YGL209W / MIG2

Zinc finger transcriptional repressor; cooperates with Mig1p in glucose-induced repression of many genes; under low glucose conditions Mig2p relocalizes to mitochondrion, where it interacts with Ups1p and antagonizes mitochondrial fission factor, Dnm1p, indicative of a role in mitochondrial fusion or regulating morphology; regulates filamentous growth along with Mig2p in response to glucose depletion; MIG2 has a paralog, MIG3, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL209W / MIG2

Click on Significant Values for Screen Details ID:SGTC_67|Compound:0335-0847|FD-Score:3.15|P-value:4.67E-4 ID:SGTC_87|Compound:0100-0052|FD-Score:3.88|P-value:2.24E-5 ID:SGTC_95|Compound:0471-0001|FD-Score:-3.16|P-value:4.30E-4 ID:SGTC_150|Compound:3970-0969|FD-Score:-3.58|P-value:7.89E-5 ID:SGTC_156|Compound:3474-0145|FD-Score:3.69|P-value:5.34E-5 ID:SGTC_426|Compound:0988-0037|FD-Score:3.14|P-value:4.87E-4 ID:SGTC_504|Compound:lovastatin|FD-Score:-3.16|P-value:4.30E-4 ID:SGTC_524|Compound:r073-0010|FD-Score:-3.04|P-value:6.80E-4 ID:SGTC_530|Compound:4358-1714|FD-Score:-3.16|P-value:4.23E-4 ID:SGTC_607|Compound:4491-0986|FD-Score:3.19|P-value:3.97E-4 ID:SGTC_615|Compound:k087-0205|FD-Score:-3.20|P-value:3.68E-4 ID:SGTC_638|Compound:3970-0837|FD-Score:-3.04|P-value:6.63E-4 ID:SGTC_963|Compound:1269-2853|FD-Score:3.84|P-value:2.73E-5 ID:SGTC_1103|Compound:duloxetine|FD-Score:3.27|P-value:3.00E-4 ID:SGTC_1124|Compound:fisetin|FD-Score:3.47|P-value:1.30E-4 ID:SGTC_1127|Compound:asiatic acid|FD-Score:3.63|P-value:6.72E-5 ID:SGTC_1298|Compound:1079-1278|FD-Score:3.34|P-value:2.25E-4 ID:SGTC_1427|Compound:4048-4900|FD-Score:3.30|P-value:2.66E-4 ID:SGTC_1493|Compound:4348-0038|FD-Score:3.05|P-value:6.70E-4 ID:SGTC_1562|Compound:morin hydrate|FD-Score:3.04|P-value:6.96E-4 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:2.96|P-value:9.52E-4 ID:SGTC_1732|Compound:st034308|FD-Score:3.30|P-value:2.58E-4 ID:SGTC_1858|Compound:4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione|FD-Score:3.31|P-value:2.58E-4 ID:SGTC_2005|Compound:4024620|FD-Score:-4.16|P-value:5.92E-6 ID:SGTC_2278|Compound:7948257|FD-Score:3.18|P-value:4.18E-4 ID:SGTC_2339|Compound:9000433|FD-Score:-3.11|P-value:5.12E-4 ID:SGTC_2364|Compound:9055074|FD-Score:4.53|P-value:9.63E-7 ID:SGTC_2391|Compound:6285546|FD-Score:3.11|P-value:5.43E-4 ID:SGTC_2396|Compound:5342950|FD-Score:3.59|P-value:8.21E-5 ID:SGTC_2431|Compound:5490079|FD-Score:3.57|P-value:8.73E-5 ID:SGTC_2435|Compound:5706476|FD-Score:4.07|P-value:9.39E-6 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:3.15|P-value:4.67E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:5.45|P-value:4.94E-9 ID:SGTC_2601|Compound:securinine|FD-Score:-3.00|P-value:7.83E-4 ID:SGTC_2748|Compound:diazoxide|FD-Score:3.73|P-value:4.47E-5 ID:SGTC_2934|Compound:9036370|FD-Score:3.09|P-value:5.78E-4 ID:SGTC_3217|Compound:9129673|FD-Score:3.72|P-value:4.54E-5 ID:SGTC_3297|Compound:9117502|FD-Score:3.08|P-value:6.03E-4 ID:SGTC_3334|Compound:9142812|FD-Score:-2.97|P-value:8.58E-4 ID:SGTC_67|Compound:0335-0847|FD-Score:3.15|P-value:4.67E-4 ID:SGTC_87|Compound:0100-0052|FD-Score:3.88|P-value:2.24E-5 ID:SGTC_95|Compound:0471-0001|FD-Score:-3.16|P-value:4.30E-4 ID:SGTC_150|Compound:3970-0969|FD-Score:-3.58|P-value:7.89E-5 ID:SGTC_156|Compound:3474-0145|FD-Score:3.69|P-value:5.34E-5 ID:SGTC_426|Compound:0988-0037|FD-Score:3.14|P-value:4.87E-4 