YGL216W / KIP3

Kinesin-related motor protein involved in mitotic spindle positioning

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL216W / KIP3

Click on Significant Values for Screen Details ID:SGTC_236|Compound:1509-0011|FD-Score:2.85|P-value:8.35E-4 ID:SGTC_383|Compound:2324-0395|FD-Score:3.20|P-value:2.11E-4 ID:SGTC_398|Compound:bronopol|FD-Score:5.04|P-value:1.60E-8 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:-4.96|P-value:3.98E-8 ID:SGTC_409|Compound:arachidonic acid|FD-Score:-4.82|P-value:9.19E-8 ID:SGTC_410|Compound:α-linolenic acid|FD-Score:-4.64|P-value:2.60E-7 ID:SGTC_414|Compound:piperonyl butoxide|FD-Score:3.94|P-value:7.26E-6 ID:SGTC_415|Compound:dibenzyl ketone|FD-Score:2.99|P-value:4.81E-4 ID:SGTC_426|Compound:0988-0037|FD-Score:3.72|P-value:2.10E-5 ID:SGTC_431|Compound:k089-0097|FD-Score:3.32|P-value:1.26E-4 ID:SGTC_635|Compound:k038-0028|FD-Score:3.04|P-value:4.00E-4 ID:SGTC_813|Compound:k007-0158|FD-Score:2.87|P-value:7.60E-4 ID:SGTC_865|Compound:0488-0499|FD-Score:2.87|P-value:7.82E-4 ID:SGTC_874|Compound:0599-0792|FD-Score:2.91|P-value:6.68E-4 ID:SGTC_975|Compound:1335-0046|FD-Score:4.13|P-value:2.78E-6 ID:SGTC_1056|Compound:3448-1962|FD-Score:3.35|P-value:1.14E-4 ID:SGTC_1059|Compound:3448-6867|FD-Score:3.72|P-value:2.17E-5 ID:SGTC_1580|Compound:hydrocortisone 21-hemisuccinate|FD-Score:-2.88|P-value:9.84E-4 ID:SGTC_1589|Compound:2',5'-dimethoxyflavone|FD-Score:3.80|P-value:1.45E-5 ID:SGTC_1744|Compound:st037937|FD-Score:4.62|P-value:1.89E-7 ID:SGTC_1748|Compound:st037455|FD-Score:2.85|P-value:8.16E-4 ID:SGTC_2126|Compound:5251174|FD-Score:2.83|P-value:8.92E-4 ID:SGTC_2172|Compound:5754775|FD-Score:-2.89|P-value:9.29E-4 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:-2.98|P-value:6.67E-4 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:4.79|P-value:7.36E-8 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:3.27|P-value:1.59E-4 ID:SGTC_2989|Compound:9073649|FD-Score:3.26|P-value:1.62E-4 ID:SGTC_2994|Compound:9053520|FD-Score:3.06|P-value:3.65E-4 ID:SGTC_3107|Compound:9121808|FD-Score:2.90|P-value:6.74E-4 ID:SGTC_3301|Compound:9125354|FD-Score:-3.94|P-value:1.03E-5 ID:SGTC_3303|Compound:9125618|FD-Score:-4.26|P-value:2.04E-6 ID:SGTC_236|Compound:1509-0011|FD-Score:2.85|P-value:8.35E-4 ID:SGTC_383|Compound:2324-0395|FD-Score:3.20|P-value:2.11E-4 ID:SGTC_398|Compound:bronopol|FD-Score:5.04|P-value:1.60E-8 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:-4.96|P-value:3.98E-8 ID:SGTC_409|Compound:arachidonic acid|FD-Score:-4.82|P-value:9.19E-8 ID:SGTC_410|Compound:α-linolenic acid|FD-Score:-4.64|P-value:2.60E-7 ID:SGTC_414|Compound:piperonyl butoxide|FD-Score:3.94|P-value:7.26E-6 ID:SGTC_415|Compound:dibenzyl ketone|FD-Score:2.99|P-value:4.81E-4 ID:SGTC_426|Compound:0988-0037|FD-Score:3.72|P-value:2.10E-5 ID:SGTC_431|Compound:k089-0097|FD-Score:3.32|P-value:1.26E-4 ID:SGTC_635|Compound:k038-0028|FD-Score:3.04|P-value:4.00E-4 ID:SGTC_813|Compound:k007-0158|FD-Score:2.87|P-value:7.60E-4 ID:SGTC_865|Compound:0488-0499|FD-Score:2.87|P-value:7.82E-4 ID:SGTC_874|Compound:0599-0792|FD-Score:2.91|P-value:6.68E-4 ID:SGTC_975|Compound:1335-0046|FD-Score:4.13|P-value:2.78E-6 ID:SGTC_1056|Compound:3448-1962|FD-Score:3.35|P-value:1.14E-4 ID:SGTC_1059|Compound:3448-6867|FD-Score:3.72|P-value:2.17E-5 ID:SGTC_1580|Compound:hydrocortisone 21-hemisuccinate|FD-Score:-2.88|P-value:9.84E-4 ID:SGTC_1589|Compound:2',5'-dimethoxyflavone|FD-Score:3.80|P-value:1.45E-5 ID:SGTC_1744|Compound:st037937|FD-Score:4.62|P-value:1.89E-7 ID:SGTC_1748|Compound:st037455|FD-Score:2.85|P-value:8.16E-4 ID:SGTC_2126|Compound:5251174|FD-Score:2.83|P-value:8.92E-4 ID:SGTC_2172|Compound:5754775|FD-Score:-2.89|P-value:9.29E-4 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:-2.98|P-value:6.67E-4 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:4.79|P-value:7.36E-8 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:3.27|P-value:1.59E-4 ID:SGTC_2989|Compound:9073649|FD-Score:3.26|P-value:1.62E-4 ID:SGTC_2994|Compound:9053520|FD-Score:3.06|P-value:3.65E-4 ID:SGTC_3107|Compound:9121808|FD-Score:2.90|P-value:6.74E-4 ID:SGTC_3301|Compound:9125354|FD-Score:-3.94|P-value:1.03E-5 ID:SGTC_3303|Compound:9125618|FD-Score:-4.26|P-value:2.04E-6

