YGL205W / POX1

Fatty-acyl coenzyme A oxidase, involved in the fatty acid beta-oxidation pathway; localized to the peroxisomal matrix

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL205W / POX1

Click on Significant Values for Screen Details ID:SGTC_252|Compound:miconazole|FD-Score:3.04|P-value:2.45E-4 ID:SGTC_284|Compound:0988-0104|FD-Score:2.72|P-value:9.08E-4 ID:SGTC_300|Compound:r073-0011|FD-Score:3.08|P-value:2.12E-4 ID:SGTC_350|Compound:k064-0020|FD-Score:3.01|P-value:2.88E-4 ID:SGTC_545|Compound:4218-0007|FD-Score:-5.01|P-value:4.77E-9 ID:SGTC_557|Compound:1315-0110|FD-Score:-3.75|P-value:8.77E-6 ID:SGTC_652|Compound:0437-0092|FD-Score:-5.21|P-value:1.21E-9 ID:SGTC_656|Compound:4090-1979|FD-Score:3.34|P-value:6.53E-5 ID:SGTC_665|Compound:3914-0008|FD-Score:-2.82|P-value:6.04E-4 ID:SGTC_668|Compound:1682-0499|FD-Score:-3.32|P-value:7.04E-5 ID:SGTC_669|Compound:0108-0021|FD-Score:3.15|P-value:1.53E-4 ID:SGTC_877|Compound:0771-0151|FD-Score:3.36|P-value:5.93E-5 ID:SGTC_923|Compound:1900-2434|FD-Score:2.72|P-value:9.23E-4 ID:SGTC_930|Compound:2810-3379|FD-Score:4.31|P-value:4.00E-7 ID:SGTC_945|Compound:3381-0768|FD-Score:-2.83|P-value:5.82E-4 ID:SGTC_953|Compound:1188-0045|FD-Score:4.04|P-value:1.80E-6 ID:SGTC_996|Compound:3970-0799|FD-Score:13.90|P-value:3.71E-57 ID:SGTC_1283|Compound:0922-0125|FD-Score:4.64|P-value:5.36E-8 ID:SGTC_1290|Compound:0986-0249|FD-Score:3.87|P-value:4.53E-6 ID:SGTC_1296|Compound:1068-0102|FD-Score:-2.89|P-value:4.67E-4 ID:SGTC_1311|Compound:1190-0148|FD-Score:4.09|P-value:1.38E-6 ID:SGTC_1376|Compound:2910-0861|FD-Score:3.20|P-value:1.22E-4 ID:SGTC_1512|Compound:0259-0544|FD-Score:3.49|P-value:3.17E-5 ID:SGTC_1715|Compound:st032160|FD-Score:2.77|P-value:7.69E-4 ID:SGTC_1720|Compound:st037298|FD-Score:2.79|P-value:6.84E-4 ID:SGTC_1766|Compound:st045414|FD-Score:-2.83|P-value:5.78E-4 ID:SGTC_2269|Compound:7935389|FD-Score:-2.71|P-value:9.27E-4 ID:SGTC_2272|Compound:7805186|FD-Score:2.81|P-value:6.41E-4 ID:SGTC_2281|Compound:7943571|FD-Score:3.97|P-value:2.71E-6 ID:SGTC_2284|Compound:7945075|FD-Score:2.79|P-value:6.89E-4 ID:SGTC_2287|Compound:7945887|FD-Score:2.95|P-value:3.64E-4 ID:SGTC_2394|Compound:5221648|FD-Score:2.75|P-value:8.17E-4 ID:SGTC_2404|Compound:5161160|FD-Score:3.87|P-value:4.53E-6 ID:SGTC_2473|Compound:5854593|FD-Score:-3.45|P-value:3.73E-5 ID:SGTC_2537|Compound:larixol|FD-Score:2.75|P-value:8.17E-4 ID:SGTC_2568|Compound:diosmetin|FD-Score:5.21|P-value:1.16E-9 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:3.32|P-value:7.30E-5 ID:SGTC_2782|Compound:7736369|FD-Score:-3.45|P-value:3.75E-5 ID:SGTC_2790|Compound:5423970|FD-Score:4.42|P-value:2.04E-7 ID:SGTC_2795|Compound:7780010|FD-Score:3.38|P-value:5.31E-5 