ID:SGTC_504|Compound:lovastatin|FD-Score:-3.16|P-value:4.30E-4 ID:SGTC_524|Compound:r073-0010|FD-Score:-3.04|P-value:6.80E-4 ID:SGTC_530|Compound:4358-1714|FD-Score:-3.16|P-value:4.23E-4 ID:SGTC_607|Compound:4491-0986|FD-Score:3.19|P-value:3.97E-4 ID:SGTC_615|Compound:k087-0205|FD-Score:-3.20|P-value:3.68E-4 ID:SGTC_638|Compound:3970-0837|FD-Score:-3.04|P-value:6.63E-4 ID:SGTC_963|Compound:1269-2853|FD-Score:3.84|P-value:2.73E-5 ID:SGTC_1103|Compound:duloxetine|FD-Score:3.27|P-value:3.00E-4 ID:SGTC_1124|Compound:fisetin|FD-Score:3.47|P-value:1.30E-4 ID:SGTC_1127|Compound:asiatic acid|FD-Score:3.63|P-value:6.72E-5 ID:SGTC_1298|Compound:1079-1278|FD-Score:3.34|P-value:2.25E-4 ID:SGTC_1427|Compound:4048-4900|FD-Score:3.30|P-value:2.66E-4 ID:SGTC_1493|Compound:4348-0038|FD-Score:3.05|P-value:6.70E-4 ID:SGTC_1562|Compound:morin hydrate|FD-Score:3.04|P-value:6.96E-4 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:2.96|P-value:9.52E-4 ID:SGTC_1732|Compound:st034308|FD-Score:3.30|P-value:2.58E-4 ID:SGTC_1858|Compound:4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione|FD-Score:3.31|P-value:2.58E-4 ID:SGTC_2005|Compound:4024620|FD-Score:-4.16|P-value:5.92E-6 ID:SGTC_2278|Compound:7948257|FD-Score:3.18|P-value:4.18E-4 ID:SGTC_2339|Compound:9000433|FD-Score:-3.11|P-value:5.12E-4 ID:SGTC_2364|Compound:9055074|FD-Score:4.53|P-value:9.63E-7 ID:SGTC_2391|Compound:6285546|FD-Score:3.11|P-value:5.43E-4 ID:SGTC_2396|Compound:5342950|FD-Score:3.59|P-value:8.21E-5 ID:SGTC_2431|Compound:5490079|FD-Score:3.57|P-value:8.73E-5 ID:SGTC_2435|Compound:5706476|FD-Score:4.07|P-value:9.39E-6 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:3.15|P-value:4.67E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:5.45|P-value:4.94E-9 ID:SGTC_2601|Compound:securinine|FD-Score:-3.00|P-value:7.83E-4 ID:SGTC_2748|Compound:diazoxide|FD-Score:3.73|P-value:4.47E-5 ID:SGTC_2934|Compound:9036370|FD-Score:3.09|P-value:5.78E-4 ID:SGTC_3217|Compound:9129673|FD-Score:3.72|P-value:4.54E-5 ID:SGTC_3297|Compound:9117502|FD-Score:3.08|P-value:6.03E-4 ID:SGTC_3334|Compound:9142812|FD-Score:-2.97|P-value:8.58E-4

Top fitness defect scores for YGL209W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2563 tomatine 5.45 8.5 µM 4.94E-9 16 2.49E-8
2 SGTC_2364 9055074 4.53 200.0 µM 9.63E-7 13 2.96E-6
3 SGTC_2435 5706476 4.07 10.6 µM 9.39E-6 22 2.34E-5
4 SGTC_87 0100-0052 3.88 35.5 µM 2.24E-5 111 5.16E-5
5 SGTC_963 1269-2853 3.84 151.0 µM 2.73E-5 27 6.17E-5
6 SGTC_2748 diazoxide 3.73 86.7 µM 4.47E-5 9 9.66E-5
7 SGTC_3217 9129673 3.72 49.5 µM 4.54E-5 47 9.80E-5
8 SGTC_156 3474-0145 3.69 5.6 µM 5.34E-5 endomembrane recycling 60 1.13E-4
9 SGTC_1127 asiatic acid 3.63 681.4 nM 6.72E-5 32 1.40E-4
10 SGTC_2396 5342950 3.59 42.8 µM 8.21E-5 RSC complex & mRNA processing 60 1.68E-4
11 SGTC_2431 5490079 3.57 200.0 µM 8.73E-5 50 1.77E-4
12 SGTC_1124 fisetin 3.47 1.2 µM 1.30E-4 53 2.56E-4
13 SGTC_1298 1079-1278 3.34 263.0 µM 2.25E-4 DNA damage response 42 4.20E-4
14 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 3.31 62.6 µM 2.58E-4 TSC3-RPN4 29 4.75E-4
15 SGTC_1732 st034308 3.30 51.8 µM 2.58E-4 51 4.76E-4
16 SGTC_1427 4048-4900 3.30 550.0 nM 2.66E-4 50 4.89E-4
17 SGTC_1103 duloxetine 3.27 36.1 µM 3.00E-4 59 5.45E-4
18 SGTC_607 4491-0986 3.19 66.8 µM 3.97E-4 heme requiring 44 7.03E-4
19 SGTC_2278 7948257 3.18 134.3 µM 4.18E-4 45 7.38E-4
