YGL220W / FRA2

Protein involved in negative regulation of transcription of iron regulon; forms an iron independent complex with Fra2p, Grx3p, and Grx4p; null mutant fails to repress iron regulon and is sensitive to nickel

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL220W / FRA2

Click on Significant Values for Screen Details ID:SGTC_42|Compound:0133-0086|FD-Score:3.29|P-value:6.75E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:3.29|P-value:6.68E-4 ID:SGTC_129|Compound:0088-0017|FD-Score:6.51|P-value:1.38E-10 ID:SGTC_156|Compound:3474-0145|FD-Score:7.58|P-value:1.04E-13 ID:SGTC_158|Compound:k038-0087|FD-Score:4.42|P-value:8.60E-6 ID:SGTC_222|Compound:nsc-310342|FD-Score:3.57|P-value:2.60E-4 ID:SGTC_223|Compound:busulfan|FD-Score:6.42|P-value:2.42E-10 ID:SGTC_224|Compound:benfluorex|FD-Score:3.81|P-value:1.06E-4 ID:SGTC_225|Compound:nsc-122657|FD-Score:5.92|P-value:4.67E-9 ID:SGTC_295|Compound:k015-0027|FD-Score:3.24|P-value:8.11E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:3.77|P-value:1.22E-4 ID:SGTC_314|Compound:1671-0008|FD-Score:4.78|P-value:1.69E-6 ID:SGTC_365|Compound:0121-0052|FD-Score:-3.80|P-value:1.35E-4 ID:SGTC_366|Compound:0181-0206|FD-Score:-3.49|P-value:4.24E-4 ID:SGTC_367|Compound:0335-0881|FD-Score:5.08|P-value:4.00E-7 ID:SGTC_373|Compound:0844-0104|FD-Score:4.99|P-value:6.34E-7 ID:SGTC_374|Compound:0880-0231|FD-Score:-3.85|P-value:1.14E-4 ID:SGTC_451|Compound:chloral hydrate|FD-Score:3.59|P-value:2.40E-4 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:4.54|P-value:5.11E-6 ID:SGTC_464|Compound:bw-b 70c|FD-Score:-3.87|P-value:1.05E-4 ID:SGTC_520|Compound:3584-0023|FD-Score:-5.67|P-value:2.63E-8 ID:SGTC_521|Compound:r062-0005|FD-Score:-4.27|P-value:2.16E-5 ID:SGTC_522|Compound:1273-0010|FD-Score:-3.90|P-value:9.15E-5 ID:SGTC_773|Compound:4358-1457|FD-Score:9.64|P-value:5.10E-21 ID:SGTC_804|Compound:1595-0054|FD-Score:3.55|P-value:2.73E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:3.37|P-value:5.20E-4 ID:SGTC_1174|Compound:0739-0097|FD-Score:3.69|P-value:1.65E-4 ID:SGTC_1188|Compound:1403-0014|FD-Score:5.16|P-value:2.75E-7 ID:SGTC_1190|Compound:1486-1332|FD-Score:4.52|P-value:5.64E-6 ID:SGTC_1197|Compound:1601-0112|FD-Score:-3.96|P-value:7.51E-5 ID:SGTC_1198|Compound:1612-1005|FD-Score:-3.40|P-value:5.72E-4 ID:SGTC_1251|Compound:0490-5699|FD-Score:3.32|P-value:6.04E-4 ID:SGTC_1288|Compound:0973-0013|FD-Score:3.69|P-value:1.62E-4 ID:SGTC_1310|Compound:1188-0297|FD-Score:3.36|P-value:5.28E-4 ID:SGTC_1375|Compound:2910-0797|FD-Score:3.82|P-value:1.02E-4 ID:SGTC_1380|Compound:2291-0730|FD-Score:3.67|P-value:1.75E-4 ID:SGTC_1424|Compound:4048-1941|FD-Score:3.20|P-value:9.20E-4 ID:SGTC_1478|Compound:0453-0656|FD-Score:6.07|P-value:1.97E-9 ID:SGTC_1653|Compound:st012112|FD-Score:3.87|P-value:8.29E-5 ID:SGTC_1663|Compound:st014140|FD-Score:4.06|P-value:3.88E-5 ID:SGTC_1755|Compound:st041960|FD-Score:4.66|P-value:2.93E-6 ID:SGTC_1759|Compound:st043059|FD-Score:3.47|P-value:3.62E-4 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:4.10|P-value:3.42E-5 ID:SGTC_1940|Compound:st075990|FD-Score:3.95|P-value:6.22E-5 ID:SGTC_2050|Compound:5263056|FD-Score:-3.56|P-value:3.31E-4 ID:SGTC_2053|Compound:5265679|FD-Score:3.34|P-value:5.78E-4 ID:SGTC_2056|Compound:5235370|FD-Score:5.56|P-value:3.45E-8 ID:SGTC_2364|Compound:9055074|FD-Score:-3.38|P-value:6.02E-4 