ID:SGTC_2821|Compound:7996764|FD-Score:2.98|P-value:3.17E-4 ID:SGTC_2923|Compound:7992654|FD-Score:-3.15|P-value:1.52E-4 ID:SGTC_3080|Compound:9117754|FD-Score:3.36|P-value:5.99E-5 ID:SGTC_3312|Compound:9133330|FD-Score:2.83|P-value:5.94E-4 ID:SGTC_3313|Compound:9133968|FD-Score:3.48|P-value:3.41E-5 ID:SGTC_3337|Compound:9144342|FD-Score:5.18|P-value:1.44E-9 ID:SGTC_3338|Compound:9144300|FD-Score:-3.46|P-value:3.65E-5 ID:SGTC_3350|Compound:9150499|FD-Score:-4.23|P-value:6.04E-7 ID:SGTC_3355|Compound:9151058|FD-Score:-3.73|P-value:9.37E-6 ID:SGTC_3356|Compound:9151811|FD-Score:-3.27|P-value:8.82E-5 ID:SGTC_252|Compound:miconazole|FD-Score:3.04|P-value:2.45E-4 ID:SGTC_284|Compound:0988-0104|FD-Score:2.72|P-value:9.08E-4 ID:SGTC_300|Compound:r073-0011|FD-Score:3.08|P-value:2.12E-4 ID:SGTC_350|Compound:k064-0020|FD-Score:3.01|P-value:2.88E-4 ID:SGTC_545|Compound:4218-0007|FD-Score:-5.01|P-value:4.77E-9 ID:SGTC_557|Compound:1315-0110|FD-Score:-3.75|P-value:8.77E-6 ID:SGTC_652|Compound:0437-0092|FD-Score:-5.21|P-value:1.21E-9 ID:SGTC_656|Compound:4090-1979|FD-Score:3.34|P-value:6.53E-5 ID:SGTC_665|Compound:3914-0008|FD-Score:-2.82|P-value:6.04E-4 ID:SGTC_668|Compound:1682-0499|FD-Score:-3.32|P-value:7.04E-5 ID:SGTC_669|Compound:0108-0021|FD-Score:3.15|P-value:1.53E-4 ID:SGTC_877|Compound:0771-0151|FD-Score:3.36|P-value:5.93E-5 ID:SGTC_923|Compound:1900-2434|FD-Score:2.72|P-value:9.23E-4 ID:SGTC_930|Compound:2810-3379|FD-Score:4.31|P-value:4.00E-7 ID:SGTC_945|Compound:3381-0768|FD-Score:-2.83|P-value:5.82E-4 ID:SGTC_953|Compound:1188-0045|FD-Score:4.04|P-value:1.80E-6 ID:SGTC_996|Compound:3970-0799|FD-Score:13.90|P-value:3.71E-57 ID:SGTC_1283|Compound:0922-0125|FD-Score:4.64|P-value:5.36E-8 ID:SGTC_1290|Compound:0986-0249|FD-Score:3.87|P-value:4.53E-6 ID:SGTC_1296|Compound:1068-0102|FD-Score:-2.89|P-value:4.67E-4 ID:SGTC_1311|Compound:1190-0148|FD-Score:4.09|P-value:1.38E-6 ID:SGTC_1376|Compound:2910-0861|FD-Score:3.20|P-value:1.22E-4 ID:SGTC_1512|Compound:0259-0544|FD-Score:3.49|P-value:3.17E-5 ID:SGTC_1715|Compound:st032160|FD-Score:2.77|P-value:7.69E-4 ID:SGTC_1720|Compound:st037298|FD-Score:2.79|P-value:6.84E-4 ID:SGTC_1766|Compound:st045414|FD-Score:-2.83|P-value:5.78E-4 ID:SGTC_2269|Compound:7935389|FD-Score:-2.71|P-value:9.27E-4 ID:SGTC_2272|Compound:7805186|FD-Score:2.81|P-value:6.41E-4 ID:SGTC_2281|Compound:7943571|FD-Score:3.97|P-value:2.71E-6 ID:SGTC_2284|Compound:7945075|FD-Score:2.79|P-value:6.89E-4 ID:SGTC_2287|Compound:7945887|FD-Score:2.95|P-value:3.64E-4 ID:SGTC_2394|Compound:5221648|FD-Score:2.75|P-value:8.17E-4 ID:SGTC_2404|Compound:5161160|FD-Score:3.87|P-value:4.53E-6 ID:SGTC_2473|Compound:5854593|FD-Score:-3.45|P-value:3.73E-5 ID:SGTC_2537|Compound:larixol|FD-Score:2.75|P-value:8.17E-4 