20 SGTC_2539 epi(13)torulosol 3.15 80.0 µM 4.67E-4 53 8.15E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.174 2.91E-24 YNR032C-A HUB1 hom Ubiquitin-like protein modifier; promotes alternative splicing of SRC1 pre-mRNA; binds non-covalently to the HIND domain of Snu66, may function in modification of Sph1p and Hbt1p, functionally complemented by the human or S. pombe ortholog; mechanism of Hub1p adduct formation not yet clear
0.105 1.20E-9 YNL134C YNL134C hom Protein of unknown function; similar to dehydrogenases from other model organisms; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus; protein abundance increases in response to DNA replication stress
0.097 1.64E-8 YDR299W BFR2 het Essential protein that is a component of 90S preribosomes; may be involved in rRNA processing; multicopy suppressor of sensitivity to Brefeldin A; expression is induced during lag phase and also by cold shock
0.094 4.32E-8 YMR110C HFD1 hom Hexadecenal dehydrogenase; involved in the conversion of sphingosine 1-phosphate breakdown product hexadecenal to hexadecenoic acid; located in the mitochondrial outer membrane and also in lipid particles; has similarity to ALDH3A2, a human fatty aldehyde dehydrogenase (FALDH) mutated in Sjogren-Larsson syndrome, a neurocutaneous disorder
0.092 8.42E-8 YOR242C SSP2 hom Sporulation specific protein that localizes to the spore wall; required for sporulation at a point after meiosis II and during spore wall formation; SSP2 expression is induced midway in meiosis
0.092 8.53E-8 YIL018W RPL2B hom Ribosomal 60S subunit protein L2B; homologous to mammalian ribosomal protein L2 and bacterial L2; RPL2B has a paralog, RPL2A, that arose from the whole genome duplication; expression is upregulated at low temperatures
0.088 2.95E-7 YPL242C IQG1 het Essential protein required for determination of budding pattern; promotes localization of axial markers Bud4p and Cdc12p and functionally interacts with Sec3p, localizes to the contractile ring during anaphase, member of the IQGAP family; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.087 4.66E-7 YPR024W YME1 hom Catalytic subunit of the mitochondrial inner membrane i-AAA protease complex, which is responsible for degradation of unfolded or misfolded mitochondrial gene products; also has a role in intermembrane space protein folding; mutation causes an elevated rate of mitochondrial turnover
0.085 7.06E-7 YBR003W COQ1 hom Hexaprenyl pyrophosphate synthetase, catalyzes the first step in ubiquinone (coenzyme Q) biosynthesis
0.085 8.92E-7 YNL067W-B_p YNL067W-B_p hom Putative protein of unknown function
0.084 1.16E-6 YGR038W ORM1 hom Evolutionarily conserved protein, similar to Orm2p, required for resistance to agents that induce unfolded protein response; Orm1p and Orm2p together control membrane biogenesis by coordinating lipid homeostasis with protein quality control
0.083 1.41E-6 YPL165C SET6 hom SET domain protein of unknown function; deletion heterozygote is sensitive to compounds that target ergosterol biosynthesis, may be involved in compound availability
0.083 1.60E-6 YDR534C FIT1 hom Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall
0.081 2.71E-6 YLR453C RIF2 hom Protein that binds to the Rap1p C-terminus and acts synergistically with Rif1p to help control telomere length and establish telomeric silencing; deletion results in telomere elongation
0.079 4.43E-6 YGR153W_p YGR153W_p hom Putative protein of unknown function