YGL215W / CLG1

Cyclin-like protein that interacts with Pho85p; has sequence similarity to G1 cyclins PCL1 and PCL2

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL215W / CLG1

Click on Significant Values for Screen Details ID:SGTC_122|Compound:0236-0016|FD-Score:3.38|P-value:6.80E-4 ID:SGTC_150|Compound:3970-0969|FD-Score:-5.47|P-value:8.52E-8 ID:SGTC_601|Compound:0986-0029|FD-Score:3.48|P-value:4.85E-4 ID:SGTC_948|Compound:3448-0295|FD-Score:3.30|P-value:8.85E-4 ID:SGTC_1079|Compound:idarubicin|FD-Score:3.33|P-value:8.02E-4 ID:SGTC_1092|Compound:toremifene|FD-Score:4.11|P-value:4.85E-5 ID:SGTC_1468|Compound:k284-1086|FD-Score:3.64|P-value:2.79E-4 ID:SGTC_1488|Compound:4013-0813|FD-Score:7.45|P-value:7.68E-13 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:3.51|P-value:4.52E-4 ID:SGTC_1745|Compound:st081495|FD-Score:3.98|P-value:8.11E-5 ID:SGTC_1844|Compound:rapamycin|FD-Score:4.35|P-value:1.87E-5 ID:SGTC_1871|Compound:st057448|FD-Score:-3.63|P-value:2.51E-4 ID:SGTC_1914|Compound:st062367|FD-Score:3.31|P-value:8.72E-4 ID:SGTC_1957|Compound:st077035|FD-Score:4.01|P-value:7.33E-5 ID:SGTC_2082|Compound:5219693|FD-Score:4.78|P-value:2.90E-6 ID:SGTC_2135|Compound:5326629|FD-Score:3.56|P-value:3.72E-4 ID:SGTC_2297|Compound:7971671|FD-Score:3.73|P-value:2.08E-4 ID:SGTC_2316|Compound:5844804|FD-Score:3.46|P-value:5.19E-4 ID:SGTC_2326|Compound:6164455|FD-Score:3.77|P-value:1.76E-4 ID:SGTC_2367|Compound:9070478|FD-Score:3.31|P-value:8.69E-4 ID:SGTC_2608|Compound:thymoquinone|FD-Score:-3.31|P-value:7.43E-4 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:3.78|P-value:1.73E-4 ID:SGTC_2622|Compound:2-methoxyxanthone|FD-Score:5.80|P-value:1.89E-8 ID:SGTC_2679|Compound:rapamycin|FD-Score:3.91|P-value:1.07E-4 ID:SGTC_2764|Compound:methyldopa|FD-Score:4.24|P-value:2.90E-5 ID:SGTC_3020|Compound:9089140|FD-Score:3.41|P-value:6.32E-4 ID:SGTC_3033|Compound:9090887|FD-Score:3.86|P-value:1.30E-4 ID:SGTC_3074|Compound:9116018|FD-Score:5.23|P-value:3.49E-7 ID:SGTC_3143|Compound:9086658|FD-Score:4.96|P-value:1.25E-6 ID:SGTC_3195|Compound:9113082|FD-Score:-3.45|P-value:4.71E-4 ID:SGTC_122|Compound:0236-0016|FD-Score:3.38|P-value:6.80E-4 ID:SGTC_150|Compound:3970-0969|FD-Score:-5.47|P-value:8.52E-8 ID:SGTC_601|Compound:0986-0029|FD-Score:3.48|P-value:4.85E-4 ID:SGTC_948|Compound:3448-0295|FD-Score:3.30|P-value:8.85E-4 ID:SGTC_1079|Compound:idarubicin|FD-Score:3.33|P-value:8.02E-4 ID:SGTC_1092|Compound:toremifene|FD-Score:4.11|P-value:4.85E-5 ID:SGTC_1468|Compound:k284-1086|FD-Score:3.64|P-value:2.79E-4 ID:SGTC_1488|Compound:4013-0813|FD-Score:7.45|P-value:7.68E-13 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:3.51|P-value:4.52E-4 ID:SGTC_1745|Compound:st081495|FD-Score:3.98|P-value:8.11E-5 ID:SGTC_1844|Compound:rapamycin|FD-Score:4.35|P-value:1.87E-5 ID:SGTC_1871|Compound:st057448|FD-Score:-3.63|P-value:2.51E-4 ID:SGTC_1914|Compound:st062367|FD-Score:3.31|P-value:8.72E-4 ID:SGTC_1957|Compound:st077035|FD-Score:4.01|P-value:7.33E-5 