YGL219C / MDM34

Mitochondrial component of the ERMES complex that links the ER to mitochondria and may promote inter-organellar calcium and phospholipid exchange as well as coordinating mitochondrial DNA replication and growth

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL219C / MDM34

Click on Significant Values for Screen Details ID:SGTC_9|Compound:0092-0002|FD-Score:3.80|P-value:3.22E-4 ID:SGTC_68|Compound:0986-0284|FD-Score:4.91|P-value:4.71E-6 ID:SGTC_100|Compound:0086-0128|FD-Score:6.43|P-value:3.03E-9 ID:SGTC_236|Compound:1509-0011|FD-Score:5.20|P-value:1.38E-6 ID:SGTC_311|Compound:1315-0136|FD-Score:3.54|P-value:7.44E-4 ID:SGTC_368|Compound:fentichlor|FD-Score:5.39|P-value:5.65E-7 ID:SGTC_410|Compound:α-linolenic acid|FD-Score:-3.42|P-value:7.08E-4 ID:SGTC_438|Compound:sphingosine|FD-Score:-3.88|P-value:1.49E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-4.55|P-value:1.19E-5 ID:SGTC_475|Compound:α-linolenic acid|FD-Score:-4.70|P-value:6.52E-6 ID:SGTC_567|Compound:1080-0542|FD-Score:-3.40|P-value:7.50E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:7.55|P-value:3.96E-12 ID:SGTC_781|Compound:4335-2806|FD-Score:4.60|P-value:1.72E-5 ID:SGTC_832|Compound:4083-0019|FD-Score:4.67|P-value:1.30E-5 ID:SGTC_941|Compound:3237-0776|FD-Score:-3.75|P-value:2.34E-4 ID:SGTC_1026|Compound:k007-1105|FD-Score:3.77|P-value:3.63E-4 ID:SGTC_1030|Compound:k029-0042|FD-Score:-5.37|P-value:3.17E-7 ID:SGTC_1195|Compound:1502-0147|FD-Score:3.62|P-value:5.81E-4 ID:SGTC_1199|Compound:1638-0010|FD-Score:4.03|P-value:1.48E-4 ID:SGTC_1208|Compound:2323-2347|FD-Score:4.63|P-value:1.52E-5 ID:SGTC_1247|Compound:0448-0043|FD-Score:4.75|P-value:9.23E-6 ID:SGTC_1321|Compound:1326-2144|FD-Score:5.24|P-value:1.12E-6 ID:SGTC_1326|Compound:1431-2094|FD-Score:-3.42|P-value:7.09E-4 ID:SGTC_1332|Compound:1480-0653|FD-Score:-3.70|P-value:2.79E-4 ID:SGTC_1338|Compound:1486-1223|FD-Score:-3.41|P-value:7.25E-4 ID:SGTC_1411|Compound:3909-8223|FD-Score:3.51|P-value:8.32E-4 ID:SGTC_1423|Compound:4048-0112|FD-Score:5.37|P-value:6.16E-7 ID:SGTC_1515|Compound:3460-0031|FD-Score:4.28|P-value:5.88E-5 ID:SGTC_1518|Compound:st038567|FD-Score:6.29|P-value:6.45E-9 ID:SGTC_1534|Compound:6-azauridine|FD-Score:-3.77|P-value:2.21E-4 ID:SGTC_1573|Compound:oleylamine|FD-Score:4.99|P-value:3.49E-6 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:4.32|P-value:5.05E-5 ID:SGTC_1750|Compound:st081859|FD-Score:6.14|P-value:1.44E-8 ID:SGTC_1787|Compound:fluconazole|FD-Score:-6.66|P-value:3.76E-10 ID:SGTC_1847|Compound:st056231|FD-Score:4.51|P-value:2.45E-5 ID:SGTC_1853|Compound:st056710|FD-Score:4.54|P-value:2.21E-5 ID:SGTC_1876|Compound:myriocin|FD-Score:-4.17|P-value:5.31E-5 ID:SGTC_1878|Compound:temozolomide|FD-Score:-3.97|P-value:1.08E-4 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:4.70|P-value:1.15E-5 ID:SGTC_2330|Compound:7979373|FD-Score:3.88|P-value:2.47E-4 ID:SGTC_2365|Compound:9042475|FD-Score:4.11|P-value:1.12E-4 