:3.07|P-value:3.46E-4 ID:SGTC_2326|Compound:6164455|FD-Score:3.07|P-value:3.35E-4 ID:SGTC_2349|Compound:9023730|FD-Score:3.08|P-value:3.32E-4 ID:SGTC_2386|Compound:9075165|FD-Score:2.98|P-value:4.86E-4 ID:SGTC_2587|Compound:piperic acid|FD-Score:4.53|P-value:2.54E-7 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:-2.85|P-value:7.17E-4 ID:SGTC_2701|Compound:st077767|FD-Score:-3.08|P-value:2.89E-4 ID:SGTC_2824|Compound:7998404|FD-Score:-2.83|P-value:7.79E-4 ID:SGTC_2835|Compound:9006588|FD-Score:-2.78|P-value:9.57E-4 ID:SGTC_2841|Compound:9004761|FD-Score:3.38|P-value:9.26E-5 ID:SGTC_2898|Compound:9056270|FD-Score:2.86|P-value:7.73E-4 ID:SGTC_2950|Compound:9072895|FD-Score:-3.50|P-value:4.60E-5 ID:SGTC_2960|Compound:9079389|FD-Score:6.30|P-value:1.40E-12 ID:SGTC_2962|Compound:9082311|FD-Score:3.09|P-value:3.14E-4 ID:SGTC_3025|Compound:9087895|FD-Score:2.83|P-value:8.61E-4 ID:SGTC_3042|Compound:9091578|FD-Score:2.82|P-value:9.23E-4 ID:SGTC_3043|Compound:9092303|FD-Score:-2.93|P-value:5.35E-4 ID:SGTC_3155|Compound:9099265|FD-Score:-4.14|P-value:1.93E-6 ID:SGTC_3212|Compound:9128307|FD-Score:-3.45|P-value:5.84E-5 ID:SGTC_3236|Compound:9132701|FD-Score:-3.09|P-value:2.82E-4 ID:SGTC_3266|Compound:9136860|FD-Score:2.88|P-value:7.32E-4 ID:SGTC_3272|Compound:9137413|FD-Score:-3.16|P-value:2.13E-4 ID:SGTC_3340|Compound:9146634|FD-Score:3.11|P-value:2.92E-4 ID:SGTC_3354|Compound:9151612|FD-Score:3.31|P-value:1.26E-4

Top fitness defect scores for YGL202W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2960 9079389 6.30 6.0 µM 1.40E-12 3 1.48E-10
2 SGTC_1241 0364-0022 5.12 50.8 µM 6.82E-9 ERG2 12 1.50E-7
3 SGTC_1245 0418-0076 4.54 17.2 µM 2.51E-7 ERG2 18 2.87E-6
4 SGTC_2587 piperic acid 4.53 92.2 µM 2.54E-7 13 2.89E-6
5 SGTC_1249 0481-0015 4.19 10.2 µM 1.71E-6 19 1.38E-5
6 SGTC_1604 st002052 3.40 72.4 µM 8.26E-5 TSC3-RPN4 38 3.33E-4
7 SGTC_2841 9004761 3.38 39.0 µM 9.26E-5 amide catabolism 58 3.65E-4
8 SGTC_3354 9151612 3.31 71.4 µM 1.26E-4 34 4.72E-4
9 SGTC_1452 4194-0072 3.28 190.0 µM 1.44E-4 38 5.26E-4
10 SGTC_3340 9146634 3.11 11.1 µM 2.92E-4 48 9.40E-4
11 SGTC_2962 9082311 3.09 13.2 µM 3.14E-4 62 0.00100
12 SGTC_463 ikarugamyin 3.08 104.0 µM 3.29E-4 9 0.00104
13 SGTC_2349 9023730 3.08 187.1 µM 3.32E-4 74 0.00104
14 SGTC_2326 6164455 3.07 177.6 µM 3.35E-4 mitochondrial processes 58 0.00105
15 SGTC_2316 5844804 3.07 197.4 µM 3.46E-4 86 0.00108
16 SGTC_1940 st075990 3.02 51.1 µM 4.25E-4 60S ribosome export 63 0.00128
17 SGTC_2386 9075165 2.98 157.4 µM 4.86E-4 32 0.00143
18 SGTC_1089 terbinafine 2.94 2.2 µM 5.80E-4 57 0.00166
19 SGTC_488 nitrendipine 2.92 139.0 µM 6.19E-4 94 0.00175
20 SGTC_132 0417-1715 2.90 25.8 µM 6.60E-4 RPP1 & pyrimidine depletion 58 0.00184

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.104 1.79E-9 YPR105C COG4 het Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
0.099 7.66E-9 YPR032W SRO7 hom Effector of Rab GTPase Sec4p; forms a complex with Sec4p and t-SNARE Sec9p; involved in exocytosis and docking and fusion of post-Golgi vesicles with plasma membrane; homolog of Drosophila lgl tumor suppressor; SRO7 has a paralog, SRO77, that arose from the whole genome duplication
