YGL223C / COG1

Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL223C / COG1

Click on Significant Values for Screen Details ID:SGTC_4|Compound:0960-0234|FD-Score:4.90|P-value:2.13E-5 ID:SGTC_12|Compound:0849-0099|FD-Score:-3.97|P-value:2.87E-4 ID:SGTC_22|Compound:0964-0034|FD-Score:5.18|P-value:7.35E-6 ID:SGTC_31|Compound:0508-1974|FD-Score:4.11|P-value:3.12E-4 ID:SGTC_143|Compound:4032-1194|FD-Score:4.11|P-value:3.08E-4 ID:SGTC_223|Compound:busulfan|FD-Score:4.10|P-value:3.15E-4 ID:SGTC_227|Compound:fluconazole|FD-Score:3.83|P-value:7.19E-4 ID:SGTC_391|Compound:gliotoxin|FD-Score:3.95|P-value:5.00E-4 ID:SGTC_426|Compound:0988-0037|FD-Score:5.04|P-value:1.26E-5 ID:SGTC_431|Compound:k089-0097|FD-Score:-5.35|P-value:1.96E-6 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-4.88|P-value:1.21E-5 ID:SGTC_500|Compound:h-89|FD-Score:3.93|P-value:5.29E-4 ID:SGTC_557|Compound:1315-0110|FD-Score:4.21|P-value:2.24E-4 ID:SGTC_582|Compound:0987-0078|FD-Score:3.97|P-value:4.73E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:4.80|P-value:2.99E-5 ID:SGTC_662|Compound:k832-1615|FD-Score:5.14|P-value:8.68E-6 ID:SGTC_682|Compound:0kpi-0099|FD-Score:-4.10|P-value:1.87E-4 ID:SGTC_736|Compound:0958-0254|FD-Score:3.79|P-value:8.15E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:4.16|P-value:2.65E-4 ID:SGTC_912|Compound:3474-0017|FD-Score:-3.94|P-value:3.17E-4 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:-3.92|P-value:3.38E-4 ID:SGTC_917|Compound:harmaline|FD-Score:-7.38|P-value:1.12E-10 ID:SGTC_927|Compound:2425-1185|FD-Score:4.77|P-value:3.41E-5 ID:SGTC_936|Compound:3005-4620|FD-Score:3.85|P-value:6.70E-4 ID:SGTC_984|Compound:1492-0255|FD-Score:-3.60|P-value:8.66E-4 ID:SGTC_1178|Compound:0988-0033|FD-Score:4.85|P-value:2.54E-5 ID:SGTC_1193|Compound:1488-0126|FD-Score:4.18|P-value:2.46E-4 ID:SGTC_1362|Compound:1611-0397|FD-Score:-4.57|P-value:3.90E-5 ID:SGTC_1450|Compound:4112-4260|FD-Score:4.05|P-value:3.71E-4 ID:SGTC_1503|Compound:4585-0012|FD-Score:3.81|P-value:7.65E-4 ID:SGTC_1547|Compound:harmine|FD-Score:-3.57|P-value:9.62E-4 ID:SGTC_1639|Compound:Lupinine o-methylbenzoicacid ester hydrochloride|FD-Score:-3.90|P-value:3.55E-4 ID:SGTC_1646|Compound:st011709|FD-Score:3.74|P-value:9.35E-4 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:-4.38|P-value:7.40E-5 ID:SGTC_1687|Compound:st020778|FD-Score:4.20|P-value:2.28E-4 ID:SGTC_1743|Compound:st037606|FD-Score:4.08|P-value:3.41E-4 ID:SGTC_1748|Compound:st037455|FD-Score:-3.96|P-value:2.93E-4 ID:SGTC_1750|Compound:st081859|FD-Score:-5.02|P-value:7.26E-6 ID:SGTC_1888|Compound:azatryptophan|FD-Score:-3.82|P-value:4.58E-4 ID:SGTC_1908|Compound:st060353|FD-Score:4.79|P-value:3.16E-5 ID:SGTC_1909|Compound:st060837|FD-Score:-4.02|P-value:2.43E-4 ID:SGTC_1933|Compound:st074711|FD-Score:-4.44|P-value:6.16E-5 ID:SGTC_1934|Compound:st074720|FD-Score:-4.68|P-value:2.60E-5 