YGL212W / VAM7

Vacuolar SNARE protein; functions with Vam3p in vacuolar protein trafficking; has an N-terminal PX domain (phosphoinositide-binding module) that binds PtdIns-3-P and mediates membrane binding; SNAP-25 homolog; protein abundance increases in response to DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL212W / VAM7

Click on Significant Values for Screen Details ID:SGTC_37|Compound:0566-0070|FD-Score:3.39|P-value:6.16E-4 ID:SGTC_117|Compound:lucigenin|FD-Score:7.69|P-value:9.63E-14 ID:SGTC_123|Compound:0083-0120|FD-Score:5.76|P-value:1.89E-8 ID:SGTC_149|Compound:3970-0822|FD-Score:12.40|P-value:5.39E-33 ID:SGTC_157|Compound:1348-1695|FD-Score:3.79|P-value:1.50E-4 ID:SGTC_159|Compound:3970-0959|FD-Score:5.60|P-value:4.45E-8 ID:SGTC_178|Compound:4092-0806|FD-Score:-4.19|P-value:2.78E-5 ID:SGTC_221|Compound:trifluoperazine|FD-Score:5.71|P-value:2.39E-8 ID:SGTC_232|Compound:clozapine|FD-Score:4.91|P-value:1.35E-6 ID:SGTC_245|Compound:methotrexate|FD-Score:5.03|P-value:7.86E-7 ID:SGTC_263|Compound:alizarin|FD-Score:4.78|P-value:2.53E-6 ID:SGTC_266|Compound:formosanin C|FD-Score:-4.39|P-value:1.21E-5 ID:SGTC_281|Compound:1672-3440|FD-Score:3.45|P-value:4.94E-4 ID:SGTC_288|Compound:1315-0019|FD-Score:5.34|P-value:1.69E-7 ID:SGTC_291|Compound:4130-1278|FD-Score:3.65|P-value:2.52E-4 ID:SGTC_300|Compound:r073-0011|FD-Score:3.42|P-value:5.50E-4 ID:SGTC_301|Compound:4119-0100|FD-Score:5.02|P-value:8.22E-7 ID:SGTC_304|Compound:1310-0298|FD-Score:-3.78|P-value:1.40E-4 ID:SGTC_309|Compound:k408-0051|FD-Score:-5.27|P-value:2.06E-7 ID:SGTC_351|Compound:caspofungin|FD-Score:3.68|P-value:2.25E-4 ID:SGTC_391|Compound:gliotoxin|FD-Score:17.30|P-value:7.44E-62 ID:SGTC_445|Compound:e6 berbamine|FD-Score:5.53|P-value:6.23E-8 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:4.11|P-value:4.31E-5 ID:SGTC_459|Compound:nigericin|FD-Score:11.60|P-value:5.25E-29 ID:SGTC_528|Compound:3492-0019|FD-Score:8.84|P-value:1.42E-17 ID:SGTC_562|Compound:3772-2733|FD-Score:4.64|P-value:4.73E-6 ID:SGTC_590|Compound:k048-0076|FD-Score:3.40|P-value:5.95E-4 ID:SGTC_619|Compound:1652-1634|FD-Score:3.87|P-value:1.12E-4 ID:SGTC_660|Compound:4031-1742|FD-Score:3.56|P-value:3.47E-4 ID:SGTC_674|Compound:0498-0004|FD-Score:-4.97|P-value:8.94E-7 ID:SGTC_683|Compound:panaxydol|FD-Score:-4.52|P-value:6.88E-6 ID:SGTC_690|Compound:glyoxal|FD-Score:-5.66|P-value:2.63E-8 ID:SGTC_722|Compound:3534-0461|FD-Score:5.97|P-value:5.91E-9 ID:SGTC_733|Compound:4069-0007|FD-Score:4.74|P-value:3.05E-6 ID:SGTC_754|Compound:3474-0146|FD-Score:-4.21|P-value:2.53E-5 ID:SGTC_769|Compound:0302-0231|FD-Score:-4.19|P-value:2.81E-5 ID:SGTC_794|Compound:k038-0031|FD-Score:-3.66|P-value:2.14E-4 ID:SGTC_805|Compound:3852-0218|FD-Score:9.03|P-value:2.96E-18 ID:SGTC_812|Compound:4251-0442|FD-Score:3.65|P-value:2.46E-4 ID:SGTC_841|Compound:0251-0215|FD-Score:16.70|P-value:1.25E-57 ID:SGTC_842|Compound:0271-0008|FD-Score:-3.24|P-value:8.97E-4 