ID:SGTC_2396|Compound:5342950|FD-Score:-10.80|P-value:1.49E-23 ID:SGTC_2399|Compound:5884133|FD-Score:4.11|P-value:1.10E-4 ID:SGTC_2409|Compound:alverine citrate|FD-Score:3.54|P-value:7.52E-4 ID:SGTC_2486|Compound:5283202|FD-Score:3.50|P-value:8.57E-4 ID:SGTC_2498|Compound:4'-Methoxychalcone|FD-Score:-4.26|P-value:3.66E-5 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:5.32|P-value:7.87E-7 ID:SGTC_2546|Compound:rhodinyl acetate|FD-Score:4.63|P-value:1.55E-5 ID:SGTC_2553|Compound:4-methylesculetin|FD-Score:4.09|P-value:1.18E-4 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:3.49|P-value:8.78E-4 ID:SGTC_2628|Compound:lathosterol|FD-Score:-3.56|P-value:4.43E-4 ID:SGTC_2635|Compound:hydroquinidine|FD-Score:4.80|P-value:7.62E-6 ID:SGTC_2679|Compound:rapamycin|FD-Score:-3.82|P-value:1.84E-4 ID:SGTC_2838|Compound:9002687|FD-Score:3.51|P-value:8.40E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-3.65|P-value:3.39E-4 ID:SGTC_3160|Compound:9100216|FD-Score:3.96|P-value:1.87E-4 ID:SGTC_3215|Compound:9129942|FD-Score:4.15|P-value:9.63E-5 ID:SGTC_3216|Compound:9129716|FD-Score:-3.61|P-value:3.76E-4 ID:SGTC_9|Compound:0092-0002|FD-Score:3.80|P-value:3.22E-4 ID:SGTC_68|Compound:0986-0284|FD-Score:4.91|P-value:4.71E-6 ID:SGTC_100|Compound:0086-0128|FD-Score:6.43|P-value:3.03E-9 ID:SGTC_236|Compound:1509-0011|FD-Score:5.20|P-value:1.38E-6 ID:SGTC_311|Compound:1315-0136|FD-Score:3.54|P-value:7.44E-4 ID:SGTC_368|Compound:fentichlor|FD-Score:5.39|P-value:5.65E-7 ID:SGTC_410|Compound:α-linolenic acid|FD-Score:-3.42|P-value:7.08E-4 ID:SGTC_438|Compound:sphingosine|FD-Score:-3.88|P-value:1.49E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-4.55|P-value:1.19E-5 ID:SGTC_475|Compound:α-linolenic acid|FD-Score:-4.70|P-value:6.52E-6 ID:SGTC_567|Compound:1080-0542|FD-Score:-3.40|P-value:7.50E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:7.55|P-value:3.96E-12 ID:SGTC_781|Compound:4335-2806|FD-Score:4.60|P-value:1.72E-5 ID:SGTC_832|Compound:4083-0019|FD-Score:4.67|P-value:1.30E-5 ID:SGTC_941|Compound:3237-0776|FD-Score:-3.75|P-value:2.34E-4 ID:SGTC_1026|Compound:k007-1105|FD-Score:3.77|P-value:3.63E-4 ID:SGTC_1030|Compound:k029-0042|FD-Score:-5.37|P-value:3.17E-7 ID:SGTC_1195|Compound:1502-0147|FD-Score:3.62|P-value:5.81E-4 ID:SGTC_1199|Compound:1638-0010|FD-Score:4.03|P-value:1.48E-4 ID:SGTC_1208|Compound:2323-2347|FD-Score:4.63|P-value:1.52E-5 ID:SGTC_1247|Compound:0448-0043|FD-Score:4.75|P-value:9.23E-6 ID:SGTC_1321|Compound:1326-2144|FD-Score:5.24|P-value:1.12E-6 ID:SGTC_1326|Compound:1431-2094|FD-Score:-3.42|P-value:7.09E-4 ID:SGTC_1332|Compound:1480-0653|FD-Score:-3.70|P-value:2.79E-4 ID:SGTC_1338|Compound:1486-1223|FD-Score:-3.41|P-value:7.25E-4 ID:SGTC_1411|Compound:3909-8223|FD-Score:3.51|P-value:8.32E-4 ID:SGTC_1423|Compound:4048-0112|FD-Score:5.37|P-value:6.16E-7 ID:SGTC_1515|Compound:3460-0031|FD-Score:4.28|P-value:5.88E-5 