ID:SGTC_2082|Compound:5219693|FD-Score:4.78|P-value:2.90E-6 ID:SGTC_2135|Compound:5326629|FD-Score:3.56|P-value:3.72E-4 ID:SGTC_2297|Compound:7971671|FD-Score:3.73|P-value:2.08E-4 ID:SGTC_2316|Compound:5844804|FD-Score:3.46|P-value:5.19E-4 ID:SGTC_2326|Compound:6164455|FD-Score:3.77|P-value:1.76E-4 ID:SGTC_2367|Compound:9070478|FD-Score:3.31|P-value:8.69E-4 ID:SGTC_2608|Compound:thymoquinone|FD-Score:-3.31|P-value:7.43E-4 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:3.78|P-value:1.73E-4 ID:SGTC_2622|Compound:2-methoxyxanthone|FD-Score:5.80|P-value:1.89E-8 ID:SGTC_2679|Compound:rapamycin|FD-Score:3.91|P-value:1.07E-4 ID:SGTC_2764|Compound:methyldopa|FD-Score:4.24|P-value:2.90E-5 ID:SGTC_3020|Compound:9089140|FD-Score:3.41|P-value:6.32E-4 ID:SGTC_3033|Compound:9090887|FD-Score:3.86|P-value:1.30E-4 ID:SGTC_3074|Compound:9116018|FD-Score:5.23|P-value:3.49E-7 ID:SGTC_3143|Compound:9086658|FD-Score:4.96|P-value:1.25E-6 ID:SGTC_3195|Compound:9113082|FD-Score:-3.45|P-value:4.71E-4

Top fitness defect scores for YGL215W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1488 4013-0813 7.45 75.9 µM 7.68E-13 RPP1 & pyrimidine depletion 1 4.84E-14
2 SGTC_2622 2-methoxyxanthone 5.80 59.9 µM 1.89E-8 4 3.38E-9
3 SGTC_3074 9116018 5.23 49.5 µM 3.49E-7 RNA processing & uracil transport 7 8.43E-8
4 SGTC_3143 9086658 4.96 49.5 µM 1.25E-6 15 3.44E-7
5 SGTC_2082 5219693 4.78 150.0 µM 2.90E-6 RNA processing & uracil transport 12 8.72E-7
6 SGTC_1844 rapamycin 4.35 4.0 nM 1.87E-5 135 6.81E-6
7 SGTC_2764 methyldopa 4.24 94.7 µM 2.90E-5 14 1.10E-5
8 SGTC_1092 toremifene 4.11 6.3 µM 4.85E-5 16 1.95E-5
9 SGTC_1957 st077035 4.01 62.4 µM 7.33E-5 14 3.07E-5
10 SGTC_1745 st081495 3.98 74.0 µM 8.11E-5 RNA processing & uracil transport 74 3.43E-5
11 SGTC_2679 rapamycin 3.91 1.0 nM 1.07E-4 147 4.67E-5
12 SGTC_3033 9090887 3.86 49.5 µM 1.30E-4 fatty acid desaturase (OLE1) 25 5.79E-5
13 SGTC_2614 arthonioic acid 3.78 13.4 µM 1.73E-4 25 7.88E-5
14 SGTC_2326 6164455 3.77 177.6 µM 1.76E-4 mitochondrial processes 28 8.05E-5
15 SGTC_2297 7971671 3.73 152.3 µM 2.08E-4 RNA processing & uracil transport 34 9.67E-5
16 SGTC_1468 k284-1086 3.64 134.0 µM 2.79E-4 DNA intercalators 53 1.34E-4
17 SGTC_2135 5326629 3.56 150.4 µM 3.72E-4 RPP1 & pyrimidine depletion 42 1.84E-4
18 SGTC_1575 cyproterone acetate 3.51 48.0 µM 4.52E-4 35 2.27E-4
19 SGTC_601 0986-0029 3.48 62.9 µM 4.85E-4 calcium & mitochondrial duress 57 2.46E-4
20 SGTC_2316 5844804 3.46 197.4 µM 5.19E-4 55 2.65E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.175 1.76E-24 YKL203C TOR2 het PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that regulates growth in response to nutrients and TORC2, a complex that regulates cell-cycle dependent polarization of the actin cytoskeleton; involved in meiosis; TOR2 has a paralog, TOR1, that arose from the whole genome duplication