ID:SGTC_848|Compound:0368-0089|FD-Score:5.93|P-value:7.16E-9 ID:SGTC_854|Compound:0422-0053|FD-Score:4.77|P-value:2.59E-6 ID:SGTC_855|Compound:0428-0020|FD-Score:4.75|P-value:2.86E-6 ID:SGTC_878|Compound:0828-0289|FD-Score:5.08|P-value:5.98E-7 ID:SGTC_1026|Compound:k007-1105|FD-Score:4.79|P-value:2.40E-6 ID:SGTC_1057|Compound:3448-5381|FD-Score:3.70|P-value:2.09E-4 ID:SGTC_1158|Compound:4092-0494|FD-Score:4.80|P-value:2.23E-6 ID:SGTC_1174|Compound:0739-0097|FD-Score:4.31|P-value:1.92E-5 ID:SGTC_1448|Compound:4255-0083|FD-Score:4.95|P-value:1.11E-6 ID:SGTC_1457|Compound:k015-0032|FD-Score:3.51|P-value:4.08E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:7.53|P-value:3.07E-13 ID:SGTC_1522|Compound:st012842|FD-Score:-3.82|P-value:1.19E-4 ID:SGTC_1581|Compound:himbacine|FD-Score:5.54|P-value:5.92E-8 ID:SGTC_1626|Compound:st003712|FD-Score:3.43|P-value:5.39E-4 ID:SGTC_1658|Compound:st012944|FD-Score:4.80|P-value:2.24E-6 ID:SGTC_1660|Compound:st012960|FD-Score:3.49|P-value:4.33E-4 ID:SGTC_1677|Compound:st019204|FD-Score:-3.46|P-value:4.38E-4 ID:SGTC_1687|Compound:st020778|FD-Score:17.90|P-value:7.67E-66 ID:SGTC_1744|Compound:st037937|FD-Score:4.47|P-value:1.00E-5 ID:SGTC_1750|Compound:st081859|FD-Score:7.88|P-value:2.37E-14 ID:SGTC_1800|Compound:st050079|FD-Score:5.98|P-value:5.39E-9 ID:SGTC_1803|Compound:st050068|FD-Score:6.14|P-value:2.16E-9 ID:SGTC_1844|Compound:rapamycin|FD-Score:9.19|P-value:7.09E-19 ID:SGTC_1873|Compound:rapamycin|FD-Score:8.78|P-value:2.33E-17 ID:SGTC_1877|Compound:wortmannin|FD-Score:11.40|P-value:3.32E-28 ID:SGTC_1884|Compound:5633444|FD-Score:4.20|P-value:3.04E-5 ID:SGTC_1919|Compound:st067113|FD-Score:-4.64|P-value:4.07E-6 ID:SGTC_1930|Compound:st074634|FD-Score:-3.23|P-value:9.27E-4 ID:SGTC_2077|Compound:5212015|FD-Score:4.26|P-value:2.42E-5 ID:SGTC_2132|Compound:5317594|FD-Score:-3.26|P-value:8.38E-4 ID:SGTC_2135|Compound:5326629|FD-Score:3.67|P-value:2.30E-4 ID:SGTC_2291|Compound:7917025|FD-Score:5.60|P-value:4.45E-8 ID:SGTC_2322|Compound:7413319|FD-Score:11.70|P-value:2.96E-29 ID:SGTC_2354|Compound:9060492|FD-Score:3.45|P-value:5.01E-4 ID:SGTC_2356|Compound:9061756|FD-Score:3.48|P-value:4.44E-4 ID:SGTC_2471|Compound:5466956|FD-Score:3.69|P-value:2.19E-4 ID:SGTC_2475|Compound:5812728|FD-Score:6.03|P-value:4.06E-9 ID:SGTC_2481|Compound:5478948|FD-Score:7.90|P-value:2.15E-14 ID:SGTC_2482|Compound:5981709|FD-Score:4.26|P-value:2.37E-5 ID:SGTC_2514|Compound:salinomycin|FD-Score:9.28|P-value:3.53E-19 ID:SGTC_2533|Compound:agelasine|FD-Score:3.28|P-value:8.71E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:6.00|P-value:4.82E-9 ID:SGTC_2586|Compound:curcumin|FD-Score:4.23|P-value:2.74E-5 ID:SGTC_2619|Compound:obliquin|FD-Score:6.34|P-value:6.96E-10 ID:SGTC_2648|Compound:atorvastatin|FD-Score:3.35|P-value:6.89E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:-3.70|P-value:1.86E-4 ID:SGTC_2658|Compound:polymyxin b