ID:SGTC_1939|Compound:st074455|FD-Score:4.62|P-value:5.70E-5 ID:SGTC_1953|Compound:st076800|FD-Score:4.65|P-value:5.13E-5 ID:SGTC_2013|Compound:4024628|FD-Score:4.18|P-value:2.48E-4 ID:SGTC_2359|Compound:9039622|FD-Score:-4.01|P-value:2.53E-4 ID:SGTC_2479|Compound:5617353|FD-Score:-3.64|P-value:7.90E-4 ID:SGTC_2568|Compound:diosmetin|FD-Score:4.91|P-value:2.00E-5 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:-5.10|P-value:5.35E-6 ID:SGTC_2698|Compound:st077697|FD-Score:-3.87|P-value:3.93E-4 ID:SGTC_2737|Compound:bleomycin|FD-Score:5.15|P-value:8.05E-6 ID:SGTC_2838|Compound:9002687|FD-Score:-4.23|P-value:1.22E-4 ID:SGTC_2841|Compound:9004761|FD-Score:-4.01|P-value:2.52E-4 ID:SGTC_3063|Compound:1327-0034|FD-Score:-4.62|P-value:3.18E-5 ID:SGTC_3133|Compound:9127736|FD-Score:4.12|P-value:2.99E-4 ID:SGTC_3314|Compound:9135860|FD-Score:-3.60|P-value:8.64E-4 ID:SGTC_3347|Compound:9188721|FD-Score:-3.99|P-value:2.70E-4 ID:SGTC_3353|Compound:9151644|FD-Score:-4.28|P-value:1.05E-4 ID:SGTC_4|Compound:0960-0234|FD-Score:4.90|P-value:2.13E-5 ID:SGTC_12|Compound:0849-0099|FD-Score:-3.97|P-value:2.87E-4 ID:SGTC_22|Compound:0964-0034|FD-Score:5.18|P-value:7.35E-6 ID:SGTC_31|Compound:0508-1974|FD-Score:4.11|P-value:3.12E-4 ID:SGTC_143|Compound:4032-1194|FD-Score:4.11|P-value:3.08E-4 ID:SGTC_223|Compound:busulfan|FD-Score:4.10|P-value:3.15E-4 ID:SGTC_227|Compound:fluconazole|FD-Score:3.83|P-value:7.19E-4 ID:SGTC_391|Compound:gliotoxin|FD-Score:3.95|P-value:5.00E-4 ID:SGTC_426|Compound:0988-0037|FD-Score:5.04|P-value:1.26E-5 ID:SGTC_431|Compound:k089-0097|FD-Score:-5.35|P-value:1.96E-6 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-4.88|P-value:1.21E-5 ID:SGTC_500|Compound:h-89|FD-Score:3.93|P-value:5.29E-4 ID:SGTC_557|Compound:1315-0110|FD-Score:4.21|P-value:2.24E-4 ID:SGTC_582|Compound:0987-0078|FD-Score:3.97|P-value:4.73E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:4.80|P-value:2.99E-5 ID:SGTC_662|Compound:k832-1615|FD-Score:5.14|P-value:8.68E-6 ID:SGTC_682|Compound:0kpi-0099|FD-Score:-4.10|P-value:1.87E-4 ID:SGTC_736|Compound:0958-0254|FD-Score:3.79|P-value:8.15E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:4.16|P-value:2.65E-4 ID:SGTC_912|Compound:3474-0017|FD-Score:-3.94|P-value:3.17E-4 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:-3.92|P-value:3.38E-4 ID:SGTC_917|Compound:harmaline|FD-Score:-7.38|P-value:1.12E-10 ID:SGTC_927|Compound:2425-1185|FD-Score:4.77|P-value:3.41E-5 ID:SGTC_936|Compound:3005-4620|FD-Score:3.85|P-value:6.70E-4 ID:SGTC_984|Compound:1492-0255|FD-Score:-3.60|P-value:8.66E-4 ID:SGTC_1178|Compound:0988-0033|FD-Score:4.85|P-value:2.54E-5 ID:SGTC_1193|Compound:1488-0126|FD-Score:4.18|P-value:2.46E-4 ID:SGTC_1362|Compound:1611-0397|FD-Score:-4.57|P-value:3.90E-5 ID:SGTC_1450|Compound:4112-4260|FD-Score:4.05|P-value:3.71E-4 ID:SGTC_1503|Compound:4585-0012|FD-Score:3.81|P-value:7.65E-4 ID:SGTC_1547|Compound:harmine|FD-Score:-3.57|P-value:9.62E-4 