0.172 1.16E-23 YJR066W TOR1 hom PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that controls growth in response to nutrients by regulating translation, transcription, ribosome biogenesis, nutrient transport and autophagy; involved in meiosis; TOR1 has a paralog, TOR2, that arose from the whole genome duplication
0.162 3.11E-21 YLR114C AVL9 hom Conserved protein involved in exocytic transport from the Golgi; mutation is synthetically lethal with apl2 vps1 double mutation; member of a protein superfamily with orthologs in diverse organisms; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.150 1.92E-18 YKL110C KTI12 hom Protein that plays a role, with Elongator complex, in modification of wobble nucleosides in tRNA; involved in sensitivity to G1 arrest induced by zymocin; interacts with chromatin throughout the genome; also interacts with Cdc19p
0.138 1.09E-15 YBR021W FUR4 hom Plasma membrane localized uracil permease; expression is tightly regulated by uracil levels and environmental cues; conformational alterations induced by unfolding or substrate binding result in Rsp5p-mediated ubiquitination and degradation
0.134 6.18E-15 YML121W GTR1 hom Cytoplasmic GTP binding protein and negative regulator of the Ran/Tc4 GTPase cycle; component of GSE complex, which is required for sorting of Gap1p; involved in phosphate transport and telomeric silencing; similar to human RagA and RagB
0.133 1.04E-14 YDL172C_d YDL172C_d hom Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data
0.123 7.57E-13 YHR186C KOG1 het Subunit of TORC1, a rapamycin-sensitive complex involved in growth control that contains Tor1p or Tor2p, Lst8p and Tco89p; contains four HEAT repeats and seven WD-40 repeats; may act as a scaffold protein to couple TOR and its effectors
0.123 7.74E-13 YHR187W IKI1 hom Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; iki1 mutations confer resistance to the K. lactis toxin zymocin
0.120 3.63E-12 YLR384C IKI3 hom Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; maintains structural integrity of Elongator; homolog of human IKAP, mutations in which cause familial dysautonomia (FD)
0.115 2.64E-11 YNL119W NCS2 hom Protein required for thiolation of the uridine at the wobble position of Lys(UUU) and Glu(UUC) tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae
0.113 4.47E-11 YDL169C UGX2 hom Protein of unknown function, transcript accumulates in response to any combination of stress conditions
0.112 7.78E-11 YGR208W SER2 hom Phosphoserine phosphatase of the phosphoglycerate pathway, involved in serine and glycine biosynthesis, expression is regulated by the available nitrogen source
0.110 1.55E-10 YKR007W MEH1 hom Component of the EGO complex, which is involved in the regulation of microautophagy, and of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; loss results in a defect in vacuolar acidification
0.110 1.52E-10 YDR023W SES1 het Cytosolic seryl-tRNA synthetase, class II aminoacyl-tRNA synthetase that aminoacylates tRNA(Ser), displays tRNA-dependent amino acid recognition which enhances discrimination of the serine substrate, interacts with peroxin Pex21p