0.095 3.60E-8 YAL048C GEM1 hom Outer mitochondrial membrane GTPase, subunit of the ERMES complex; potential regulatory subunit of the ERMES complex that links the ER to mitochondria and may promote inter-organellar calcium and phospholipid exchange as well as coordinating mitochondrial DNA replication and growth; cells lacking Gem1p contain collapsed, globular, or grape-like mitochondria; ortholog of metazoan Miro GTPases
0.089 2.57E-7 YOL071W EMI5 hom Subunit of succinate dehydrogenase, which couples succinate oxidation to ubiquinone reduction; required for FAD cofactor attachment to Sdh1p; mutations in human ortholog PGL2 are associated with neuroendocrine tumors (paraganglioma)
0.089 2.66E-7 YLR241W_p YLR241W_p hom Putative protein of unknown function, may be involved in detoxification
0.089 2.70E-7 YGR138C TPO2 hom Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; specific for spermine; localizes to the plasma membrane; transcription of TPO2 is regulated by Haa1p; TPO2 has a paralog, TPO3, that arose from the whole genome duplication
0.089 2.66E-7 YDR021W FAL1 het Nucleolar protein required for maturation of 18S rRNA, member of the eIF4A subfamily of DEAD-box ATP-dependent RNA helicases
0.087 4.27E-7 YGL170C SPO74 hom Component of the meiotic outer plaque of the spindle pole body, involved in modifying the meiotic outer plaque that is required prior to prospore membrane formation
0.082 1.81E-6 YJR103W URA8 hom Minor CTP synthase isozyme (see also URA7); catalyzes the ATP-dependent transfer of the amide nitrogen from glutamine to UTP, forming CTP, the final step in de novo biosynthesis of pyrimidines; involved in phospholipid biosynthesis; capable of forming cytoplasmic filaments termed cytoophidium, especially during conditions of glucose depletion; URA8 has a paralog, URA7, that arose from the whole genome duplication
0.079 4.30E-6 YCR095W-A_p YCR095W-A_p hom Putative protein of unknown function
0.079 5.04E-6 YGL236C MTO1 hom Mitochondrial protein, forms a heterodimer complex with Mss1p that performs the 5-carboxymethylaminomethyl modification of the wobble uridine base in mitochondrial tRNAs; required for respiration in paromomycin-resistant 15S rRNA mutants
0.078 5.32E-6 YLR115W CFT2 het Subunit of the mRNA cleavage and polyadenlylation factor (CPF); required for pre-mRNA cleavage, polyadenylation and poly(A) site recognition, 43% similarity with the mammalian CPSF-100 protein.
0.078 6.13E-6 YDL242W_d YDL242W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.077 7.68E-6 YKL011C CCE1 hom Mitochondrial cruciform cutting endonuclease, cleaves Holliday junctions formed during recombination of mitochondrial DNA
0.076 9.38E-6 YGL131C SNT2 hom DNA binding protein with similarity to the S. pombe Snt2 protein; RING finger ubiquitin ligase (E3) involved in ubiquitylation and degradation of excess histones; interacts with Ubc4p; null mutant sensitive to hydroxyurea (HU); computational analysis suggests that Snt2p is a transcription factor with a role in regulation of expression of genes encoding amine transporters; relocalizes from nucleus to cytoplasm upon DNA replication stress