ID:SGTC_1639|Compound:Lupinine o-methylbenzoicacid ester hydrochloride|FD-Score:-3.90|P-value:3.55E-4 ID:SGTC_1646|Compound:st011709|FD-Score:3.74|P-value:9.35E-4 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:-4.38|P-value:7.40E-5 ID:SGTC_1687|Compound:st020778|FD-Score:4.20|P-value:2.28E-4 ID:SGTC_1743|Compound:st037606|FD-Score:4.08|P-value:3.41E-4 ID:SGTC_1748|Compound:st037455|FD-Score:-3.96|P-value:2.93E-4 ID:SGTC_1750|Compound:st081859|FD-Score:-5.02|P-value:7.26E-6 ID:SGTC_1888|Compound:azatryptophan|FD-Score:-3.82|P-value:4.58E-4 ID:SGTC_1908|Compound:st060353|FD-Score:4.79|P-value:3.16E-5 ID:SGTC_1909|Compound:st060837|FD-Score:-4.02|P-value:2.43E-4 ID:SGTC_1933|Compound:st074711|FD-Score:-4.44|P-value:6.16E-5 ID:SGTC_1934|Compound:st074720|FD-Score:-4.68|P-value:2.60E-5 ID:SGTC_1939|Compound:st074455|FD-Score:4.62|P-value:5.70E-5 ID:SGTC_1953|Compound:st076800|FD-Score:4.65|P-value:5.13E-5 ID:SGTC_2013|Compound:4024628|FD-Score:4.18|P-value:2.48E-4 ID:SGTC_2359|Compound:9039622|FD-Score:-4.01|P-value:2.53E-4 ID:SGTC_2479|Compound:5617353|FD-Score:-3.64|P-value:7.90E-4 ID:SGTC_2568|Compound:diosmetin|FD-Score:4.91|P-value:2.00E-5 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:-5.10|P-value:5.35E-6 ID:SGTC_2698|Compound:st077697|FD-Score:-3.87|P-value:3.93E-4 ID:SGTC_2737|Compound:bleomycin|FD-Score:5.15|P-value:8.05E-6 ID:SGTC_2838|Compound:9002687|FD-Score:-4.23|P-value:1.22E-4 ID:SGTC_2841|Compound:9004761|FD-Score:-4.01|P-value:2.52E-4 ID:SGTC_3063|Compound:1327-0034|FD-Score:-4.62|P-value:3.18E-5 ID:SGTC_3133|Compound:9127736|FD-Score:4.12|P-value:2.99E-4 ID:SGTC_3314|Compound:9135860|FD-Score:-3.60|P-value:8.64E-4 ID:SGTC_3347|Compound:9188721|FD-Score:-3.99|P-value:2.70E-4 ID:SGTC_3353|Compound:9151644|FD-Score:-4.28|P-value:1.05E-4

Top fitness defect scores for YGL223C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_22 0964-0034 5.18 14.5 µM 7.35E-6 unfolded protein response 27 1.12E-7
2 SGTC_2737 bleomycin 5.15 30.5 nM 8.05E-6 Golgi 45 1.27E-7
3 SGTC_662 k832-1615 5.14 104.0 µM 8.68E-6 5 1.41E-7
4 SGTC_426 0988-0037 5.04 14.6 µM 1.26E-5 ERAD & cell cycle 17 2.37E-7
5 SGTC_2568 diosmetin 4.91 100.0 µM 2.00E-5 10 4.48E-7
6 SGTC_4 0960-0234 4.90 25.7 µM 2.13E-5 Golgi 5 4.89E-7
7 SGTC_1178 0988-0033 4.85 191.0 µM 2.54E-5 16 6.24E-7
8 SGTC_625 k213-0058 4.80 121.0 µM 2.99E-5 translation 63 7.81E-7
9 SGTC_1908 st060353 4.79 56.5 µM 3.16E-5 RPP1 & pyrimidine depletion 23 8.46E-7
10 SGTC_927 2425-1185 4.77 123.0 µM 3.41E-5 11 9.41E-7
11 SGTC_1953 st076800 4.65 12.1 µM 5.13E-5 32 1.66E-6
12 SGTC_1939 st074455 4.62 53.6 µM 5.70E-5 16 1.91E-6
13 SGTC_557 1315-0110 4.21 16.2 µM 2.24E-4 Golgi 18 1.27E-5
14 SGTC_1687 st020778 4.20 55.4 µM 2.28E-4 160 1.31E-5
15 SGTC_1193 1488-0126 4.18 41.5 µM 2.46E-4 21 1.45E-5
16 SGTC_2013 4024628 4.18 200.0 µM 2.48E-4 36 1.47E-5
17 SGTC_908 3448-7491 4.16 47.7 µM 2.65E-4 mitochondrial stress 113 1.61E-5