ID:SGTC_2496|Compound:diffractaic acid|FD-Score:3.55|P-value:2.72E-4 ID:SGTC_2497|Compound:7-hydroxyflavone|FD-Score:-3.79|P-value:1.44E-4 ID:SGTC_2543|Compound:pimpinellin|FD-Score:3.67|P-value:1.77E-4 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:-4.15|P-value:3.49E-5 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:3.55|P-value:2.79E-4 ID:SGTC_2665|Compound:lovastatin|FD-Score:4.95|P-value:7.51E-7 ID:SGTC_2718|Compound:lomofungin|FD-Score:3.38|P-value:4.99E-4 ID:SGTC_2724|Compound:maprotiline|FD-Score:3.27|P-value:7.23E-4 ID:SGTC_2803|Compound:7707263|FD-Score:6.03|P-value:2.45E-9 ID:SGTC_2967|Compound:9089538|FD-Score:5.00|P-value:5.95E-7 ID:SGTC_3122|Compound:9126309|FD-Score:3.34|P-value:5.62E-4 ID:SGTC_3175|Compound:9106517|FD-Score:-3.90|P-value:9.38E-5 ID:SGTC_3193|Compound:9111931|FD-Score:3.58|P-value:2.45E-4 ID:SGTC_3198|Compound:9112019|FD-Score:4.32|P-value:1.34E-5 ID:SGTC_3217|Compound:9129673|FD-Score:4.05|P-value:4.18E-5 ID:SGTC_3251|Compound:9135047|FD-Score:-3.25|P-value:9.47E-4 ID:SGTC_3331|Compound:9141060|FD-Score:3.65|P-value:1.92E-4 ID:SGTC_3332|Compound:9141069|FD-Score:3.80|P-value:1.09E-4 ID:SGTC_42|Compound:0133-0086|FD-Score:3.29|P-value:6.75E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:3.29|P-value:6.68E-4 ID:SGTC_129|Compound:0088-0017|FD-Score:6.51|P-value:1.38E-10 ID:SGTC_156|Compound:3474-0145|FD-Score:7.58|P-value:1.04E-13 ID:SGTC_158|Compound:k038-0087|FD-Score:4.42|P-value:8.60E-6 ID:SGTC_222|Compound:nsc-310342|FD-Score:3.57|P-value:2.60E-4 ID:SGTC_223|Compound:busulfan|FD-Score:6.42|P-value:2.42E-10 ID:SGTC_224|Compound:benfluorex|FD-Score:3.81|P-value:1.06E-4 ID:SGTC_225|Compound:nsc-122657|FD-Score:5.92|P-value:4.67E-9 ID:SGTC_295|Compound:k015-0027|FD-Score:3.24|P-value:8.11E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:3.77|P-value:1.22E-4 ID:SGTC_314|Compound:1671-0008|FD-Score:4.78|P-value:1.69E-6 ID:SGTC_365|Compound:0121-0052|FD-Score:-3.80|P-value:1.35E-4 ID:SGTC_366|Compound:0181-0206|FD-Score:-3.49|P-value:4.24E-4 ID:SGTC_367|Compound:0335-0881|FD-Score:5.08|P-value:4.00E-7 ID:SGTC_373|Compound:0844-0104|FD-Score:4.99|P-value:6.34E-7 ID:SGTC_374|Compound:0880-0231|FD-Score:-3.85|P-value:1.14E-4 ID:SGTC_451|Compound:chloral hydrate|FD-Score:3.59|P-value:2.40E-4 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:4.54|P-value:5.11E-6 ID:SGTC_464|Compound:bw-b 70c|FD-Score:-3.87|P-value:1.05E-4 ID:SGTC_520|Compound:3584-0023|FD-Score:-5.67|P-value:2.63E-8 ID:SGTC_521|Compound:r062-0005|FD-Score:-4.27|P-value:2.16E-5 ID:SGTC_522|Compound:1273-0010|FD-Score:-3.90|P-value:9.15E-5 ID:SGTC_773|Compound:4358-1457|FD-Score:9.64|P-value:5.10E-21 ID:SGTC_804|Compound:1595-0054|FD-Score:3.55|P-value:2.73E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:3.37|P-value:5.20E-4 ID:SGTC_1174|Compound:0739-0097|FD-Score:3.69|P-value:1.65E-4 ID:SGTC_1188|Compound:1403-0014|FD-Score:5.16|P-value:2.75E-7 ID:SGTC_1190|Compound:1486-1332|FD-Score:4.52|P-value:5.64E-6 ID:SGTC_1197|Compound:1601-0112|FD-Score:-3.96|P-value:7.51E-5 ID:SGTC_1198|Compound:1612-1005|FD-Score:-3.40|P-value:5.72E-4 ID:SGTC_1251|Compound:0490-5699|FD-Score:3.32|P-value:6.04E-4 ID:SGTC_1288|Compound:0973-0013|FD-Score:3.69|P-value:1.62E-4 ID:SGTC_1310|Compound:1188-0297|FD-Score:3.36|P-value:5.28E-4 