sulfate|FD-Score:3.73|P-value:1.84E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:12.70|P-value:2.12E-34 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.51|P-value:4.13E-4 ID:SGTC_2737|Compound:bleomycin|FD-Score:5.08|P-value:6.00E-7 ID:SGTC_2743|Compound:auranofin|FD-Score:4.78|P-value:2.50E-6 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:-6.11|P-value:2.19E-9 ID:SGTC_2795|Compound:7780010|FD-Score:-3.79|P-value:1.31E-4 ID:SGTC_2991|Compound:9074669|FD-Score:4.11|P-value:4.37E-5 ID:SGTC_3205|Compound:9113483|FD-Score:4.32|P-value:1.86E-5 ID:SGTC_3206|Compound:9114350|FD-Score:-6.77|P-value:3.96E-11 ID:SGTC_37|Compound:0566-0070|FD-Score:3.39|P-value:6.16E-4 ID:SGTC_117|Compound:lucigenin|FD-Score:7.69|P-value:9.63E-14 ID:SGTC_123|Compound:0083-0120|FD-Score:5.76|P-value:1.89E-8 ID:SGTC_149|Compound:3970-0822|FD-Score:12.40|P-value:5.39E-33 ID:SGTC_157|Compound:1348-1695|FD-Score:3.79|P-value:1.50E-4 ID:SGTC_159|Compound:3970-0959|FD-Score:5.60|P-value:4.45E-8 ID:SGTC_178|Compound:4092-0806|FD-Score:-4.19|P-value:2.78E-5 ID:SGTC_221|Compound:trifluoperazine|FD-Score:5.71|P-value:2.39E-8 ID:SGTC_232|Compound:clozapine|FD-Score:4.91|P-value:1.35E-6 ID:SGTC_245|Compound:methotrexate|FD-Score:5.03|P-value:7.86E-7 ID:SGTC_263|Compound:alizarin|FD-Score:4.78|P-value:2.53E-6 ID:SGTC_266|Compound:formosanin C|FD-Score:-4.39|P-value:1.21E-5 ID:SGTC_281|Compound:1672-3440|FD-Score:3.45|P-value:4.94E-4 ID:SGTC_288|Compound:1315-0019|FD-Score:5.34|P-value:1.69E-7 ID:SGTC_291|Compound:4130-1278|FD-Score:3.65|P-value:2.52E-4 ID:SGTC_300|Compound:r073-0011|FD-Score:3.42|P-value:5.50E-4 ID:SGTC_301|Compound:4119-0100|FD-Score:5.02|P-value:8.22E-7 ID:SGTC_304|Compound:1310-0298|FD-Score:-3.78|P-value:1.40E-4 ID:SGTC_309|Compound:k408-0051|FD-Score:-5.27|P-value:2.06E-7 ID:SGTC_351|Compound:caspofungin|FD-Score:3.68|P-value:2.25E-4 ID:SGTC_391|Compound:gliotoxin|FD-Score:17.30|P-value:7.44E-62 ID:SGTC_445|Compound:e6 berbamine|FD-Score:5.53|P-value:6.23E-8 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:4.11|P-value:4.31E-5 ID:SGTC_459|Compound:nigericin|FD-Score:11.60|P-value:5.25E-29 ID:SGTC_528|Compound:3492-0019|FD-Score:8.84|P-value:1.42E-17 ID:SGTC_562|Compound:3772-2733|FD-Score:4.64|P-value:4.73E-6 ID:SGTC_590|Compound:k048-0076|FD-Score:3.40|P-value:5.95E-4 ID:SGTC_619|Compound:1652-1634|FD-Score:3.87|P-value:1.12E-4 ID:SGTC_660|Compound:4031-1742|FD-Score:3.56|P-value:3.47E-4 ID:SGTC_674|Compound:0498-0004|FD-Score:-4.97|P-value:8.94E-7 ID:SGTC_683|Compound:panaxydol|FD-Score:-4.52|P-value:6.88E-6 ID:SGTC_690|Compound:glyoxal|FD-Score:-5.66|P-value:2.63E-8 ID:SGTC_722|Compound:3534-0461|FD-Score:5.97|P-value:5.91E-9 ID:SGTC_733|Compound:4069-0007|FD-Score:4.74|P-value:3.05E-6 ID:SGTC_754|Compound:3474-0146|FD-Score:-4.21|P-value:2.53E-5 ID:SGTC_769|Compound:0302-0231|FD-Score:-4.19|P-value:2.81E-5 ID:SGTC_794|Compound:k038-0031|FD-Score:-3.66|P-value:2.14E-4 