YGL203C / KEX1

Protease involved in the processing of killer toxin and alpha factor precursor; cleaves Lys and Arg residues from the C-terminus of peptides and proteins

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL203C / KEX1

Click on Significant Values for Screen Details ID:SGTC_249|Compound:wiskostatin|FD-Score:-3.39|P-value:2.42E-4 ID:SGTC_320|Compound:4092-0846|FD-Score:4.85|P-value:3.62E-7 ID:SGTC_346|Compound:4513-0042|FD-Score:3.71|P-value:7.83E-5 ID:SGTC_351|Compound:caspofungin|FD-Score:6.82|P-value:1.61E-12 ID:SGTC_447|Compound:ml7|FD-Score:4.14|P-value:1.18E-5 ID:SGTC_528|Compound:3492-0019|FD-Score:6.46|P-value:2.01E-11 ID:SGTC_740|Compound:k014-0057|FD-Score:-3.50|P-value:1.61E-4 ID:SGTC_791|Compound:1348-1292|FD-Score:-3.04|P-value:8.91E-4 ID:SGTC_869|Compound:0564-0080|FD-Score:-3.05|P-value:8.53E-4 ID:SGTC_1019|Compound:4262-0212|FD-Score:4.82|P-value:4.41E-7 ID:SGTC_1228|Compound:0124-0032|FD-Score:5.81|P-value:1.50E-9 ID:SGTC_1237|Compound:0330-0133|FD-Score:-3.19|P-value:5.22E-4 ID:SGTC_1376|Compound:2910-0861|FD-Score:3.34|P-value:3.35E-4 ID:SGTC_1412|Compound:3909-8563|FD-Score:3.69|P-value:8.28E-5 ID:SGTC_1431|Compound:4049-0260|FD-Score:5.17|P-value:6.63E-8 ID:SGTC_1439|Compound:4092-1168|FD-Score:4.06|P-value:1.74E-5 ID:SGTC_1465|Compound:k213-0056|FD-Score:3.24|P-value:4.85E-4 ID:SGTC_1512|Compound:0259-0544|FD-Score:5.70|P-value:2.85E-9 ID:SGTC_1563|Compound:conessine|FD-Score:4.74|P-value:6.57E-7 ID:SGTC_1566|Compound:6,7-dimethoxy-4-ethylcoumarin|FD-Score:3.15|P-value:6.62E-4 ID:SGTC_1569|Compound:carminic acid|FD-Score:3.04|P-value:9.74E-4 ID:SGTC_1572|Compound:epiandrosterone|FD-Score:4.61|P-value:1.27E-6 ID:SGTC_1687|Compound:st020778|FD-Score:3.87|P-value:3.96E-5 ID:SGTC_1712|Compound:st032288|FD-Score:9.09|P-value:7.36E-21 ID:SGTC_1801|Compound:st050089|FD-Score:3.31|P-value:3.74E-4 ID:SGTC_1803|Compound:st050068|FD-Score:3.97|P-value:2.56E-5 ID:SGTC_1835|Compound:st008666|FD-Score:-3.72|P-value:6.53E-5 ID:SGTC_2014|Compound:4013930|FD-Score:3.09|P-value:8.19E-4 ID:SGTC_2021|Compound:4019055|FD-Score:9.83|P-value:4.37E-24 ID:SGTC_2386|Compound:9075165|FD-Score:3.06|P-value:9.03E-4 ID:SGTC_2419|Compound:paclitaxel|FD-Score:6.18|P-value:1.34E-10 ID:SGTC_2930|Compound:9013230|FD-Score:3.04|P-value:9.70E-4 ID:SGTC_2948|Compound:9070189|FD-Score:3.05|P-value:9.24E-4 ID:SGTC_2949|Compound:9072542|FD-Score:-3.20|P-value:5.05E-4 ID:SGTC_3153|Compound:9100258|FD-Score:-3.06|P-value:8.39E-4 ID:SGTC_249|Compound:wiskostatin|FD-Score:-3.39|P-value:2.42E-4 ID:SGTC_320|Compound:4092-0846|FD-Score:4.85|P-value:3.62E-7 ID:SGTC_346|Compound:4513-0042|FD-Score:3.71|P-value:7.83E-5 ID:SGTC_351|Compound:caspofungin|FD-Score:6.82|P-value:1.61E-12 ID:SGTC_447|Compound:ml7|FD-Score:4.14|P-value:1.18E-5 ID:SGTC_528|Compound:3492-0019|FD-Score:6.46|P-value:2.01E-11 ID:SGTC_740|Compound:k014-0057|FD-Score:-3.50|P-value:1.61E-4 ID:SGTC_791|Compound:1348-1292|FD-Score:-3.04|P-value:8.91E-4 ID:SGTC_869|Compound:0564-0080|FD-Score:-3.05|P-value:8.53E-4 ID:SGTC_1019|Compound:4262-0212|FD-Score:4.82|P-value:4.41E-7 ID:SGTC_1228|Compound:0124-0032|FD-Score:5.81|P-value:1.50E-9 