ID:SGTC_1375|Compound:2910-0797|FD-Score:3.82|P-value:1.02E-4 ID:SGTC_1380|Compound:2291-0730|FD-Score:3.67|P-value:1.75E-4 ID:SGTC_1424|Compound:4048-1941|FD-Score:3.20|P-value:9.20E-4 ID:SGTC_1478|Compound:0453-0656|FD-Score:6.07|P-value:1.97E-9 ID:SGTC_1653|Compound:st012112|FD-Score:3.87|P-value:8.29E-5 ID:SGTC_1663|Compound:st014140|FD-Score:4.06|P-value:3.88E-5 ID:SGTC_1755|Compound:st041960|FD-Score:4.66|P-value:2.93E-6 ID:SGTC_1759|Compound:st043059|FD-Score:3.47|P-value:3.62E-4 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:4.10|P-value:3.42E-5 ID:SGTC_1940|Compound:st075990|FD-Score:3.95|P-value:6.22E-5 ID:SGTC_2050|Compound:5263056|FD-Score:-3.56|P-value:3.31E-4 ID:SGTC_2053|Compound:5265679|FD-Score:3.34|P-value:5.78E-4 ID:SGTC_2056|Compound:5235370|FD-Score:5.56|P-value:3.45E-8 ID:SGTC_2364|Compound:9055074|FD-Score:-3.38|P-value:6.02E-4 ID:SGTC_2496|Compound:diffractaic acid|FD-Score:3.55|P-value:2.72E-4 ID:SGTC_2497|Compound:7-hydroxyflavone|FD-Score:-3.79|P-value:1.44E-4 ID:SGTC_2543|Compound:pimpinellin|FD-Score:3.67|P-value:1.77E-4 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:-4.15|P-value:3.49E-5 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:3.55|P-value:2.79E-4 ID:SGTC_2665|Compound:lovastatin|FD-Score:4.95|P-value:7.51E-7 ID:SGTC_2718|Compound:lomofungin|FD-Score:3.38|P-value:4.99E-4 ID:SGTC_2724|Compound:maprotiline|FD-Score:3.27|P-value:7.23E-4 ID:SGTC_2803|Compound:7707263|FD-Score:6.03|P-value:2.45E-9 ID:SGTC_2967|Compound:9089538|FD-Score:5.00|P-value:5.95E-7 ID:SGTC_3122|Compound:9126309|FD-Score:3.34|P-value:5.62E-4 ID:SGTC_3175|Compound:9106517|FD-Score:-3.90|P-value:9.38E-5 ID:SGTC_3193|Compound:9111931|FD-Score:3.58|P-value:2.45E-4 ID:SGTC_3198|Compound:9112019|FD-Score:4.32|P-value:1.34E-5 ID:SGTC_3217|Compound:9129673|FD-Score:4.05|P-value:4.18E-5 ID:SGTC_3251|Compound:9135047|FD-Score:-3.25|P-value:9.47E-4 ID:SGTC_3331|Compound:9141060|FD-Score:3.65|P-value:1.92E-4 ID:SGTC_3332|Compound:9141069|FD-Score:3.80|P-value:1.09E-4

Top fitness defect scores for YGL220W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_773 4358-1457 9.64 44.6 µM 5.10E-21 2 2.73E-22
2 SGTC_156 3474-0145 7.58 5.6 µM 1.04E-13 endomembrane recycling 11 1.76E-14
3 SGTC_129 0088-0017 6.51 176.6 µM 1.38E-10 27 3.78E-11
4 SGTC_223 busulfan 6.42 5.0 mM 2.42E-10 2 6.92E-11
5 SGTC_1478 0453-0656 6.07 35.7 µM 1.97E-9 5 6.46E-10
6 SGTC_2803 7707263 6.03 71.4 µM 2.45E-9 6 8.17E-10
7 SGTC_225 nsc-122657 5.92 1.0 µM 4.67E-9 3 1.62E-9
8 SGTC_2056 5235370 5.56 200.0 µM 3.45E-8 16 1.37E-8
9 SGTC_1188 1403-0014 5.16 4.6 µM 2.75E-7 mitochondrial stress 25 1.25E-7
10 SGTC_367 0335-0881 5.08 7.1 µM 4.00E-7 ubiquinone biosynthesis & proteasome 40 1.86E-7
11 SGTC_2967 9089538 5.00 49.9 µM 5.95E-7 11 2.84E-7
12 SGTC_373 0844-0104 4.99 25.9 µM 6.34E-7 ERAD & cell cycle 29 3.03E-7
13 SGTC_2665 lovastatin 4.95 100.0 µM 7.51E-7 4 3.63E-7
14 SGTC_314 1671-0008 4.78 2.7 µM 1.69E-6 26 8.64E-7
15 SGTC_1755 st041960 4.66 45.2 µM 2.93E-6 13 1.54E-6
16 SGTC_454 lyso-paf C-16 4.54 6.7 µM 5.11E-6 10 2.79E-6
17 SGTC_1190 1486-1332 4.52 13.0 µM 5.64E-6 7 3.11E-6
18 SGTC_158 k038-0087 4.42 26.4 µM 8.60E-6 ubiquinone biosynthesis & proteasome 110 4.86E-6
19 SGTC_3198 9112019 4.32 49.5 µM 1.34E-5 mitochondrial processes 9 7.81E-6