ID:SGTC_1518|Compound:st038567|FD-Score:6.29|P-value:6.45E-9 ID:SGTC_1534|Compound:6-azauridine|FD-Score:-3.77|P-value:2.21E-4 ID:SGTC_1573|Compound:oleylamine|FD-Score:4.99|P-value:3.49E-6 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:4.32|P-value:5.05E-5 ID:SGTC_1750|Compound:st081859|FD-Score:6.14|P-value:1.44E-8 ID:SGTC_1787|Compound:fluconazole|FD-Score:-6.66|P-value:3.76E-10 ID:SGTC_1847|Compound:st056231|FD-Score:4.51|P-value:2.45E-5 ID:SGTC_1853|Compound:st056710|FD-Score:4.54|P-value:2.21E-5 ID:SGTC_1876|Compound:myriocin|FD-Score:-4.17|P-value:5.31E-5 ID:SGTC_1878|Compound:temozolomide|FD-Score:-3.97|P-value:1.08E-4 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:4.70|P-value:1.15E-5 ID:SGTC_2330|Compound:7979373|FD-Score:3.88|P-value:2.47E-4 ID:SGTC_2365|Compound:9042475|FD-Score:4.11|P-value:1.12E-4 ID:SGTC_2396|Compound:5342950|FD-Score:-10.80|P-value:1.49E-23 ID:SGTC_2399|Compound:5884133|FD-Score:4.11|P-value:1.10E-4 ID:SGTC_2409|Compound:alverine citrate|FD-Score:3.54|P-value:7.52E-4 ID:SGTC_2486|Compound:5283202|FD-Score:3.50|P-value:8.57E-4 ID:SGTC_2498|Compound:4'-Methoxychalcone|FD-Score:-4.26|P-value:3.66E-5 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:5.32|P-value:7.87E-7 ID:SGTC_2546|Compound:rhodinyl acetate|FD-Score:4.63|P-value:1.55E-5 ID:SGTC_2553|Compound:4-methylesculetin|FD-Score:4.09|P-value:1.18E-4 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:3.49|P-value:8.78E-4 ID:SGTC_2628|Compound:lathosterol|FD-Score:-3.56|P-value:4.43E-4 ID:SGTC_2635|Compound:hydroquinidine|FD-Score:4.80|P-value:7.62E-6 ID:SGTC_2679|Compound:rapamycin|FD-Score:-3.82|P-value:1.84E-4 ID:SGTC_2838|Compound:9002687|FD-Score:3.51|P-value:8.40E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-3.65|P-value:3.39E-4 ID:SGTC_3160|Compound:9100216|FD-Score:3.96|P-value:1.87E-4 ID:SGTC_3215|Compound:9129942|FD-Score:4.15|P-value:9.63E-5 ID:SGTC_3216|Compound:9129716|FD-Score:-3.61|P-value:3.76E-4

Top fitness defect scores for YGL219C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_778 3456-2434 7.55 196.0 µM 3.96E-12 mitochondrial response to ROS 11 2.18E-14
2 SGTC_100 0086-0128 6.43 49.6 µM 3.03E-9 copper-dependent oxidative stress 14 6.41E-11
3 SGTC_1518 st038567 6.29 90.8 µM 6.45E-9 2 1.59E-10
4 SGTC_1750 st081859 6.14 2.4 µM 1.44E-8 endomembrane recycling 105 4.18E-10
5 SGTC_368 fentichlor 5.39 4.6 µM 5.65E-7 6 3.46E-8
6 SGTC_1423 4048-0112 5.37 5.6 µM 6.16E-7 10 3.84E-8
7 SGTC_2540 epiandrosterone 5.32 100.0 µM 7.87E-7 27 5.16E-8
8 SGTC_1321 1326-2144 5.24 215.0 µM 1.12E-6 2 7.87E-8
9 SGTC_236 1509-0011 5.20 5.3 µM 1.38E-6 318 1.01E-7
10 SGTC_1573 oleylamine 4.99 1.1 µM 3.49E-6 13 3.10E-7
11 SGTC_68 0986-0284 4.91 82.8 µM 4.71E-6 36 4.45E-7
12 SGTC_2635 hydroquinidine 4.80 100.0 µM 7.62E-6 9 7.93E-7
13 SGTC_1247 0448-0043 4.75 5.8 µM 9.23E-6 ERG2 23 9.99E-7
14 SGTC_2232 chlorophetanol 4.70 41.5 µM 1.15E-5 TRP & mitochondrial translation 92 1.30E-6