ID:SGTC_1237|Compound:0330-0133|FD-Score:-3.19|P-value:5.22E-4 ID:SGTC_1376|Compound:2910-0861|FD-Score:3.34|P-value:3.35E-4 ID:SGTC_1412|Compound:3909-8563|FD-Score:3.69|P-value:8.28E-5 ID:SGTC_1431|Compound:4049-0260|FD-Score:5.17|P-value:6.63E-8 ID:SGTC_1439|Compound:4092-1168|FD-Score:4.06|P-value:1.74E-5 ID:SGTC_1465|Compound:k213-0056|FD-Score:3.24|P-value:4.85E-4 ID:SGTC_1512|Compound:0259-0544|FD-Score:5.70|P-value:2.85E-9 ID:SGTC_1563|Compound:conessine|FD-Score:4.74|P-value:6.57E-7 ID:SGTC_1566|Compound:6,7-dimethoxy-4-ethylcoumarin|FD-Score:3.15|P-value:6.62E-4 ID:SGTC_1569|Compound:carminic acid|FD-Score:3.04|P-value:9.74E-4 ID:SGTC_1572|Compound:epiandrosterone|FD-Score:4.61|P-value:1.27E-6 ID:SGTC_1687|Compound:st020778|FD-Score:3.87|P-value:3.96E-5 ID:SGTC_1712|Compound:st032288|FD-Score:9.09|P-value:7.36E-21 ID:SGTC_1801|Compound:st050089|FD-Score:3.31|P-value:3.74E-4 ID:SGTC_1803|Compound:st050068|FD-Score:3.97|P-value:2.56E-5 ID:SGTC_1835|Compound:st008666|FD-Score:-3.72|P-value:6.53E-5 ID:SGTC_2014|Compound:4013930|FD-Score:3.09|P-value:8.19E-4 ID:SGTC_2021|Compound:4019055|FD-Score:9.83|P-value:4.37E-24 ID:SGTC_2386|Compound:9075165|FD-Score:3.06|P-value:9.03E-4 ID:SGTC_2419|Compound:paclitaxel|FD-Score:6.18|P-value:1.34E-10 ID:SGTC_2930|Compound:9013230|FD-Score:3.04|P-value:9.70E-4 ID:SGTC_2948|Compound:9070189|FD-Score:3.05|P-value:9.24E-4 ID:SGTC_2949|Compound:9072542|FD-Score:-3.20|P-value:5.05E-4 ID:SGTC_3153|Compound:9100258|FD-Score:-3.06|P-value:8.39E-4

Top fitness defect scores for YGL203C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2021 4019055 9.83 173.0 µM 4.37E-24 endomembrane recycling 11 4.00E-23
2 SGTC_1712 st032288 9.09 53.4 µM 7.36E-21 calcium & mitochondrial duress 32 4.85E-20
3 SGTC_351 caspofungin 6.82 25.0 nM 1.61E-12 cell wall 30 4.57E-12
4 SGTC_528 3492-0019 6.46 172.0 µM 2.01E-11 calcium & mitochondrial duress 108 5.12E-11
5 SGTC_2419 paclitaxel 6.18 166.5 µM 1.34E-10 4 3.16E-10
6 SGTC_1228 0124-0032 5.81 52.5 µM 1.50E-9 2 3.18E-9
7 SGTC_1512 0259-0544 5.70 12.2 µM 2.85E-9 1 5.88E-9
8 SGTC_1431 4049-0260 5.17 9.1 µM 6.63E-8 2 1.20E-7
9 SGTC_320 4092-0846 4.85 5.3 µM 3.62E-7 ergosterol depletion effects on membrane 27 6.07E-7
10 SGTC_1019 4262-0212 4.82 3.4 µM 4.41E-7 ergosterol depletion effects on membrane 35 7.35E-7
11 SGTC_1563 conessine 4.74 56.1 µM 6.57E-7 6 1.08E-6
12 SGTC_1572 epiandrosterone 4.61 68.9 µM 1.27E-6 20 2.02E-6
13 SGTC_447 ml7 4.14 120.0 µM 1.18E-5 NEO1-PIK1 25 1.71E-5
14 SGTC_1439 4092-1168 4.06 46.0 µM 1.74E-5 8 2.49E-5
15 SGTC_1803 st050068 3.97 52.4 µM 2.56E-5 NEO1-PIK1 178 3.61E-5
16 SGTC_1687 st020778 3.87 55.4 µM 3.96E-5 179 5.47E-5
17 SGTC_346 4513-0042 3.71 7.2 µM 7.83E-5 azole & statin 50 1.05E-4
18 SGTC_1412 3909-8563 3.69 178.0 µM 8.28E-5 13 1.11E-4
19 SGTC_1376 2910-0861 3.34 41.3 µM 3.35E-4 40 4.25E-4
20 SGTC_1801 st050089 3.31 28.4 µM 3.74E-4 NEO1-PIK1 165 4.73E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.377 1.77E-113 YKL051W SFK1 hom Plasma membrane protein that may act together with or upstream of Stt4p to generate normal levels of the essential phospholipid PI4P, at least partially mediates proper localization of Stt4p to the plasma membrane