20 SGTC_1785 bathophenanthroline 4.10 24.0 µM 3.42E-5 heme requiring 42 2.11E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.289 9.18E-65 YLR271W_p YLR271W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus and is induced in response to the DNA-damaging agent MMS
0.199 5.16E-31 YLR212C TUB4 het Gamma-tubulin; involved in nucleating microtubules from both the cytoplasmic and nuclear faces of the spindle pole body; protein abundance increases in response to DNA replication stress
0.153 5.84E-19 YHR163W SOL3 hom 6-phosphogluconolactonase; catalyzes the second step of the pentose phosphate pathway; weak multicopy suppressor of los1-1 mutation; homologous to Sol2p and Sol1p; SOL3 has a paralog, SOL4, that arose from the whole genome duplication
0.149 5.12E-18 YFL024C EPL1 het Subunit of NuA4, an essential histone H4/H2A acetyltransferase complex; conserved region at N-terminus is essential for interaction with the NPC (nucleosome core particle); required for autophagy; homologous to Drosophila Enhancer of Polycomb
0.145 4.12E-17 YAL043C PTA1 het Subunit of holo-CPF, a multiprotein complex and functional homolog of mammalian CPSF, required for the cleavage and polyadenylation of mRNA and snoRNA 3' ends; involved in pre-tRNA processing; binds to the phosphorylated CTD of RNAPII
0.135 5.62E-15 YJR001W AVT1 hom Vacuolar transporter, imports large neutral amino acids into the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
0.132 1.96E-14 YDR371W_p CTS2_p hom Putative chitinase, functionally complements A. gossypii cts2 mutant sporulation defect
0.126 2.58E-13 YKR054C DYN1 hom Cytoplasmic heavy chain dynein, microtubule motor protein, required for anaphase spindle elongation; involved in spindle assembly, chromosome movement, and spindle orientation during cell division, targeted to microtubule tips by Pac1p
0.121 2.88E-12 YLR053C_p YLR053C_p hom Putative protein of unknown function
0.118 7.66E-12 YCL026C-A FRM2 hom Type II nitroreductase, using NADH as reductant; mutants are defective in fatty acid mediated repression of genes involved in fatty acid biosynthesis indicative of a role in lipid signaling; involved in the oxidative stress response; transcription induction by cadmium and selenite indicates a possible role in the metal stress response; expression induced in cells treated with the mycotoxin patulin
0.111 1.34E-10 YOR238W_p YOR238W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.093 7.74E-8 YDR055W PST1 hom Cell wall protein that contains a putative GPI-attachment site; secreted by regenerating protoplasts; up-regulated by activation of the cell integrity pathway, as mediated by Rlm1p; upregulated by cell wall damage via disruption of FKS1
0.088 3.22E-7 YPL251W_d YPL251W_d het Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps 5' end of the verified, essential gene YAH1/YPL252C
0.086 6.07E-7 YLR378C SEC61 het Essential subunit of Sec61 complex (Sec61p, Sbh1p, and Sss1p); forms a channel for SRP-dependent protein import and retrograde transport of misfolded proteins out of the ER; with Sec63 complex allows SRP-independent protein import into ER
0.086 7.83E-7 YMR302C YME2 hom Integral inner mitochondrial membrane protein with a role in maintaining mitochondrial nucleoid structure and number; mutants exhibit an increased rate of mitochondrial DNA escape; shows some sequence similarity to exonucleases