ID:SGTC_805|Compound:3852-0218|FD-Score:9.03|P-value:2.96E-18 ID:SGTC_812|Compound:4251-0442|FD-Score:3.65|P-value:2.46E-4 ID:SGTC_841|Compound:0251-0215|FD-Score:16.70|P-value:1.25E-57 ID:SGTC_842|Compound:0271-0008|FD-Score:-3.24|P-value:8.97E-4 ID:SGTC_848|Compound:0368-0089|FD-Score:5.93|P-value:7.16E-9 ID:SGTC_854|Compound:0422-0053|FD-Score:4.77|P-value:2.59E-6 ID:SGTC_855|Compound:0428-0020|FD-Score:4.75|P-value:2.86E-6 ID:SGTC_878|Compound:0828-0289|FD-Score:5.08|P-value:5.98E-7 ID:SGTC_1026|Compound:k007-1105|FD-Score:4.79|P-value:2.40E-6 ID:SGTC_1057|Compound:3448-5381|FD-Score:3.70|P-value:2.09E-4 ID:SGTC_1158|Compound:4092-0494|FD-Score:4.80|P-value:2.23E-6 ID:SGTC_1174|Compound:0739-0097|FD-Score:4.31|P-value:1.92E-5 ID:SGTC_1448|Compound:4255-0083|FD-Score:4.95|P-value:1.11E-6 ID:SGTC_1457|Compound:k015-0032|FD-Score:3.51|P-value:4.08E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:7.53|P-value:3.07E-13 ID:SGTC_1522|Compound:st012842|FD-Score:-3.82|P-value:1.19E-4 ID:SGTC_1581|Compound:himbacine|FD-Score:5.54|P-value:5.92E-8 ID:SGTC_1626|Compound:st003712|FD-Score:3.43|P-value:5.39E-4 ID:SGTC_1658|Compound:st012944|FD-Score:4.80|P-value:2.24E-6 ID:SGTC_1660|Compound:st012960|FD-Score:3.49|P-value:4.33E-4 ID:SGTC_1677|Compound:st019204|FD-Score:-3.46|P-value:4.38E-4 ID:SGTC_1687|Compound:st020778|FD-Score:17.90|P-value:7.67E-66 ID:SGTC_1744|Compound:st037937|FD-Score:4.47|P-value:1.00E-5 ID:SGTC_1750|Compound:st081859|FD-Score:7.88|P-value:2.37E-14 ID:SGTC_1800|Compound:st050079|FD-Score:5.98|P-value:5.39E-9 ID:SGTC_1803|Compound:st050068|FD-Score:6.14|P-value:2.16E-9 ID:SGTC_1844|Compound:rapamycin|FD-Score:9.19|P-value:7.09E-19 ID:SGTC_1873|Compound:rapamycin|FD-Score:8.78|P-value:2.33E-17 ID:SGTC_1877|Compound:wortmannin|FD-Score:11.40|P-value:3.32E-28 ID:SGTC_1884|Compound:5633444|FD-Score:4.20|P-value:3.04E-5 ID:SGTC_1919|Compound:st067113|FD-Score:-4.64|P-value:4.07E-6 ID:SGTC_1930|Compound:st074634|FD-Score:-3.23|P-value:9.27E-4 ID:SGTC_2077|Compound:5212015|FD-Score:4.26|P-value:2.42E-5 ID:SGTC_2132|Compound:5317594|FD-Score:-3.26|P-value:8.38E-4 ID:SGTC_2135|Compound:5326629|FD-Score:3.67|P-value:2.30E-4 ID:SGTC_2291|Compound:7917025|FD-Score:5.60|P-value:4.45E-8 ID:SGTC_2322|Compound:7413319|FD-Score:11.70|P-value:2.96E-29 ID:SGTC_2354|Compound:9060492|FD-Score:3.45|P-value:5.01E-4 ID:SGTC_2356|Compound:9061756|FD-Score:3.48|P-value:4.44E-4 ID:SGTC_2471|Compound:5466956|FD-Score:3.69|P-value:2.19E-4 ID:SGTC_2475|Compound:5812728|FD-Score:6.03|P-value:4.06E-9 ID:SGTC_2481|Compound:5478948|FD-Score:7.90|P-value:2.15E-14 ID:SGTC_2482|Compound:5981709|FD-Score:4.26|P-value:2.37E-5 ID:SGTC_2514|Compound:salinomycin|FD-Score:9.28|P-value:3.53E-19 ID:SGTC_2533|Compound:agelasine|FD-Score:3.28|P-value:8.71E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:6.00|P-value:4.82E-9 ID:SGTC_2586|Compound:curcumin|FD-Score:4.23|P-value:2.74E-5 