HIPHOP chemogenomics database
YGL202W / ARO8 
Aromatic aminotransferase I, expression is regulated by general control of amino acid biosynthesis
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YGL202W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.104 | 1.79E-9 | YPR105C | COG4 | het | Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments |
| 0.099 | 7.66E-9 | YPR032W | SRO7 | hom | Effector of Rab GTPase Sec4p; forms a complex with Sec4p and t-SNARE Sec9p; involved in exocytosis and docking and fusion of post-Golgi vesicles with plasma membrane; homolog of Drosophila lgl tumor suppressor; SRO7 has a paralog, SRO77, that arose from the whole genome duplication |
| 0.095 | 3.60E-8 | YAL048C | GEM1 | hom | Outer mitochondrial membrane GTPase, subunit of the ERMES complex; potential regulatory subunit of the ERMES complex that links the ER to mitochondria and may promote inter-organellar calcium and phospholipid exchange as well as coordinating mitochondrial DNA replication and growth; cells lacking Gem1p contain collapsed, globular, or grape-like mitochondria; ortholog of metazoan Miro GTPases |
| 0.089 | 2.57E-7 | YOL071W | EMI5 | hom | Subunit of succinate dehydrogenase, which couples succinate oxidation to ubiquinone reduction; required for FAD cofactor attachment to Sdh1p; mutations in human ortholog PGL2 are associated with neuroendocrine tumors (paraganglioma) |
| 0.089 | 2.66E-7 | YLR241W_p | YLR241W_p | hom | Putative protein of unknown function, may be involved in detoxification |
| 0.089 | 2.70E-7 | YGR138C | TPO2 | hom | Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; specific for spermine; localizes to the plasma membrane; transcription of TPO2 is regulated by Haa1p; TPO2 has a paralog, TPO3, that arose from the whole genome duplication |
| 0.089 | 2.66E-7 | YDR021W | FAL1 | het | Nucleolar protein required for maturation of 18S rRNA, member of the eIF4A subfamily of DEAD-box ATP-dependent RNA helicases |
| 0.087 | 4.27E-7 | YGL170C | SPO74 | hom | Component of the meiotic outer plaque of the spindle pole body, involved in modifying the meiotic outer plaque that is required prior to prospore membrane formation |
| 0.082 | 1.81E-6 | YJR103W | URA8 | hom | Minor CTP synthase isozyme (see also URA7); catalyzes the ATP-dependent transfer of the amide nitrogen from glutamine to UTP, forming CTP, the final step in de novo biosynthesis of pyrimidines; involved in phospholipid biosynthesis; capable of forming cytoplasmic filaments termed cytoophidium, especially during conditions of glucose depletion; URA8 has a paralog, URA7, that arose from the whole genome duplication |
| 0.079 | 4.30E-6 | YCR095W-A_p | YCR095W-A_p | hom | Putative protein of unknown function |
| 0.079 | 5.04E-6 | YGL236C | MTO1 | hom | Mitochondrial protein, forms a heterodimer complex with Mss1p that performs the 5-carboxymethylaminomethyl modification of the wobble uridine base in mitochondrial tRNAs; required for respiration in paromomycin-resistant 15S rRNA mutants |
| 0.078 | 5.32E-6 | YLR115W | CFT2 | het | Subunit of the mRNA cleavage and polyadenlylation factor (CPF); required for pre-mRNA cleavage, polyadenylation and poly(A) site recognition, 43% similarity with the mammalian CPSF-100 protein. |
| 0.078 | 6.13E-6 | YDL242W_d | YDL242W_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data |
| 0.077 | 7.68E-6 | YKL011C | CCE1 | hom | Mitochondrial cruciform cutting endonuclease, cleaves Holliday junctions formed during recombination of mitochondrial DNA |
| 0.076 | 9.38E-6 | YGL131C | SNT2 | hom | DNA binding protein with similarity to the S. pombe Snt2 protein; RING finger ubiquitin ligase (E3) involved in ubiquitylation and degradation of excess histones; interacts with Ubc4p; null mutant sensitive to hydroxyurea (HU); computational analysis suggests that Snt2p is a transcription factor with a role in regulation of expression of genes encoding amine transporters; relocalizes from nucleus to cytoplasm upon DNA replication stress |