Kinesin-related motor protein involved in mitotic spindle positioning
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YGL216W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Correlation | pval | ORF | Gene | Zygosity | Description |
---|---|---|---|---|---|
0.127 | 1.85E-13 | YPR010C | RPA135 | het | RNA polymerase I second largest subunit A135 |
0.100 | 6.12E-9 | YNL168C_p | FMP41_p | hom | Putative protein of unknown function; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies |
0.091 | 1.35E-7 | YHR045W_p | YHR045W_p | hom | Putative protein of unknown function; possible role in iron metabolism and/or amino acid and carbohydrate metabolism; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum |
0.084 | 1.05E-6 | YPL036W | PMA2 | hom | Plasma membrane H+-ATPase, isoform of Pma1p, involved in pumping protons out of the cell; regulator of cytoplasmic pH and plasma membrane potential |
0.081 | 2.33E-6 | YBR256C | RIB5 | het | Riboflavin synthase; catalyzes the last step of the riboflavin biosynthesis pathway |
0.081 | 2.58E-6 | YMR023C | MSS1 | hom | Mitochondrial protein, forms a heterodimer complex with Mto1p that performs the 5-carboxymethylaminomethyl modification of the wobble uridine base in mitochondrial tRNAs; similar to human GTPBP3 |
0.080 | 3.55E-6 | YBR144C_d | YBR144C_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YBR144C is not an essential gene |
0.078 | 6.19E-6 | YKL213C | DOA1 | hom | WD repeat protein required for ubiquitin-mediated protein degradation; forms a complex with Cdc48p; plays a role in controlling cellular ubiquitin concentration; also promotes efficient NHEJ in postdiauxic/stationary phase; protein increases in abundance and relocalizes from nucleus to nuclear periphery upon DNA replication stress |
0.078 | 6.35E-6 | YNL074C | MLF3 | hom | Serine-rich protein of unknown function, predicted to be palmitoylated; overproduction suppresses the growth inhibition caused by exposure to the immunosuppressant leflunomide |
0.076 | 9.81E-6 | YDR357C_p | CNL1_p | hom | Protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; null mutant is sensitive to drug inducing secretion of vacuolar cargo; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm |
0.075 | 1.39E-5 | YOR193W | PEX27 | hom | Peripheral peroxisomal membrane protein involved in controlling peroxisome size and number, interacts with homologous protein Pex25p |
0.074 | 1.82E-5 | YIL086C_d | YIL086C_d | hom | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
0.073 | 2.38E-5 | YNR063W_p | YNR063W_p | hom | Putative zinc-cluster protein of unknown function |
0.072 | 2.92E-5 | YDR233C | RTN1 | hom | Reticulon protein; stabilizes membrane curvature; involved in nuclear pore assembly and maintenance of tubular ER morphology; mutant overexpressing RTN1 shows increase in tubular ER; interacts with exocyst subunit Sec6p, Yip3p, and Sbh1p; more abundant than Rtn2p; member of the RTNLA subfamily; mutants have reduced phosphatidylserine transfer between the ER and mitochondria; RTN1 has a paralog, RTN2, that arose from the whole genome duplication |
0.071 | 3.77E-5 | YER180C | ISC10 | hom | Protein required for sporulation, transcript is induced 7.5 hours after induction of meiosis, expected to play significant role in the formation of reproductive cells |