ID:SGTC_2619|Compound:obliquin|FD-Score:6.34|P-value:6.96E-10 ID:SGTC_2648|Compound:atorvastatin|FD-Score:3.35|P-value:6.89E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:-3.70|P-value:1.86E-4 ID:SGTC_2658|Compound:polymyxin b sulfate|FD-Score:3.73|P-value:1.84E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:12.70|P-value:2.12E-34 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.51|P-value:4.13E-4 ID:SGTC_2737|Compound:bleomycin|FD-Score:5.08|P-value:6.00E-7 ID:SGTC_2743|Compound:auranofin|FD-Score:4.78|P-value:2.50E-6 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:-6.11|P-value:2.19E-9 ID:SGTC_2795|Compound:7780010|FD-Score:-3.79|P-value:1.31E-4 ID:SGTC_2991|Compound:9074669|FD-Score:4.11|P-value:4.37E-5 ID:SGTC_3205|Compound:9113483|FD-Score:4.32|P-value:1.86E-5 ID:SGTC_3206|Compound:9114350|FD-Score:-6.77|P-value:3.96E-11

Top fitness defect scores for YGL212W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1687 st020778 17.90 55.4 µM 7.67E-66 11 1.24E-71
2 SGTC_391 gliotoxin 17.30 8.3 µM 7.44E-62 4 2.75E-67
3 SGTC_841 0251-0215 16.70 91.2 µM 1.25E-57 4 1.10E-62
4 SGTC_2679 rapamycin 12.70 1.0 nM 2.12E-34 11 2.27E-37
5 SGTC_149 3970-0822 12.40 46.1 µM 5.39E-33 tubulin folding & SWR complex 9 7.71E-36
6 SGTC_2322 7413319 11.70 38.2 µM 2.96E-29 ERAD & cell cycle 10 9.17E-32
7 SGTC_459 nigericin 11.60 15.3 µM 5.25E-29 3 1.71E-31
8 SGTC_1877 wortmannin 11.40 25.0 µM 3.32E-28 7 1.28E-30
9 SGTC_2514 salinomycin 9.28 42.7 µM 3.53E-19 6 8.76E-21
10 SGTC_1844 rapamycin 9.19 4.0 nM 7.09E-19 45 1.88E-20
11 SGTC_805 3852-0218 9.03 479.0 µM 2.96E-18 ERAD & cell cycle 5 8.89E-20
12 SGTC_528 3492-0019 8.84 172.0 µM 1.42E-17 calcium & mitochondrial duress 56 4.90E-19
13 SGTC_1873 rapamycin 8.78 2.0 nM 2.33E-17 9 8.43E-19
14 SGTC_2481 5478948 7.90 45.2 µM 2.15E-14 PDR1 4 1.43E-15
15 SGTC_1750 st081859 7.88 2.4 µM 2.37E-14 endomembrane recycling 69 1.60E-15
16 SGTC_117 lucigenin 7.69 22.1 µM 9.63E-14 redox potentiating 20 7.35E-15
17 SGTC_1495 4469-0029 7.53 237.0 µM 3.07E-13 29 2.60E-14
18 SGTC_2619 obliquin 6.34 87.9 µM 6.96E-10 cell wall 67 1.18E-10
19 SGTC_1803 st050068 6.14 52.4 µM 2.16E-9 NEO1-PIK1 78 4.05E-10
20 SGTC_2475 5812728 6.03 15.0 µM 4.06E-9 mitochondrial processes 6 8.05E-10

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.655 0 YDR080W VPS41 hom Vacuolar membrane protein that is a subunit of the homotypic vacuole fusion and vacuole protein sorting (HOPS) complex; essential for membrane docking and fusion at the Golgi-to-endosome and endosome-to-vacuole stages of protein transport
0.611 0 YDL077C VAM6 hom Vacuolar protein that plays a critical role in the tethering steps of vacuolar membrane fusion by facilitating guanine nucleotide exchange on small guanosine triphosphatase Ypt7p
0.557 5.82E-272 YML001W YPT7 hom Rab family GTPase; GTP-binding protein of the rab family; required for homotypic fusion event in vacuole inheritance, for endosome-endosome fusion; interacts with the cargo selection/retromer complex for retrograde sorting; similar to mammalian Rab7