0.359 1.41E-102 YDL019C OSH2 hom Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability
0.338 1.23E-90 YOR086C TCB1 hom Lipid-binding ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; contains three calcium and lipid binding domains; non-tagged protein also localizes to mitochondria; C-termini of Tcb1p, Tcb2p and Tcb3p interact
0.328 9.95E-85 YDR475C JIP4 hom Protein of unknown function; previously annotated as two separate ORFs, YDR474C and YDR475C, which were merged as a result of corrections to the systematic reference sequence
0.316 1.99E-78 YGL035C MIG1 hom Transcription factor involved in glucose repression; sequence specific DNA binding protein containing two Cys2His2 zinc finger motifs; regulated by the SNF1 kinase and the GLC7 phosphatase; regulates filamentous growth along with Mig2p in response to glucose depletion
0.290 3.63E-66 YCL021W-A_p YCL021W-A_p hom Putative protein of unknown function
0.288 3.50E-65 YDR467C_d YDR467C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.288 4.01E-65 YIL170W HXT12 hom Possible pseudogene in strain S288C; YIL170W/HXT12 and the adjacent ORF, YIL171W, together encode a non-functional member of the hexose transporter family
0.269 7.35E-57 YPR091C NVJ2 hom Lipid-binding ER protein, enriched at nucleus-vacuolar junctions (NVJ); may be involved in sterol metabolism or signaling at the NVJ; contains a synaptotagmin-like-mitochondrial- lipid binding protein (SMP) domain; binds phosphatidylinositols and other lipids in a large-scale study; may interact with ribosomes, based on co-purification experiments
0.257 8.03E-52 YER120W SCS2 hom Integral ER membrane protein, regulates phospholipid metabolism; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PI4P levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; interacts with FFAT motif of Opi1p; involved in telomeric silencing; null shows inositol auxotrophy above 34 deg C; VAP homolog; SCS2 has a paralog, SCS22, that arose from the whole genome duplication
0.257 1.16E-51 YDR491C_d YDR491C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.247 9.43E-48 YDR357C_p CNL1_p hom Protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; null mutant is sensitive to drug inducing secretion of vacuolar cargo; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.243 3.83E-46 YPL145C KES1 hom One of seven members of the yeast oxysterol binding protein family; involved in negative regulation of Sec14p-dependent Golgi complex secretory functions, peripheral membrane protein that localizes to the Golgi complex; KES1 has a paralog, HES1, that arose from the whole genome duplication
0.242 4.47E-46 YDR492W IZH1 hom Membrane protein involved in zinc ion homeostasis, member of the four-protein IZH family; transcription is regulated directly by Zap1p, expression induced by zinc deficiency and fatty acids; deletion increases sensitivity to elevated zinc
0.231 5.65E-42 YGL151W NUT1 hom Component of the RNA polymerase II mediator complex, which is required for transcriptional activation and also has a role in basal transcription