ID:SGTC_2568|Compound:diosmetin|FD-Score:5.21|P-value:1.16E-9 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:3.32|P-value:7.30E-5 ID:SGTC_2782|Compound:7736369|FD-Score:-3.45|P-value:3.75E-5 ID:SGTC_2790|Compound:5423970|FD-Score:4.42|P-value:2.04E-7 ID:SGTC_2795|Compound:7780010|FD-Score:3.38|P-value:5.31E-5 ID:SGTC_2821|Compound:7996764|FD-Score:2.98|P-value:3.17E-4 ID:SGTC_2923|Compound:7992654|FD-Score:-3.15|P-value:1.52E-4 ID:SGTC_3080|Compound:9117754|FD-Score:3.36|P-value:5.99E-5 ID:SGTC_3312|Compound:9133330|FD-Score:2.83|P-value:5.94E-4 ID:SGTC_3313|Compound:9133968|FD-Score:3.48|P-value:3.41E-5 ID:SGTC_3337|Compound:9144342|FD-Score:5.18|P-value:1.44E-9 ID:SGTC_3338|Compound:9144300|FD-Score:-3.46|P-value:3.65E-5 ID:SGTC_3350|Compound:9150499|FD-Score:-4.23|P-value:6.04E-7 ID:SGTC_3355|Compound:9151058|FD-Score:-3.73|P-value:9.37E-6 ID:SGTC_3356|Compound:9151811|FD-Score:-3.27|P-value:8.82E-5

Top fitness defect scores for YGL205W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_996 3970-0799 13.90 1.8 µM 3.71E-57 7 5.09E-44
2 SGTC_2568 diosmetin 5.21 100.0 µM 1.16E-9 7 9.25E-8
3 SGTC_3337 9144342 5.18 33.5 µM 1.44E-9 16 1.09E-7
4 SGTC_1283 0922-0125 4.64 16.4 µM 5.36E-8 11 1.76E-6
5 SGTC_2790 5423970 4.42 71.4 µM 2.04E-7 endomembrane recycling 52 4.92E-6
6 SGTC_930 2810-3379 4.31 265.0 µM 4.00E-7 9 8.25E-6
7 SGTC_1311 1190-0148 4.09 100.0 µM 1.38E-6 azole & statin 27 2.14E-5
8 SGTC_953 1188-0045 4.04 9.7 µM 1.80E-6 60S ribosome export 23 2.62E-5
9 SGTC_2281 7943571 3.97 200.0 µM 2.71E-6 11 3.60E-5
10 SGTC_2404 5161160 3.87 200.0 µM 4.53E-6 22 5.35E-5
11 SGTC_1290 0986-0249 3.87 10.2 µM 4.53E-6 DNA intercalators 24 5.35E-5
12 SGTC_1512 0259-0544 3.49 12.2 µM 3.17E-5 32 2.40E-4
13 SGTC_3313 9133968 3.48 57.0 µM 3.41E-5 11 2.54E-4
14 SGTC_2795 7780010 3.38 54.5 µM 5.31E-5 56 3.58E-4
15 SGTC_877 0771-0151 3.36 33.1 µM 5.93E-5 26 3.90E-4
16 SGTC_3080 9117754 3.36 49.5 µM 5.99E-5 37 3.93E-4
17 SGTC_656 4090-1979 3.34 187.0 µM 6.53E-5 39 4.20E-4
18 SGTC_2572 astragaloside iv 3.32 100.0 µM 7.30E-5 52 4.58E-4
19 SGTC_1376 2910-0861 3.20 41.3 µM 1.22E-4 51 6.80E-4
20 SGTC_669 0108-0021 3.15 26.2 µM 1.53E-4 fatty acid desaturase (OLE1) 142 8.11E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.499 2.37E-210 YML118W NGL3 hom 3'-5' exonuclease specific for poly-A RNAs; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p; NGL3 has a paralog, NGL2, that arose from the whole genome duplication
0.404 1.33E-131 YDL099W BUG1 hom Cis-golgi localized protein involved in ER to Golgi transport; forms a complex with the mammalian GRASP65 homolog, Grh1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes
0.397 6.57E-127 YOR037W CYC2 hom Mitochondrial peripheral inner membrane protein, contains a FAD cofactor in a domain exposed in the intermembrane space; exhibits redox activity in vitro; likely participates in ligation of heme to acytochromes c and c1 (Cyc1p and Cyt1p)
0.358 6.62E-102 YDR505C PSP1 hom Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition; PSP1 has a paralog, YLR177W, that arose from the whole genome duplication
0.331 3.16E-86 YGL222C EDC1 hom RNA-binding protein that activates mRNA decapping directly; binds to the mRNA substrate and enhances the activity of the decapping proteins Dcp1p and Dcp2p; has a role in translation during heat stress; protein becomes more abundant and forms cytoplasmic foci in response to DNA replication stress
0.318 1.36E-79 YGL040C HEM2 het Aminolevulinate dehydratase, a homo-octameric enzyme, catalyzes the conversion of 5-aminolevulinate to porphobilinogen, the second step in heme biosynthesis; enzymatic activity is zinc-dependent; localizes to the cytoplasm and nucleus
0.279 4.92E-61 YDL186W_p YDL186W_p hom Putative protein of unknown function; YDL186W is not an essential gene
0.277 3.95E-60 YDL177C_p YDL177C_p hom Putative protein of unknown function; similar to the mouse IMPACT gene; YDL177C is not an essential gene
0.270 5.66E-57 YJR094C IME1 hom Master regulator of meiosis that is active only during meiotic events, activates transcription of early meiotic genes through interaction with Ume6p, degraded by the 26S proteasome following phosphorylation by Ime2p
0.267 7.14E-56 YNR033W ABZ1 hom Para-aminobenzoate (PABA) synthase; has similarity to Escherichia coli PABA synthase components PabA and PabB; required for the synthesis of para-aminobenzoic acid, an important intermediate for folate and ubiquinone Q biosynthesis; protein abundance increases in response to DNA replication stress
0.264 2.16E-54 YGL096W TOS8 hom Homeodomain-containing protein and putative transcription factor; found associated with chromatin; target of SBF transcription factor; induced during meiosis and under cell-damaging conditions; TOS8 has a paralog, CUP9, that arose from the whole genome duplication
0.261 2.20E-53 YGR035C_p YGR035C_p hom Putative protein of unknown function, potential Cdc28p substrate; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance
0.255 5.40E-51 YGL083W SCY1 hom Putative kinase, suppressor of GTPase mutant, similar to bovine rhodopsin kinase
0.249 1.80E-48 YBR067C TIP1 hom Major cell wall mannoprotein with possible lipase activity; transcription is induced by heat- and cold-shock; member of the Srp1p/Tip1p family of serine-alanine-rich proteins
0.248 2.83E-48 YJL149W DAS1 hom Putative SCF ubiquitin ligase F-box protein; interacts physically with both Cdc53p and Skp1 and genetically with CDC34; similar to putative F-box protein YDR131C