18 SGTC_3133 9127736 4.12 49.5 µM 2.99E-4 14 1.90E-5
19 SGTC_143 4032-1194 4.11 15.7 µM 3.08E-4 59 1.98E-5
20 SGTC_31 0508-1974 4.11 57.2 µM 3.12E-4 24 2.01E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.215 2.25E-36 YLR262C YPT6 hom Rab family GTPase, Ras-like GTP binding protein involved in the secretory pathway, required for fusion of endosome-derived vesicles with the late Golgi, maturation of the vacuolar carboxypeptidase Y; has similarity to the human GTPase, Rab6
0.203 1.56E-32 YDR137W RGP1 hom Subunit of a Golgi membrane exchange factor (Ric1p-Rgp1p) that catalyzes nucleotide exchange on Ypt6p
0.197 1.17E-30 YDR136C_d VPS61_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 4% of ORF overlaps the verified gene RGP1; deletion causes a vacuolar protein sorting defect
0.176 1.38E-24 YNL041C COG6 hom Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
0.174 2.87E-24 YLR261C_d VPS63_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene YPT6; deletion causes a vacuolar protein sorting defect
0.167 2.48E-22 YLR039C RIC1 hom Protein involved in retrograde transport to the cis-Golgi network; forms heterodimer with Rgp1p that acts as a GTP exchange factor for Ypt6p; involved in transcription of rRNA and ribosomal protein genes
0.151 1.78E-18 YGL005C COG7 hom Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
0.145 3.17E-17 YDR320C SWA2 hom Auxilin-like protein involved in vesicular transport; clathrin-binding protein required for uncoating of clathrin-coated vesicles
0.143 9.40E-17 YNL051W COG5 hom Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
0.135 3.81E-15 YDL192W ARF1 hom ADP-ribosylation factor; GTPase of the Ras superfamily involved in regulation of coated vesicle formation in intracellular trafficking within the Golgi; ARF1 has a paralog, ARF2, that arose from the whole genome duplication
0.119 5.72E-12 YKR019C IRS4 hom EH domain-containing protein; involved in regulating phosphatidylinositol 4,5-bisphosphate levels and autophagy; Irs4p and Tax4p bind and activate the PtdIns phosphatase Inp51p; Irs4p and Tax4p are involved in localizing Atg17p to the PAS; IRS4 has a paralog, TAX4, that arose from the whole genome duplication
0.116 1.58E-11 YGR167W CLC1 hom Clathrin light chain; subunit of the major coat protein involved in intracellular protein transport and endocytosis; thought to regulate clathrin function; two Clathrin heavy chains (CHC1) form the clathrin triskelion structural component; YGR167W
0.115 2.35E-11 YKR020W VPS51 hom Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; links the (VFT/GARP) complex to the SNARE Tlg1p
0.111 1.34E-10 YML071C COG8 hom Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
0.110 2.18E-10 YJL004C SYS1 hom Integral membrane protein of the Golgi required for targeting of the Arf-like GTPase Arl3p to the Golgi; multicopy suppressor of ypt6 null mutation