15 SGTC_832 4083-0019 4.67 164.0 µM 1.30E-5 translation 52 1.50E-6
16 SGTC_1208 2323-2347 4.63 50.3 µM 1.52E-5 2 1.82E-6
17 SGTC_2546 rhodinyl acetate 4.63 100.0 µM 1.55E-5 6 1.87E-6
18 SGTC_781 4335-2806 4.60 94.4 µM 1.72E-5 10 2.11E-6
19 SGTC_1853 st056710 4.54 91.2 µM 2.21E-5 amide catabolism 15 2.86E-6
20 SGTC_1847 st056231 4.51 15.0 µM 2.45E-5 24 3.24E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.174 3.67E-24 YHR008C SOD2 hom Mitochondrial manganese superoxide dismutase, protects cells against oxygen toxicity; phosphorylated
0.169 7.74E-23 YGL218W_d YGL218W_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 93% of ORF overlaps the verified gene MDM34; deletion in cyr1 mutant results in loss of stress resistance
0.156 7.97E-20 YNL252C MRPL17 hom Mitochondrial ribosomal protein of the large subunit
0.154 2.46E-19 YNR037C RSM19 hom Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S19 ribosomal protein
0.153 5.95E-19 YMR193W MRPL24 hom Mitochondrial ribosomal protein of the large subunit; two mitochondrial ribosomal proteins, YmL14 and YmL24, have been assigned to the same gene
0.143 7.92E-17 YLL006W MMM1 hom ER integral membrane protein, component of the ERMES complex that links the ER to mitochondria and may promote inter-organellar calcium and phospholipid exchange as well as coordinating mitochondrial DNA replication and growth
0.142 1.33E-16 YDR268W MSW1 hom Mitochondrial tryptophanyl-tRNA synthetase
0.141 2.04E-16 YDR375C BCS1 hom Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases
0.141 2.16E-16 YGR101W PCP1 hom Mitochondrial serine protease required for the processing of various mitochondrial proteins and maintenance of mitochondrial DNA and morphology; belongs to the rhomboid-GlpG superfamily of intramembrane peptidases
0.141 2.82E-16 YLR439W MRPL4 hom Mitochondrial ribosomal protein of the large subunit, homolog of prokaryotic L29 ribosomal protein; located at the ribosomal tunnel exit
0.139 8.34E-16 YGR150C CCM1 hom Mitochondrial 15s rRNA-binding protein; required for intron removal of COB and COX1 pre-mRNAs; contains pentatricopeptide repeat (PPR) motifs; mutant is respiratory deficient and has defective plasma membrane electron transport
0.134 6.25E-15 YGR219W_d YGR219W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF MRPL9/YGR220C
0.132 2.06E-14 YIL014C-A_p YIL014C-A_p hom Putative protein of unknown function
0.131 2.82E-14 YJL209W CBP1 hom Mitochondrial protein, regulator of COB mRNA stability and translation; interacts with the 5'-untranslated region of the COB mRNA; found in a complex at the inner membrane along with Pet309p; localizes to mitochondrial foci upon DNA replication stress
0.131 3.35E-14 YGR222W PET54 hom Mitochondrial inner membrane protein; binds to the 5' UTR of the COX3 mRNA to activate its translation together with Pet122p and Pet494p; also binds to the COX1 Group I intron AI5 beta to facilitate exon ligation during splicing