0.386 1.37E-119 YBR288C APM3 hom Mu3-like subunit of the clathrin associated protein complex (AP-3); functions in transport of alkaline phosphatase to the vacuole via the alternate pathway
0.382 9.60E-117 YJL024C APS3 hom Small subunit of the clathrin-associated adaptor complex AP-3; involved in vacuolar protein sorting; related to the sigma subunit of the mammalian clathrin AP-3 complex; suppressor of loss of casein kinase 1 function; protein abundance increases in response to DNA replication stress
0.377 3.64E-113 YDL192W ARF1 hom ADP-ribosylation factor; GTPase of the Ras superfamily involved in regulation of coated vesicle formation in intracellular trafficking within the Golgi; ARF1 has a paralog, ARF2, that arose from the whole genome duplication
0.372 1.35E-110 YGR261C APL6 hom Beta3-like subunit of the yeast AP-3 complex; functions in transport of alkaline phosphatase to the vacuole via the alternate pathway; exists in both cytosolic and peripherally associated membrane-bound pools
0.371 1.11E-109 YDR323C PEP7 hom Multivalent adaptor protein that facilitates vesicle-mediated vacuolar protein sorting by ensuring high-fidelity vesicle docking and fusion, which are essential for targeting of vesicles to the endosome; required for vacuole inheritance
0.367 1.76E-107 YPL195W APL5 hom Delta adaptin-like subunit of the clathrin associated protein complex (AP-3); functions in transport of alkaline phosphatase to the vacuole via the alternate pathway, suppressor of loss of casein kinase 1 function
0.346 1.16E-94 YDR495C VPS3 hom Component of CORVET tethering complex; cytoplasmic protein required for the sorting and processing of soluble vacuolar proteins, acidification of the vacuolar lumen, and assembly of the vacuolar H+-ATPase
0.344 2.10E-93 YPL084W BRO1 hom Cytoplasmic class E vacuolar protein sorting (VPS) factor that coordinates deubiquitination in the multivesicular body (MVB) pathway by recruiting Doa4p to endosomes
0.342 1.42E-92 YOR036W PEP12 hom Target membrane receptor (t-SNARE) for vesicular intermediates traveling between the Golgi apparatus and the vacuole; controls entry of biosynthetic, endocytic, and retrograde traffic into the prevacuolar compartment; syntaxin
0.317 3.08E-79 YPR173C VPS4 hom AAA-ATPase involved in multivesicular body (MVB) protein sorting, ATP-bound Vps4p localizes to endosomes and catalyzes ESCRT-III disassembly and membrane release; ATPase activity is activated by Vta1p; regulates cellular sterol metabolism
0.317 4.22E-79 YBR131W CCZ1 hom Protein involved in vacuolar assembly, essential for autophagy and the cytoplasm-to-vacuole pathway
0.313 7.60E-77 YGL124C MON1 hom Protein required for fusion of cvt-vesicles and autophagosomes with the vacuole; associates, as a complex with Ccz1p, with a perivacuolar compartment; potential Cdc28p substrate