Top fitness defect scores for YGL216W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_398 bronopol 5.04 33.3 µM 1.60E-8 RNA processing & uracil transport 14 2.36E-7
2 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 4.79 100.0 µM 7.36E-8 16 8.50E-7
3 SGTC_1744 st037937 4.62 38.9 µM 1.89E-7 10 1.88E-6
4 SGTC_975 1335-0046 4.13 28.5 µM 2.78E-6 RPP1 & pyrimidine depletion 30 1.80E-5
5 SGTC_414 piperonyl butoxide 3.94 100.0 µM 7.26E-6 8 4.04E-5
6 SGTC_1589 2',5'-dimethoxyflavone 3.80 47.2 µM 1.45E-5 20 7.25E-5
7 SGTC_426 0988-0037 3.72 14.6 µM 2.10E-5 ERAD & cell cycle 39 9.87E-5
8 SGTC_1059 3448-6867 3.72 171.0 µM 2.17E-5 16 1.02E-4
9 SGTC_1056 3448-1962 3.35 115.0 µM 1.14E-4 amide catabolism 39 4.11E-4
10 SGTC_431 k089-0097 3.32 107.0 µM 1.26E-4 iron homeostasis 71 4.48E-4
11 SGTC_2633 5,7-dihydroxyisoflavone 3.27 100.0 µM 1.59E-4 59 5.43E-4
12 SGTC_2989 9073649 3.26 71.4 µM 1.62E-4 74 5.53E-4
13 SGTC_383 2324-0395 3.20 7.4 µM 2.11E-4 azole & statin 73 6.89E-4
14 SGTC_2994 9053520 3.06 71.4 µM 3.65E-4 RPP1 & pyrimidine depletion 49 0.00110
15 SGTC_635 k038-0028 3.04 24.7 µM 4.00E-4 ubiquinone biosynthesis & proteasome 94 0.00118
16 SGTC_415 dibenzyl ketone 2.99 100.0 µM 4.81E-4 42 0.00138
17 SGTC_874 0599-0792 2.91 117.0 µM 6.68E-4 89 0.00182
18 SGTC_3107 9121808 2.90 49.5 µM 6.74E-4 29 0.00184
19 SGTC_813 k007-0158 2.87 173.0 µM 7.60E-4 fatty acid desaturase (OLE1) 113 0.00203
20 SGTC_865 0488-0499 2.87 301.0 µM 7.82E-4 57 0.00208

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.127 1.85E-13 YPR010C RPA135 het RNA polymerase I second largest subunit A135
0.100 6.12E-9 YNL168C_p FMP41_p hom Putative protein of unknown function; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.091 1.35E-7 YHR045W_p YHR045W_p hom Putative protein of unknown function; possible role in iron metabolism and/or amino acid and carbohydrate metabolism; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum
0.084 1.05E-6 YPL036W PMA2 hom Plasma membrane H+-ATPase, isoform of Pma1p, involved in pumping protons out of the cell; regulator of cytoplasmic pH and plasma membrane potential
0.081 2.33E-6 YBR256C RIB5 het Riboflavin synthase; catalyzes the last step of the riboflavin biosynthesis pathway
0.081 2.58E-6 YMR023C MSS1 hom Mitochondrial protein, forms a heterodimer complex with Mto1p that performs the 5-carboxymethylaminomethyl modification of the wobble uridine base in mitochondrial tRNAs; similar to human GTPBP3
0.080 3.55E-6 YBR144C_d YBR144C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YBR144C is not an essential gene
0.078 6.19E-6 YKL213C DOA1 hom WD repeat protein required for ubiquitin-mediated protein degradation; forms a complex with Cdc48p; plays a role in controlling cellular ubiquitin concentration; also promotes efficient NHEJ in postdiauxic/stationary phase; protein increases in abundance and relocalizes from nucleus to nuclear periphery upon DNA replication stress
0.078 6.35E-6 YNL074C MLF3 hom Serine-rich protein of unknown function, predicted to be palmitoylated; overproduction suppresses the growth inhibition caused by exposure to the immunosuppressant leflunomide
0.076 9.81E-6 YDR357C_p CNL1_p hom Protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; null mutant is sensitive to drug inducing secretion of vacuolar cargo; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.075 1.39E-5 YOR193W PEX27 hom Peripheral peroxisomal membrane protein involved in controlling peroxisome size and number, interacts with homologous protein Pex25p
0.074 1.82E-5 YIL086C_d YIL086C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.073 2.38E-5 YNR063W_p YNR063W_p hom Putative zinc-cluster protein of unknown function
0.072 2.92E-5 YDR233C RTN1 hom Reticulon protein; stabilizes membrane curvature; involved in nuclear pore assembly and maintenance of tubular ER morphology; mutant overexpressing RTN1 shows increase in tubular ER; interacts with exocyst subunit Sec6p, Yip3p, and Sbh1p; more abundant than Rtn2p; member of the RTNLA subfamily; mutants have reduced phosphatidylserine transfer between the ER and mitochondria; RTN1 has a paralog, RTN2, that arose from the whole genome duplication
0.071 3.77E-5 YER180C ISC10 hom Protein required for sporulation, transcript is induced 7.5 hours after induction of meiosis, expected to play significant role in the formation of reproductive cells